BindingDB PrimarySearch

Found 26 hits of ic50 for UniProtKB: P47747
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50036754 ((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company Curated by ChEMBL					Assay Description Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium				J Med Chem 37: 57-66 (1994) BindingDB Entry DOI: 10.7270/Q2FN16TT
Fujisawa Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213876 (CHEMBL50524) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	442	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213878 (CHEMBL301294) Show SMILES CN(C)Cc1cc(OC\C=C/CN=c2c(O)c(O)c2=N)cs1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	684	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM77970 (3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...) Show SMILES CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213879 (CHEMBL298354) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem		n/a	n/a	747	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213959 (CHEMBL50294) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	809	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM31005 (2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...) Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM22889 ((Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidaz...) Show SMILES CNC(NC#N)=NCCSCc1[nH]cnc1C \|w:6.6\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of guinea pig histamine H2 receptor				Bioorg Med Chem 18: 7675-99 (2010) Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213877 (CHEMBL50523) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213880 (CHEMBL50503) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213960 (CHEMBL49928) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50036755 (CHEMBL556048 \| N-[6-(2-Guanidino-thiazol-4-yl)-pyr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company Curated by ChEMBL					Assay Description Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium				J Med Chem 37: 57-66 (1994) BindingDB Entry DOI: 10.7270/Q2FN16TT
Fujisawa Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50079527 ((3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimet...) Show SMILES CN(C)CC\C=C1\c2ccccc2COc2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213875 (CHEMBL52637) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem		n/a	n/a	1.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50010859 (CHEMBL11 \| IMIPRAMINE HYDROCHLORIDE \| IMIPRAMINE P...) Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50213958 (CHEMBL298928) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	1.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50103506 (Ranitidine \| Tritec \| Zantac) Show SMILES CNC(NCCSCc1ccc(CN(C)C)o1)=C[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars		n/a	n/a	3.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM22893 (CHEMBL512 \| Ranitidine \| ZANTAC \| dimethyl[(5-{[(2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company Curated by ChEMBL					Assay Description Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium				J Med Chem 37: 57-66 (1994) BindingDB Entry DOI: 10.7270/Q2FN16TT
Fujisawa Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM31005 (2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...) Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptor				J Med Chem 26: 1116-22 (1983) BindingDB Entry DOI: 10.7270/Q2SN07ZR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM35229 (3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...) Show SMILES CNCCCN1c2ccccc2CCc2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50404032 (ROXATIDINE ACETATE) Show SMILES CC(=O)OCC(=O)NCCCOc1cccc(CN2CCCCC2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem		n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM112777 (NORTRIPTYLINE \| US8629135, SW-02) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Valencia Curated by ChEMBL					Assay Description Inhibitory activity against brain adenylate cyclase Histamine H2 receptor				J Med Chem 42: 3154-62 (1999) Article DOI: 10.1021/jm9910369 BindingDB Entry DOI: 10.7270/Q2N0176G
Universidad de Valencia Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50027226 (3-Methyl-1,2,3,4,4a,8-hexahydro-7-thia-3,12b-diaza...) Show SMILES CN1CCN2C(C1)c1ccsc1Cc1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptor				J Med Chem 26: 1116-22 (1983) BindingDB Entry DOI: 10.7270/Q2SN07ZR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50103595 (Brumetadina \| CHEBI:3699 \| Cimetidine \| Tagamet \| ...) Show SMILES CN\C(NC#N)=N/CCSCc1nc[nH]c1C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars		n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Histamine H2 receptor antagonistic activity				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP773S
TBA					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50027227 (3-Methyl-1,2,3,4,4a,8-hexahydro-5-thia-3,12b-diaza...) Show SMILES CN1CCN2C(C1)c1sccc1Cc1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptor				J Med Chem 26: 1116-22 (1983) BindingDB Entry DOI: 10.7270/Q2SN07ZR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair