Compile Data Set for Download or QSAR

Found 670 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1/2A'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50111396 (CHEMBL273636 | [[(S)-1-(4-Bromo-phenyl)-ethylamino...) Show SMILES C[C@H](NC(c1cccc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O)c1ccc(Br)cc1 Show InChI InChI=1S/C17H17BrN3O5P/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26)/t9-,17?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Homo sapiens (Human))	BDBM50130937 (Dexoxadrol | Dioxadrol) Show SMILES [H][C@@]1(COC(O1)(c1ccccc1)c1ccccc1)[C@]1([H])CCCCN1 |r| Show InChI InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Camerino Curated by ChEMBL					Assay Description Inhibition of [3H]-U-69,593 binding to Opioid receptor kappa 1				J Med Chem 58: 8601-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b01214 BindingDB Entry DOI: 10.7270/Q2GM894Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Homo sapiens (Human))	BDBM50130938 (Etoxadrol) Show SMILES [H][C@@]1(CO[C@@](CC)(O1)c1ccccc1)[C@]1([H])CCCCN1 |r| Show InChI InChI=1S/C16H23NO2/c1-2-16(13-8-4-3-5-9-13)18-12-15(19-16)14-10-6-7-11-17-14/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3/t14-,15+,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Camerino Curated by ChEMBL					Assay Description Binding affinity to NMDA receptor (unknown origin)				J Med Chem 58: 8601-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b01214 BindingDB Entry DOI: 10.7270/Q2GM894Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50050704 ((R)-4-(3-Phosphono-propyl)-piperazine-2-carboxylic...) Show SMILES OC(=O)[C@H]1CN(CCCP(O)(O)=O)CCN1 |r| Show InChI InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A (Homo sapiens (Human))	BDBM50044140 (2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...) Show SMILES CNC1(CCCCC1=O)c1ccccc1Cl Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-MK801 from human forebrain GluN1/GluN2B expressed in HEK293 cells by at -70 mV holding potential by patch-clamp assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01193 BindingDB Entry DOI: 10.7270/Q2T15797
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50044140 (2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...) Show SMILES CNC1(CCCCC1=O)c1ccccc1Cl Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-MK801 from rat brain GluN1/GluN2A expressed in HEK293 cells				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01193 BindingDB Entry DOI: 10.7270/Q2T15797
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419775 (CHEMBL1950808) Show SMILES OC(=O)[C@@H]1NCCN([C@@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1 |r| Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50004897 ((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...) Show SMILES NC(CCCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3cc(Br)ccc23)c1 Show InChI InChI=1S/C21H17BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3cc(Br)ccc23)c1 Show InChI InChI=1S/C21H17BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM81977 (CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV) Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...				J Med Chem 60: 9885-9904 (2017) Article DOI: 10.1021/acs.jmedchem.7b01624 BindingDB Entry DOI: 10.7270/Q21R6SXD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50017226 ((R)-2-Amino-7-phosphono-heptanoic acid | 2-Amino-7...) Show SMILES N[C@H](CCCCCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)/t6-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164540 ((2R,3S)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164556 ((2R,3S)-1-((E)-3-Naphthalen-2-yl-acryloyl)-piperaz...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)\C=C\c1ccc2ccccc2c1 Show InChI InChI=1S/C19H18N2O5/c22-15(21-10-9-20-16(18(23)24)17(21)19(25)26)8-6-12-5-7-13-3-1-2-4-14(13)11-12/h1-8,11,16-17,20H,9-10H2,(H,23,24)(H,25,26)/b8-6+/t16-,17+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164555 ((2R,3S)-1-(9,10-Dihydro-phenanthrene-2-carbonyl)-p...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3ccccc-23)c1 Show InChI InChI=1S/C21H20N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-4,7-8,11,17-18,22H,5-6,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164555 ((2R,3S)-1-(9,10-Dihydro-phenanthrene-2-carbonyl)-p...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3ccccc-23)c1 Show InChI InChI=1S/C21H20N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-4,7-8,11,17-18,22H,5-6,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419786 (CHEMBL1950795) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(I)ccc2c1 |r| Show InChI InChI=1S/C17H15IN2O5/c18-12-4-3-9-7-11(2-1-10(9)8-12)15(21)20-6-5-19-13(16(22)23)14(20)17(24)25/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164548 ((2R,3S)-1-(7-Bromo-9,10-dihydro-phenanthrene-2-car...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3cc(Br)ccc-23)c1 Show InChI InChI=1S/C21H19BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h3-6,9-10,17-18,23H,1-2,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.88E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164548 ((2R,3S)-1-(7-Bromo-9,10-dihydro-phenanthrene-2-car...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc-2c(CCc3cc(Br)ccc-23)c1 Show InChI InChI=1S/C21H19BrN2O5/c22-14-4-6-16-12(10-14)2-1-11-9-13(3-5-15(11)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h3-6,9-10,17-18,23H,1-2,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419787 (CHEMBL1950794) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(Br)ccc2c1 |r| Show InChI InChI=1S/C17H15BrN2O5/c18-12-4-3-9-7-11(2-1-10(9)8-12)15(21)20-6-5-19-13(16(22)23)14(20)17(24)25/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50246910 (CHEMBL4084540) Show SMILES Cl.OC(=O)[C@H]1NCC[C@@H]1c1ccc(Cl)c(c1)C(O)=O |r| Show InChI InChI=1S/C12H12ClNO4.ClH/c13-9-2-1-6(5-8(9)11(15)16)7-3-4-14-10(7)12(17)18;/h1-2,5,7,10,14H,3-4H2,(H,15,16)(H,17,18);1H/t7-,10+;/m1./s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Antagonist activity at recombinant rat GluN1a/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...				J Med Chem 60: 9885-9904 (2017) Article DOI: 10.1021/acs.jmedchem.7b01624 BindingDB Entry DOI: 10.7270/Q21R6SXD
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419784 (CHEMBL1950797) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)CCc1ccc2ccccc2c1 |r| Show InChI InChI=1S/C19H20N2O5/c22-15(21-10-9-20-16(18(23)24)17(21)19(25)26)8-6-12-5-7-13-3-1-2-4-14(13)11-12/h1-5,7,11,16-17,20H,6,8-10H2,(H,23,24)(H,25,26)/t16-,17+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419778 (CHEMBL1950803) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(Cl)c3ccccc3c2c1 |r| Show InChI InChI=1S/C21H17ClN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419788 (CHEMBL1950793) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(F)ccc2c1 |r| Show InChI InChI=1S/C17H15FN2O5/c18-12-4-3-9-7-11(2-1-10(9)8-12)15(21)20-6-5-19-13(16(22)23)14(20)17(24)25/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50364074 (CHEMBL1950805) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(I)c3ccccc3c2c1 |r| Show InChI InChI=1S/C21H17IN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164545 ((2R,3S)-1-(9-Oxo-9H-fluorene-2-carbonyl)-piperazin...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2-c3ccccc3C(=O)c2c1 Show InChI InChI=1S/C20H16N2O6/c23-17-13-4-2-1-3-11(13)12-6-5-10(9-14(12)17)18(24)22-8-7-21-15(19(25)26)16(22)20(27)28/h1-6,9,15-16,21H,7-8H2,(H,25,26)(H,27,28)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.97E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164550 ((2R,3S)-1-(4'-Fluoro-biphenyl-4-carbonyl)-piperazi...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN2O5/c20-14-7-5-12(6-8-14)11-1-3-13(4-2-11)17(23)22-10-9-21-15(18(24)25)16(22)19(26)27/h1-8,15-16,21H,9-10H2,(H,24,25)(H,26,27)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.78E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164551 ((2R,3S)-1-(Naphthalene-2-carbonyl)-piperazine-2,3-...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C17H16N2O5/c20-15(12-6-5-10-3-1-2-4-11(10)9-12)19-8-7-18-13(16(21)22)14(19)17(23)24/h1-6,9,13-14,18H,7-8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164551 ((2R,3S)-1-(Naphthalene-2-carbonyl)-piperazine-2,3-...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C17H16N2O5/c20-15(12-6-5-10-3-1-2-4-11(10)9-12)19-8-7-18-13(16(21)22)14(19)17(23)24/h1-6,9,13-14,18H,7-8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Homo sapiens (Human))	BDBM50033369 (AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL) Show SMILES NC12CC3CC(CC(C3)C1)C2 |THB:6:5:2:8.7.9,6:7:4.5.10:2,9:7:4:10.1.2,9:1:4:8.6.7,0:1:4:8.6.7| Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Displacement of [3H]-(+)-MK-801 from phencyclidine binding site of NMDA receptor in human frontal cortex after 22 hrs by scintillation counting analy...				Bioorg Med Chem 23: 4277-85 (2015) Article DOI: 10.1016/j.bmc.2015.06.030 BindingDB Entry DOI: 10.7270/Q29Z96NG
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164543 ((2R,3R)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164543 ((2R,3R)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419776 (CHEMBL1950806) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc3ccccc3cc2c1 |r| Show InChI InChI=1S/C21H18N2O5/c24-19(23-8-7-22-17(20(25)26)18(23)21(27)28)15-6-5-14-9-12-3-1-2-4-13(12)10-16(14)11-15/h1-6,9-11,17-18,22H,7-8H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164541 ((2R,3S)-1-Phenanthren-2-ylmethyl-piperazine-2,3-di...) Show SMILES OC(=O)[C@H]1NCCN(Cc2ccc3c(ccc4ccccc34)c2)[C@H]1C(O)=O Show InChI InChI=1S/C21H20N2O4/c24-20(25)18-19(21(26)27)23(10-9-22-18)12-13-5-8-17-15(11-13)7-6-14-3-1-2-4-16(14)17/h1-8,11,18-19,22H,9-10,12H2,(H,24,25)(H,26,27)/t18-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164541 ((2R,3S)-1-Phenanthren-2-ylmethyl-piperazine-2,3-di...) Show SMILES OC(=O)[C@H]1NCCN(Cc2ccc3c(ccc4ccccc34)c2)[C@H]1C(O)=O Show InChI InChI=1S/C21H20N2O4/c24-20(25)18-19(21(26)27)23(10-9-22-18)12-13-5-8-17-15(11-13)7-6-14-3-1-2-4-16(14)17/h1-8,11,18-19,22H,9-10,12H2,(H,24,25)(H,26,27)/t18-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419777 (CHEMBL1950804) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(Br)c3ccccc3c2c1 |r| Show InChI InChI=1S/C21H17BrN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164554 ((2R,3S)-1-[(E)-(3-Phenyl-acryloyl)]-piperazine-2,3...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)\C=C\c1ccccc1 Show InChI InChI=1S/C15H16N2O5/c18-11(7-6-10-4-2-1-3-5-10)17-9-8-16-12(14(19)20)13(17)15(21)22/h1-7,12-13,16H,8-9H2,(H,19,20)(H,21,22)/b7-6+/t12-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164544 ((2R,3S)-1-(Biphenyl-4-sulfonyl)-piperazine-2,3-dic...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C18H18N2O6S/c21-17(22)15-16(18(23)24)20(11-10-19-15)27(25,26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,19H,10-11H2,(H,21,22)(H,23,24)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164544 ((2R,3S)-1-(Biphenyl-4-sulfonyl)-piperazine-2,3-dic...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C18H18N2O6S/c21-17(22)15-16(18(23)24)20(11-10-19-15)27(25,26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,19H,10-11H2,(H,21,22)(H,23,24)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164553 ((2R,3S)-1-(Phenanthrene-3-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccc3ccccc3c2c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-8-7-13-6-5-12-3-1-2-4-15(12)16(13)11-14/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164552 ((2R,3S)-1-(Biphenyl-4-carbonyl)-piperazine-2,3-dic...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C19H18N2O5/c22-17(21-11-10-20-15(18(23)24)16(21)19(25)26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,20H,10-11H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164552 ((2R,3S)-1-(Biphenyl-4-carbonyl)-piperazine-2,3-dic...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C19H18N2O5/c22-17(21-11-10-20-15(18(23)24)16(21)19(25)26)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,20H,10-11H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164540 ((2R,3S)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.76E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164540 ((2R,3S)-1-(Phenanthrene-2-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3ccccc23)c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.76E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164553 ((2R,3S)-1-(Phenanthrene-3-carbonyl)-piperazine-2,3...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2ccc3ccccc3c2c1 Show InChI InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-8-7-13-6-5-12-3-1-2-4-15(12)16(13)11-14/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164542 ((2R,3S)-1-(2'-Bromo-biphenyl-4-carbonyl)-piperazin...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccccc1Br Show InChI InChI=1S/C19H17BrN2O5/c20-14-4-2-1-3-13(14)11-5-7-12(8-6-11)17(23)22-10-9-21-15(18(24)25)16(22)19(26)27/h1-8,15-16,21H,9-10H2,(H,24,25)(H,26,27)/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.29E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419780 (CHEMBL1950801) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(cc1)\N=N\c1ccccc1 |r| Show InChI InChI=1S/C19H18N4O5/c24-17(23-11-10-20-15(18(25)26)16(23)19(27)28)12-6-8-14(9-7-12)22-21-13-4-2-1-3-5-13/h1-9,15-16,20H,10-11H2,(H,25,26)(H,27,28)/b22-21+/t15-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.93E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419783 (CHEMBL1950798) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(ccc2c1)C(O)=O |r| Show InChI InChI=1S/C18H16N2O7/c21-15(20-6-5-19-13(17(24)25)14(20)18(26)27)11-3-1-10-8-12(16(22)23)4-2-9(10)7-11/h1-4,7-8,13-14,19H,5-6H2,(H,22,23)(H,24,25)(H,26,27)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50419779 (CHEMBL1950802) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc(CCc2ccccc2)cc1 |r| Show InChI InChI=1S/C21H22N2O5/c24-19(23-13-12-22-17(20(25)26)18(23)21(27)28)16-10-8-15(9-11-16)7-6-14-4-2-1-3-5-14/h1-5,8-11,17-18,22H,6-7,12-13H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response...				J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A (Rattus norvegicus (Rat)-RAT)	BDBM50164547 ((2R,3S)-1-Benzoyl-piperazine-2,3-dicarboxylic acid...) Show SMILES OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C13H14N2O5/c16-11(8-4-2-1-3-5-8)15-7-6-14-9(12(17)18)10(15)13(19)20/h1-5,9-10,14H,6-7H2,(H,17,18)(H,19,20)/t9-,10+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
					More data for this Ligand-Target Pair

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