Found 127 hits of ki for UniProtKB: P30419 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50033422
(CHEMBL3357688)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C Show InChI InChI=1S/C22H26Cl2N6O2S/c1-14-21(15(2)29(4)26-14)27-33(31,32)22-18(23)11-17(12-19(22)24)16-5-6-25-20(13-16)30-9-7-28(3)8-10-30/h5-6,11-13,27H,7-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148269
(CHEMBL3770219)Show SMILES Cc1nn(C)c(C)c1Cc1nnc(o1)-c1cc(Cl)ccc1OC1CCNCC1 Show InChI InChI=1S/C20H24ClN5O2/c1-12-16(13(2)26(3)25-12)11-19-23-24-20(28-19)17-10-14(21)4-5-18(17)27-15-6-8-22-9-7-15/h4-5,10,15,22H,6-9,11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50033422
(CHEMBL3357688)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C Show InChI InChI=1S/C22H26Cl2N6O2S/c1-14-21(15(2)29(4)26-14)27-33(31,32)22-18(23)11-17(12-19(22)24)16-5-6-25-20(13-16)30-9-7-28(3)8-10-30/h5-6,11-13,27H,7-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 W297F/A452M/L453V/L462V/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in pres... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50033422
(CHEMBL3357688)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C Show InChI InChI=1S/C22H26Cl2N6O2S/c1-14-21(15(2)29(4)26-14)27-33(31,32)22-18(23)11-17(12-19(22)24)16-5-6-25-20(13-16)30-9-7-28(3)8-10-30/h5-6,11-13,27H,7-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510906
(CHEMBL4435880)Show InChI InChI=1S/C20H29N5O/c1-15-12-21-14-25(15)16(2)20(26)23-13-18-6-4-9-22-19(18)17-7-5-10-24(3)11-8-17/h4,6,9,12,14,16-17H,5,7-8,10-11,13H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510908
(CHEMBL4449105)Show InChI InChI=1S/C21H26N6O/c1-26-13-5-6-17(26)9-11-22-21-23-12-10-18(25-21)16-14-24-27(15-16)19-7-3-4-8-20(19)28-2/h3-4,7-8,10,12,14-15,17H,5-6,9,11,13H2,1-2H3,(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510905
(CHEMBL4532268)Show SMILES [H][C@]12CCCN1CCN(CCCc1cc(Cl)c(c(Cl)c1)S(=O)(=O)N(C)c1c(C)nn(C)c1C)C2 |r| Show InChI InChI=1S/C23H33Cl2N5O2S/c1-16-22(17(2)27(3)26-16)28(4)33(31,32)23-20(24)13-18(14-21(23)25)7-5-9-29-11-12-30-10-6-8-19(30)15-29/h13-14,19H,5-12,15H2,1-4H3/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510905
(CHEMBL4532268)Show SMILES [H][C@]12CCCN1CCN(CCCc1cc(Cl)c(c(Cl)c1)S(=O)(=O)N(C)c1c(C)nn(C)c1C)C2 |r| Show InChI InChI=1S/C23H33Cl2N5O2S/c1-16-22(17(2)27(3)26-16)28(4)33(31,32)23-20(24)13-18(14-21(23)25)7-5-9-29-11-12-30-10-6-8-19(30)15-29/h13-14,19H,5-12,15H2,1-4H3/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510904
(CHEMBL3912318)Show SMILES CN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(CCCN2CCNCC2)cc1Cl Show InChI InChI=1S/C20H29Cl2N5O2S/c1-14-19(15(2)25(3)24-14)26(4)30(28,29)20-17(21)12-16(13-18(20)22)6-5-9-27-10-7-23-8-11-27/h12-13,23H,5-11H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148269
(CHEMBL3770219)Show SMILES Cc1nn(C)c(C)c1Cc1nnc(o1)-c1cc(Cl)ccc1OC1CCNCC1 Show InChI InChI=1S/C20H24ClN5O2/c1-12-16(13(2)26(3)25-12)11-19-23-24-20(28-19)17-10-14(21)4-5-18(17)27-15-6-8-22-9-7-15/h4-5,10,15,22H,6-9,11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Binding affinity to human N-myristoyltransferase by fluorescence analysis |
Medchemcomm 6: 1761-1766 (2016)
BindingDB Entry DOI: 10.7270/Q2TB18R2 |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135488
(CHEMBL3754571)Show SMILES C(c1noc(n1)-c1cccnc1OC1CCNCC1)c1cccc2ncccc12 Show InChI InChI=1S/C22H21N5O2/c1-4-15(17-5-2-10-24-19(17)7-1)14-20-26-22(29-27-20)18-6-3-11-25-21(18)28-16-8-12-23-13-9-16/h1-7,10-11,16,23H,8-9,12-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay |
Medchemcomm 6: 1767-1772 (2016)
BindingDB Entry DOI: 10.7270/Q27M09RK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510907
(CHEMBL4470652)Show SMILES COc1cccc(c1)-n1cc(cn1)-c1ccnc(NCCC2CCCN2C)n1 Show InChI InChI=1S/C21H26N6O/c1-26-12-4-6-17(26)8-10-22-21-23-11-9-20(25-21)16-14-24-27(15-16)18-5-3-7-19(13-18)28-2/h3,5,7,9,11,13-15,17H,4,6,8,10,12H2,1-2H3,(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510904
(CHEMBL3912318)Show SMILES CN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(CCCN2CCNCC2)cc1Cl Show InChI InChI=1S/C20H29Cl2N5O2S/c1-14-19(15(2)25(3)24-14)26(4)30(28,29)20-17(21)12-16(13-18(20)22)6-5-9-27-10-7-23-8-11-27/h12-13,23H,5-11H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50027680
(CHEMBL3357975)Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)c(NC(=O)Cc2ccc(F)cc2)c1)Cc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C29H30Cl2FN3O3/c30-22-6-1-18(2-7-22)11-24(33)14-29(38)35-15-21(17-36)25(16-35)20-5-10-26(31)27(13-20)34-28(37)12-19-3-8-23(32)9-4-19/h1-10,13,21,24-25,36H,11-12,14-17,33H2,(H,34,37)/t21-,24-,25-/m1/s1 | PDB
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay |
J Med Chem 57: 8664-70 (2014)
Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50027677
(CHEMBL3344387)Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19-,20-/m1/s1 | PDB
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1/2
(Homo sapiens (Human)) | BDBM50034993
((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...)Show SMILES Cc1nccn1CCCCc1ccc(CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC2CCCCC2)cc1 Show InChI InChI=1S/C33H52N6O4/c1-25-35-20-22-39(25)21-8-6-11-27-13-15-28(16-14-27)23-31(41)37-30(24-40)33(43)38-29(12-5-7-18-34)32(42)36-19-17-26-9-3-2-4-10-26/h13-16,20,22,26,29-30,40H,2-12,17-19,21,23-24,34H2,1H3,(H,36,42)(H,37,41)(H,38,43)/t29-,30-/m0/s1 | PDB
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| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co.
Curated by ChEMBL
| Assay Description
Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT). |
J Med Chem 38: 1837-40 (1995)
Article DOI: 10.1021/jm00011a001
BindingDB Entry DOI: 10.7270/Q23J3GPZ |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135481
(CHEMBL3754110)Show InChI InChI=1S/C21H23N3O3/c1-25-17-6-4-5-15(13-17)14-20-23-21(27-24-20)18-7-2-3-8-19(18)26-16-9-11-22-12-10-16/h2-8,13,16,22H,9-12,14H2,1H3 | PDB
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| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as subst... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148269
(CHEMBL3770219)Show SMILES Cc1nn(C)c(C)c1Cc1nnc(o1)-c1cc(Cl)ccc1OC1CCNCC1 Show InChI InChI=1S/C20H24ClN5O2/c1-12-16(13(2)26(3)25-12)11-19-23-24-20(28-19)17-10-14(21)4-5-18(17)27-15-6-8-22-9-7-15/h4-5,10,15,22H,6-9,11H2,1-3H3 | PDB
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| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrC... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50033422
(CHEMBL3357688)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C Show InChI InChI=1S/C22H26Cl2N6O2S/c1-14-21(15(2)29(4)26-14)27-33(31,32)22-18(23)11-17(12-19(22)24)16-5-6-25-20(13-16)30-9-7-28(3)8-10-30/h5-6,11-13,27H,7-10H2,1-4H3 | PDB
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510908
(CHEMBL4449105)Show InChI InChI=1S/C21H26N6O/c1-26-13-5-6-17(26)9-11-22-21-23-12-10-18(25-21)16-14-24-27(15-16)19-7-3-4-8-20(19)28-2/h3-4,7-8,10,12,14-15,17H,5-6,9,11,13H2,1-2H3,(H,22,23,25) | PDB
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| >40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510907
(CHEMBL4470652)Show SMILES COc1cccc(c1)-n1cc(cn1)-c1ccnc(NCCC2CCCN2C)n1 Show InChI InChI=1S/C21H26N6O/c1-26-12-4-6-17(26)8-10-22-21-23-11-9-20(25-21)16-14-24-27(15-16)18-5-3-7-19(13-18)28-2/h3,5,7,9,11,13-15,17H,4,6,8,10,12H2,1-2H3,(H,22,23,25) | PDB
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| >40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148269
(CHEMBL3770219)Show SMILES Cc1nn(C)c(C)c1Cc1nnc(o1)-c1cc(Cl)ccc1OC1CCNCC1 Show InChI InChI=1S/C20H24ClN5O2/c1-12-16(13(2)26(3)25-12)11-19-23-24-20(28-19)17-10-14(21)4-5-18(17)27-15-6-8-22-9-7-15/h4-5,10,15,22H,6-9,11H2,1-3H3 | PDB
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510904
(CHEMBL3912318)Show SMILES CN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(CCCN2CCNCC2)cc1Cl Show InChI InChI=1S/C20H29Cl2N5O2S/c1-14-19(15(2)25(3)24-14)26(4)30(28,29)20-17(21)12-16(13-18(20)22)6-5-9-27-10-7-23-8-11-27/h12-13,23H,5-11H2,1-4H3 | PDB
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| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 R295Q mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1/2
(Homo sapiens (Human)) | BDBM50034988
(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)Show SMILES NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC1CCCCC1 Show InChI InChI=1S/C28H55N5O4/c29-19-12-6-4-2-1-3-5-10-17-26(35)32-25(22-34)28(37)33-24(16-11-13-20-30)27(36)31-21-18-23-14-8-7-9-15-23/h23-25,34H,1-22,29-30H2,(H,31,36)(H,32,35)(H,33,37)/t24-,25-/m0/s1 | PDB
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| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co.
Curated by ChEMBL
| Assay Description
Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT). |
J Med Chem 38: 1837-40 (1995)
Article DOI: 10.1021/jm00011a001
BindingDB Entry DOI: 10.7270/Q23J3GPZ |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148267
(CHEMBL3770442)Show SMILES COc1cccc(Cc2noc(n2)-c2cc(Cl)ccc2OC2CCNCC2)c1 Show InChI InChI=1S/C21H22ClN3O3/c1-26-17-4-2-3-14(11-17)12-20-24-21(28-25-20)18-13-15(22)5-6-19(18)27-16-7-9-23-10-8-16/h2-6,11,13,16,23H,7-10,12H2,1H3 | PDB
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| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Binding affinity to human N-myristoyltransferase by fluorescence analysis |
Medchemcomm 6: 1761-1766 (2016)
BindingDB Entry DOI: 10.7270/Q2TB18R2 |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 A452M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1/2
(Homo sapiens (Human)) | BDBM50034988
(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)Show SMILES NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC1CCCCC1 Show InChI InChI=1S/C28H55N5O4/c29-19-12-6-4-2-1-3-5-10-17-26(35)32-25(22-34)28(37)33-24(16-11-13-20-30)27(36)31-21-18-23-14-8-7-9-15-23/h23-25,34H,1-22,29-30H2,(H,31,36)(H,32,35)(H,33,37)/t24-,25-/m0/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
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| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co.
Curated by ChEMBL
| Assay Description
Apparent binding affinity against Human NMT. |
J Med Chem 38: 1837-40 (1995)
Article DOI: 10.1021/jm00011a001
BindingDB Entry DOI: 10.7270/Q23J3GPZ |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510904
(CHEMBL3912318)Show SMILES CN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(CCCN2CCNCC2)cc1Cl Show InChI InChI=1S/C20H29Cl2N5O2S/c1-14-19(15(2)25(3)24-14)26(4)30(28,29)20-17(21)12-16(13-18(20)22)6-5-9-27-10-7-23-8-11-27/h12-13,23H,5-11H2,1-4H3 | PDB
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| Article
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| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148269
(CHEMBL3770219)Show SMILES Cc1nn(C)c(C)c1Cc1nnc(o1)-c1cc(Cl)ccc1OC1CCNCC1 Show InChI InChI=1S/C20H24ClN5O2/c1-12-16(13(2)26(3)25-12)11-19-23-24-20(28-19)17-10-14(21)4-5-18(17)27-15-6-8-22-9-7-15/h4-5,10,15,22H,6-9,11H2,1-3H3 | PDB
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| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 A452M/L453V/L462V mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1/2
(Homo sapiens (Human)) | BDBM50470170
(CHEMBL54883)Show SMILES NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC1CCCCCCC1 Show InChI InChI=1S/C30H59N5O4/c31-21-14-9-4-2-1-3-8-12-19-28(37)34-27(24-36)30(39)35-26(18-13-15-22-32)29(38)33-23-20-25-16-10-6-5-7-11-17-25/h25-27,36H,1-24,31-32H2,(H,33,38)(H,34,37)(H,35,39)/t26-,27-/m0/s1 | PDB
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| Article
PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co.
Curated by ChEMBL
| Assay Description
Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT). |
J Med Chem 38: 1837-40 (1995)
Article DOI: 10.1021/jm00011a001
BindingDB Entry DOI: 10.7270/Q23J3GPZ |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135490
(CHEMBL3753789)Show SMILES CC(C)N1CCC(CC1)Oc1ncccc1-c1nc(Cc2c(C)nn(C)c2C)no1 Show InChI InChI=1S/C22H30N6O2/c1-14(2)28-11-8-17(9-12-28)29-21-18(7-6-10-23-21)22-24-20(26-30-22)13-19-15(3)25-27(5)16(19)4/h6-7,10,14,17H,8-9,11-13H2,1-5H3 | PDB
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| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay |
Medchemcomm 6: 1767-1772 (2016)
BindingDB Entry DOI: 10.7270/Q27M09RK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510906
(CHEMBL4435880)Show InChI InChI=1S/C20H29N5O/c1-15-12-21-14-25(15)16(2)20(26)23-13-18-6-4-9-22-19(18)17-7-5-10-24(3)11-8-17/h4,6,9,12,14,16-17H,5,7-8,10-11,13H2,1-3H3,(H,23,26) | PDB
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| Article
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| >200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135530
(CHEMBL3752766)Show InChI InChI=1S/C19H24N6O2/c1-12-16(13(2)25(3)23-12)11-17-22-19(27-24-17)15-5-4-8-21-18(15)26-14-6-9-20-10-7-14/h4-5,8,14,20H,6-7,9-11H2,1-3H3 | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay |
Medchemcomm 6: 1767-1772 (2016)
BindingDB Entry DOI: 10.7270/Q27M09RK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 L453V mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50148265
(CHEMBL3770815)Show SMILES COc1cccc(Cc2noc(n2)-c2ccc(Br)cc2OC2CCNCC2)c1 Show InChI InChI=1S/C21H22BrN3O3/c1-26-17-4-2-3-14(11-17)12-20-24-21(28-25-20)18-6-5-15(22)13-19(18)27-16-7-9-23-10-8-16/h2-6,11,13,16,23H,7-10,12H2,1H3 | PDB
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| PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Binding affinity to human N-myristoyltransferase by fluorescence analysis |
Medchemcomm 6: 1761-1766 (2016)
BindingDB Entry DOI: 10.7270/Q2TB18R2 |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135487
(CHEMBL3753421)Show InChI InChI=1S/C20H22N4O3/c1-25-16-5-2-4-14(12-16)13-18-23-20(27-24-18)17-6-3-9-22-19(17)26-15-7-10-21-11-8-15/h2-6,9,12,15,21H,7-8,10-11,13H2,1H3 | PDB
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| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay |
Medchemcomm 6: 1767-1772 (2016)
BindingDB Entry DOI: 10.7270/Q27M09RK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135492
(CHEMBL3754763)Show SMILES CCN1CCC(CC1)Oc1ncccc1-c1nc(Cc2c(C)nn(C)c2C)no1 Show InChI InChI=1S/C21H28N6O2/c1-5-27-11-8-16(9-12-27)28-20-17(7-6-10-22-20)21-23-19(25-29-21)13-18-14(2)24-26(4)15(18)3/h6-7,10,16H,5,8-9,11-13H2,1-4H3 | PDB
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| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay |
Medchemcomm 6: 1767-1772 (2016)
BindingDB Entry DOI: 10.7270/Q27M09RK |
More data for this
Ligand-Target Pair | |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50510905
(CHEMBL4532268)Show SMILES [H][C@]12CCCN1CCN(CCCc1cc(Cl)c(c(Cl)c1)S(=O)(=O)N(C)c1c(C)nn(C)c1C)C2 |r| Show InChI InChI=1S/C23H33Cl2N5O2S/c1-16-22(17(2)27(3)26-16)28(4)33(31,32)23-20(24)13-18(14-21(23)25)7-5-9-29-11-12-30-10-6-8-19(30)15-29/h13-14,19H,5-12,15H2,1-4H3/t19-/m1/s1 | PDB
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| PDB
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| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 A452M/L453V/L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50364113
(CHEMBL1230468)Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3 | PDB
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| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universit£t Mainz
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 A452M/L453V mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 ... |
J Med Chem 63: 2095-2113 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00586
BindingDB Entry DOI: 10.7270/Q2R214QK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycylpeptide N-tetradecanoyltransferase 1
(Homo sapiens (Human)) | BDBM50135531
(CHEMBL3753053)Show SMILES COc1cccc(Cc2noc(n2)-c2ccc(Cl)cc2OC2CCNCC2)c1 Show InChI InChI=1S/C21H22ClN3O3/c1-26-17-4-2-3-14(11-17)12-20-24-21(28-25-20)18-6-5-15(22)13-19(18)27-16-7-9-23-10-8-16/h2-6,11,13,16,23H,7-10,12H2,1H3 | PDB
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| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay |
Medchemcomm 6: 1767-1772 (2016)
BindingDB Entry DOI: 10.7270/Q27M09RK |
More data for this
Ligand-Target Pair | |
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