Compile Data Set for Download or QSAR

Found 100 hits Enz. Inhib. hit(s) with all data for entry = 6471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130711 (US8822448, 23) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)NCC1(CCCCC1)N1CCOCC1 Show InChI InChI=1S/C28H37N5O4/c1-19-15-24-22(25-23(27(35)31-24)17-30-33(25)20-5-11-36-12-6-20)16-21(19)26(34)29-18-28(7-3-2-4-8-28)32-9-13-37-14-10-32/h15-17,20H,2-14,18H2,1H3,(H,29,34)(H,31,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130738 (US8822448, 129) Show SMILES CCc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCCOC)[C@H](C)C1 |r| Show InChI InChI=1S/C28H39N5O4/c1-4-20-15-25-23(26-24(27(34)30-25)17-29-33(26)21-7-13-37-14-8-21)16-22(20)28(35)32-11-10-31(19(2)18-32)9-5-6-12-36-3/h15-17,19,21H,4-14,18H2,1-3H3,(H,30,34)/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130781 (US8822448, 211) Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C25H30F3N5O2/c1-15-10-21-19(22-20(23(34)30-21)12-29-33(22)14-17-4-3-5-17)11-18(15)24(35)32-9-8-31(16(2)13-32)7-6-25(26,27)28/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,30,34)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130780 (US8822448, 210) Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C24H28F3N5O2/c1-14-9-20-18(21-19(22(33)29-20)11-28-32(21)13-16-3-4-16)10-17(14)23(34)31-8-7-30(15(2)12-31)6-5-24(25,26)27/h9-11,15-16H,3-8,12-13H2,1-2H3,(H,29,33)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130778 (US8822448, 207) Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r| Show InChI InChI=1S/C25H30F3N5O3/c1-15-11-21-19(22-20(23(34)30-21)13-29-33(22)17-3-9-36-10-4-17)12-18(15)24(35)32-8-7-31(16(2)14-32)6-5-25(26,27)28/h11-13,16-17H,3-10,14H2,1-2H3,(H,30,34)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130779 (US8822448, 208) Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C26H30F5N5O2/c1-15-11-21-19(12-18(15)24(38)35-10-9-34(16(2)14-35)8-7-26(29,30)31)22-20(23(37)33-21)13-32-36(22)17-3-5-25(27,28)6-4-17/h11-13,16-17H,3-10,14H2,1-2H3,(H,33,37)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130729 (US8822448, 94) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OCC(F)F Show InChI InChI=1S/C24H28F2N4O4/c1-14-10-20-18(11-17(14)24(32)29-6-2-16(3-7-29)34-13-21(25)26)22-19(23(31)28-20)12-27-30(22)15-4-8-33-9-5-15/h10-12,15-16,21H,2-9,13H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130794 (US8822448, 648) Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C26H35N5O3/c1-17-12-23-21(24-22(25(32)28-23)14-27-31(24)16-19-6-4-7-19)13-20(17)26(33)30-10-9-29(18(2)15-30)8-5-11-34-3/h12-14,18-19H,4-11,15-16H2,1-3H3,(H,28,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130709 (US8822448, 17) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C26H28N6O3/c1-17-14-22-20(24-21(25(33)29-22)16-28-32(24)18-5-12-35-13-6-18)15-19(17)26(34)31-10-8-30(9-11-31)23-4-2-3-7-27-23/h2-4,7,14-16,18H,5-6,8-13H2,1H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130710 (US8822448, 22) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)Oc1ccccn1 Show InChI InChI=1S/C27H29N5O4/c1-17-14-23-21(25-22(26(33)30-23)16-29-32(25)18-7-12-35-13-8-18)15-20(17)27(34)31-10-5-19(6-11-31)36-24-4-2-3-9-28-24/h2-4,9,14-16,18-19H,5-8,10-13H2,1H3,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130782 (US8822448, 212) Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCCC1 |r| Show InChI InChI=1S/C25H30F3N5O2/c1-15-11-21-19(22-20(23(34)30-21)13-29-33(22)17-5-3-4-6-17)12-18(15)24(35)32-10-9-31(16(2)14-32)8-7-25(26,27)28/h11-13,16-17H,3-10,14H2,1-2H3,(H,30,34)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130751 (US8822448, 169) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OC1CCC1 Show InChI InChI=1S/C26H32N4O4/c1-16-13-23-21(24-22(25(31)28-23)15-27-30(24)17-7-11-33-12-8-17)14-20(16)26(32)29-9-5-19(6-10-29)34-18-3-2-4-18/h13-15,17-19H,2-12H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130776 (US8822448, 203) Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OCC(F)(F)F |r| Show InChI InChI=1S/C23H25F3N4O4/c1-13-8-19-17(20-18(21(31)28-19)10-27-30(20)14-4-7-33-11-14)9-16(13)22(32)29-5-2-15(3-6-29)34-12-23(24,25)26/h8-10,14-15H,2-7,11-12H2,1H3,(H,28,31)/t14-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130740 (US8822448, 139) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCC(F)(F)F)CC1 Show InChI InChI=1S/C25H30F3N5O3/c1-16-13-21-19(22-20(23(34)30-21)15-29-33(22)17-3-11-36-12-4-17)14-18(16)24(35)32-9-7-31(8-10-32)6-2-5-25(26,27)28/h13-15,17H,2-12H2,1H3,(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130771 (US8822448, 198) Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OCC1CC1 |r| Show InChI InChI=1S/C25H30N4O4/c1-15-10-22-20(23-21(24(30)27-22)12-26-29(23)17-6-9-32-14-17)11-19(15)25(31)28-7-4-18(5-8-28)33-13-16-2-3-16/h10-12,16-18H,2-9,13-14H2,1H3,(H,27,30)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130726 (US8822448, 86) Show SMILES CCOCC1CN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C23H28N4O4/c1-3-30-13-15-11-26(12-15)23(29)17-9-18-20(8-14(17)2)25-22(28)19-10-24-27(21(18)19)16-4-6-31-7-5-16/h8-10,15-16H,3-7,11-13H2,1-2H3,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130793 (US8822448, 640) Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C25H33N5O3/c1-16-11-22-20(23-21(24(31)27-22)13-26-30(23)15-18-5-6-18)12-19(16)25(32)29-9-8-28(17(2)14-29)7-4-10-33-3/h11-13,17-18H,4-10,14-15H2,1-3H3,(H,27,31)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130759 (US8822448, 183) Show SMILES COCCCCN1C[C@H](C)N(C[C@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r| Show InChI InChI=1S/C28H39N5O4/c1-18-13-25-23(26-24(27(34)30-25)15-29-33(26)21-7-11-37-12-8-21)14-22(18)28(35)32-17-19(2)31(16-20(32)3)9-5-6-10-36-4/h13-15,19-21H,5-12,16-17H2,1-4H3,(H,30,34)/t19-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130775 (US8822448, 202) Show SMILES Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OC1CCC1 |r| Show InChI InChI=1S/C25H30N4O4/c1-15-11-22-20(23-21(24(30)27-22)13-26-29(23)16-7-10-32-14-16)12-19(15)25(31)28-8-5-18(6-9-28)33-17-3-2-4-17/h11-13,16-18H,2-10,14H2,1H3,(H,27,30)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130762 (US8822448, 186) Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCCC1 |r| Show InChI InChI=1S/C27H37N5O3/c1-18-14-24-22(25-23(26(33)29-24)16-28-32(25)20-8-4-5-9-20)15-21(18)27(34)31-12-11-30(19(2)17-31)10-6-7-13-35-3/h14-16,19-20H,4-13,17H2,1-3H3,(H,29,33)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130715 (US8822448, 49) Show SMILES CN1CCN(CC1c1cccnc1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C27H30N6O3/c1-17-12-23-21(25-22(26(34)30-23)15-29-33(25)19-5-10-36-11-6-19)13-20(17)27(35)32-9-8-31(2)24(16-32)18-4-3-7-28-14-18/h3-4,7,12-15,19,24H,5-6,8-11,16H2,1-2H3,(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130717 (US8822448, 53) Show SMILES CCCOC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C25H32N4O4/c1-3-10-33-18-4-8-28(9-5-18)25(31)19-14-20-22(13-16(19)2)27-24(30)21-15-26-29(23(20)21)17-6-11-32-12-7-17/h13-15,17-18H,3-12H2,1-2H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130721 (US8822448, 66) Show SMILES COCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C25H32N4O4/c1-16-13-22-20(14-19(16)25(31)28-8-3-17(4-9-28)5-10-32-2)23-21(24(30)27-22)15-26-29(23)18-6-11-33-12-7-18/h13-15,17-18H,3-12H2,1-2H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130750 (US8822448, 168) Show SMILES CCOCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C26H34N4O4/c1-3-33-11-6-18-4-9-29(10-5-18)26(32)20-15-21-23(14-17(20)2)28-25(31)22-16-27-30(24(21)22)19-7-12-34-13-8-19/h14-16,18-19H,3-13H2,1-2H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130770 (US8822448, 195) Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C26H35N5O3/c1-17-12-23-21(24-22(25(32)28-23)14-27-31(24)16-19-6-7-19)13-20(17)26(33)30-10-9-29(18(2)15-30)8-4-5-11-34-3/h12-14,18-19H,4-11,15-16H2,1-3H3,(H,28,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130757 (US8822448, 181) Show SMILES C[C@H]1CN(CCN1c1ccc(F)c(C)n1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCN(C)C1 |r| Show InChI InChI=1S/C28H32FN7O2/c1-16-11-24-21(26-22(27(37)32-24)13-30-36(26)19-7-8-33(4)15-19)12-20(16)28(38)34-9-10-35(17(2)14-34)25-6-5-23(29)18(3)31-25/h5-6,11-13,17,19H,7-10,14-15H2,1-4H3,(H,32,37)/t17-,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130755 (US8822448, 178) Show SMILES C[C@H](F)COC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r| Show InChI InChI=1S/C24H29FN4O4/c1-14-9-21-19(22-20(23(30)27-21)11-26-29(22)16-5-8-32-13-16)10-18(14)24(31)28-6-3-17(4-7-28)33-12-15(2)25/h9-11,15-17H,3-8,12-13H2,1-2H3,(H,27,30)/t15-,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130785 (US8822448, 217) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(COC2CC2)CC1 Show InChI InChI=1S/C26H32N4O4/c1-16-12-23-21(24-22(25(31)28-23)14-27-30(24)18-6-10-33-11-7-18)13-20(16)26(32)29-8-4-17(5-9-29)15-34-19-2-3-19/h12-14,17-19H,2-11,15H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130719 (US8822448, 56) Show SMILES CCOCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C25H32N4O4/c1-3-32-15-17-4-8-28(9-5-17)25(31)19-13-20-22(12-16(19)2)27-24(30)21-14-26-29(23(20)21)18-6-10-33-11-7-18/h12-14,17-18H,3-11,15H2,1-2H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130795 (US8822448, 655) Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCCC1 |r| Show InChI InChI=1S/C26H35N5O3/c1-17-13-23-21(24-22(25(32)28-23)15-27-31(24)19-7-4-5-8-19)14-20(17)26(33)30-11-10-29(18(2)16-30)9-6-12-34-3/h13-15,18-19H,4-12,16H2,1-3H3,(H,28,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130760 (US8822448, 184) Show SMILES C[C@@H]1CN([C@@H](C)CN1CCC(F)(F)F)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r| Show InChI InChI=1S/C26H32F3N5O3/c1-15-10-22-20(23-21(24(35)31-22)12-30-34(23)18-4-8-37-9-5-18)11-19(15)25(36)33-14-16(2)32(13-17(33)3)7-6-26(27,28)29/h10-12,16-18H,4-9,13-14H2,1-3H3,(H,31,35)/t16-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130772 (US8822448, 199) Show SMILES CCCOC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r| Show InChI InChI=1S/C24H30N4O4/c1-3-9-32-17-4-7-27(8-5-17)24(30)18-12-19-21(11-15(18)2)26-23(29)20-13-25-28(22(19)20)16-6-10-31-14-16/h11-13,16-17H,3-10,14H2,1-2H3,(H,26,29)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130736 (US8822448, 127) Show SMILES COCCCCN(C)[C@H]1CCN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r| Show InChI InChI=1S/C27H37N5O4/c1-18-14-24-22(25-23(26(33)29-24)16-28-32(25)19-7-12-36-13-8-19)15-21(18)27(34)31-10-6-20(17-31)30(2)9-4-5-11-35-3/h14-16,19-20H,4-13,17H2,1-3H3,(H,29,33)/t20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130743 (US8822448, 148) Show SMILES CCOCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r| Show InChI InChI=1S/C24H30N4O4/c1-3-31-13-16-4-7-27(8-5-16)24(30)18-11-19-21(10-15(18)2)26-23(29)20-12-25-28(22(19)20)17-6-9-32-14-17/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,26,29)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130742 (US8822448, 146) Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC1 |r| Show InChI InChI=1S/C26H35N5O3/c1-17-13-23-21(24-22(25(32)28-23)15-27-31(24)19-7-6-8-19)14-20(17)26(33)30-11-10-29(18(2)16-30)9-4-5-12-34-3/h13-15,18-19H,4-12,16H2,1-3H3,(H,28,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130737 (US8822448, 128) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCC(F)(F)F)CC1 Show InChI InChI=1S/C24H28F3N5O3/c1-15-12-20-18(21-19(22(33)29-20)14-28-32(21)16-2-10-35-11-3-16)13-17(15)23(34)31-8-6-30(7-9-31)5-4-24(25,26)27/h12-14,16H,2-11H2,1H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130758 (US8822448, 182) Show SMILES C[C@@H]1CN(CCN1c1ccc(F)c(C)n1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCN(C)C1 |r| Show InChI InChI=1S/C28H32FN7O2/c1-16-11-24-21(26-22(27(37)32-24)13-30-36(26)19-7-8-33(4)15-19)12-20(16)28(38)34-9-10-35(17(2)14-34)25-6-5-23(29)18(3)31-25/h5-6,11-13,17,19H,7-10,14-15H2,1-4H3,(H,32,37)/t17-,19+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130769 (US8822448, 193) Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C28H37F2N5O3/c1-18-14-24-22(15-21(18)27(37)34-12-11-33(19(2)17-34)10-4-5-13-38-3)25-23(26(36)32-24)16-31-35(25)20-6-8-28(29,30)9-7-20/h14-16,19-20H,4-13,17H2,1-3H3,(H,32,36)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130714 (US8822448, 41) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OCC1CC1 Show InChI InChI=1S/C26H32N4O4/c1-16-12-23-21(24-22(25(31)28-23)14-27-30(24)18-6-10-33-11-7-18)13-20(16)26(32)29-8-4-19(5-9-29)34-15-17-2-3-17/h12-14,17-19H,2-11,15H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130733 (US8822448, 109) Show SMILES CCOCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 |r| Show InChI InChI=1S/C28H39N5O4/c1-4-36-12-6-5-9-31-10-11-32(18-20(31)3)28(35)22-16-23-25(15-19(22)2)30-27(34)24-17-29-33(26(23)24)21-7-13-37-14-8-21/h15-17,20-21H,4-14,18H2,1-3H3,(H,30,34)/t20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130790 (US8822448, 283) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC2(COc3ccccc23)CC1 Show InChI InChI=1S/C29H30N4O4/c1-18-14-24-21(26-22(27(34)31-24)16-30-33(26)19-6-12-36-13-7-19)15-20(18)28(35)32-10-8-29(9-11-32)17-37-25-5-3-2-4-23(25)29/h2-5,14-16,19H,6-13,17H2,1H3,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130728 (US8822448, 92) Show SMILES CCOCC1CCN(C1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCOCC1 Show InChI InChI=1S/C24H30N4O4/c1-3-31-14-16-4-7-27(13-16)24(30)18-11-19-21(10-15(18)2)26-23(29)20-12-25-28(22(19)20)17-5-8-32-9-6-17/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130777 (US8822448, 204) Show SMILES COCCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CC(F)(F)C4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C27H35F2N5O3/c1-17-10-23-21(24-22(25(35)31-23)14-30-34(24)16-19-12-27(28,29)13-19)11-20(17)26(36)33-8-7-32(18(2)15-33)6-4-5-9-37-3/h10-11,14,18-19H,4-9,12-13,15-16H2,1-3H3,(H,31,35)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130752 (US8822448, 173) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCOC(F)(F)F)CC1 Show InChI InChI=1S/C25H30F3N5O4/c1-16-13-21-19(22-20(23(34)30-21)15-29-33(22)17-3-11-36-12-4-17)14-18(16)24(35)32-8-6-31(7-9-32)5-2-10-37-25(26,27)28/h13-15,17H,2-12H2,1H3,(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130774 (US8822448, 201) Show SMILES CCOCCC1CCN(CC1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCOC1 |r| Show InChI InChI=1S/C25H32N4O4/c1-3-32-10-6-17-4-8-28(9-5-17)25(31)19-13-20-22(12-16(19)2)27-24(30)21-14-26-29(23(20)21)18-7-11-33-15-18/h12-14,17-18H,3-11,15H2,1-2H3,(H,27,30)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130756 (US8822448, 179) Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)C1CCC1 |r| Show InChI InChI=1S/C25H33N5O3/c1-16-12-22-20(23-21(24(31)27-22)14-26-30(23)18-6-4-7-18)13-19(16)25(32)29-10-9-28(17(2)15-29)8-5-11-33-3/h12-14,17-18H,4-11,15H2,1-3H3,(H,27,31)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130765 (US8822448, 189) Show SMILES COCCCCN1C[C@H](C)N(C[C@H]1C)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C28H39N5O3/c1-18-12-25-23(26-24(27(34)30-25)14-29-33(26)17-21-8-7-9-21)13-22(18)28(35)32-16-19(2)31(15-20(32)3)10-5-6-11-36-4/h12-14,19-21H,5-11,15-17H2,1-4H3,(H,30,34)/t19-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130748 (US8822448, 162) Show SMILES CCc1cc2[nH]c(=O)c3cnn(C4CCC4)c3c2cc1C(=O)N1CCN(CCC(F)(F)F)CC1 Show InChI InChI=1S/C24H28F3N5O2/c1-2-15-12-20-18(21-19(22(33)29-20)14-28-32(21)16-4-3-5-16)13-17(15)23(34)31-10-8-30(9-11-31)7-6-24(25,26)27/h12-14,16H,2-11H2,1H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130716 (US8822448, 50) Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC1)c1cnccn1 Show InChI InChI=1S/C25H27N7O3/c1-16-12-21-19(23-20(24(33)29-21)14-28-32(23)17-2-10-35-11-3-17)13-18(16)25(34)31-8-6-30(7-9-31)22-15-26-4-5-27-22/h4-5,12-15,17H,2-3,6-11H2,1H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Rattus norvegicus (Rat))	BDBM130766 (US8822448, 190) Show SMILES C[C@@H]1CN([C@@H](C)CN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C26H32F3N5O2/c1-15-9-22-20(23-21(24(35)31-22)11-30-34(23)14-18-5-4-6-18)10-19(15)25(36)33-13-16(2)32(12-17(33)3)8-7-26(27,28)29/h9-11,16-18H,4-8,12-14H2,1-3H3,(H,31,35)/t16-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair

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