Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120132 (US8697708, 18) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.300 | -53.8 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120141 (US8697708, 224) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.300 | -53.8 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120140 (US8697708, 223) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.400 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120143 (US8697708, 236) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.5 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120128 (US8697708, 2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.5 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120142 (US8697708, 227) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.800 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120133 (US8697708, 22) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1 | -50.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120131 (US8697708, 16) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | -50.0 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120129 (US8697708, 9) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | -50.0 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120139 (US8697708, 213) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.5 | -49.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120137 (US8697708, 129) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.60 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120138 (US8697708, 138) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.10 | -47.4 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120134 (US8697708, 24) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.20 | -46.4 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120136 (US8697708, 56) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 8.60 | -45.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120130 (US8697708, 10) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 23 | -43.2 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM120135 (US8697708, 25) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 87 | -39.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
F. Hoffmann-La Roche AG US Patent | Assay Description To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai... | US Patent US8697708 (2014) BindingDB Entry DOI: 10.7270/Q2J38R6F | |||||||||||
More data for this Ligand-Target Pair |