Found 129 hits of ic50 for UniProtKB: P48546 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245060
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50171817
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |(6.78,6.58,;6.79,5.04,;8.33,5.04,;5.25,5.03,;6.79,3.5,;8.12,2.72,;8.12,1.19,;6.78,.42,;5.45,1.18,;5.45,2.73,;6.78,-1.12,;5.45,-1.89,;4.11,-1.12,;2.78,-1.9,;1.44,-1.12,;1.44,.42,;2.77,1.19,;4.11,.43,;.11,1.19,;.11,2.73,;-1.22,.42,;-2.56,1.19,;-3.89,.42,;-5.22,1.19,;-5.23,2.73,;-6.56,.42,;8.12,-1.89,;8.12,-3.43,;9.45,-1.12,;10.78,-1.88,;10.78,-3.42,;12.11,-4.19,;13.44,-3.42,;14.78,-4.19,;14.79,-5.73,;14.77,-7.26,;16.33,-5.73,;13.25,-5.72,;13.44,-1.87,;12.1,-1.11,)| Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50202060
(3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxy...)Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-15H,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50334486
(CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexy...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r,wU:7.10,wD:4.3,(26.38,-4.09,;27.72,-3.32,;29.05,-4.09,;27.7,-4.85,;27.72,-1.78,;29.05,-1.01,;29.05,.54,;27.72,1.29,;26.38,.53,;26.38,-1.01,;27.71,2.83,;26.38,3.6,;25.05,2.82,;25.05,1.27,;23.71,.5,;22.38,1.27,;22.38,2.82,;23.71,3.59,;21.05,.5,;21.04,-1.04,;19.71,1.27,;18.38,.5,;16.98,1.14,;15.95,-.01,;16.72,-1.34,;18.23,-1.02,;29.04,3.61,;29.04,5.15,;30.38,2.84,;31.71,3.62,;33.04,2.85,;34.37,3.62,;34.37,5.16,;35.7,5.94,;37.03,5.18,;38.36,5.96,;37.04,3.64,;38.36,4.41,;33.02,5.93,;31.7,5.15,)| Show InChI InChI=1S/C27H32F3N7O3/c1-26(2,3)19-8-12-21(13-9-19)37(25(39)31-20-10-14-22(15-11-20)40-27(28,29)30)16-17-4-6-18(7-5-17)23(38)32-24-33-35-36-34-24/h4-7,10-11,14-15,19,21H,8-9,12-13,16H2,1-3H3,(H,31,39)(H2,32,33,34,35,36,38)/t19-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 21: 76-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.11.074
BindingDB Entry DOI: 10.7270/Q2R211PW |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50566470
(CHEMBL4857523)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O)C(O)=O |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human GIPR expressed in HEK293 cells assessed as inhibition of GIP-induced cAMP production |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02069
BindingDB Entry DOI: 10.7270/Q23J3HQT |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50202031
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1 |t:33| Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245062
((R)-3-{4-[3-(3-tert-Butylphenyl)-1-(4-cyclohexylph...)Show SMILES CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1 |r| Show InChI InChI=1S/C34H41N3O5/c1-34(2,3)27-10-7-11-28(20-27)36-33(42)37(29-18-16-25(17-19-29)24-8-5-4-6-9-24)22-23-12-14-26(15-13-23)31(39)35-21-30(38)32(40)41/h7,10-20,24,30,38H,4-6,8-9,21-22H2,1-3H3,(H,35,39)(H,36,42)(H,40,41)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245099
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(2,2,4,4-t...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc3OC(F)(F)OC(F)(F)c3c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:38| Show InChI InChI=1S/C32H29F4N3O7/c33-31(34)25-16-23(12-15-27(25)45-32(35,36)46-31)38-30(44)39(24-13-10-21(11-14-24)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(41)37-17-26(40)29(42)43/h4,6-16,26,40H,1-3,5,17-18H2,(H,37,41)(H,38,44)(H,42,43)/t26-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244457
((R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,22.24,wD:7.10,(4.8,4.42,;4.81,2.87,;6.35,2.88,;3.27,2.87,;4.8,1.33,;6.14,.56,;6.13,-.98,;4.8,-1.74,;3.46,-.98,;3.47,.56,;4.8,-3.28,;3.47,-4.05,;2.13,-3.29,;.79,-4.06,;-.54,-3.29,;-.54,-1.74,;.79,-.97,;2.12,-1.74,;-1.87,-.97,;-1.87,.57,;-3.21,-1.74,;-4.54,-.97,;-5.87,-1.74,;-5.87,-3.28,;-7.21,-.97,;-7.21,.57,;-8.54,-1.74,;6.13,-4.05,;6.13,-5.59,;7.46,-3.28,;8.8,-4.05,;10.12,-3.27,;11.45,-4.03,;11.46,-5.58,;10.13,-6.35,;8.79,-5.59,;10.13,-7.89,;10.12,-9.43,;11.67,-7.9,;8.59,-7.9,;12.78,-3.26,;14.11,-2.47,;13.56,-4.58,;12,-1.93,)| Show InChI InChI=1S/C30H35F6N3O5/c1-28(2,3)19-8-10-23(11-9-19)39(16-17-4-6-18(7-5-17)25(41)37-15-24(40)26(42)43)27(44)38-22-13-20(29(31,32)33)12-21(14-22)30(34,35)36/h4-7,12-14,19,23-24,40H,8-11,15-16H2,1-3H3,(H,37,41)(H,38,44)(H,42,43)/t19-,23-,24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50202041
(CHEMBL375167 | trans-3-{4-[3-(3,5-Bis(trifluoromet...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,wD:7.10,(30.95,-37.95,;30.96,-39.49,;32.5,-39.49,;29.42,-39.5,;30.95,-41.03,;32.28,-41.81,;32.28,-43.34,;30.94,-44.11,;29.61,-43.35,;29.62,-41.8,;30.95,-45.65,;29.61,-46.42,;28.28,-45.65,;26.94,-46.42,;25.61,-45.65,;25.61,-44.11,;26.94,-43.34,;28.27,-44.1,;24.28,-43.34,;24.28,-41.8,;22.94,-44.11,;21.61,-43.34,;20.27,-44.11,;18.94,-43.34,;18.94,-41.8,;17.61,-44.11,;32.28,-46.42,;32.28,-47.96,;33.61,-45.64,;34.95,-46.41,;36.27,-45.64,;37.6,-46.4,;37.61,-47.95,;36.28,-48.72,;34.94,-47.95,;36.28,-50.26,;36.27,-51.79,;37.82,-50.26,;34.74,-50.26,;38.93,-45.62,;40.26,-44.84,;39.71,-46.95,;38.15,-44.3,)| Show InChI InChI=1S/C30H35F6N3O4/c1-28(2,3)20-8-10-24(11-9-20)39(17-18-4-6-19(7-5-18)26(42)37-13-12-25(40)41)27(43)38-23-15-21(29(31,32)33)14-22(16-23)30(34,35)36/h4-7,14-16,20,24H,8-13,17H2,1-3H3,(H,37,42)(H,38,43)(H,40,41)/t20-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245098
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3,5-dichloroph...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C30H31Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h6-16,20,27,36H,1-5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245057
((R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-m...)Show SMILES Cc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)cc(c1)C(F)(F)F |r,wU:27.31,19.20,wD:24.24,(9.34,-6,;9.33,-4.46,;8,-3.69,;8.01,-2.15,;6.67,-1.38,;5.34,-2.15,;5.34,-3.69,;4,-1.38,;2.67,-2.16,;1.34,-1.39,;-0,-2.16,;-1.33,-1.39,;-1.33,.16,;-0,.93,;1.33,.16,;-2.67,.93,;-2.67,2.47,;-4,.15,;-5.33,.92,;-6.67,.15,;-6.67,-1.39,;-8,.92,;-8,2.46,;-9.34,.15,;4,.16,;5.34,.92,;5.34,2.46,;4.01,3.23,;2.67,2.46,;2.67,.92,;4.01,4.77,;4.01,6.32,;5.55,4.77,;2.47,4.76,;9.33,-1.38,;10.66,-2.14,;10.67,-3.68,;11.99,-1.36,;13.32,-.58,;12.77,-2.69,;11.21,-.03,)| Show InChI InChI=1S/C30H38F3N3O5/c1-18-13-22(30(31,32)33)15-23(14-18)35-28(41)36(24-11-9-21(10-12-24)29(2,3)4)17-19-5-7-20(8-6-19)26(38)34-16-25(37)27(39)40/h5-8,13-15,21,24-25,37H,9-12,16-17H2,1-4H3,(H,34,38)(H,35,41)(H,39,40)/t21-,24-,25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199497
(1-(7-((2H-tetrazol-5-yl)carbamoyl)-3,4-dihydro-2H-...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCOc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(22.57,-53.2,;22.58,-51.66,;24.12,-51.67,;21.04,-51.66,;22.58,-50.12,;23.92,-49.35,;23.92,-47.81,;22.6,-47.05,;21.25,-47.81,;21.25,-49.35,;22.6,-45.51,;23.93,-44.73,;23.93,-43.18,;25.27,-42.41,;26.61,-43.19,;26.6,-44.74,;27.92,-45.49,;27.93,-47.04,;26.59,-47.81,;25.26,-47.04,;25.27,-45.5,;29.26,-47.8,;29.27,-49.34,;30.6,-47.03,;31.93,-47.8,;32.1,-49.33,;33.61,-49.64,;34.38,-48.31,;33.34,-47.17,;21.27,-44.74,;21.26,-43.2,;19.93,-45.51,;18.6,-44.74,;17.26,-45.51,;15.92,-44.74,;15.93,-43.2,;14.59,-42.43,;14.59,-40.89,;14.58,-39.35,;16.13,-40.88,;13.05,-40.9,;17.25,-42.43,;18.59,-43.19,)| Show InChI InChI=1S/C29H34F3N7O4/c1-28(2,3)18-5-9-20(10-6-18)39(27(41)33-19-7-11-21(12-8-19)43-29(30,31)32)23-14-15-42-24-16-17(4-13-22(23)24)25(40)34-26-35-37-38-36-26/h4,7-8,11-13,16,18,20,23H,5-6,9-10,14-15H2,1-3H3,(H,33,41)(H2,34,35,36,37,38,40)/t18-,20-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199493
(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(triflu...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Cc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(23.62,-41.57,;23.63,-40.04,;25.17,-40.04,;22.09,-40.03,;23.64,-38.5,;24.97,-37.73,;24.98,-36.18,;23.65,-35.42,;22.31,-36.19,;22.3,-37.72,;23.65,-33.88,;24.99,-33.11,;25.31,-31.61,;27.17,-31.64,;27.64,-33.1,;28.97,-33.86,;28.98,-35.41,;27.65,-36.18,;26.31,-35.41,;26.32,-33.88,;30.32,-36.18,;30.32,-37.72,;31.65,-35.41,;32.98,-36.17,;33.15,-37.7,;34.65,-38.02,;35.42,-36.68,;34.39,-35.54,;22.32,-33.11,;22.32,-31.57,;20.99,-33.88,;19.65,-33.11,;18.31,-33.89,;16.98,-33.11,;16.98,-31.57,;15.65,-30.8,;15.64,-29.26,;15.63,-27.72,;17.18,-29.25,;14.1,-29.27,;18.3,-30.8,;19.64,-31.56,)| Show InChI InChI=1S/C30H35F3N6O3/c1-29(2,3)21-8-10-22(11-9-21)39(26(40)16-18-4-12-23(13-5-18)42-30(31,32)33)25-15-7-19-17-20(6-14-24(19)25)27(41)34-28-35-37-38-36-28/h4-6,12-14,17,21-22,25H,7-11,15-16H2,1-3H3,(H2,34,35,36,37,38,41)/t21-,22-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199498
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-2.01,-7.56,;-2,-6.03,;-.46,-6.04,;-3.54,-6.03,;-2,-4.49,;-.66,-3.72,;-.65,-2.17,;-1.98,-1.41,;-3.33,-2.18,;-3.33,-3.71,;-1.98,.13,;-.64,.9,;-.33,2.4,;1.53,2.36,;2.01,.91,;3.34,.15,;3.35,-1.4,;2.01,-2.17,;.68,-1.41,;.69,.13,;4.68,-2.17,;4.69,-3.71,;6.02,-1.4,;7.35,-2.16,;8.68,-1.39,;10.02,-2.16,;11.35,-1.39,;10.02,-3.7,;-3.31,.9,;-3.32,2.44,;-4.65,.13,;-5.98,.89,;-7.32,.12,;-8.65,.89,;-8.65,2.44,;-9.99,3.21,;-9.99,4.75,;-10,6.29,;-8.45,4.75,;-11.53,4.74,;-7.33,3.21,;-5.99,2.45,)| Show InChI InChI=1S/C31H38F3N3O5/c1-30(2,3)21-6-10-23(11-7-21)37(29(41)36-22-8-12-24(13-9-22)42-31(32,33)34)26-15-5-19-18-20(4-14-25(19)26)28(40)35-17-16-27(38)39/h4,8-9,12-14,18,21,23,26H,5-7,10-11,15-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t21-,23-,26? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244509
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-tr...)Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C32H34F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h7-17,21,28,39H,2-6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199488
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-1.2,-37.43,;-1.19,-35.89,;.35,-35.9,;-2.73,-35.89,;-1.18,-34.35,;.15,-33.59,;.16,-32.04,;-1.17,-31.28,;-2.51,-32.04,;-2.51,-33.58,;-1.17,-29.74,;.16,-28.96,;.16,-27.42,;1.5,-26.65,;2.84,-27.42,;2.83,-28.97,;4.15,-29.72,;4.16,-31.27,;2.83,-32.04,;1.49,-31.27,;1.5,-29.74,;5.5,-32.04,;5.5,-33.58,;6.83,-31.26,;8.16,-32.03,;9.5,-31.26,;10.83,-32.02,;12.16,-31.25,;10.83,-33.56,;-2.5,-28.97,;-2.5,-27.43,;-3.83,-29.74,;-5.17,-28.97,;-6.51,-29.74,;-7.84,-28.97,;-7.84,-27.43,;-9.17,-26.66,;-9.18,-25.12,;-9.19,-23.58,;-7.64,-25.11,;-10.71,-25.13,;-6.51,-26.66,;-5.17,-27.42,)| Show InChI InChI=1S/C32H40F3N3O5/c1-31(2,3)22-8-12-24(13-9-22)38(30(42)37-23-10-14-25(15-11-23)43-32(33,34)35)27-6-4-5-20-19-21(7-16-26(20)27)29(41)36-18-17-28(39)40/h7,10-11,14-16,19,22,24,27H,4-6,8-9,12-13,17-18H2,1-3H3,(H,36,41)(H,37,42)(H,39,40)/t22-,24-,27? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 171 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199491
(1-(6-((2H-tetrazol-5-yl)carbamoyl)-1,2,3,4-tetrahy...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(22,-37.36,;22.01,-35.83,;23.55,-35.83,;20.47,-35.82,;22.01,-34.29,;23.35,-33.52,;23.35,-31.97,;22.03,-31.21,;20.68,-31.98,;20.68,-33.51,;22.03,-29.67,;23.36,-28.89,;23.35,-27.35,;24.7,-26.58,;26.04,-27.35,;26.03,-28.9,;27.35,-29.65,;27.35,-31.2,;26.02,-31.97,;24.69,-31.2,;24.69,-29.67,;28.69,-31.97,;28.69,-33.51,;30.02,-31.2,;31.36,-31.96,;31.53,-33.49,;33.04,-33.81,;33.8,-32.47,;32.77,-31.33,;20.69,-28.9,;20.69,-27.36,;19.36,-29.67,;18.03,-28.9,;16.68,-29.68,;15.35,-28.9,;15.35,-27.36,;14.02,-26.59,;14.02,-25.05,;14,-23.51,;15.56,-25.04,;12.48,-25.06,;16.68,-26.59,;18.02,-27.35,)| Show InChI InChI=1S/C30H36F3N7O3/c1-29(2,3)20-8-12-22(13-9-20)40(28(42)34-21-10-14-23(15-11-21)43-30(31,32)33)25-6-4-5-18-17-19(7-16-24(18)25)26(41)35-27-36-38-39-37-27/h7,10-11,14-17,20,22,25H,4-6,8-9,12-13H2,1-3H3,(H,34,42)(H2,35,36,37,38,39,41)/t20-,22-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 178 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245061
((R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C32H31F3N4O5/c33-32(34,35)27-16-25(13-10-24(27)17-36)38-31(44)39(26-14-11-22(12-15-26)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(41)37-18-28(40)30(42)43/h6-16,21,28,40H,1-5,18-19H2,(H,37,41)(H,38,44)(H,42,43)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 198 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29106
(aminothiazole, 3)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc(cc2)C2=CCCCC2)cc1 |t:39| Show InChI InChI=1S/C33H30F3N3O4S/c34-33(35,36)43-28-16-12-25(13-17-28)29-21-44-32(38-29)39(27-14-10-24(11-15-27)23-4-2-1-3-5-23)20-22-6-8-26(9-7-22)31(42)37-19-18-30(40)41/h4,6-17,21H,1-3,5,18-20H2,(H,37,42)(H,40,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 207 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244506
((R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Br)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O |r| Show InChI InChI=1S/C30H32BrN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4,7-17,21,27,35H,1-3,5-6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199489
(3-(4-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCOc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(.09,-52.81,;.1,-51.28,;1.64,-51.28,;-1.44,-51.28,;.1,-49.74,;1.44,-48.97,;1.44,-47.42,;.12,-46.66,;-1.23,-47.43,;-1.23,-48.96,;.12,-45.12,;1.45,-44.34,;1.44,-42.8,;2.79,-42.03,;4.13,-42.81,;4.12,-44.35,;5.44,-45.1,;5.44,-46.65,;4.11,-47.42,;2.78,-46.66,;2.78,-45.12,;6.78,-47.42,;6.78,-48.96,;8.11,-46.65,;9.45,-47.41,;10.78,-46.64,;12.11,-47.41,;13.45,-46.63,;12.12,-48.95,;-1.22,-44.35,;-1.22,-42.81,;-2.55,-45.12,;-3.89,-44.35,;-5.23,-45.13,;-6.56,-44.36,;-6.56,-42.81,;-7.89,-42.04,;-7.89,-40.5,;-7.91,-38.96,;-6.35,-40.5,;-9.43,-40.51,;-5.23,-42.04,;-3.89,-42.8,)| Show InChI InChI=1S/C31H38F3N3O6/c1-30(2,3)20-5-9-22(10-6-20)37(29(41)36-21-7-11-23(12-8-21)43-31(32,33)34)25-15-17-42-26-18-19(4-13-24(25)26)28(40)35-16-14-27(38)39/h4,7-8,11-13,18,20,22,25H,5-6,9-10,14-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t20-,22-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 217 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244505
((R)-trans-3-{4-[1-(4-tert-Butylcyclohexyl)-3-(3,5-...)Show SMILES Cc1cc(C)cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)c1 |r,wU:30.34,22.23,wD:27.27,(41.34,-18.77,;40.01,-19.54,;40.02,-21.09,;38.69,-21.86,;38.69,-23.4,;37.35,-21.1,;37.36,-19.55,;36.02,-18.79,;34.69,-19.56,;34.69,-21.1,;33.36,-18.79,;32.03,-19.56,;30.69,-18.79,;29.35,-19.57,;28.02,-18.8,;28.02,-17.25,;29.35,-16.48,;30.68,-17.24,;26.69,-16.48,;26.69,-14.94,;25.35,-17.25,;24.02,-16.48,;22.69,-17.25,;22.69,-18.79,;21.35,-16.48,;21.35,-14.94,;20.02,-17.25,;33.36,-17.25,;34.69,-16.48,;34.7,-14.95,;33.36,-14.18,;32.03,-14.95,;32.02,-16.49,;33.37,-12.64,;33.36,-11.09,;34.91,-12.63,;31.83,-12.64,;38.68,-18.78,)| Show InChI InChI=1S/C30H41N3O5/c1-19-14-20(2)16-24(15-19)32-29(38)33(25-12-10-23(11-13-25)30(3,4)5)18-21-6-8-22(9-7-21)27(35)31-17-26(34)28(36)37/h6-9,14-16,23,25-26,34H,10-13,17-18H2,1-5H3,(H,31,35)(H,32,38)(H,36,37)/t23-,25-,26-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245100
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-fluoro-...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(F)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:34| Show InChI InChI=1S/C31H29F4N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244508
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy...)Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)cc(c1)C(F)(F)F |r,t:33| Show InChI InChI=1S/C32H32F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h5,7-17,28,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 279 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199486
(3-(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Cc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-1.44,-41.26,;-1.43,-39.72,;.11,-39.73,;-2.97,-39.72,;-1.42,-38.18,;-.09,-37.41,;-.08,-35.87,;-1.4,-35.1,;-2.75,-35.87,;-2.75,-37.4,;-1.41,-33.56,;-.07,-32.8,;.25,-31.29,;2.11,-31.33,;2.58,-32.79,;3.92,-33.55,;3.92,-35.09,;2.59,-35.87,;1.25,-35.1,;1.26,-33.56,;5.26,-35.86,;5.26,-37.4,;6.59,-35.09,;7.92,-35.86,;9.26,-35.08,;10.59,-35.85,;11.92,-35.08,;10.6,-37.39,;-2.74,-32.79,;-2.74,-31.25,;-4.07,-33.57,;-5.41,-32.8,;-6.75,-33.57,;-8.08,-32.8,;-8.08,-31.25,;-9.41,-30.48,;-9.41,-28.94,;-9.43,-27.4,;-7.87,-28.94,;-10.95,-28.95,;-6.75,-30.48,;-5.41,-31.25,)| Show InChI InChI=1S/C32H39F3N2O5/c1-31(2,3)23-8-10-24(11-9-23)37(28(38)18-20-4-12-25(13-5-20)42-32(33,34)35)27-15-7-21-19-22(6-14-26(21)27)30(41)36-17-16-29(39)40/h4-6,12-14,19,23-24,27H,7-11,15-18H2,1-3H3,(H,36,41)(H,39,40)/t23-,24-,27? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50358373
(CHEMBL1922839)Show SMILES CCCOc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(cc3)C(C)(C)C)n(C)c12)C(F)(F)F |w:26.28| Show InChI InChI=1S/C31H33F3N8O2/c1-6-15-44-25-17-22(31(32,33)34)16-24-26(25)41(5)29(35-23-13-11-21(12-14-23)30(2,3)4)42(24)18-19-7-9-20(10-8-19)27(43)36-28-37-39-40-38-28/h7-14,16-17H,6,15,18H2,1-5H3,(H2,36,37,38,39,40,43) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GIP receptor by cAMP assay |
Bioorg Med Chem Lett 21: 7131-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.085
BindingDB Entry DOI: 10.7270/Q2C829QP |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199492
(1-(5-((2H-tetrazol-5-yl)carbamoyl)-2,3-dihydro-1H-...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(22.92,-7.75,;22.93,-6.22,;24.47,-6.22,;21.39,-6.21,;22.93,-4.68,;24.27,-3.91,;24.28,-2.36,;22.95,-1.6,;21.61,-2.37,;21.6,-3.9,;22.95,-.06,;24.29,.71,;24.6,2.21,;26.46,2.18,;26.94,.72,;28.27,-.04,;28.28,-1.59,;26.94,-2.36,;25.61,-1.59,;25.62,-.06,;29.61,-2.36,;29.62,-3.9,;30.95,-1.59,;32.28,-2.35,;32.45,-3.88,;33.95,-4.2,;34.72,-2.86,;33.69,-1.72,;21.62,.71,;21.62,2.25,;20.28,-.06,;18.95,.71,;17.61,-.07,;16.28,.71,;16.28,2.25,;14.94,3.02,;14.94,4.56,;14.93,6.1,;16.48,4.57,;13.4,4.55,;17.6,3.02,;18.94,2.26,)| Show InChI InChI=1S/C29H34F3N7O3/c1-28(2,3)19-6-10-21(11-7-19)39(27(41)33-20-8-12-22(13-9-20)42-29(30,31)32)24-15-5-17-16-18(4-14-23(17)24)25(40)34-26-35-37-38-36-26/h4,8-9,12-14,16,19,21,24H,5-7,10-11,15H2,1-3H3,(H,33,41)(H2,34,35,36,37,38,40)/t19-,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 296 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50393781
(CHEMBL2159337)Show SMILES C[C@@H](c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(cc1-c1ccc2cc(OC(F)(F)F)ccc2c1)-c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C32H24Cl2F3N3O4/c1-18(19-2-4-20(5-3-19)31(43)38-11-10-30(41)42)40-29(17-28(39-40)24-13-25(33)16-26(34)14-24)23-7-6-22-15-27(44-32(35,36)37)9-8-21(22)12-23/h2-9,12-18H,10-11H2,1H3,(H,38,43)(H,41,42)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 307 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ... |
J Med Chem 55: 6137-48 (2012)
Article DOI: 10.1021/jm300579z
BindingDB Entry DOI: 10.7270/Q2X63P2C |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245056
((R/S)-3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluorom...)Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCC(O)C(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N3O6/c1-28(2,3)20-8-12-22(13-9-20)35(27(40)34-21-10-14-23(15-11-21)41-29(30,31)32)17-18-4-6-19(7-5-18)25(37)33-16-24(36)26(38)39/h4-15,24,36H,16-17H2,1-3H3,(H,33,37)(H,34,40)(H,38,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 315 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29132
(thiazole, 29)Show SMILES OC(=O)CCNC(=O)c1ccc(CC(c2nc(cs2)-c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C28H22ClF3N2O4S/c29-21-9-5-19(6-10-21)24-16-39-27(34-24)23(18-7-11-22(12-8-18)38-28(30,31)32)15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244455
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31| Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 359 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29107
(aminothiazole, 4)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1 |t:38| Show InChI InChI=1S/C33H30F3N3O3S/c34-33(35,36)27-14-10-25(11-15-27)29-21-43-32(38-29)39(28-16-12-24(13-17-28)23-4-2-1-3-5-23)20-22-6-8-26(9-7-22)31(42)37-19-18-30(40)41/h4,6-17,21H,1-3,5,18-20H2,(H,37,42)(H,40,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 368 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50358368
(CHEMBL1922834)Show SMILES CCCOc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12)C(F)(F)F |w:26.28| Show InChI InChI=1S/C28H24F6N8O3/c1-3-12-44-22-14-18(27(29,30)31)13-21-23(22)41(2)26(35-19-8-10-20(11-9-19)45-28(32,33)34)42(21)15-16-4-6-17(7-5-16)24(43)36-25-37-39-40-38-25/h4-11,13-14H,3,12,15H2,1-2H3,(H2,36,37,38,39,40,43) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GIP receptor by cAMP assay |
Bioorg Med Chem Lett 21: 7131-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.085
BindingDB Entry DOI: 10.7270/Q2C829QP |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244458
((S)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,wD:22.24,7.10,(31.73,3.82,;31.73,2.27,;33.27,2.28,;30.19,2.27,;31.73,.73,;33.06,-.04,;33.06,-1.57,;31.72,-2.34,;30.39,-1.58,;30.39,-.04,;31.72,-3.88,;30.39,-4.65,;29.06,-3.88,;27.72,-4.66,;26.39,-3.89,;26.39,-2.34,;27.72,-1.57,;29.05,-2.33,;25.05,-1.57,;25.05,-.03,;23.72,-2.34,;22.39,-1.57,;21.05,-2.34,;21.05,-3.88,;19.72,-1.57,;19.72,-.03,;18.38,-2.34,;33.06,-4.65,;33.06,-6.19,;34.39,-3.88,;35.73,-4.64,;35.72,-6.19,;37.05,-6.95,;38.39,-6.18,;38.38,-4.63,;37.05,-3.87,;39.71,-3.86,;41.04,-3.07,;40.49,-5.18,;38.93,-2.53,;37.06,-8.49,;37.05,-10.03,;38.6,-8.5,;35.52,-8.5,)| Show InChI InChI=1S/C30H35F6N3O5/c1-28(2,3)19-8-10-23(11-9-19)39(16-17-4-6-18(7-5-17)25(41)37-15-24(40)26(42)43)27(44)38-22-13-20(29(31,32)33)12-21(14-22)30(34,35)36/h4-7,12-14,19,23-24,40H,8-11,15-16H2,1-3H3,(H,37,41)(H,38,44)(H,42,43)/t19-,23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 373 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50393783
(CHEMBL2159339)Show SMILES C[C@@H](c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(cc1-c1ccc2cc(ccc2c1)C(F)(F)F)-c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C32H24Cl2F3N3O3/c1-18(19-2-4-20(5-3-19)31(43)38-11-10-30(41)42)40-29(17-28(39-40)24-14-26(33)16-27(34)15-24)23-7-6-22-13-25(32(35,36)37)9-8-21(22)12-23/h2-9,12-18H,10-11H2,1H3,(H,38,43)(H,41,42)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ... |
J Med Chem 55: 6137-48 (2012)
Article DOI: 10.1021/jm300579z
BindingDB Entry DOI: 10.7270/Q2X63P2C |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244507
((R)-3-{4-[3-(3-Bromo-5-trifluoromethylphenyl)-1-(4...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Br)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:34| Show InChI InChI=1S/C31H29BrF3N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29130
(thiazole, 27)Show SMILES OC(=O)CCNC(=O)c1ccc(CC(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C28H22ClF3N2O3S/c29-22-11-7-18(8-12-22)23(15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36)27-34-24(16-38-27)19-5-9-21(10-6-19)28(30,31)32/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29104
(aminothiazole, 1)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccccc2)c2ccc(cc2)C2=CCCCC2)cc1 |t:34| Show InChI InChI=1S/C32H31N3O3S/c36-30(37)19-20-33-31(38)27-13-11-23(12-14-27)21-35(32-34-29(22-39-32)26-9-5-2-6-10-26)28-17-15-25(16-18-28)24-7-3-1-4-8-24/h2,5-7,9-18,22H,1,3-4,8,19-21H2,(H,33,38)(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 389 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245059
((R)-3-{4-[3-(3-Chlorophenyl)-1-(4-cyclohex-1-enylp...)Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:30| Show InChI InChI=1S/C30H30ClN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4-5,7-17,27,35H,1-3,6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 406 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245101
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methylthio)p...)Show SMILES CSc1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1 |r| Show InChI InChI=1S/C31H35N3O5S/c1-40-27-9-5-8-25(18-27)33-31(39)34(26-16-14-23(15-17-26)22-6-3-2-4-7-22)20-21-10-12-24(13-11-21)29(36)32-19-28(35)30(37)38/h5,8-18,22,28,35H,2-4,6-7,19-20H2,1H3,(H,32,36)(H,33,39)(H,37,38)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 411 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29131
(thiazole, 28)Show SMILES OC(=O)CCNC(=O)c1ccc(CC(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C28H22ClF3N2O4S/c29-21-9-5-18(6-10-21)23(15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36)27-34-24(16-39-27)19-7-11-22(12-8-19)38-28(30,31)32/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 429 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50171819
(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)Show SMILES CC(C)(C)C1CCC2(CC1)CCN(C(=O)N2Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)c1ccc(OC(F)(F)F)cc1 |(-2.46,-2.45,;-3.55,-1.37,;-4.65,-2.45,;-4.65,-.28,;-2.46,-.29,;-.25,.02,;1.21,-.52,;2.5,.76,;.28,.48,;-1.23,1.41,;2.51,2.3,;3.85,3.05,;5.17,2.28,;5.17,.76,;6.5,-.02,;3.82,-.02,;3.82,-1.56,;5.15,-2.33,;5.15,-3.86,;6.48,-4.63,;7.82,-3.86,;7.82,-2.31,;6.48,-1.54,;9.15,-4.63,;9.15,-6.17,;10.48,-3.85,;11.81,-4.62,;13.22,-3.99,;14.25,-5.13,;13.48,-6.45,;11.98,-6.14,;6.5,3.04,;6.5,4.58,;7.83,5.34,;9.17,4.58,;10.5,5.33,;11.83,4.55,;11.05,3.23,;13.16,3.79,;12.59,5.9,;9.15,3.03,;7.83,2.27,)| Show InChI InChI=1S/C29H34F3N7O3/c1-27(2,3)21-12-14-28(15-13-21)16-17-38(22-8-10-23(11-9-22)42-29(30,31)32)26(41)39(28)18-19-4-6-20(7-5-19)24(40)33-25-34-36-37-35-25/h4-11,21H,12-18H2,1-3H3,(H2,33,34,35,36,37,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human gastric inhibitory polypeptide receptor (hGIP) mediated cAMP accumulation |
Bioorg Med Chem Lett 15: 4564-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.101
BindingDB Entry DOI: 10.7270/Q26T0M5F |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50393786
(CHEMBL2159342)Show SMILES CC(C)c1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C34H31Cl2N3O3/c1-20(2)24-8-9-26-15-27(11-10-25(26)14-24)32-19-31(28-16-29(35)18-30(36)17-28)38-39(32)21(3)22-4-6-23(7-5-22)34(42)37-13-12-33(40)41/h4-11,14-21H,12-13H2,1-3H3,(H,37,42)(H,40,41)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 431 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ... |
J Med Chem 55: 6137-48 (2012)
Article DOI: 10.1021/jm300579z
BindingDB Entry DOI: 10.7270/Q2X63P2C |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50199487
(1-(5-((2H-tetrazol-5-yl)carbamoyl)-2,3-dihydro-1H-...)Show SMILES CC(C)(C)[C@@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wD:4.3,7.10,(23.95,-19.68,;23.96,-18.14,;25.5,-18.15,;22.42,-18.14,;23.96,-16.6,;22.63,-15.83,;22.63,-14.29,;23.98,-13.53,;25.3,-14.29,;25.3,-15.83,;23.98,-11.99,;25.31,-11.22,;25.63,-9.72,;27.49,-9.75,;27.97,-11.21,;29.3,-11.97,;29.31,-13.52,;27.97,-14.29,;26.64,-13.52,;26.65,-11.98,;30.64,-14.28,;30.64,-15.82,;31.97,-13.51,;33.31,-14.28,;33.47,-15.81,;34.98,-16.12,;35.75,-14.79,;34.71,-13.65,;22.64,-11.22,;22.64,-9.68,;21.31,-11.99,;19.98,-11.22,;18.63,-11.99,;17.3,-11.22,;17.3,-9.68,;15.97,-8.91,;15.97,-7.37,;15.96,-5.83,;17.51,-7.36,;14.43,-7.38,;18.63,-8.91,;19.97,-9.67,)| Show InChI InChI=1S/C29H34F3N7O3/c1-28(2,3)19-6-10-21(11-7-19)39(27(41)33-20-8-12-22(13-9-20)42-29(30,31)32)24-15-5-17-16-18(4-14-23(17)24)25(40)34-26-35-37-38-36-26/h4,8-9,12-14,16,19,21,24H,5-7,10-11,15H2,1-3H3,(H,33,41)(H2,34,35,36,37,38,40)/t19-,21+,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 435 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014
BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50244456
((S)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)Show SMILES O[C@@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O |r,t:31| Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 445 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50393774
(CHEMBL2159335)Show SMILES CCCOc1ccc(cc1Cl)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C30H28Cl3N3O4/c1-3-12-40-28-9-8-21(15-25(28)33)27-17-26(22-13-23(31)16-24(32)14-22)35-36(27)18(2)19-4-6-20(7-5-19)30(39)34-11-10-29(37)38/h4-9,13-18H,3,10-12H2,1-2H3,(H,34,39)(H,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 478 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ... |
J Med Chem 55: 6137-48 (2012)
Article DOI: 10.1021/jm300579z
BindingDB Entry DOI: 10.7270/Q2X63P2C |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM29109
(aminothiazole, 6)Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc-3c(Cc4ccccc-34)c2)cc1 Show InChI InChI=1S/C34H26F3N3O4S/c35-34(36,37)44-27-12-9-22(10-13-27)30-20-45-33(39-30)40(19-21-5-7-23(8-6-21)32(43)38-16-15-31(41)42)26-11-14-29-25(18-26)17-24-3-1-2-4-28(24)29/h1-14,18,20H,15-17,19H2,(H,38,43)(H,41,42) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 488 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
| Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum... |
J Med Chem 52: 2989-3000 (2009)
Article DOI: 10.1021/jm8016249
BindingDB Entry DOI: 10.7270/Q21Z42RS |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50245102
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methane...)Show SMILES CS(=O)(=O)c1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)ccc1OC(F)(F)F |r,t:35| Show InChI InChI=1S/C32H32F3N3O8S/c1-47(44,45)28-17-24(13-16-27(28)46-32(33,34)35)37-31(43)38(25-14-11-22(12-15-25)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-26(39)30(41)42/h5,7-17,26,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t26-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 497 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells |
J Med Chem 51: 5387-96 (2008)
Article DOI: 10.1021/jm7015599
BindingDB Entry DOI: 10.7270/Q2X34X9R |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50358369
(CHEMBL1922835)Show SMILES CCCOc1cc(Cl)cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12 |w:27.29| Show InChI InChI=1S/C27H24ClF3N8O3/c1-3-12-41-22-14-18(28)13-21-23(22)38(2)26(32-19-8-10-20(11-9-19)42-27(29,30)31)39(21)15-16-4-6-17(7-5-16)24(40)33-25-34-36-37-35-25/h4-11,13-14H,3,12,15H2,1-2H3,(H2,33,34,35,36,37,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GIP receptor by cAMP assay |
Bioorg Med Chem Lett 21: 7131-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.085
BindingDB Entry DOI: 10.7270/Q2C829QP |
More data for this
Ligand-Target Pair | |
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