Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-lactamase (Escherichia coli) | BDBM50274047 (CHEMBL3613796) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UCL School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of Escherichia coli AmpC using CENTA as substrate by spectrometry based Lineweaver-Burk plot analysis | Bioorg Med Chem 26: 2921-2927 (2018) Article DOI: 10.1016/j.bmc.2018.04.055 BindingDB Entry DOI: 10.7270/Q25T3P0V | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase 1 (Bacillus cereus) | BDBM50450973 (CHEMBL4209255) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Santiago de Compostela Curated by ChEMBL | Assay Description Inhibition of Bacillus cereus beta-lactamase AmpC using CENTA as substrate up to 30 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 4221-4228 (2017) Article DOI: 10.1016/j.bmcl.2017.08.027 BindingDB Entry DOI: 10.7270/Q2N0193Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase 1 (Bacillus cereus) | BDBM50450974 (CHEMBL4206040) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Santiago de Compostela Curated by ChEMBL | Assay Description Inhibition of Bacillus cereus beta-lactamase AmpC using CENTA as substrate up to 30 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 4221-4228 (2017) Article DOI: 10.1016/j.bmcl.2017.08.027 BindingDB Entry DOI: 10.7270/Q2N0193Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
OXA23 carbapenemase (Acinetobacter baumannii) | BDBM50541448 (CHEMBL4633785) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Qpex Biopharma, Inc. Curated by ChEMBL | Assay Description Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ... | J Med Chem 63: 7491-7507 (2020) Article DOI: 10.1021/acs.jmedchem.9b01976 BindingDB Entry DOI: 10.7270/Q2377D7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase 1 (Bacillus cereus) | BDBM50450969 (CHEMBL4217629) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Santiago de Compostela Curated by ChEMBL | Assay Description Inhibition of Bacillus cereus beta-lactamase AmpC using CENTA as substrate up to 30 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 4221-4228 (2017) Article DOI: 10.1016/j.bmcl.2017.08.027 BindingDB Entry DOI: 10.7270/Q2N0193Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase 1 (Bacillus cereus) | BDBM50450975 (CHEMBL4204887) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Santiago de Compostela Curated by ChEMBL | Assay Description Inhibition of Bacillus cereus beta-lactamase AmpC using CENTA as substrate up to 30 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 4221-4228 (2017) Article DOI: 10.1016/j.bmcl.2017.08.027 BindingDB Entry DOI: 10.7270/Q2N0193Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase L1 type 3 (Stenotrophomonas maltophilia) | BDBM50191983 (3-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamase | Bioorg Med Chem Lett 16: 5169-75 (2006) Article DOI: 10.1016/j.bmcl.2006.07.001 BindingDB Entry DOI: 10.7270/Q2WQ03DJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase L1 type 3 (Stenotrophomonas maltophilia) | BDBM50191983 (3-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamase | Bioorg Med Chem Lett 16: 5169-75 (2006) Article DOI: 10.1016/j.bmcl.2006.07.001 BindingDB Entry DOI: 10.7270/Q2WQ03DJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Acinetobacter baumannii) | BDBM50240480 ((2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-...) | PDB UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Activity of Acinetobacter baumannii ADC-33 beta-lactamase | Antimicrob Agents Chemother 54: 3484-8 (2010) Article DOI: 10.1128/AAC.00050-10 BindingDB Entry DOI: 10.7270/Q2348KM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VIM-1 metallo-beta-lactamase (Klebsiella pneumoniae) | BDBM50541448 (CHEMBL4633785) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Qpex Biopharma, Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every... | J Med Chem 63: 7491-7507 (2020) Article DOI: 10.1021/acs.jmedchem.9b01976 BindingDB Entry DOI: 10.7270/Q2377D7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225373 (CHEMBL396872 | pinacol 5-[(3,4-dichlorophenylamino...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase L1 type 3 (Stenotrophomonas maltophilia) | BDBM50191986 ((2R)-2-(2-(5-fluoro-1H-indole-2-carboxamido)-4-mer...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamase | Bioorg Med Chem Lett 16: 5169-75 (2006) Article DOI: 10.1016/j.bmcl.2006.07.001 BindingDB Entry DOI: 10.7270/Q2WQ03DJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase VIM-2 (Pseudomonas aeruginosa (g-Proteobacteria)) | BDBM580196 (US11491146, Compound 3) | PDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To identify potential MBL inhibitors, the relative change in the formation of hydrolyzed nitrocefin between treated and untreated VIM2 was determined... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7TB3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50115618 (2-[(2-Amino-thiazol-4-yl)-(dihydroxyboranylmethyl-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Binding affinity of the compound towards AmpC beta-lactamase binding site from Escherichia coli | J Med Chem 45: 3222-34 (2002) BindingDB Entry DOI: 10.7270/Q2CN737M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50339869 (5-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin as substrate after 30 mins by spectrophotometric analysis | Bioorg Med Chem Lett 21: 2533-6 (2011) Article DOI: 10.1016/j.bmcl.2011.02.024 BindingDB Entry DOI: 10.7270/Q2G44QK5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50339868 (4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin as substrate after 30 mins by spectrophotometric analysis | Bioorg Med Chem Lett 21: 2533-6 (2011) Article DOI: 10.1016/j.bmcl.2011.02.024 BindingDB Entry DOI: 10.7270/Q2G44QK5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM39816 (Acylglycineboronic acid, 15) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli. | Chem Biol 8: 17-31 (2001) Article DOI: 10.1016/S1074-5521(00)00052-1 BindingDB Entry DOI: 10.7270/Q2CC0Z3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase [24-383] (Acinetobacter baumannii (g-Proteobacteria)) | BDBM152694 (SM23) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem | PDB Article PubMed | 21.1 | -43.8 | n/a | 90 | n/a | n/a | n/a | 7.4 | 25 |
Grand Valley State University | Assay Description Steady state kinetics assays were performed on a Cary 100 UV−vis spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4) with 2 nM ADC-7.... | Biochemistry 53: 7670-9 (2014) Article DOI: 10.1021/bi500887n BindingDB Entry DOI: 10.7270/Q2GM8614 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metallo-beta-lactamase L1 type 3 (Stenotrophomonas maltophilia) | BDBM50191996 (6-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamase | Bioorg Med Chem Lett 16: 5169-75 (2006) Article DOI: 10.1016/j.bmcl.2006.07.001 BindingDB Entry DOI: 10.7270/Q2WQ03DJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM26139 (1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM26139 (1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Binding affinity of the compound towards AmpC beta-lactamase binding site from Escherichia coli | J Med Chem 45: 3222-34 (2002) BindingDB Entry DOI: 10.7270/Q2CN737M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase (Escherichia coli) | BDBM26139 (1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School Curated by ChEMBL | Assay Description Inhibitory activity against E. coli AmpC beta-lactamase. | J Med Chem 41: 4577-86 (1998) Article DOI: 10.1021/jm980343w BindingDB Entry DOI: 10.7270/Q22N51FX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225381 (CHEMBL235293 | pinacol5-{[4-(1-hydroxy-2,2,2-trifl...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225393 (CHEMBL235526 | pinacol 5-[(carboxymethylamino)meth...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxa40 (Acinetobacter baumannii) | BDBM227598 (Penem 1) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 30 | n/a | 150 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Case Western Reserve University | Assay Description Steady-state kinetics were performed on an Agilent 8453 diode array spectrophotometer (Palo Alto, CA) in 50 mM sodium phosphate buffer (pH 7.2) suppl... | J Biol Chem 289: 6152-64 (2014) Article DOI: 10.1074/jbc.M113.533562 BindingDB Entry DOI: 10.7270/Q2CN72SC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225376 (CHEMBL397522 | pinacol 5-bromomethylbenzo[b]thioph...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225371 (5-methyl-benzo[b]thiophen-2-ylboronic acid | CHEMB...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM39812 (Acylglycineboronic acid, 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli. | Chem Biol 8: 17-31 (2001) Article DOI: 10.1016/S1074-5521(00)00052-1 BindingDB Entry DOI: 10.7270/Q2CC0Z3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225379 (CHEMBL235292 | pinacol 5-[(3-nitrophenylamino)meth...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225378 (CHEMBL235073 | pinacol 5-diformylaminomethylbenzo[...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50516761 (CHEMBL3286879) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
S£o Paulo State University Curated by ChEMBL | Assay Description Inhibition of bacterial beta lactamase TEM-1 | Eur J Med Chem 179: 791-804 (2019) Article DOI: 10.1016/j.ejmech.2019.06.092 BindingDB Entry DOI: 10.7270/Q28055ZM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225392 (5-hydroxymethylbenzo[b]thiophen-2-ylboronic acid |...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase [24-383] (Acinetobacter baumannii (g-Proteobacteria)) | BDBM152695 (S02030) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 44.5 | -42.0 | n/a | 590 | n/a | n/a | n/a | 7.4 | 25 |
Grand Valley State University | Assay Description Steady state kinetics assays were performed on a Cary 100 UV−vis spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4) with 2 nM ADC-7.... | Biochemistry 53: 7670-9 (2014) Article DOI: 10.1021/bi500887n BindingDB Entry DOI: 10.7270/Q2GM8614 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225380 (CHEMBL235308 | pinacol 5-[(phenylamino3-boronicaci...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase OXA-1 (Escherichia coli (Enterobacteria)) | BDBM227598 (Penem 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 50 | n/a | 30 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Case Western Reserve University | Assay Description Steady-state kinetics were performed on an Agilent 8453 diode array spectrophotometer (Palo Alto, CA) in 50 mM sodium phosphate buffer (pH 7.2) suppl... | J Biol Chem 289: 6152-64 (2014) Article DOI: 10.1074/jbc.M113.533562 BindingDB Entry DOI: 10.7270/Q2CN72SC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Citrobacter freundii) | BDBM50049708 (CHEMBL148 | IMIPENEM) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires Curated by ChEMBL | Assay Description Inhibition of Citrobacter freundii PER2 beta lactamase | Antimicrob Agents Chemother 51: 2359-65 (2007) Article DOI: 10.1128/AAC.01395-06 BindingDB Entry DOI: 10.7270/Q24X57J4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM39849 (Amide and sulfonamide derivatives, 33) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Inhibition assay against beta lactamase enzymes. | Chem Biol 8: 593-611 (2001) Article DOI: 10.1016/S1074-5521(01)00034-5 BindingDB Entry DOI: 10.7270/Q27M06BZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM39815 (Acylglycineboronic acid, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli. | Chem Biol 8: 17-31 (2001) Article DOI: 10.1016/S1074-5521(00)00052-1 BindingDB Entry DOI: 10.7270/Q2CC0Z3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM39856 (Amide and sulfonamide derivatives, 41) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Inhibition assay against beta lactamase enzymes. | Chem Biol 8: 593-611 (2001) Article DOI: 10.1016/S1074-5521(01)00034-5 BindingDB Entry DOI: 10.7270/Q27M06BZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50339870 (2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin as substrate after 30 mins by spectrophotometric analysis | Bioorg Med Chem Lett 21: 2533-6 (2011) Article DOI: 10.1016/j.bmcl.2011.02.024 BindingDB Entry DOI: 10.7270/Q2G44QK5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50115616 (3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem | MMDB PDB PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Binding affinity of the compound towards AmpC beta-lactamase binding site from Escherichia coli | J Med Chem 45: 3222-34 (2002) BindingDB Entry DOI: 10.7270/Q2CN737M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50115616 (3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Apparent inhibition constant against Escherichia coli AmpC beta-lactamase | Bioorg Med Chem Lett 14: 3979-83 (2004) Article DOI: 10.1016/j.bmcl.2004.05.054 BindingDB Entry DOI: 10.7270/Q2XW4J8P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225383 (CHEMBL236203 | pinacol 5-phenylsulphanylmethylbenz...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50115616 (3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Inhibition assay against beta lactamase enzymes. | Chem Biol 8: 593-611 (2001) Article DOI: 10.1016/S1074-5521(01)00034-5 BindingDB Entry DOI: 10.7270/Q27M06BZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225389 (5-imidazol-1-yl-methylbenzo[b]thiophen-2-ylboronic...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50225377 (CHEMBL237390 | pinacol 5-(3,4-dichlorophenoxymethy...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase | J Med Chem 50: 5644-54 (2007) Article DOI: 10.1021/jm070643q BindingDB Entry DOI: 10.7270/Q21N80W5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase type 2 (Bacillus cereus) | BDBM50174303 (CHEMBL3809419) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwest University Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus cereus 569/H/9 metallo-beta-lactamase Bc2 expressed in Escherichia coli GI724 cells using nitrocefin as substrate ... | ACS Med Chem Lett 7: 413-7 (2016) Article DOI: 10.1021/acsmedchemlett.5b00495 BindingDB Entry DOI: 10.7270/Q2GQ70PT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-lactamase (Escherichia coli) | BDBM39819 (Amide and sulfonamide derivatives, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Northwestern University | Assay Description Inhibition assay against beta lactamase enzymes. | Chem Biol 8: 593-611 (2001) Article DOI: 10.1016/S1074-5521(01)00034-5 BindingDB Entry DOI: 10.7270/Q27M06BZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Acinetobacter baumannii) | BDBM50335563 ((6R,7R)-3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-(...) | PDB UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Activity of Acinetobacter baumannii ADC-33 beta-lactamase | Antimicrob Agents Chemother 54: 3484-8 (2010) Article DOI: 10.1128/AAC.00050-10 BindingDB Entry DOI: 10.7270/Q2348KM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase L1 type 3 (Stenotrophomonas maltophilia) | BDBM50092976 (CHEMBL3586478) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwest University Curated by ChEMBL | Assay Description Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi... | ACS Med Chem Lett 6: 660-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00098 BindingDB Entry DOI: 10.7270/Q2M04769 | |||||||||||
More data for this Ligand-Target Pair |
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