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Compile Data Set for Download or QSAR

Found 71 hits with Last Name = 'zhi' and Initial = 'j'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sulfotransferase 1E1


(Bos taurus)		BDBM50404964
PNG
(CHEMBL2367720)
Show SMILES [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(OP(O)(=O)OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4OP(O)(O)=O)n4c(Br)nc5c(N)ncnc45)cc3CC[C@@]21[H]
Show InChI InChI=1S/C28H35BrN5O14P3/c1-28-9-8-16-15-5-3-14(10-13(15)2-4-17(16)18(28)6-7-20(28)35)46-51(42,43)48-50(40,41)44-11-19-23(47-49(37,38)39)22(36)26(45-19)34-25-21(33-27(34)29)24(30)31-12-32-25/h3,5,10,12,16-19,22-23,26,36H,2,4,6-9,11H2,1H3,(H,40,41)(H,42,43)(H2,30,31,32)(H2,37,38,39)/t16-,17-,18+,19-,22-,23-,26-,28+/m1/s1
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 250n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50028411
PNG
(3-Methoxy-13-methyl-4-nitro-6,7,8,9,11,12,13,14,15...)
Show SMILES COc1ccc2[C@H]3CC[C@@]4(C)[C@@H](CCC4=O)[C@@H]3CCc2c1[N+]([O-])=O
Show InChI InChI=1S/C19H23NO4/c1-19-10-9-12-11-5-7-16(24-2)18(20(22)23)14(11)4-3-13(12)15(19)6-8-17(19)21/h5,7,12-13,15H,3-4,6,8-10H2,1-2H3/t12-,13-,15+,19+/m1/s1
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 4.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50367130
PNG
(CHEMBL1628097)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4c3ccc(OCCOC[C@H]3OC([C@H](O)[C@@H]3O)n3cnc5c(N)ncnc35)c4[N+]([O-])=O)[C@@H]1CCC2=O |r|
Show InChI InChI=1S/C30H36N6O8/c1-30-9-8-16-15-4-6-20(24(36(40)41)18(15)3-2-17(16)19(30)5-7-22(30)37)43-11-10-42-12-21-25(38)26(39)29(44-21)35-14-34-23-27(31)32-13-33-28(23)35/h4,6,13-14,16-17,19,21,25-26,29,38-39H,2-3,5,7-12H2,1H3,(H2,31,32,33)/t16-,17-,19+,21-,25-,26-,29?,30+/m1/s1
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 3.20E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50367129
PNG
(CHEMBL1628095)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4c3ccc(OCCCOC[C@H]3OC([C@H](O)[C@@H]3O)n3cnc5c(N)ncnc35)c4[N+]([O-])=O)[C@@H]1CCC2=O |r|
Show InChI InChI=1S/C31H38N6O8/c1-31-10-9-17-16-5-7-21(25(37(41)42)19(16)4-3-18(17)20(31)6-8-23(31)38)44-12-2-11-43-13-22-26(39)27(40)30(45-22)36-15-35-24-28(32)33-14-34-29(24)36/h5,7,14-15,17-18,20,22,26-27,30,39-40H,2-4,6,8-13H2,1H3,(H2,32,33,34)/t17-,18-,20+,22-,26-,27-,30?,31+/m1/s1
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 8.40E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50404963
PNG
(CHEMBL2067995)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4c3ccc(OCCCCn3cnc5c(N)ncnc35)c4[N+]([O-])=O)[C@@H]1CCC2=O |r|
Show InChI InChI=1S/C27H32N6O4/c1-27-11-10-17-16-6-8-21(24(33(35)36)19(16)5-4-18(17)20(27)7-9-22(27)34)37-13-3-2-12-32-15-31-23-25(28)29-14-30-26(23)32/h6,8,14-15,17-18,20H,2-5,7,9-13H2,1H3,(H2,28,29,30)/t17-,18-,20+,27+/m1/s1
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 1.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50367131
PNG
(CHEMBL1628164)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4c3ccc(OCCCn3cnc5c(N)ncnc35)c4[N+]([O-])=O)[C@@H]1CCC2=O |r|
Show InChI InChI=1S/C26H30N6O4/c1-26-10-9-16-15-5-7-20(36-12-2-11-31-14-30-22-24(27)28-13-29-25(22)31)23(32(34)35)18(15)4-3-17(16)19(26)6-8-21(26)33/h5,7,13-14,16-17,19H,2-4,6,8-12H2,1H3,(H2,27,28,29)/t16-,17-,19+,26+/m1/s1
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 3.50E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50404965
PNG
(CHEMBL2067994)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4c3ccc(OCCn3cnc5c(N)ncnc35)c4[N+]([O-])=O)[C@@H]1CCC2=O |r|
Show InChI InChI=1S/C25H28N6O4/c1-25-9-8-15-14-4-6-19(35-11-10-30-13-29-21-23(26)27-12-28-24(21)30)22(31(33)34)17(14)3-2-16(15)18(25)5-7-20(25)32/h4,6,12-13,15-16,18H,2-3,5,7-11H2,1H3,(H2,26,27,28)/t15-,16-,18+,25+/m1/s1
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 1.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Sulfotransferase 1E1


(Bos taurus)		BDBM50404966
PNG
(CHEMBL2067996)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(OCCCn5cnc6c(N)ncnc56)ccc34)[C@@H]1CCC2=O |r|
Show InChI InChI=1S/C26H31N5O2/c1-26-10-9-19-18-6-4-17(13-16(18)3-5-20(19)21(26)7-8-22(26)32)33-12-2-11-31-15-30-23-24(27)28-14-29-25(23)31/h4,6,13-15,19-21H,2-3,5,7-12H2,1H3,(H2,27,28,29)/t19-,20-,21+,26+/m1/s1
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 1.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine estrogen sulfotransferase by the compound

J Med Chem 26: 162-6 (1983)


BindingDB Entry DOI: 10.7270/Q22F7P13
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251300
PNG
(CHEMBL4066684)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H17F2N5O3/c1-14-12-22(33)32(17-5-2-15(26)3-6-17)31-23(14)25(34)30-16-4-7-21(19(27)13-16)35-20-9-11-29-24-18(20)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 1.10n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50251300
PNG
(CHEMBL4066684)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H17F2N5O3/c1-14-12-22(33)32(17-5-2-15(26)3-6-17)31-23(14)25(34)30-16-4-7-21(19(27)13-16)35-20-9-11-29-24-18(20)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 1.30n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of Flt-3 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 2.10n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50251300
PNG
(CHEMBL4066684)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H17F2N5O3/c1-14-12-22(33)32(17-5-2-15(26)3-6-17)31-23(14)25(34)30-16-4-7-21(19(27)13-16)35-20-9-11-29-24-18(20)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 3.30n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251333
PNG
(CHEMBL4093275)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccccc1F
Show InChI InChI=1S/C25H17F2N5O3/c1-14-12-22(33)32(19-5-3-2-4-17(19)26)31-23(14)25(34)30-15-6-7-21(18(27)13-15)35-20-9-11-29-24-16(20)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 5n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251304
PNG
(CHEMBL4087981)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1cccc(F)c1
Show InChI InChI=1S/C25H17F2N5O3/c1-14-11-22(33)32(17-4-2-3-15(26)12-17)31-23(14)25(34)30-16-5-6-21(19(27)13-16)35-20-8-10-29-24-18(20)7-9-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 5.60n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251311
PNG
(CHEMBL4104755)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H18FN5O3/c1-15-14-22(32)31(18-6-2-16(26)3-7-18)30-23(15)25(33)29-17-4-8-19(9-5-17)34-21-11-13-28-24-20(21)10-12-27-24/h2-14H,1H3,(H,27,28)(H,29,33)
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n/an/a 8.40n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251293
PNG
(CHEMBL4068286)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H20FN5O3/c1-16-15-23(33)32(19-7-3-17(27)4-8-19)30-24(16)26(34)29-18-5-9-20(10-6-18)35-22-11-13-28-25-21(22)12-14-31(25)2/h3-15H,1-2H3,(H,29,34)
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n/an/a 9.20n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251303
PNG
(CHEMBL4078189)
Show SMILES Cc1ccccc1-n1nc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(C)cc1=O
Show InChI InChI=1S/C26H20FN5O3/c1-15-5-3-4-6-20(15)32-23(33)13-16(2)24(31-32)26(34)30-17-7-8-22(19(27)14-17)35-21-10-12-29-25-18(21)9-11-28-25/h3-14H,1-2H3,(H,28,29)(H,30,34)
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n/an/a 10n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251324
PNG
(CHEMBL4089464)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1cccc(Br)c1
Show InChI InChI=1S/C26H20BrN5O3/c1-16-14-23(33)32(19-5-3-4-17(27)15-19)30-24(16)26(34)29-18-6-8-20(9-7-18)35-22-10-12-28-25-21(22)11-13-31(25)2/h3-15H,1-2H3,(H,29,34)
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n/an/a 10n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251332
PNG
(CHEMBL4102463)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H17F4N5O3/c1-14-12-22(36)35(19-5-3-2-4-17(19)26(28,29)30)34-23(14)25(37)33-15-6-7-21(18(27)13-15)38-20-9-11-32-24-16(20)8-10-31-24/h2-13H,1H3,(H,31,32)(H,33,37)
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n/an/a 11n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251312
PNG
(CHEMBL4066710)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1cccc(F)c1
Show InChI InChI=1S/C25H18FN5O3/c1-15-13-22(32)31(18-4-2-3-16(26)14-18)30-23(15)25(33)29-17-5-7-19(8-6-17)34-21-10-12-28-24-20(21)9-11-27-24/h2-14H,1H3,(H,27,28)(H,29,33)
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n/an/a 12n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251337
PNG
(CHEMBL4062107)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccccc1F
Show InChI InChI=1S/C25H18FN5O3/c1-15-14-22(32)31(20-5-3-2-4-19(20)26)30-23(15)25(33)29-16-6-8-17(9-7-16)34-21-11-13-28-24-18(21)10-12-27-24/h2-14H,1H3,(H,27,28)(H,29,33)
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n/an/a 13n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251299
PNG
(CHEMBL4079155)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccccc1F
Show InChI InChI=1S/C26H20FN5O3/c1-16-15-23(33)32(21-6-4-3-5-20(21)27)30-24(16)26(34)29-17-7-9-18(10-8-17)35-22-11-13-28-25-19(22)12-14-31(25)2/h3-15H,1-2H3,(H,29,34)
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n/an/a 14n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251294
PNG
(CHEMBL4097171)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1cccc(F)c1
Show InChI InChI=1S/C26H20FN5O3/c1-16-14-23(33)32(19-5-3-4-17(27)15-19)30-24(16)26(34)29-18-6-8-20(9-7-18)35-22-10-12-28-25-21(22)11-13-31(25)2/h3-15H,1-2H3,(H,29,34)
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n/an/a 15n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251326
PNG
(CHEMBL4087017)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccc(Br)cc1F
Show InChI InChI=1S/C25H16BrF2N5O3/c1-13-10-22(34)33(19-4-2-14(26)11-17(19)27)32-23(13)25(35)31-15-3-5-21(18(28)12-15)36-20-7-9-30-24-16(20)6-8-29-24/h2-12H,1H3,(H,29,30)(H,31,35)
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n/an/a 18n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251302
PNG
(CHEMBL4094711)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(C)cc1=O
Show InChI InChI=1S/C26H20FN5O4/c1-15-13-23(33)32(17-4-6-18(35-2)7-5-17)31-24(15)26(34)30-16-3-8-22(20(27)14-16)36-21-10-12-29-25-19(21)9-11-28-25/h3-14H,1-2H3,(H,28,29)(H,30,34)
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n/an/a 18n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251313
PNG
(CHEMBL4075470)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccccc1
Show InChI InChI=1S/C25H19N5O3/c1-16-15-22(31)30(18-5-3-2-4-6-18)29-23(16)25(32)28-17-7-9-19(10-8-17)33-21-12-14-27-24-20(21)11-13-26-24/h2-15H,1H3,(H,26,27)(H,28,32)
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n/an/a 18n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251309
PNG
(CHEMBL4101008)
Show SMILES Cc1ccccc1-n1nc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c(C)cc1=O
Show InChI InChI=1S/C26H21N5O3/c1-16-5-3-4-6-21(16)31-23(32)15-17(2)24(30-31)26(33)29-18-7-9-19(10-8-18)34-22-12-14-28-25-20(22)11-13-27-25/h3-15H,1-2H3,(H,27,28)(H,29,33)
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n/an/a 19n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 19n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition by mobility shift...

Eur J Med Chem 141: 538-551 (2017)


Article DOI: 10.1016/j.ejmech.2017.10.027
BindingDB Entry DOI: 10.7270/Q2V98BMQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251325
PNG
(CHEMBL4104881)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccccc1
Show InChI InChI=1S/C26H21N5O3/c1-17-16-23(32)31(19-6-4-3-5-7-19)29-24(17)26(33)28-18-8-10-20(11-9-18)34-22-12-14-27-25-21(22)13-15-30(25)2/h3-16H,1-2H3,(H,28,33)
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n/an/a 20n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251301
PNG
(CHEMBL4067260)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H16Cl2FN5O3/c1-13-10-22(34)33(19-4-2-14(26)11-17(19)27)32-23(13)25(35)31-15-3-5-21(18(28)12-15)36-20-7-9-30-24-16(20)6-8-29-24/h2-12H,1H3,(H,29,30)(H,31,35)
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n/an/a 22n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251322
PNG
(CHEMBL4076617)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)c(F)c1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H19F4N5O3/c1-15-12-23(37)36(18-5-3-4-16(13-18)27(29,30)31)34-24(15)26(38)33-17-6-7-22(20(28)14-17)39-21-8-10-32-25-19(21)9-11-35(25)2/h3-14H,1-2H3,(H,33,38)
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n/an/a 29n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251291
PNG
(CHEMBL4088695)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H20F3N5O3/c1-16-14-23(36)35(19-5-3-4-17(15-19)27(28,29)30)33-24(16)26(37)32-18-6-8-20(9-7-18)38-22-10-12-31-25-21(22)11-13-34(25)2/h3-15H,1-2H3,(H,32,37)
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n/an/a 32n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251334
PNG
(CHEMBL4062885)
Show SMILES Cc1ccc(C)c(c1)-n1nc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c(C)cc1=O
Show InChI InChI=1S/C27H23N5O3/c1-16-4-5-17(2)22(14-16)32-24(33)15-18(3)25(31-32)27(34)30-19-6-8-20(9-7-19)35-23-11-13-29-26-21(23)10-12-28-26/h4-15H,1-3H3,(H,28,29)(H,30,34)
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n/an/a 34n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251310
PNG
(CHEMBL4074260)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H18F3N5O3/c1-15-13-22(35)34(18-4-2-3-16(14-18)26(27,28)29)33-23(15)25(36)32-17-5-7-19(8-6-17)37-21-10-12-31-24-20(21)9-11-30-24/h2-14H,1H3,(H,30,31)(H,32,36)
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n/an/a 35n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251315
PNG
(CHEMBL4097410)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccc(Br)cc1F
Show InChI InChI=1S/C26H19BrFN5O3/c1-15-13-23(34)33(21-8-3-16(27)14-20(21)28)31-24(15)26(35)30-17-4-6-18(7-5-17)36-22-9-11-29-25-19(22)10-12-32(25)2/h3-14H,1-2H3,(H,30,35)
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n/an/a 36n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251335
PNG
(CHEMBL4080532)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H18F3N5O3/c1-15-14-22(35)34(20-5-3-2-4-19(20)26(27,28)29)33-23(15)25(36)32-16-6-8-17(9-7-16)37-21-11-13-31-24-18(21)10-12-30-24/h2-14H,1H3,(H,30,31)(H,32,36)
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n/an/a 40n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251317
PNG
(CHEMBL4061741)
Show SMILES Cc1ccc(C)c(c1)-n1nc(C(=O)Nc2ccc(Oc3ccnc4n(C)ccc34)cc2)c(C)cc1=O
Show InChI InChI=1S/C28H25N5O3/c1-17-5-6-18(2)23(15-17)33-25(34)16-19(3)26(31-33)28(35)30-20-7-9-21(10-8-20)36-24-11-13-29-27-22(24)12-14-32(27)4/h5-16H,1-4H3,(H,30,35)
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n/an/a 41n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251305
PNG
(CHEMBL4065638)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccc(Br)cc1F
Show InChI InChI=1S/C25H17BrFN5O3/c1-14-12-22(33)32(20-7-2-15(26)13-19(20)27)31-23(14)25(34)30-16-3-5-17(6-4-16)35-21-9-11-29-24-18(21)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 41n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251306
PNG
(CHEMBL4085528)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C25H17ClFN5O3/c1-14-12-22(33)32(16-4-7-20(27)19(26)13-16)31-23(14)25(34)30-15-2-5-17(6-3-15)35-21-9-11-29-24-18(21)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 42n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251316
PNG
(CHEMBL4078622)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H19ClFN5O3/c1-15-13-23(34)33(17-5-8-21(28)20(27)14-17)31-24(15)26(35)30-16-3-6-18(7-4-16)36-22-9-11-29-25-19(22)10-12-32(25)2/h3-14H,1-2H3,(H,30,35)
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n/an/a 45n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251292
PNG
(CHEMBL4066651)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H20F3N5O3/c1-16-15-23(36)35(21-6-4-3-5-20(21)27(28,29)30)33-24(16)26(37)32-17-7-9-18(10-8-17)38-22-11-13-31-25-19(22)12-14-34(25)2/h3-15H,1-2H3,(H,32,37)
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n/an/a 46n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251308
PNG
(CHEMBL4084557)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c(C)cc1=O
Show InChI InChI=1S/C26H21N5O4/c1-16-15-23(32)31(18-5-9-19(34-2)10-6-18)30-24(16)26(33)29-17-3-7-20(8-4-17)35-22-12-14-28-25-21(22)11-13-27-25/h3-15H,1-2H3,(H,27,28)(H,29,33)
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n/an/a 47n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251323
PNG
(CHEMBL4091384)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3n(C)ccc23)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H19Cl2N5O3/c1-15-13-23(34)33(21-8-3-16(27)14-20(21)28)31-24(15)26(35)30-17-4-6-18(7-5-17)36-22-9-11-29-25-19(22)10-12-32(25)2/h3-14H,1-2H3,(H,30,35)
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n/an/a 49n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50251307
PNG
(CHEMBL4103455)
Show SMILES Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H17Cl2N5O3/c1-14-12-22(33)32(20-7-2-15(26)13-19(20)27)31-23(14)25(34)30-16-3-5-17(6-4-16)35-21-9-11-29-24-18(21)8-10-28-24/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 56n/an/an/an/an/an/a



School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China. Electronic address: tangqidongcn@126.com.

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Eur J Med Chem 133: 97-106 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.045
BindingDB Entry DOI: 10.7270/Q2K35X3B
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay

Bioorg Med Chem 25: 5754-5763 (2017)


Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50283690
PNG
(CHEMBL4165199)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-n1ccc(=O)c(n1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C25H15ClF3N5O3/c26-19-6-3-15(13-18(19)25(27,28)29)34-12-9-20(35)22(33-34)24(36)32-14-1-4-16(5-2-14)37-21-8-11-31-23-17(21)7-10-30-23/h1-13H,(H,30,31)(H,32,36)
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n/an/a 73n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition by mobility shift...

Eur J Med Chem 141: 538-551 (2017)


Article DOI: 10.1016/j.ejmech.2017.10.027
BindingDB Entry DOI: 10.7270/Q2V98BMQ
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 120n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of CRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay

Bioorg Med Chem 25: 5754-5763 (2017)


Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 170n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay

Bioorg Med Chem 25: 5754-5763 (2017)


Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50283693
PNG
(CHEMBL4169694)
Show SMILES Fc1cc(ccc1Cl)-n1ccc(=O)c(n1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C24H15ClFN5O3/c25-18-6-3-15(13-19(18)26)31-12-9-20(32)22(30-31)24(33)29-14-1-4-16(5-2-14)34-21-8-11-28-23-17(21)7-10-27-23/h1-13H,(H,27,28)(H,29,33)
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n/an/a 170n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition by mobility shift...

Eur J Med Chem 141: 538-551 (2017)


Article DOI: 10.1016/j.ejmech.2017.10.027
BindingDB Entry DOI: 10.7270/Q2V98BMQ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 310n/an/an/an/an/an/a



Jiangxi Science & Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of BRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assay

Bioorg Med Chem 25: 5754-5763 (2017)


Article DOI: 10.1016/j.bmc.2017.09.003
BindingDB Entry DOI: 10.7270/Q2057JGW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
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