Found 16 hits Enz. Inhib. hit(s) with all data for entry = 50046012 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50091030
(CHEMBL3582033)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ccn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/p+1/t10-,13-/m1/s1 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090969
(CHEMBL3582034)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ncn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-13-20(34-14-37)23-12-19-25(41-23)22(9-10-33-19)40-21-8-7-16(11-18(21)29)36-27(39)24-26(28(30,31)32)38(15-35-24)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317324
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090968
(CHEMBL3582035)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H17F4N7O2S/c1-37-13-19(33-14-37)22-12-18-24(41-22)21(9-10-32-18)40-20-8-7-15(11-17(20)28)34-26(39)23-25(27(29,30)31)38(36-35-23)16-5-3-2-4-6-16/h2-14H,1H3,(H,34,39) | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON phosphorylation in human PC3 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON phosphorylation in human HT29 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090966
(CHEMBL3582037)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H17F5N6O2S/c1-38-13-21(35-14-38)24-11-20-25(42-24)23(8-9-34-20)41-22-7-4-16(10-19(22)30)37-27(40)18-12-36-39(26(18)28(31,32)33)17-5-2-15(29)3-6-17/h2-14H,1H3,(H,37,40) | PDB
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| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090967
(CHEMBL3582036)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)35-27(39)18-13-38(17-5-3-2-4-6-17)36-26(18)28(30,31)32/h2-15H,1H3,(H,35,39) | PDB
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| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50091026
(CHEMBL3580678)Show SMILES CN(C(=O)c1cnn(c1C(F)(F)F)-c1ccccc1)c1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1 Show InChI InChI=1S/C26H31NO3/c1-17-23-13-18-9-10-21(28)14-22(18)25(17,2)11-12-27(23)16-20-15-26(20,24(29)30-3)19-7-5-4-6-8-19/h4-10,14,17,20,23,28H,11-13,15-16H2,1-3H3/t17?,20?,23?,25-,26+/m1/s1 | PDB
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| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50090968
(CHEMBL3582035)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H17F4N7O2S/c1-37-13-19(33-14-37)22-12-18-24(41-22)21(9-10-32-18)40-20-8-7-15(11-17(20)28)34-26(39)23-25(27(29,30)31)38(36-35-23)16-5-3-2-4-6-16/h2-14H,1H3,(H,34,39) | PDB
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| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317324
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37) | PDB
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| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50090969
(CHEMBL3582034)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ncn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-13-20(34-14-37)23-12-19-25(41-23)22(9-10-33-19)40-21-8-7-16(11-18(21)29)36-27(39)24-26(28(30,31)32)38(15-35-24)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50090967
(CHEMBL3582036)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)35-27(39)18-13-38(17-5-3-2-4-6-17)36-26(18)28(30,31)32/h2-15H,1H3,(H,35,39) | PDB
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| n/a | n/a | 3.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50090966
(CHEMBL3582037)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H17F5N6O2S/c1-38-13-21(35-14-38)24-11-20-25(42-24)23(8-9-34-20)41-22-7-4-16(10-19(22)30)37-27(40)18-12-36-39(26(18)28(31,32)33)17-5-2-15(29)3-6-17/h2-14H,1H3,(H,37,40) | PDB
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| n/a | n/a | 4.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| n/a | n/a | 6.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
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