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Compile Data Set for Download or QSAR

Found 119 hits Enz. Inhib. hit(s) with all data for entry = 50040661   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398003
PNG
(CHEMBL2180402)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3cccc(OC(C)C)c3C2=O)nc2nc(C)ccc2c1=O
Show InChI InChI=1S/C28H26N4O5/c1-16(2)37-22-7-5-6-20-24(22)28(35)31(26(20)33)15-14-23-30-25-21(13-8-17(3)29-25)27(34)32(23)18-9-11-19(36-4)12-10-18/h5-13,16H,14-15H2,1-4H3
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 0.100n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398003
PNG
(CHEMBL2180402)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3cccc(OC(C)C)c3C2=O)nc2nc(C)ccc2c1=O
Show InChI InChI=1S/C28H26N4O5/c1-16(2)37-22-7-5-6-20-24(22)28(35)31(26(20)33)15-14-23-30-25-21(13-8-17(3)29-25)27(34)32(23)18-9-11-19(36-4)12-10-18/h5-13,16H,14-15H2,1-4H3
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 0.100n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398012
PNG
(CHEMBL2180422 | US8492392, 1-17)
Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)S(=O)(=O)c1cccnc1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C20H20ClN5O3S/c1-13(2)29-20-16-12-26(30(27,28)15-4-3-8-22-11-15)9-7-17(16)24-19(25-20)14-5-6-18(21)23-10-14/h3-6,8,10-11,13H,7,9,12H2,1-2H3
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 0.630n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398013
PNG
(CHEMBL2180421 | US8492392, K-2)
Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnn(C)c1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C20H22ClN7O2/c1-12(2)30-19-15-11-28(20(29)24-14-9-23-27(3)10-14)7-6-16(15)25-18(26-19)13-4-5-17(21)22-8-13/h4-5,8-10,12H,6-7,11H2,1-3H3,(H,24,29)
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 0.900n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398011
PNG
(CHEMBL2180423 | US8492392, O-2)
Show SMILES COCCOc1nc(nc2CCN(Cc12)C(=O)c1cnn2ccccc12)-c1ccc(Cl)nc1
Show InChI InChI=1S/C23H21ClN6O3/c1-32-10-11-33-22-17-14-29(23(31)16-13-26-30-8-3-2-4-19(16)30)9-7-18(17)27-21(28-22)15-5-6-20(24)25-12-15/h2-6,8,12-13H,7,9-11,14H2,1H3
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 0.920n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398004
PNG
(CHEMBL2180401)
Show SMILES COc1cccc2C(=O)N(CCc3nc4ccccc4c(=O)n3-c3ccc4cnn(C)c4c3)C(=O)c12
Show InChI InChI=1S/C27H21N5O4/c1-30-21-14-17(11-10-16(21)15-28-30)32-23(29-20-8-4-3-6-18(20)26(32)34)12-13-31-25(33)19-7-5-9-22(36-2)24(19)27(31)35/h3-11,14-15H,12-13H2,1-2H3
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 0.950n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398008
PNG
(CHEMBL2180426)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3cccc(OC)c3C2=O)nc2ccccc2c1=O
Show InChI InChI=1S/C26H21N3O5/c1-33-17-12-10-16(11-13-17)29-22(27-20-8-4-3-6-18(20)25(29)31)14-15-28-24(30)19-7-5-9-21(34-2)23(19)26(28)32/h3-13H,14-15H2,1-2H3
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 2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM119778
PNG
(CHEMBL2180429 | US8691827, I-9)
Show SMILES O=C(Nc1ccccc1)N1CCc2nc(nc(NCc3cnc([nH]3)-c3ccccc3)c2C1)-c1cccnc1
Show InChI InChI=1S/C29H26N8O/c38-29(34-22-11-5-2-6-12-22)37-15-13-25-24(19-37)28(36-27(35-25)21-10-7-14-30-16-21)32-18-23-17-31-26(33-23)20-8-3-1-4-9-20/h1-12,14,16-17H,13,15,18-19H2,(H,31,33)(H,34,38)(H,32,35,36)
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 2.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398005
PNG
(CHEMBL2180430 | US8691827, I-8)
Show SMILES CC(C)CC(=O)N1CCc2nc(nc(N(C)Cc3ccccc3)c2C1)-c1cncc(c1)-c1cn[nH]c1
Show InChI InChI=1S/C28H31N7O/c1-19(2)11-26(36)35-10-9-25-24(18-35)28(34(3)17-20-7-5-4-6-8-20)33-27(32-25)22-12-21(13-29-14-22)23-15-30-31-16-23/h4-8,12-16,19H,9-11,17-18H2,1-3H3,(H,30,31)
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 15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398007
PNG
(CHEMBL2180428 | US8691827, I-1)
Show SMILES O=C(Nc1ccccc1)N1CCc2nc(nc(NCCc3ccccn3)c2C1)-c1ccncc1
Show InChI InChI=1S/C26H25N7O/c34-26(30-21-7-2-1-3-8-21)33-17-12-23-22(18-33)25(29-16-11-20-6-4-5-13-28-20)32-24(31-23)19-9-14-27-15-10-19/h1-10,13-15H,11-12,16-18H2,(H,30,34)(H,29,31,32)
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 48n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398010
PNG
(CHEMBL2180424)
Show SMILES COc1ccc(cc1)-n1c(CCN2C(=O)c3ccccc3C2=O)nc2ccccc2c1=O
Show InChI InChI=1S/C25H19N3O4/c1-32-17-12-10-16(11-13-17)28-22(26-21-9-5-4-8-20(21)25(28)31)14-15-27-23(29)18-6-2-3-7-19(18)24(27)30/h2-13H,14-15H2,1H3
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 87n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003980
PNG
(CHEMBL2180434)
Show SMILES Cc1ncccc1-c1cccc(c1)-c1nc(NCc2ccncc2)c2ccncc2n1
Show InChI InChI=1S/C25H20N6/c1-17-21(6-3-10-28-17)19-4-2-5-20(14-19)24-30-23-16-27-13-9-22(23)25(31-24)29-15-18-7-11-26-12-8-18/h2-14,16H,15H2,1H3,(H,29,30,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003984
PNG
(CHEMBL2180437)
Show SMILES COC(=O)NC1CCCN(C1)c1nc(nc2cnccc12)-c1cccc(c1)-c1cccnc1OC
Show InChI InChI=1S/C26H26N6O3/c1-34-25-20(9-4-11-28-25)17-6-3-7-18(14-17)23-30-22-15-27-12-10-21(22)24(31-23)32-13-5-8-19(16-32)29-26(33)35-2/h3-4,6-7,9-12,14-15,19H,5,8,13,16H2,1-2H3,(H,29,33)
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003983
PNG
(CHEMBL2180435)
Show SMILES C(Oc1nc(nc2cnccc12)-c1cccc(c1)-c1ncco1)c1ccncc1
Show InChI InChI=1S/C22H15N5O2/c1-2-16(12-17(3-1)21-25-10-11-28-21)20-26-19-13-24-9-6-18(19)22(27-20)29-14-15-4-7-23-8-5-15/h1-13H,14H2
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003985
PNG
(CHEMBL2180436)
Show SMILES O=S(=O)(N1CCOCC1)c1cccc2CCN(Cc12)c1nc(NCc2ccncc2)c2ccncc2n1
Show InChI InChI=1S/C26H27N7O3S/c34-37(35,33-12-14-36-15-13-33)24-3-1-2-20-7-11-32(18-22(20)24)26-30-23-17-28-10-6-21(23)25(31-26)29-16-19-4-8-27-9-5-19/h1-6,8-10,17H,7,11-16,18H2,(H,29,30,31)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003979
PNG
(CHEMBL2180433)
Show SMILES C(Oc1ccc(cc1)-c1cccnc1N1CCc2ncccc2C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C29H24N4O/c1-2-8-28-22(5-1)9-12-24(32-28)20-34-25-13-10-21(11-14-25)26-7-4-17-31-29(26)33-18-15-27-23(19-33)6-3-16-30-27/h1-14,16-17H,15,18-20H2
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003982
PNG
(CHEMBL2180432)
Show SMILES C(Oc1ccc(cc1)-c1cccnc1N1CCOCC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23N3O2/c1-2-6-24-20(4-1)7-10-21(27-24)18-30-22-11-8-19(9-12-22)23-5-3-13-26-25(23)28-14-16-29-17-15-28/h1-13H,14-18H2
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003981
PNG
(CHEMBL2180431)
Show SMILES COc1c(C)cc(COc2ccc(cc2)-c2cccnc2N2CCc3ncccc3C2)nc1C
Show InChI InChI=1S/C28H28N4O2/c1-19-16-23(31-20(2)27(19)33-3)18-34-24-10-8-21(9-11-24)25-7-5-14-30-28(25)32-15-12-26-22(17-32)6-4-13-29-26/h4-11,13-14,16H,12,15,17-18H2,1-3H3
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<1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398009
PNG
(CHEMBL2180425)
Show SMILES COc1ccc(cc1)-n1c(CN2C(=O)c3ccccc3C2=O)nc2ccccc2c1=O
Show InChI InChI=1S/C24H17N3O4/c1-31-16-12-10-15(11-13-16)27-21(25-20-9-5-4-8-19(20)24(27)30)14-26-22(28)17-6-2-3-7-18(17)23(26)29/h2-13H,14H2,1H3
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 1.90E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A by fluorescence polarization assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397973
PNG
(CHEMBL2180441)
Show SMILES Cc1nc2ccc(cc2nc1\C=C\c1nc(N[C@@H]2CCS(=O)(=O)C2)cc(n1)N1CCCC1)C(F)(F)F |r|
Show InChI InChI=1S/C24H25F3N6O2S/c1-15-18(30-20-12-16(24(25,26)27)4-5-19(20)28-15)6-7-21-31-22(29-17-8-11-36(34,35)14-17)13-23(32-21)33-9-2-3-10-33/h4-7,12-13,17H,2-3,8-11,14H2,1H3,(H,29,31,32)/b7-6+/t17-/m1/s1
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n/an/a 0.00330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397987
PNG
(CHEMBL2180452)
Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)
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n/an/a 0.0500n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50004081
PNG
(CHEMBL2180797)
Show SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H20N6O2/c1-26-20(17(13-23-26)22(30)27-9-5-10-27)21(29)24-16-8-11-28-14-18(25-19(28)12-16)15-6-3-2-4-7-15/h2-4,6-8,11-14H,5,9-10H2,1H3,(H,24,29)
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n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397999
PNG
(CHEMBL2180796)
Show SMILES Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H22N6O3/c1-27-21(18(14-24-27)23(31)28-9-11-32-12-10-28)22(30)25-17-7-8-29-15-19(26-20(29)13-17)16-5-3-2-4-6-16/h2-8,13-15H,9-12H2,1H3,(H,25,30)
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n/an/a 0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398000
PNG
(CHEMBL2180795)
Show SMILES CN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C21H20N6O2/c1-25(2)21(29)16-12-22-26(3)19(16)20(28)23-15-9-10-27-13-17(24-18(27)11-15)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,23,28)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397988
PNG
(CHEMBL2180806)
Show SMILES CN1CC(CC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H20N4O3/c1-28-14-16(13-21(28)29)18-5-4-12-25-24(18)31-17-10-8-15(9-11-17)22(30)23-26-19-6-2-3-7-20(19)27-23/h2-12,16H,13-14H2,1H3,(H,26,27)
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n/an/a 0.210n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397972
PNG
(CHEMBL2180442)
Show SMILES Cc1nc2ccccc2nc1OCc1cc(OC2CCOCC2)nc(n1)N1CCCC1
Show InChI InChI=1S/C23H27N5O3/c1-16-22(26-20-7-3-2-6-19(20)24-16)30-15-17-14-21(31-18-8-12-29-13-9-18)27-23(25-17)28-10-4-5-11-28/h2-3,6-7,14,18H,4-5,8-13,15H2,1H3
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n/an/a 0.220n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397977
PNG
(CHEMBL2180420)
Show SMILES Cc1cnc(C)c2nc(CCc3cnc([nH]3)-c3ccoc3)nn12
Show InChI InChI=1S/C16H16N6O/c1-10-7-17-11(2)16-20-14(21-22(10)16)4-3-13-8-18-15(19-13)12-5-6-23-9-12/h5-9H,3-4H2,1-2H3,(H,18,19)
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n/an/a 0.270n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50390812
PNG
(CHEMBL2069321)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C18H15ClN4O2/c1-10-17-22-21-16-14(8-11(24-2)9-15(16)25-3)23(17)18(20-10)12-6-4-5-7-13(12)19/h4-9H,1-3H3
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n/an/a 0.280n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM31592
PNG
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM31596
PNG
(substituted pyrazole, 13)
Show SMILES FC(F)(F)Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H19F3N4O/c27-26(28,29)17-33-15-23(18-11-13-30-14-12-18)25(32-33)20-6-9-22(10-7-20)34-16-21-8-5-19-3-1-2-4-24(19)31-21/h1-15H,16-17H2
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n/an/a 0.300n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE10A by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398017
PNG
(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3
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n/an/a 0.320n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A using [3H]cAMP as substrate after 1 hr by scintillation counting

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50398015
PNG
(CHEMBL2180413 | US9018217, 5,7-dimethyl-2-(2-(1-me...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2c1
Show InChI InChI=1S/C20H21N5/c1-14-11-15(2)25-20(12-14)22-18(23-25)9-10-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-8,11-13H,9-10H2,1-3H3
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n/an/a 0.320n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A using [3H]cAMP as substrate after 1 hr by scintillation counting

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397978
PNG
(CHEMBL2180419)
Show SMILES Cc1cnc(C)c2nc(CCc3cnc([nH]3)-c3cccs3)nn12
Show InChI InChI=1S/C16H16N6S/c1-10-8-17-11(2)16-20-14(21-22(10)16)6-5-12-9-18-15(19-12)13-4-3-7-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)
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n/an/a 0.340n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397976
PNG
(CHEMBL2180438)
Show SMILES COc1ccc(cc1OC)-c1cc(nc(\C=C\c2nc(N(C)C)c3ccccc3n2)n1)N1CCn2ccnc2C1
Show InChI InChI=1S/C30H30N8O2/c1-36(2)30-21-7-5-6-8-22(21)32-27(35-30)12-11-26-33-23(20-9-10-24(39-3)25(17-20)40-4)18-28(34-26)38-16-15-37-14-13-31-29(37)19-38/h5-14,17-18H,15-16,19H2,1-4H3/b12-11+
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n/an/a 0.440n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397971
PNG
(CHEMBL2180443)
Show SMILES Cc1nc2ccccc2nc1OCc1nc(OC2CCOCC2)cc(n1)N1CCCC1
Show InChI InChI=1S/C23H27N5O3/c1-16-23(25-19-7-3-2-6-18(19)24-16)30-15-20-26-21(28-10-4-5-11-28)14-22(27-20)31-17-8-12-29-13-9-17/h2-3,6-7,14,17H,4-5,8-13,15H2,1H3
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n/an/a 0.610n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397966
PNG
(CHEMBL2180775)
Show SMILES COc1cc(OCc2ccccc2)cc2c1nnc1c(C)nc(-c3ccncc3C)n21
Show InChI InChI=1S/C24H21N5O2/c1-15-13-25-10-9-19(15)24-26-16(2)23-28-27-22-20(29(23)24)11-18(12-21(22)30-3)31-14-17-7-5-4-6-8-17/h4-13H,14H2,1-3H3
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397974
PNG
(CHEMBL2180440)
Show SMILES Cc1nc2ccccc2nc1\C=C\c1nc(OC2CCOCC2)cc(n1)N1CCCC1
Show InChI InChI=1S/C24H27N5O2/c1-17-19(26-21-7-3-2-6-20(21)25-17)8-9-22-27-23(29-12-4-5-13-29)16-24(28-22)31-18-10-14-30-15-11-18/h2-3,6-9,16,18H,4-5,10-15H2,1H3/b9-8+
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n/an/a 0.890n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397989
PNG
(CHEMBL2180805 | US8759532, 32)
Show SMILES C1CN(CCO1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C22H20N4O2S/c1-2-6-20-18(4-1)25-22(29-20)24-16-7-9-17(10-8-16)28-21-19(5-3-11-23-21)26-12-14-27-15-13-26/h1-11H,12-15H2,(H,24,25)
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n/an/a 0.960n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM97529
PNG
(Roche-Dataset for PDE10A, Compound 46 | US8470820,...)
Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc2ccccc2n1
Show InChI InChI=1S/C26H22N8O/c1-34-24(12-23(33-34)21-9-8-16-4-2-3-5-19(16)30-21)32-26(35)25-22(29-18-13-27-15-28-14-18)11-10-20(31-25)17-6-7-17/h2-5,8-15,17,29H,6-7H2,1H3,(H,32,35)
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n/an/a<1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM97527
PNG
(Roche-Dataset for PDE10A, Compound 53 | US8470820,...)
Show SMILES COCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C24H24N8O2/c1-34-11-10-32-22(12-21(31-32)19-4-2-3-9-27-19)30-24(33)23-20(28-17-13-25-15-26-14-17)8-7-18(29-23)16-5-6-16/h2-4,7-9,12-16,28H,5-6,10-11H2,1H3,(H,30,33)
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n/an/a<1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397979
PNG
(CHEMBL2180418 | US8927738, 5,8-Dimethyl-2-[2-(1-me...)
Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cccs3)nn12
Show InChI InChI=1S/C17H18N6S/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397964
PNG
(CHEMBL2180790)
Show SMILES FC(F)(F)COc1ccc(cc1)-n1ccc(=O)c(n1)-c1ccnn1-c1ccnc2ccccc12
Show InChI InChI=1S/C24H16F3N5O2/c25-24(26,27)15-34-17-7-5-16(6-8-17)31-14-11-22(33)23(30-31)21-10-13-29-32(21)20-9-12-28-19-4-2-1-3-18(19)20/h1-14H,15H2
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDEDA2 using [3H]cGMP as substrate after 30 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50390829
PNG
(CHEMBL2070666)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3ccncc3C)n21)C(F)(F)F
Show InChI InChI=1S/C18H14F3N5O/c1-9-8-22-5-4-12(9)17-23-10(2)16-25-24-15-13(26(16)17)6-11(18(19,20)21)7-14(15)27-3/h4-8H,1-3H3
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397993
PNG
(CHEMBL2180406)
Show SMILES CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2cc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C21H21N7O2/c1-4-26(2)20(30)15-12-22-27(3)18(15)19(29)24-17-10-11-28-13-16(23-21(28)25-17)14-8-6-5-7-9-14/h5-13H,4H2,1-3H3,(H,23,24,25,29)
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397998
PNG
(CHEMBL2180800 | Roche-Dataset for PDE10A, Compound...)
Show SMILES O=C(Nc1cnc(s1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C21H17N7OS/c29-20(28-18-11-25-21(30-18)17-3-1-2-8-24-17)19-16(26-14-9-22-12-23-10-14)7-6-15(27-19)13-4-5-13/h1-3,6-13,26H,4-5H2,(H,28,29)
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assay

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50397970
PNG
(CHEMBL2180771)
Show SMILES COc1ccc2nnc3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2c1
Show InChI InChI=1S/C17H12Cl2N4O/c1-9-16-22-21-14-6-4-11(24-2)8-15(14)23(16)17(20-9)12-7-10(18)3-5-13(12)19/h3-8H,1-2H3
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n/an/a 3.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counti...

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397975
PNG
(CHEMBL2180439)
Show SMILES Cc1nc2ccccc2nc1CCc1nc(cc(n1)C(=O)NC[C@@H]1CCCO1)N1CCCC1 |r|
Show InChI InChI=1S/C25H30N6O2/c1-17-19(28-21-9-3-2-8-20(21)27-17)10-11-23-29-22(15-24(30-23)31-12-4-5-13-31)25(32)26-16-18-7-6-14-33-18/h2-3,8-9,15,18H,4-7,10-14,16H2,1H3,(H,26,32)/t18-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50390822
PNG
(CHEMBL2070659)
Show SMILES COc1cc(F)cc2c1nnc1c(C)nc(-c3cccc(F)c3C)n21
Show InChI InChI=1S/C18H14F2N4O/c1-9-12(5-4-6-13(9)20)18-21-10(2)17-23-22-16-14(24(17)18)7-11(19)8-15(16)25-3/h4-8H,1-3H3
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n/an/a 3.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397980
PNG
(CHEMBL2180417)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(nn3C)-c3ccco3)nn12
Show InChI InChI=1S/C16H17N7O/c1-10-9-17-11(2)16-18-13(20-23(10)16)6-7-14-19-15(21-22(14)3)12-5-4-8-24-12/h4-5,8-9H,6-7H2,1-3H3
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n/an/a 4.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50397981
PNG
(CHEMBL2180416)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(nn3C)-c3ccsc3)nc12
Show InChI InChI=1S/C17H18N6S/c1-11-4-5-12(2)23-17(11)18-14(20-23)6-7-15-19-16(21-22(15)3)13-8-9-24-10-13/h4-5,8-10H,6-7H2,1-3H3
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n/an/a 5.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A

J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
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