Found 13 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 4' AND taxid = 9823 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50421360
(CHEMBL358119 | SB-207058)Show InChI InChI=1S/C22H30N2O3/c1-2-3-11-23-13-9-17(10-14-23)16-27-22(25)20-18-7-4-5-8-19(18)24-12-6-15-26-21(20)24/h4-5,7-8,17H,2-3,6,9-16H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 0.0631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50421359
(CHEMBL145075)Show InChI InChI=1S/C21H28N2O3/c1-2-3-10-22-11-8-16(9-12-22)15-26-21(24)19-17-6-4-5-7-18(17)23-13-14-25-20(19)23/h4-7,16H,2-3,8-15H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 0.0794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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UniProtKB/TrEMBL
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MCE PC cid PC sid UniChem
Patents
Similars
| Article
| 0.126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50421362
(CHEMBL143862)Show InChI InChI=1S/C23H32N2O3/c1-2-3-12-24-14-10-18(11-15-24)17-28-23(26)21-19-8-4-5-9-20(19)25-13-6-7-16-27-22(21)25/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50421361
(CHEMBL143426)Show InChI InChI=1S/C19H26N2O2/c1-2-3-10-21-11-8-15(9-12-21)14-23-19(22)17-13-20-18-7-5-4-6-16(17)18/h4-7,13,15,20H,2-3,8-12,14H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(PIGLET) | BDBM50003359
(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3 | PDB
Reactome pathway
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Similars
| Article PubMed
| 251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 125: 1413-20 (1998)
Article DOI: 10.1038/sj.bjp.0702201 BindingDB Entry DOI: 10.7270/Q2HM56ZD |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50079939
((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)Show InChI InChI=1S/C22H27ClN2O3/c1-26-20-5-3-2-4-19(20)25-10-8-16(9-11-25)13-24-14-18-15-27-21-7-6-17(23)12-22(21)28-18/h2-7,12,16,18,24H,8-11,13-15H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 4 receptor |
J Med Chem 42: 3342-55 (1999)
Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50084959
(11'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadia...)Show SMILES CN1CCC2(COc3cc4CCN(C(=O)c5ccc(cc5)-c5ccc(cc5C)-c5noc(C)n5)c4cc23)CC1 Show InChI InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3 | PDB
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UniProtKB/TrEMBL
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CHEMBL MCE PC cid PC sid UniChem
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Similars
| Article PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against piglet hippocampus 5-hydroxytryptamine 4 receptor |
J Med Chem 41: 1218-35 (1998)
Article DOI: 10.1021/jm970457s BindingDB Entry DOI: 10.7270/Q2XS5WMN |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(PIGLET) | BDBM85097
(CAS_181632-25-7 | CHEMBL14563 | SB 242084)Show SMILES Cc1cc2CCN(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2cc1Cl Show InChI InChI=1S/C21H19ClN4O2/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27) | PDB
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| 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Neuropharmacology 36: 609-20 (1997)
Article DOI: 10.1016/s0028-3908(97)00038-5 BindingDB Entry DOI: 10.7270/Q2SN07GG |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(PIGLET) | BDBM84991
(CAS_3277600 | NSC_3277600 | SB204741)Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19) | PDB
Reactome pathway
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
Patents
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Behav Brain Res 73: 149-52 (1996)
Article DOI: 10.1016/0166-4328(96)00087-3 BindingDB Entry DOI: 10.7270/Q2RX99ND |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(PIGLET) | BDBM82472
(BW-723C86 | CAS_5311036 | NSC_5311036)Show InChI InChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3 | PDB
Reactome pathway
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Behav Brain Res 73: 149-52 (1996)
Article DOI: 10.1016/0166-4328(96)00087-3 BindingDB Entry DOI: 10.7270/Q2RX99ND |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50327858
((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)Show InChI InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a |
Molecular NeuroImaging LLC
Curated by ChEMBL
| Assay Description Binding affinity to 5HT4 receptor in pig striatal membranes |
Bioorg Med Chem Lett 23: 6243-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.097 BindingDB Entry DOI: 10.7270/Q2RJ4KZ2 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Sus scrofa) | BDBM50448450
(CHEMBL3126112)Show InChI InChI=1S/C16H21ClN2O4/c1-19-4-2-10(3-5-19)9-23-16(20)11-8-12(17)13(18)15-14(11)21-6-7-22-15/h8,10H,2-7,9,18H2,1H3 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a |
Molecular NeuroImaging LLC
Curated by ChEMBL
| Assay Description Binding affinity to 5HT4 receptor in pig striatal membranes |
Bioorg Med Chem Lett 23: 6243-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.097 BindingDB Entry DOI: 10.7270/Q2RJ4KZ2 |
More data for this Ligand-Target Pair | |