Compile Data Set for Download or QSAR

Found 498 hits of ic50 for UniProtKB: P29477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096347 (CHEMBL224752) Show SMILES [H][C@@]12CC[C@]3(C=C(C#N)C(=O)C=C3[C@@]1(C)C=C(C#N)C(=O)C2(C)C)C#C |r,c:11,t:5,17| Show InChI InChI=1S/C24H20ClFN4O/c1-2-27-15-18-7-5-6-17(28-18)11-13-23-29-21-12-10-16(26)14-19(21)24(31)30(23)22-9-4-3-8-20(22)25/h3-14,27H,2,15H2,1H3/b13-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138191 ((1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-bicyclo[4.1....) Show SMILES C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12 |c:4| Show InChI InChI=1S/C7H11ClN2/c1-3-2-4(9)10-7-5(3)6(7)8/h3,5-7H,2H2,1H3,(H2,9,10)/t3-,5?,6+,7-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50363262 (CHEMBL1944717) Show SMILES Fc1ccc2c(CN(c3cccc(Cl)c3)c3cnccn3)cc(=O)[nH]c2c1F Show InChI InChI=1S/C20H13ClF2N4O/c21-13-2-1-3-14(9-13)27(17-10-24-6-7-25-17)11-12-8-18(28)26-20-15(12)4-5-16(22)19(20)23/h1-10H,11H2,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Afraxis Curated by ChEMBL					Assay Description Inhibition of mouse iNOS				Bioorg Med Chem Lett 22: 1237-41 (2012) Article DOI: 10.1016/j.bmcl.2011.11.073 BindingDB Entry DOI: 10.7270/Q26W9BJ5
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50386178 (CHEMBL1800346 | ONO-1714) Show SMILES C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12 |r,c:4| Show InChI InChI=1S/C7H11ClN2/c1-3-2-4(9)10-7-5(3)6(7)8/h3,5-7H,2H2,1H3,(H2,9,10)/t3-,5?,6+,7-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Instituto Cajal (CSIC) Curated by ChEMBL					Assay Description Inhibition of mouse recombinant iNOS activity assessed as conversion of [14C]-L-arginine to [14C]-L-citrulline by liquid scintillation counting				Eur J Med Chem 54: 439-46 (2012) Article DOI: 10.1016/j.ejmech.2012.05.031 BindingDB Entry DOI: 10.7270/Q2NC6280
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096337 (CHEMBL3577126) Show SMILES C=CC1(C=CC(=O)C(=C1)C#N)C#C |c:3,7| Show InChI InChI=1S/C22H17N3O/c1-16-8-2-5-12-20(16)25-21(14-13-17-9-6-7-15-23-17)24-19-11-4-3-10-18(19)22(25)26/h2-15H,1H3/b14-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096335 (CHEMBL2064456) Show SMILES CC1(C=CC(=O)C(=C1)C#N)C#C |c:2,6| Show InChI InChI=1S/C24H20ClFN4O/c1-29(2)15-18-7-5-6-17(27-18)11-13-23-28-21-12-10-16(26)14-19(21)24(31)30(23)22-9-4-3-8-20(22)25/h3-14H,15H2,1-2H3/b13-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50116666 (4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine ...) Show SMILES CC1=CC(N)=NCC1 |c:4,t:1| Show InChI InChI=1S/C6H10N2/c1-5-2-3-8-6(7)4-5/h4H,2-3H2,1H3,(H2,7,8)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Fukui Research Institute Curated by ChEMBL					Assay Description The concentration required for inhibition of Inducible nitric oxide synthase in mouse				Bioorg Med Chem Lett 12: 2291-4 (2002) BindingDB Entry DOI: 10.7270/Q2M32V3P
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096348 (2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...) Show SMILES [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(O)=O |r,c:19,33| Show InChI InChI=1S/C23H19N3O2/c1-16-8-3-4-11-19(16)26-21(14-13-17-9-5-6-15-24-17)25-22-18(23(26)27)10-7-12-20(22)28-2/h3-15H,1-2H3/b14-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50116674 (6-Allyl-4-methyl-5,6-dihydro-1H-pyridin-(2Z)-ylide...) Show SMILES CC1=CC(N)=NC(CC=C)C1 |c:4,t:1| Show InChI InChI=1S/C9H14N2/c1-3-4-8-5-7(2)6-9(10)11-8/h3,6,8H,1,4-5H2,2H3,(H2,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Fukui Research Institute Curated by ChEMBL					Assay Description The concentration required for inhibition of Inducible nitric oxide synthase in mouse				Bioorg Med Chem Lett 12: 2291-4 (2002) BindingDB Entry DOI: 10.7270/Q2M32V3P
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096338 (CHEMBL3577127) Show SMILES CCC1(C=CC(=O)C(=C1)C#N)C#C |c:3,7| Show InChI InChI=1S/C24H21N3O3/c1-16-8-4-5-10-20(16)27-23(12-11-17-9-6-7-13-25-17)26-19-15-22(30-3)21(29-2)14-18(19)24(27)28/h4-15H,1-3H3/b12-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50115777 ((E)-1-(4'-Fluorophenyl)-3-(3'',4'',5''-trimethoxyp...) Show SMILES COc1cc(\C=C\C(=O)c2ccc(F)cc2)cc(OC)c1OC Show InChI InChI=1S/C18H17FO4/c1-21-16-10-12(11-17(22-2)18(16)23-3)4-9-15(20)13-5-7-14(19)8-6-13/h4-11H,1-3H3/b9-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory concentration of the compound required to produce 50% inhibition of the response was determined				Bioorg Med Chem Lett 12: 1951-4 (2002) BindingDB Entry DOI: 10.7270/Q2M61JKW
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138189 ((4S,5R)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...) Show SMILES CCC[C@@H]1N=C(N)O[C@@H]1C |t:4| Show InChI InChI=1S/C7H14N2O/c1-3-4-6-5(2)10-7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50350681 (CHEMBL1813771) Show SMILES C1COc2cc(ccc2O1)-c1nnc(o1)-c1cccnc1 Show InChI InChI=1S/C15H11N3O3/c1-2-11(9-16-5-1)15-18-17-14(21-15)10-3-4-12-13(8-10)20-7-6-19-12/h1-5,8-9H,6-7H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation counting				Bioorg Med Chem 19: 4895-902 (2011) Article DOI: 10.1016/j.bmc.2011.06.061 BindingDB Entry DOI: 10.7270/Q23T9HK2
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138195 ((4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...) Show SMILES CC[C@@H]1OC(N)=N[C@H]1CC |c:5| Show InChI InChI=1S/C7H14N2O/c1-3-5-6(4-2)10-7(8)9-5/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50401339 (CHEMBL4161447) Show SMILES Cl.Cl.CC(=N)NCc1cccc(CNC(=O)[C@@H]2CCCN2)c1 |r| Show InChI InChI=1S/C15H22N4O.2ClH/c1-11(16)18-9-12-4-2-5-13(8-12)10-19-15(20)14-6-3-7-17-14;;/h2,4-5,8,14,17H,3,6-7,9-10H2,1H3,(H2,16,18)(H,19,20);2*1H/t14-;;/m0../s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...				Eur J Med Chem 152: 53-64 (2018) Article DOI: 10.1016/j.ejmech.2018.04.027 BindingDB Entry DOI: 10.7270/Q2C2500M
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138201 (5-Methyl-oxazolidin-(2Z)-ylideneamine | CHEMBL1074...) Show SMILES CC1CN=C(N)O1 |t:3| Show InChI InChI=1S/C4H8N2O/c1-3-2-6-4(5)7-3/h3H,2H2,1H3,(H2,5,6)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50350680 (CHEMBL1813770) Show SMILES C1COc2cc(ccc2O1)-c1nnc(\C=C\c2ccccc2)o1 Show InChI InChI=1S/C18H14N2O3/c1-2-4-13(5-3-1)6-9-17-19-20-18(23-17)14-7-8-15-16(12-14)22-11-10-21-15/h1-9,12H,10-11H2/b9-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation counting				Bioorg Med Chem 19: 4895-902 (2011) Article DOI: 10.1016/j.bmc.2011.06.061 BindingDB Entry DOI: 10.7270/Q23T9HK2
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50095303 (CHEMBL3589092) Show SMILES CC(=N)NCc1cccc(CNCc2ccccc2[N+]([O-])=O)c1 Show InChI InChI=1S/C17H20N4O2/c1-13(18)20-11-15-6-4-5-14(9-15)10-19-12-16-7-2-3-8-17(16)21(22)23/h2-9,19H,10-12H2,1H3,(H2,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti"G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...				ACS Med Chem Lett 6: 635-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00149 BindingDB Entry DOI: 10.7270/Q2C53NKC
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50226527 (CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...) Show SMILES CC(N)=NCc1cccc(CN)c1 |w:3.3| Show InChI InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti"G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...				ACS Med Chem Lett 6: 635-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00149 BindingDB Entry DOI: 10.7270/Q2C53NKC
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50350683 (CHEMBL1813764) Show SMILES Cc1ccccc1-c1nnc(o1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C17H14N2O3/c1-11-4-2-3-5-13(11)17-19-18-16(22-17)12-6-7-14-15(10-12)21-9-8-20-14/h2-7,10H,8-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation counting				Bioorg Med Chem 19: 4895-902 (2011) Article DOI: 10.1016/j.bmc.2011.06.061 BindingDB Entry DOI: 10.7270/Q23T9HK2
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50116668 (4-Methyl-6-propyl-5,6-dihydro-1H-pyridin-(2Z)-ylid...) Show SMILES CCCC1CC(C)=CC(N)=N1 |c:6,9| Show InChI InChI=1S/C9H16N2/c1-3-4-8-5-7(2)6-9(10)11-8/h6,8H,3-5H2,1-2H3,(H2,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Fukui Research Institute Curated by ChEMBL					Assay Description The concentration required for inhibition of Inducible nitric oxide synthase in mouse				Bioorg Med Chem Lett 12: 2291-4 (2002) BindingDB Entry DOI: 10.7270/Q2M32V3P
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50116667 (4,5,5-Trimethyl-5,6-dihydro-1H-pyridin-(2Z)-yliden...) Show SMILES CC1=CC(N)=NCC1(C)C |c:4,t:1| Show InChI InChI=1S/C8H14N2/c1-6-4-7(9)10-5-8(6,2)3/h4H,5H2,1-3H3,(H2,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Fukui Research Institute Curated by ChEMBL					Assay Description The concentration required for inhibition of Inducible nitric oxide synthase in mouse				Bioorg Med Chem Lett 12: 2291-4 (2002) BindingDB Entry DOI: 10.7270/Q2M32V3P
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50226527 (CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...) Show SMILES CC(N)=NCc1cccc(CN)c1 |w:3.3| Show InChI InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...				Eur J Med Chem 152: 53-64 (2018) Article DOI: 10.1016/j.ejmech.2018.04.027 BindingDB Entry DOI: 10.7270/Q2C2500M
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138190 ((4S,5S)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...) Show SMILES CCC[C@@H]1N=C(N)O[C@H]1C |t:4| Show InChI InChI=1S/C7H14N2O/c1-3-4-6-5(2)10-7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138194 ((4S,5S)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...) Show SMILES CC[C@@H]1OC(N)=N[C@H]1C |c:5| Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)8-6(7)9-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138192 ((4S,5R)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...) Show SMILES CC[C@@H]1N=C(N)O[C@@H]1C |t:3| Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)9-6(7)8-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50350684 (CHEMBL1813769) Show SMILES COc1cc(cc(OC)c1OC)-c1nnc(o1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H18N2O6/c1-22-15-9-12(10-16(23-2)17(15)24-3)19-21-20-18(27-19)11-4-5-13-14(8-11)26-7-6-25-13/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation counting				Bioorg Med Chem 19: 4895-902 (2011) Article DOI: 10.1016/j.bmc.2011.06.061 BindingDB Entry DOI: 10.7270/Q23T9HK2
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138198 ((4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...) Show SMILES CC[C@H]1OC(N)=N[C@H]1CC |c:5| Show InChI InChI=1S/C7H14N2O/c1-3-5-6(4-2)10-7(8)9-5/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138184 ((4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine ...) Show SMILES C[C@H]1OC(N)=N[C@H]1C |c:4| Show InChI InChI=1S/C5H10N2O/c1-3-4(2)8-5(6)7-3/h3-4H,1-2H3,(H2,6,7)/t3-,4+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096339 (CHEMBL3577128) Show SMILES O=C1C=C2CCCC2(C=C1C#N)C#C |c:9,t:2| Show InChI InChI=1S/C24H17ClFN3O3/c1-15(30)32-14-18-6-4-5-17(27-18)10-12-23-28-21-11-9-16(26)13-19(21)24(31)29(23)22-8-3-2-7-20(22)25/h2-13H,14H2,1H3/b12-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138185 ((4S,5R)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...) Show SMILES CC[C@H]1OC(N)=N[C@H]1C |c:5| Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)8-6(7)9-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50095302 (CHEMBL3589091) Show SMILES CC(=N)NCc1cccc(CNC(=O)c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C18H19N3O3/c1-12(19)20-10-13-3-2-4-14(9-13)11-21-17(22)15-5-7-16(8-6-15)18(23)24/h2-9H,10-11H2,1H3,(H2,19,20)(H,21,22)(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti"G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...				ACS Med Chem Lett 6: 635-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00149 BindingDB Entry DOI: 10.7270/Q2C53NKC
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138187 ((4S,5S)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...) Show SMILES CC[C@@H]1N=C(N)O[C@H]1C |t:3| Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)9-6(7)8-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50403157 (CHEMBL4171271) Show SMILES Cl.Cl.CC[C@H](C)[C@H](N)C(=O)NCc1cccc(CNC(C)=N)c1 |r| Show InChI InChI=1S/C17H28O7P2/c1-13(2)6-5-7-14(3)8-16-9-15(4)17(24-16)10-23-11-25(18,19)12-26(20,21)22/h6,8-9H,5,7,10-12H2,1-4H3,(H,18,19)(H2,20,21,22)/b14-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...				Eur J Med Chem 152: 53-64 (2018) Article DOI: 10.1016/j.ejmech.2018.04.027 BindingDB Entry DOI: 10.7270/Q2C2500M
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096340 (CHEMBL3577129) Show SMILES CC1(C)CCC2(C=C(C#N)C(=O)C=C12)C#C |t:6,12| Show InChI InChI=1S/C22H16BrN3O/c1-15-6-2-3-8-20(15)26-21(12-10-17-7-4-5-13-24-17)25-19-11-9-16(23)14-18(19)22(26)27/h2-14H,1H3/b12-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50292744 (1-(Benzylamino)ethaniminium bromide | CHEMBL462334) Show SMILES C\C(N)=[NH+]\Cc1ccccc1 Show InChI InChI=1S/C9H12N2/c1-8(10)11-7-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H2,10,11)/p+1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Università G. d'Annunzio Curated by ChEMBL					Assay Description Inhibition of mouse macrophage iNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobin				Bioorg Med Chem Lett 20: 6495-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.059 BindingDB Entry DOI: 10.7270/Q2GX4BTP
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096336 (CHEMBL3577125) Show SMILES O=C1C=CC(C=C1C#N)(C#C)C#C |c:2,5| Show InChI InChI=1S/C26H24ClFN4O/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27/h5-16H,3-4,17H2,1-2H3/b15-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096341 (CHEMBL3577131) Show SMILES O=C1C=C2c3ccccc3CCC2(C=C1C#N)C#C |c:15,t:2| Show InChI InChI=1S/C21H12F3N3O/c22-13-7-9-18-15(12-13)21(28)27(20-16(23)5-3-6-17(20)24)19(26-18)10-8-14-4-1-2-11-25-14/h1-12H/b10-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138196 ((4S,5R)-5-Methyl-4-pentyl-oxazolidin-(2Z)-ylidenea...) Show SMILES CCCCC[C@@H]1N=C(N)O[C@@H]1C |t:6| Show InChI InChI=1S/C9H18N2O/c1-3-4-5-6-8-7(2)12-9(10)11-8/h7-8H,3-6H2,1-2H3,(H2,10,11)/t7-,8+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50292746 ((+/-)-N-(1-Phenylpropyl)ethanimidamide hydrobromid...) Show SMILES CCC(N=C(C)N)c1ccccc1 |w:3.2| Show InChI InChI=1S/C11H16N2/c1-3-11(13-9(2)12)10-7-5-4-6-8-10/h4-8,11H,3H2,1-2H3,(H2,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Università G. d'Annunzio Curated by ChEMBL					Assay Description Inhibition of mouse macrophage iNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobin				Bioorg Med Chem Lett 20: 6495-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.059 BindingDB Entry DOI: 10.7270/Q2GX4BTP
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50403472 (CHEMBL4169004) Show SMILES Cl.Cl.CC(C)C[C@H](N)C(=O)NCc1cccc(CNC(C)=N)c1 |r| Show InChI InChI=1S/C31H43N5O5/c1-18(2)9-25(35-30(41)36-31-14-19-10-20(15-31)12-21(11-19)16-31)29(40)34-26(28(39)32-8-7-27(37)38)13-22-17-33-24-6-4-3-5-23(22)24/h3-6,17-21,25-26,33H,7-16H2,1-2H3,(H,32,39)(H,34,40)(H,37,38)(H2,35,36,41)/t19?,20?,21?,25-,26+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	253	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...				Eur J Med Chem 152: 53-64 (2018) Article DOI: 10.1016/j.ejmech.2018.04.027 BindingDB Entry DOI: 10.7270/Q2C2500M
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50403162 (CHEMBL4160671) Show SMILES Cl.Cl.C[C@H](N)C(=O)NCc1cccc(CNC(C)=N)c1 |r| Show InChI InChI=1S/C16H30O6P2/c1-15(2)9-8-11-16(3)10-6-4-5-7-12-22-13-23(17,18)14-24(19,20)21/h5,7,9-10H,4,6,8,11-14H2,1-3H3,(H,17,18)(H2,19,20,21)/b7-5+,16-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	276	n/a	n/a	n/a	n/a	n/a	n/a
University of Chieti "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...				Eur J Med Chem 152: 53-64 (2018) Article DOI: 10.1016/j.ejmech.2018.04.027 BindingDB Entry DOI: 10.7270/Q2C2500M
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50138193 (5-Ethyl-oxazolidin-(2Z)-ylideneamine | CHEMBL10835...) Show SMILES CCC1CN=C(N)O1 |t:4| Show InChI InChI=1S/C5H10N2O/c1-2-4-3-7-5(6)8-4/h4H,2-3H2,1H3,(H2,6,7)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice				Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50105335 (CHEMBL3597247) Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CCCCCCn2c3ccccc3sc2=O)CC1 Show InChI InChI=1S/C30H40N4O2S2/c35-29-33(25-13-5-7-15-27(25)37-29)19-11-3-1-9-17-31-21-23-32(24-22-31)18-10-2-4-12-20-34-26-14-6-8-16-28(26)38-30(34)36/h5-8,13-16H,1-4,9-12,17-24H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Beni-Suef University Curated by ChEMBL					Assay Description Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...				Bioorg Med Chem 23: 3248-59 (2015) Article DOI: 10.1016/j.bmc.2015.04.057 BindingDB Entry DOI: 10.7270/Q26H4K5F
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50115783 (3-(5-Ethoxy-2,4-dimethoxy-phenyl)-1-(2-trifluorome...) Show SMILES COc1cc(OC)c(\C=C\C(=O)c2ccccc2C(F)(F)F)cc1OC Show InChI InChI=1S/C19H17F3O4/c1-24-16-11-18(26-3)17(25-2)10-12(16)8-9-15(23)13-6-4-5-7-14(13)19(20,21)22/h4-11H,1-3H3/b9-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory concentration of the compound required to produce 50% inhibition of the response was determined; range-0.150.47 uM				Bioorg Med Chem Lett 12: 1951-4 (2002) BindingDB Entry DOI: 10.7270/Q2M61JKW
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50105353 (CHEMBL3597266) Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CCCCCn2c3ccccc3sc2=O)CC1 Show InChI InChI=1S/C29H38N4O2S2/c34-28-32(24-12-4-6-14-26(24)36-28)18-10-2-1-8-16-30-20-22-31(23-21-30)17-9-3-11-19-33-25-13-5-7-15-27(25)37-29(33)35/h4-7,12-15H,1-3,8-11,16-23H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Beni-Suef University Curated by ChEMBL					Assay Description Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...				Bioorg Med Chem 23: 3248-59 (2015) Article DOI: 10.1016/j.bmc.2015.04.057 BindingDB Entry DOI: 10.7270/Q26H4K5F
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50359989 (CHEMBL1927943) Show SMILES Cc1coc2C[C@](C)(C=C)[C@@H]3[C@@H](OC(=O)C3=C)c12 |r| Show InChI InChI=1S/C15H16O3/c1-5-15(4)6-10-11(8(2)7-17-10)13-12(15)9(3)14(16)18-13/h5,7,12-13H,1,3,6H2,2,4H3/t12-,13-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Kaohsiung Medical University Curated by ChEMBL					Assay Description Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method				J Nat Prod 74: 2489-96 (2011) Article DOI: 10.1021/np100874f BindingDB Entry DOI: 10.7270/Q2ST7Q8Z
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Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50226527 (CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...) Show SMILES CC(N)=NCc1cccc(CN)c1 |w:3.3| Show InChI InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Università G. d'Annunzio Curated by ChEMBL					Assay Description Inhibition of mouse macrophage iNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobin				Bioorg Med Chem Lett 20: 6495-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.059 BindingDB Entry DOI: 10.7270/Q2GX4BTP
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Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM50096345 (CHEMBL3577135) Show SMILES O=C1C=C2c3ccccc3CC2(C=C1C#N)C#C |c:14,t:2| Show InChI InChI=1S/C22H14F3N3O/c23-22(24,25)17-9-2-4-11-19(17)28-20(13-12-15-7-5-6-14-26-15)27-18-10-3-1-8-16(18)21(28)29/h1-14H/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay				J Med Chem 58: 4738-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b00393 BindingDB Entry DOI: 10.7270/Q2V126J4
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Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152698 ((S)-2-Amino-5-formimidamidopentanoic acid (7)) Show SMILES N[C@@H](CCCNC=N)C(O)=O |r| Show InChI InChI=1S/C6H13N3O2/c7-4-9-3-1-2-5(8)6(10)11/h4-5H,1-3,8H2,(H2,7,9)(H,10,11)/t5-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	180	n/a	400	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
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