Compile Data Set for Download or QSAR

Found 477 hits Enz. Inhib. hit(s) with Target = 'Protein Mdm4' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Mdm4 (Homo sapiens (Human))	BDBM50403302 (CHEMBL5290323) Show SMILES OC(=O)CN1[C@@H](SC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O)c1ccccc1 Show InChI InChI=1S/C21H22N2O4S2/c24-18(25)12-23-20(27)16(13-29-21(23)15-9-5-2-6-10-15)22-19(26)17(28)11-14-7-3-1-4-8-14/h1-10,16-17,21,28H,11-13H2,(H,22,26)(H,24,25)/t16-,17-,21-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars		6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Tested for its antagonist activity against mu receptor using DAMGO as radioligand in isolated guinea pig ileum				Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50403372 (CHEMBL5286157) Show SMILES C[C@]12C[C@H](N(C(=O)[C@H]3Cc4ccccc4CN3C(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)c3ccc(NC(=N)CN)cc3)[C@@]1(C)CCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O Show InChI InChI=1S/C64H90N18O13S/c1-63-21-5-6-22-64(63,2)82(49(30-63)55(89)77-43(60(94)95)15-8-24-72-62(69)70)59(93)48-27-37-11-3-4-12-38(37)33-80(48)57(91)45(35-83)78-53(87)44(29-41-13-10-26-96-41)75-51(85)32-73-54(88)47-28-40(84)34-81(47)58(92)46-16-9-25-79(46)56(90)42(14-7-23-71-61(67)68)76-52(86)36-17-19-39(20-18-36)74-50(66)31-65/h3-4,10-13,17-20,26,40,42-49,83-84H,5-9,14-16,21-25,27-35,65H2,1-2H3,(H2,66,74)(H,73,88)(H,75,85)(H,76,86)(H,77,89)(H,78,87)(H,94,95)(H4,67,68,71)(H4,69,70,72)/t40-,42+,43+,44+,45+,46-,47+,48-,49+,63+,64+/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars		25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]				Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50499318 (CHEMBL3735996) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(-c2ccccc2)c2ccccc2n1Cc1ccc(Cl)cc1 |(4.8,1.11,;4.2,.03,;4.82,-1.03,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-3.45,-1.38,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.23,2.7,;1.23,3.86,;-.3,3.74,;-1.27,4.93,;-2.79,4.69,;-3.34,3.25,;-2.37,2.05,;-.85,2.3,;2.04,5.16,;1.61,6.64,;2.7,7.75,;4.19,7.37,;4.62,5.87,;3.53,4.78,;3.63,3.25,;4.92,2.41,;6.29,3.11,;7.58,2.28,;8.95,2.98,;9.03,4.52,;10.13,5.08,;7.74,5.35,;6.37,4.65,)| Show InChI InChI=1S/C30H20Cl2N2O2/c31-20-12-10-18(11-13-20)17-34-25-9-5-4-8-23(25)26(19-6-2-1-3-7-19)29(34)27-22-15-14-21(32)16-24(22)33-28(27)30(35)36/h1-16,33H,17H2,(H,35,36)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Competition binding affinity to MDMX (unknown origin) using p53 mimicking peptide TSFAEYWNLLSP after 30 mins by fluorescence polarization assay				Bioorg Med Chem Lett 25: 5661-6 (2015) Article DOI: 10.1016/j.bmcl.2015.11.019 BindingDB Entry DOI: 10.7270/Q2WM1HF9
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50403369 (CHEMBL5271133) Show SMILES Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCS(=O)Cc3ccco3)c2c1 Show InChI InChI=1S/C22H20ClN3O5S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)31-20)22(28)25-24-21(27)9-11-32(29)14-17-5-3-10-30-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]				Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50499316 (CHEMBL3734953) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(-c2ccc(F)cc2)c2ccccc2n1Cc1ccc(Cl)cc1 |(4.8,1.11,;4.2,.03,;4.82,-1.03,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-3.45,-1.38,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.23,2.7,;1.23,3.86,;-.3,3.74,;-1.27,4.93,;-2.79,4.69,;-3.34,3.25,;-4.56,3.06,;-2.37,2.05,;-.85,2.3,;2.04,5.16,;1.61,6.64,;2.7,7.75,;4.19,7.37,;4.62,5.87,;3.53,4.78,;3.63,3.25,;4.92,2.41,;6.29,3.11,;7.58,2.28,;8.95,2.98,;9.03,4.52,;10.13,5.08,;7.74,5.35,;6.37,4.65,)| Show InChI InChI=1S/C30H19Cl2FN2O2/c31-19-9-5-17(6-10-19)16-35-25-4-2-1-3-23(25)26(18-7-12-21(33)13-8-18)29(35)27-22-14-11-20(32)15-24(22)34-28(27)30(36)37/h1-15,34H,16H2,(H,36,37)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Competition binding affinity to MDMX (unknown origin) using p53 mimicking peptide TSFAEYWNLLSP after 30 mins by fluorescence polarization assay				Bioorg Med Chem Lett 25: 5661-6 (2015) Article DOI: 10.1016/j.bmcl.2015.11.019 BindingDB Entry DOI: 10.7270/Q2WM1HF9
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515628 (CHEMBL4470904) Show SMILES [H][C@]12CC[C@@](C)(C(C1)NC(=O)C(N(Cc1ccc(OCc3ccc(Br)cc3)cc1)C=O)c1c([nH]c3cc(Cl)ccc13)C(O)=O)C2(C)C |r,TLB:8:6:44:2.3| Show InChI InChI=1S/C36H37BrClN3O5/c1-35(2)23-14-15-36(35,3)29(16-23)40-33(43)32(30-27-13-10-25(38)17-28(27)39-31(30)34(44)45)41(20-42)18-21-6-11-26(12-7-21)46-19-22-4-8-24(37)9-5-22/h4-13,17,20,23,29,32,39H,14-16,18-19H2,1-3H3,(H,40,43)(H,44,45)/t23-,29?,32?,36-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515627 (CHEMBL4553260) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(Cc1ccc(OCc2ccccc2Br)cc1)C=O)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:35:36:38:42.40.41,THB:40:39:36:42.41.43,40:41:36:38.39.45,43:41:38:36.45.44,43:44:38:42.40.41,(62.85,-14.7,;62.09,-13.36,;62.86,-12.03,;60.55,-13.36,;59.64,-14.6,;58.17,-14.12,;56.84,-14.9,;55.5,-14.12,;54.17,-14.89,;55.51,-12.58,;56.84,-11.81,;58.18,-12.58,;59.64,-12.11,;60.12,-10.64,;59.1,-9.5,;57.59,-9.81,;56.56,-8.66,;57.05,-7.2,;56.02,-6.06,;54.51,-6.37,;53.49,-5.23,;51.98,-5.55,;50.95,-4.4,;49.45,-4.72,;48.42,-3.58,;48.89,-2.11,;50.4,-1.79,;51.43,-2.94,;52.94,-2.62,;54.04,-7.85,;55.07,-8.99,;59.58,-8.03,;58.55,-6.88,;61.63,-10.33,;62.89,-11.2,;62.11,-8.86,;63.62,-8.55,;64.71,-9.56,;64.82,-11.31,;65.54,-9.92,;66.91,-9.28,;66.67,-7.66,;65.97,-8.92,;65.56,-6.61,;64.18,-7.24,;64.37,-8.84,)| Show InChI InChI=1S/C36H35BrClN3O5/c37-29-4-2-1-3-23(29)18-46-27-8-5-20(6-9-27)17-41(19-42)34(31-28-10-7-26(38)16-30(28)39-33(31)36(44)45)35(43)40-32-24-12-21-11-22(14-24)15-25(32)13-21/h1-10,16,19,21-22,24-25,32,34,39H,11-15,17-18H2,(H,40,43)(H,44,45)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.68E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515640 (CHEMBL4532127) Show SMILES [H][C@]12CC[C@@](C)(C(C1)NC(=O)C(N(Cc1ccc(OCc3ccccc3Br)cc1)C=O)c1c([nH]c3cc(Cl)ccc13)C(O)=O)C2(C)C |r,TLB:8:6:44:2.3| Show InChI InChI=1S/C36H37BrClN3O5/c1-35(2)23-14-15-36(35,3)29(16-23)40-33(43)32(30-26-13-10-24(38)17-28(26)39-31(30)34(44)45)41(20-42)18-21-8-11-25(12-9-21)46-19-22-6-4-5-7-27(22)37/h4-13,17,20,23,29,32,39H,14-16,18-19H2,1-3H3,(H,40,43)(H,44,45)/t23-,29?,32?,36-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266878 (CHEMBL4078749) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(14.91,-19.06,;15.68,-20.39,;14.91,-21.72,;17.22,-20.39,;18.12,-21.64,;19.59,-21.16,;20.92,-21.93,;22.25,-21.16,;23.59,-21.93,;22.25,-19.62,;20.92,-18.85,;19.59,-19.62,;18.12,-19.15,;17.64,-17.68,;18.56,-16.44,;17.64,-15.19,;16.19,-15.67,;16.19,-17.21,;14.94,-18.11,;13.53,-17.48,;12.28,-18.39,;10.88,-17.77,;10.72,-16.23,;9.31,-15.61,;11.96,-15.33,;13.37,-15.96,;20.1,-16.44,;20.86,-17.78,;22.4,-17.78,;23.17,-16.44,;24.71,-16.44,;22.39,-15.1,;20.85,-15.11,)| Show InChI InChI=1S/C25H16Cl2FN3O2/c26-16-5-1-14(2-6-16)12-31-13-29-22(15-3-8-18(28)9-4-15)24(31)21-19-10-7-17(27)11-20(19)30-23(21)25(32)33/h1-11,13,30H,12H2,(H,32,33)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.15E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515608 (CHEMBL4464726) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2cccc(Br)c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29BrClN3O5/c1-30(2,3)34-28(37)27(25-23-12-9-21(32)14-24(23)33-26(25)29(38)39)35(17-36)15-18-7-10-22(11-8-18)40-16-19-5-4-6-20(31)13-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.63E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515620 (CHEMBL4557259) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(cc2)-c2ccccc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C36H34ClN3O5/c1-36(2,3)39-34(42)33(31-29-18-15-27(37)19-30(29)38-32(31)35(43)44)40(22-41)20-23-11-16-28(17-12-23)45-21-24-9-13-26(14-10-24)25-7-5-4-6-8-25/h4-19,22,33,38H,20-21H2,1-3H3,(H,39,42)(H,43,44)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.96E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515637 (CHEMBL4531806) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2C(F)(F)F)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C31H29ClF3N3O5/c1-30(2,3)37-28(40)27(25-22-13-10-20(32)14-24(22)36-26(25)29(41)42)38(17-39)15-18-8-11-21(12-9-18)43-16-19-6-4-5-7-23(19)31(33,34)35/h4-14,17,27,36H,15-16H2,1-3H3,(H,37,40)(H,41,42)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266883 (CHEMBL4067165) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2ccccc2Br)cc1)-c1ccc(F)cc1 |(20.01,-19.68,;21.19,-18.7,;20.93,-17.18,;22.64,-19.23,;23.05,-20.72,;24.6,-20.78,;25.59,-21.97,;27.11,-21.72,;28.09,-22.91,;27.65,-20.27,;26.66,-19.08,;25.14,-19.34,;23.92,-18.37,;23.99,-16.83,;25.26,-15.97,;24.87,-14.5,;23.32,-14.44,;22.76,-15.82,;21.27,-16.2,;20.14,-15.16,;20.48,-13.63,;19.38,-12.59,;17.9,-13.06,;16.76,-12.01,;15.28,-12.47,;14.94,-13.98,;16.08,-15.01,;15.74,-16.51,;14.27,-16.97,;13.13,-15.92,;13.48,-14.42,;12.36,-13.37,;17.57,-14.55,;18.7,-15.59,;26.71,-16.49,;26.97,-18.01,;28.42,-18.53,;29.6,-17.54,;31.03,-18.06,;29.32,-16.02,;27.87,-15.5,)| Show InChI InChI=1S/C32H22BrClFN3O3/c33-26-4-2-1-3-21(26)17-41-24-12-5-19(6-13-24)16-38-18-36-29(20-7-10-23(35)11-8-20)31(38)28-25-14-9-22(34)15-27(25)37-30(28)32(39)40/h1-15,18,37H,16-17H2,(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.17E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50234681 (CHEMBL4081794) Show SMILES CCCCCNC(c1nnnn1Cc1ccc(OCc2ccccc2F)cc1)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H30ClFN6O3/c1-2-3-6-15-33-27(26-23-14-11-21(31)16-25(23)34-28(26)30(39)40)29-35-36-37-38(29)17-19-9-12-22(13-10-19)41-18-20-7-4-5-8-24(20)32/h4-5,7-14,16,27,33-34H,2-3,6,15,17-18H2,1H3,(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.29E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of 5'--FAM-LTFEHYWAQLTS peptide binding to N-terminal domain human MDMX (1 to 134 residues) measured after 15 mins by fluorescence polariz...				Eur J Med Chem 126: 384-407 (2017) Article DOI: 10.1016/j.ejmech.2016.11.029 BindingDB Entry DOI: 10.7270/Q2JQ1381
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266895 (CHEMBL4089364) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2cc(F)cc(F)c2)cc1)-c1ccc(F)cc1 |(17.67,-17.78,;18.44,-16.46,;17.67,-15.11,;19.98,-16.46,;20.88,-17.71,;22.35,-17.21,;23.69,-17.98,;25.02,-17.21,;26.35,-17.98,;25.01,-15.66,;23.68,-14.9,;22.34,-15.68,;20.88,-15.2,;20.4,-13.73,;21.3,-12.5,;20.4,-11.25,;18.94,-11.72,;18.94,-13.27,;17.69,-14.18,;16.28,-13.55,;16.12,-12.02,;14.71,-11.4,;13.47,-12.3,;12.06,-11.68,;10.82,-12.58,;9.41,-11.96,;9.25,-10.43,;7.85,-9.8,;7.68,-8.27,;6.6,-10.71,;6.77,-12.25,;5.52,-13.16,;8.17,-12.87,;13.63,-13.84,;15.04,-14.46,;22.84,-12.5,;23.61,-13.84,;25.15,-13.84,;25.93,-12.51,;27.47,-12.51,;25.16,-11.17,;23.62,-11.17,)| Show InChI InChI=1S/C32H21ClF3N3O3/c33-21-5-10-26-27(13-21)38-30(32(40)41)28(26)31-29(20-3-6-22(34)7-4-20)37-17-39(31)15-18-1-8-25(9-2-18)42-16-19-11-23(35)14-24(36)12-19/h1-14,17,38H,15-16H2,(H,40,41)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515603 (CHEMBL4514995) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2Cl)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29Cl2N3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(31)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)32/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266896 (CHEMBL4096099) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2cc(F)c(F)c(F)c2)cc1)-c1ccc(F)cc1 |(19.25,-22.18,;20.01,-20.86,;19.25,-19.51,;21.55,-20.86,;22.46,-22.11,;23.93,-21.61,;25.27,-22.38,;26.6,-21.61,;27.93,-22.38,;26.59,-20.06,;25.26,-19.3,;23.92,-20.08,;22.45,-19.6,;21.98,-18.14,;22.88,-16.9,;21.98,-15.65,;20.51,-16.13,;20.51,-17.67,;19.27,-18.58,;17.86,-17.95,;17.7,-16.43,;16.29,-15.8,;15.05,-16.7,;13.64,-16.08,;12.4,-16.99,;10.99,-16.36,;10.83,-14.83,;9.42,-14.2,;9.26,-12.67,;8.18,-15.11,;6.77,-14.49,;8.34,-16.65,;7.1,-17.56,;9.75,-17.27,;15.21,-18.24,;16.62,-18.86,;24.42,-16.9,;25.19,-18.24,;26.73,-18.24,;27.5,-16.91,;29.04,-16.91,;26.74,-15.58,;25.2,-15.57,)| Show InChI InChI=1S/C32H20ClF4N3O3/c33-20-5-10-23-26(13-20)39-30(32(41)42)27(23)31-29(19-3-6-21(34)7-4-19)38-16-40(31)14-17-1-8-22(9-2-17)43-15-18-11-24(35)28(37)25(36)12-18/h1-13,16,39H,14-15H2,(H,41,42)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.71E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515648 (CHEMBL4535119) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H28Cl3N3O5/c1-30(2,3)35-28(38)27(25-21-10-7-19(31)13-24(21)34-26(25)29(39)40)36(16-37)14-17-4-8-20(9-5-17)41-15-18-6-11-22(32)23(33)12-18/h4-13,16,27,34H,14-15H2,1-3H3,(H,35,38)(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.73E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515616 (CHEMBL4453832) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(I)cc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClIN3O5/c1-30(2,3)34-28(37)27(25-23-13-8-20(31)14-24(23)33-26(25)29(38)39)35(17-36)15-18-6-11-22(12-7-18)40-16-19-4-9-21(32)10-5-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.74E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515617 (CHEMBL4579495) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2cccc(I)c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClIN3O5/c1-30(2,3)34-28(37)27(25-23-12-9-20(31)14-24(23)33-26(25)29(38)39)35(17-36)15-18-7-10-22(11-8-18)40-16-19-5-4-6-21(32)13-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.74E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266877 (CHEMBL4098976) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(F)c(F)c1)-c1ccc(F)cc1 |(17.08,-16.49,;17.85,-15.17,;17.08,-13.82,;19.39,-15.17,;20.29,-16.42,;21.76,-15.92,;23.1,-16.69,;24.43,-15.92,;25.76,-16.69,;24.42,-14.37,;23.09,-13.61,;21.76,-14.39,;20.29,-13.91,;19.81,-12.44,;20.72,-11.21,;19.81,-9.96,;18.35,-10.43,;18.35,-11.98,;17.1,-12.89,;15.69,-12.26,;15.53,-10.73,;14.12,-10.11,;12.88,-11.01,;11.47,-10.39,;13.04,-12.55,;11.8,-13.45,;14.45,-13.17,;22.26,-11.21,;23.02,-12.55,;24.56,-12.55,;25.34,-11.22,;26.88,-11.22,;24.57,-9.88,;23.03,-9.88,)| Show InChI InChI=1S/C25H15ClF3N3O2/c26-15-4-7-17-20(10-15)31-23(25(33)34)21(17)24-22(14-2-5-16(27)6-3-14)30-12-32(24)11-13-1-8-18(28)19(29)9-13/h1-10,12,31H,11H2,(H,33,34)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.91E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50499315 (CHEMBL3735566) Show SMILES CCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(-c2ccc(F)cc2)c2ccccc2n1Cc1ccc(Cl)cc1 |(7.15,-2.34,;6.52,-1.28,;4.98,-1.29,;4.2,.03,;4.8,1.11,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-3.45,-1.38,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.23,2.7,;1.23,3.86,;-.3,3.74,;-1.27,4.93,;-2.79,4.69,;-3.34,3.25,;-4.56,3.06,;-2.37,2.05,;-.85,2.3,;2.04,5.16,;1.61,6.64,;2.7,7.75,;4.19,7.37,;4.62,5.87,;3.53,4.78,;3.63,3.25,;4.92,2.41,;6.29,3.11,;7.58,2.28,;8.95,2.98,;9.03,4.52,;10.13,5.08,;7.74,5.35,;6.37,4.65,)| Show InChI InChI=1S/C32H23Cl2FN2O2/c1-2-39-32(38)30-29(24-16-13-22(34)17-26(24)36-30)31-28(20-9-14-23(35)15-10-20)25-5-3-4-6-27(25)37(31)18-19-7-11-21(33)12-8-19/h3-17,36H,2,18H2,1H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Competition binding affinity to MDMX (unknown origin) using p53 mimicking peptide TSFAEYWNLLSP after 30 mins by fluorescence polarization assay				Bioorg Med Chem Lett 25: 5661-6 (2015) Article DOI: 10.1016/j.bmcl.2015.11.019 BindingDB Entry DOI: 10.7270/Q2WM1HF9
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515642 (CHEMBL4567532) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H30ClN3O5/c1-30(2,3)33-28(36)27(25-23-14-11-21(31)15-24(23)32-26(25)29(37)38)34(18-35)16-19-9-12-22(13-10-19)39-17-20-7-5-4-6-8-20/h4-15,18,27,32H,16-17H2,1-3H3,(H,33,36)(H,37,38)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.36E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515641 (CHEMBL4451308) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2Br)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29BrClN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(32)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)31/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515621 (CHEMBL4453590) Show SMILES COc1cccc(COc2ccc(CN(C=O)C(C(=O)NC(C)(C)C)c3c([nH]c4cc(Cl)ccc34)C(O)=O)cc2)c1 Show InChI InChI=1S/C31H32ClN3O6/c1-31(2,3)34-29(37)28(26-24-13-10-21(32)15-25(24)33-27(26)30(38)39)35(18-36)16-19-8-11-22(12-9-19)41-17-20-6-5-7-23(14-20)40-4/h5-15,18,28,33H,16-17H2,1-4H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.74E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515605 (CHEMBL4549914) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc3ccccc3c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C34H32ClN3O5/c1-34(2,3)37-32(40)31(29-27-15-12-25(35)17-28(27)36-30(29)33(41)42)38(20-39)18-21-9-13-26(14-10-21)43-19-22-8-11-23-6-4-5-7-24(23)16-22/h4-17,20,31,36H,18-19H2,1-3H3,(H,37,40)(H,41,42)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.78E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515645 (CHEMBL4519527) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(Br)cc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29BrClN3O5/c1-30(2,3)34-28(37)27(25-23-13-10-21(32)14-24(23)33-26(25)29(38)39)35(17-36)15-18-6-11-22(12-7-18)40-16-19-4-8-20(31)9-5-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515611 (CHEMBL4537477) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2cc(F)cc(F)c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H28ClF2N3O5/c1-30(2,3)35-28(38)27(25-23-9-6-19(31)12-24(23)34-26(25)29(39)40)36(16-37)14-17-4-7-22(8-5-17)41-15-18-10-20(32)13-21(33)11-18/h4-13,16,27,34H,14-15H2,1-3H3,(H,35,38)(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50499317 (CHEMBL3735043) Show SMILES Clc1ccc(Cn2c(-c3c([nH]c4cc(Cl)ccc34)C(=O)NCCN3CCOCC3)c(-c3ccccc3)c3ccccc23)cc1 |(10.13,5.08,;9.03,4.52,;8.95,2.98,;7.58,2.28,;6.29,3.11,;4.92,2.41,;3.63,3.25,;2.23,2.7,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-3.45,-1.38,;-2.38,.77,;-1.03,1.55,;.3,.77,;4.2,.03,;4.8,1.11,;4.98,-1.29,;6.52,-1.28,;7.3,-2.61,;8.84,-2.59,;9.63,-3.92,;11.17,-3.9,;11.92,-2.56,;11.14,-1.23,;9.6,-1.25,;1.23,3.86,;-.3,3.74,;-1.27,4.93,;-2.79,4.69,;-3.34,3.25,;-2.37,2.05,;-.85,2.3,;2.04,5.16,;1.61,6.64,;2.7,7.75,;4.19,7.37,;4.62,5.87,;3.53,4.78,;6.37,4.65,;7.74,5.35,)| Show InChI InChI=1S/C36H32Cl2N4O2/c37-26-12-10-24(11-13-26)23-42-31-9-5-4-8-29(31)32(25-6-2-1-3-7-25)35(42)33-28-15-14-27(38)22-30(28)40-34(33)36(43)39-16-17-41-18-20-44-21-19-41/h1-15,22,40H,16-21,23H2,(H,39,43)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.09E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Competition binding affinity to MDMX (unknown origin) using p53 mimicking peptide TSFAEYWNLLSP after 30 mins by fluorescence polarization assay				Bioorg Med Chem Lett 25: 5661-6 (2015) Article DOI: 10.1016/j.bmcl.2015.11.019 BindingDB Entry DOI: 10.7270/Q2WM1HF9
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515612 (CHEMBL4578277) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2cccc(Cl)c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29Cl2N3O5/c1-30(2,3)34-28(37)27(25-23-12-9-21(32)14-24(23)33-26(25)29(38)39)35(17-36)15-18-7-10-22(11-8-18)40-16-19-5-4-6-20(31)13-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.21E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515607 (CHEMBL4516581) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2cccc(F)c2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClFN3O5/c1-30(2,3)34-28(37)27(25-23-12-9-20(31)14-24(23)33-26(25)29(38)39)35(17-36)15-18-7-10-22(11-8-18)40-16-19-5-4-6-21(32)13-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515630 (CHEMBL4591576) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(NCc2ccc(Br)cc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H30BrClN4O4/c1-30(2,3)35-28(38)27(25-23-13-10-21(32)14-24(23)34-26(25)29(39)40)36(17-37)16-19-6-11-22(12-7-19)33-15-18-4-8-20(31)9-5-18/h4-14,17,27,33-34H,15-16H2,1-3H3,(H,35,38)(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.38E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515618 (CHEMBL4453505) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2I)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClIN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(31)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)32/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.39E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266902 (CHEMBL4104786) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)-c1ccc(F)cc1 |(20.17,-21.62,;20.94,-20.3,;20.17,-18.95,;22.48,-20.3,;23.38,-21.55,;24.85,-21.05,;26.19,-21.82,;27.53,-21.05,;28.85,-21.82,;27.52,-19.51,;26.19,-18.74,;24.85,-19.52,;23.38,-19.04,;22.9,-17.58,;23.81,-16.34,;22.91,-15.09,;21.44,-15.57,;21.44,-17.11,;20.19,-18.02,;18.79,-17.39,;18.63,-15.87,;17.22,-15.24,;15.97,-16.14,;14.57,-15.52,;13.32,-16.43,;11.91,-15.8,;10.68,-16.71,;9.27,-16.09,;9.1,-14.55,;7.69,-13.93,;10.35,-13.64,;10.19,-12.11,;11.76,-14.27,;16.14,-17.68,;17.54,-18.3,;25.35,-16.34,;26.11,-17.68,;27.65,-17.68,;28.43,-16.35,;29.97,-16.35,;27.66,-15.02,;26.12,-15.01,)| Show InChI InChI=1S/C32H21Cl3FN3O3/c33-21-6-11-24-27(14-21)38-30(32(40)41)28(24)31-29(20-4-7-22(36)8-5-20)37-17-39(31)15-18-1-9-23(10-2-18)42-16-19-3-12-25(34)26(35)13-19/h1-14,17,38H,15-16H2,(H,40,41)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6.76E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515604 (CHEMBL4562216) Show SMILES CC(C)(C)NC(=O)[C@@H](N(Cc1ccc(OCc2ccccc2Br)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O |r| Show InChI InChI=1S/C30H29BrClN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(32)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)31/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)/t27-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.76E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515622 (CHEMBL4593705) Show SMILES COc1cccc(COc2ccc(CN(C=O)C(C(=O)NC(C)(C)C)c3c([nH]c4cc(Cl)ccc34)C(O)=O)cc2)c1OC Show InChI InChI=1S/C32H34ClN3O7/c1-32(2,3)35-30(38)28(26-23-14-11-21(33)15-24(23)34-27(26)31(39)40)36(18-37)16-19-9-12-22(13-10-19)43-17-20-7-6-8-25(41-4)29(20)42-5/h6-15,18,28,34H,16-17H2,1-5H3,(H,35,38)(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.84E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50234695 (CHEMBL4065823) Show SMILES CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(NCC1CCCCC1)c1nnnn1Cc1ccc(OCc2ccccc2F)cc1 Show InChI InChI=1S/C34H36ClFN6O3/c1-2-44-34(43)32-30(27-17-14-25(35)18-29(27)38-32)31(37-19-22-8-4-3-5-9-22)33-39-40-41-42(33)20-23-12-15-26(16-13-23)45-21-24-10-6-7-11-28(24)36/h6-7,10-18,22,31,37-38H,2-5,8-9,19-21H2,1H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.99E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of 5'--FAM-LTFEHYWAQLTS peptide binding to N-terminal domain human MDMX (1 to 134 residues) measured after 15 mins by fluorescence polariz...				Eur J Med Chem 126: 384-407 (2017) Article DOI: 10.1016/j.ejmech.2016.11.029 BindingDB Entry DOI: 10.7270/Q2JQ1381
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515613 (CHEMBL4518055) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(Cl)cc2Cl)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H28Cl3N3O5/c1-30(2,3)35-28(38)27(25-22-11-8-20(32)13-24(22)34-26(25)29(39)40)36(16-37)14-17-4-9-21(10-5-17)41-15-18-6-7-19(31)12-23(18)33/h4-13,16,27,34H,14-15H2,1-3H3,(H,35,38)(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.05E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515615 (CHEMBL4560676) Show SMILES CC(C)(C)NC(=O)[C@H](N(Cc1ccc(OCc2ccccc2Br)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O |r| Show InChI InChI=1S/C30H29BrClN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(32)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)31/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)/t27-/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.25E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515619 (CHEMBL4452024) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C32H28ClF6N3O5/c1-30(2,3)41-28(44)27(25-23-9-6-21(33)13-24(23)40-26(25)29(45)46)42(16-43)14-17-4-7-22(8-5-17)47-15-18-10-19(31(34,35)36)12-20(11-18)32(37,38)39/h4-13,16,27,40H,14-15H2,1-3H3,(H,41,44)(H,45,46)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515623 (CHEMBL4444775) Show SMILES Cc1ccc(COc2ccc(CN(C=O)C(C(=O)NC(C)(C)C)c3c([nH]c4cc(Cl)ccc34)C(O)=O)cc2)cc1 Show InChI InChI=1S/C31H32ClN3O5/c1-19-5-7-21(8-6-19)17-40-23-12-9-20(10-13-23)16-35(18-36)28(29(37)34-31(2,3)4)26-24-14-11-22(32)15-25(24)33-27(26)30(38)39/h5-15,18,28,33H,16-17H2,1-4H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515636 (CHEMBL4459244) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccccc2F)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClFN3O5/c1-30(2,3)34-28(37)27(25-22-13-10-20(31)14-24(22)33-26(25)29(38)39)35(17-36)15-18-8-11-21(12-9-18)40-16-19-6-4-5-7-23(19)32/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266882 (CHEMBL4085272) Show SMILES OC(=O)CCC(=O)OCCCCCCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(11.56,-10.6,;12.33,-11.94,;11.56,-13.27,;13.87,-11.94,;14.64,-13.27,;16.18,-13.27,;16.95,-11.94,;16.95,-14.6,;18.49,-14.6,;19.26,-15.94,;20.8,-15.94,;21.57,-17.27,;23.11,-17.27,;23.88,-18.6,;25.42,-18.6,;26.19,-17.27,;25.42,-15.94,;27.73,-17.27,;28.64,-18.52,;30.1,-18.04,;31.43,-18.81,;32.77,-18.04,;34.1,-18.81,;32.77,-16.5,;31.43,-15.73,;30.1,-16.5,;28.64,-16.02,;28.16,-14.56,;29.06,-13.31,;28.16,-12.07,;26.69,-12.54,;26.69,-14.08,;25.45,-14.98,;24.04,-14.36,;22.8,-15.27,;21.39,-14.64,;21.23,-13.11,;19.82,-12.48,;22.48,-12.2,;23.88,-12.83,;30.6,-13.31,;31.37,-11.98,;32.91,-11.98,;33.68,-13.31,;35.22,-13.31,;32.91,-14.65,;31.37,-14.65,)| Show InChI InChI=1S/C35H32Cl2FN3O6/c36-24-9-5-22(6-10-24)20-41-21-39-32(23-7-12-26(38)13-8-23)34(41)31-27-14-11-25(37)19-28(27)40-33(31)35(45)47-18-4-2-1-3-17-46-30(44)16-15-29(42)43/h5-14,19,21,40H,1-4,15-18,20H2,(H,42,43)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50014089 (CHEMBL1236726) Show SMILES CN(C)CCCN(C)[C@H]1CCN(C1)C(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccccc1 |r,wD:8.7,(-5.37,10.95,;-4.13,10.05,;-2.72,10.67,;-4.29,8.51,;-3.04,7.61,;-3.2,6.08,;-1.96,5.17,;-.55,5.8,;-2.12,3.64,;-3.45,2.87,;-3.13,1.36,;-1.6,1.2,;-.97,2.61,;-.83,-.13,;-1.6,-1.46,;.71,-.13,;1.61,1.12,;3.08,.64,;4.41,1.41,;5.75,.64,;7.08,1.41,;5.75,-.9,;4.41,-1.67,;3.08,-.9,;1.61,-1.38,;1.14,-2.84,;2.04,-4.09,;1.14,-5.33,;-.33,-4.86,;-.33,-3.32,;-1.57,-2.41,;-2.98,-3.04,;-3.14,-4.57,;-4.55,-5.2,;-5.79,-4.29,;-7.2,-4.92,;-5.63,-2.76,;-4.23,-2.13,;3.58,-4.09,;4.35,-2.75,;5.89,-2.75,;6.66,-4.09,;5.89,-5.42,;4.35,-5.42,)| Show InChI InChI=1S/C35H38Cl2N6O/c1-40(2)17-7-18-41(3)28-16-19-42(22-28)35(44)33-31(29-15-14-27(37)20-30(29)39-33)34-32(25-8-5-4-6-9-25)38-23-43(34)21-24-10-12-26(36)13-11-24/h4-6,8-15,20,23,28,39H,7,16-19,21-22H2,1-3H3/t28-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]				Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Mdm4 (Homo sapiens (Human))	BDBM50515610 (CHEMBL4467420) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(cc2)C#N)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C31H29ClN4O5/c1-31(2,3)35-29(38)28(26-24-13-10-22(32)14-25(24)34-27(26)30(39)40)36(18-37)16-20-8-11-23(12-9-20)41-17-21-6-4-19(15-33)5-7-21/h4-14,18,28,34H,16-17H2,1-3H3,(H,35,38)(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266870 (CHEMBL4104110) Show SMILES OC(=O)CCC(=O)NCCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(13.19,-25.49,;13.93,-24.13,;13.12,-22.82,;15.47,-24.08,;16.2,-22.73,;15.39,-21.42,;13.85,-21.46,;16.12,-20.07,;17.66,-20.02,;18.39,-18.66,;19.93,-18.61,;20.66,-17.26,;19.85,-15.95,;22.2,-17.21,;23.14,-18.43,;24.59,-17.92,;25.95,-18.64,;27.26,-17.84,;28.62,-18.56,;27.22,-16.3,;25.86,-15.56,;24.55,-16.38,;23.07,-15.95,;22.55,-14.49,;23.42,-13.22,;22.48,-12,;21.03,-12.52,;21.07,-14.06,;19.85,-15,;18.43,-14.42,;17.21,-15.36,;15.78,-14.77,;15.58,-13.25,;14.15,-12.66,;16.8,-12.3,;18.22,-12.89,;24.96,-13.18,;25.69,-11.82,;27.23,-11.78,;28.04,-13.09,;29.58,-13.04,;27.3,-14.44,;25.77,-14.49,)| Show InChI InChI=1S/C31H25Cl2FN4O5/c32-20-5-1-18(2-6-20)16-38-17-36-28(19-3-8-22(34)9-4-19)30(38)27-23-10-7-21(33)15-24(23)37-29(27)31(42)43-14-13-35-25(39)11-12-26(40)41/h1-10,15,17,37H,11-14,16H2,(H,35,39)(H,40,41)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515635 (CHEMBL4451093) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCc2ccc(F)cc2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H29ClFN3O5/c1-30(2,3)34-28(37)27(25-23-13-8-20(31)14-24(23)33-26(25)29(38)39)35(17-36)15-18-6-11-22(12-7-18)40-16-19-4-9-21(32)10-5-19/h4-14,17,27,33H,15-16H2,1-3H3,(H,34,37)(H,38,39)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50266879 (CHEMBL4072678) Show SMILES OC(=O)c1ccc(CNC(=O)c2[nH]c3cc(Cl)ccc3c2-c2c(ncn2Cc2ccc(Cl)cc2)-c2ccc(F)cc2)cc1 |(10.42,-22.35,;11.96,-22.35,;12.74,-23.68,;12.72,-21.02,;11.95,-19.68,;12.71,-18.35,;14.25,-18.34,;15.01,-17.01,;16.55,-17,;17.32,-15.67,;16.54,-14.33,;18.85,-15.66,;19.75,-16.91,;21.21,-16.42,;22.56,-17.17,;23.87,-16.4,;25.21,-17.16,;23.86,-14.86,;22.54,-14.1,;21.21,-14.89,;19.75,-14.4,;19.27,-12.95,;20.17,-11.7,;19.26,-10.47,;17.8,-10.94,;17.8,-12.48,;16.57,-13.39,;15.17,-12.77,;13.93,-13.69,;12.51,-13.07,;12.35,-11.54,;10.95,-10.91,;13.58,-10.63,;15,-11.24,;21.71,-11.7,;22.46,-10.36,;24,-10.35,;24.77,-11.69,;26.31,-11.67,;24.01,-13.01,;22.47,-13.03,;15.02,-19.67,;14.26,-21.01,)| Show InChI InChI=1S/C33H23Cl2FN4O3/c34-23-9-3-20(4-10-23)17-40-18-38-29(21-7-12-25(36)13-8-21)31(40)28-26-14-11-24(35)15-27(26)39-30(28)32(41)37-16-19-1-5-22(6-2-19)33(42)43/h1-15,18,39H,16-17H2,(H,37,41)(H,42,43)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50515638 (CHEMBL4552428) Show SMILES CC(C)(C)NC(=O)C(N(Cc1ccc(OCC2CCCCC2)cc1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI InChI=1S/C30H36ClN3O5/c1-30(2,3)33-28(36)27(25-23-14-11-21(31)15-24(23)32-26(25)29(37)38)34(18-35)16-19-9-12-22(13-10-19)39-17-20-7-5-4-6-8-20/h9-15,18,20,27,32H,4-8,16-17H2,1-3H3,(H,33,36)(H,37,38)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 ...				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111588 BindingDB Entry DOI: 10.7270/Q25H7KM3
					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50234678 (CHEMBL4098742) Show SMILES CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(NC1CCCC1)c1nnnn1-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C31H31ClN6O3/c1-2-40-31(39)29-27(25-16-15-21(32)17-26(25)34-29)28(33-22-11-6-7-12-22)30-35-36-37-38(30)23-13-8-14-24(18-23)41-19-20-9-4-3-5-10-20/h3-5,8-10,13-18,22,28,33-34H,2,6-7,11-12,19H2,1H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.62E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of 5'--FAM-LTFEHYWAQLTS peptide binding to N-terminal domain human MDMX (1 to 134 residues) measured after 15 mins by fluorescence polariz...				Eur J Med Chem 126: 384-407 (2017) Article DOI: 10.1016/j.ejmech.2016.11.029 BindingDB Entry DOI: 10.7270/Q2JQ1381
					More data for this Ligand-Target Pair

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