Found 57 hits Enz. Inhib. hit(s) with all data for entry = 50007532 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3096
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3095
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 62 | 6-(2,...)Show SMILES CCN(CC)CCOc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-13.08,-10.99,;-11.59,-10.59,;-10.82,-9.26,;-9.48,-10.03,;-8.4,-8.94,;-11.59,-7.93,;-10.82,-6.59,;-10.82,-5.05,;-9.48,-4.28,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)12-13-35-19-9-6-8-18(15-19)30-26-29-16-17-14-20(25(34)32(3)24(17)31-26)23-21(27)10-7-11-22(23)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,29,30,31) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3101
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 68 | 6-(2,...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.03,-11.21,;-8.03,-9.67,;-9.39,-8.95,;-9.45,-7.41,;-8.15,-6.59,;-6.79,-7.31,;-6.73,-8.85,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C25H24Cl2N6O/c1-31-10-12-33(13-11-31)18-8-6-17(7-9-18)29-25-28-15-16-14-19(24(34)32(2)23(16)30-25)22-20(26)4-3-5-21(22)27/h3-9,14-15H,10-13H2,1-2H3,(H,28,29,30) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3104
(2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H...)Show SMILES Cn1c2nc(Nc3ccc(CC(O)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-9.48,-2.74,;-9.48,-4.28,;-8.15,-5.05,;-8.15,-6.59,;-7.38,-7.93,;-5.84,-7.93,;-8.15,-9.26,;-6.82,-4.28,;-6.82,-2.74,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C22H16Cl2N4O3/c1-28-20-13(10-15(21(28)31)19-16(23)3-2-4-17(19)24)11-25-22(27-20)26-14-7-5-12(6-8-14)9-18(29)30/h2-8,10-11H,9H2,1H3,(H,29,30)(H,25,26,27) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3451
(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl |(-13.55,.59,;-13.15,2.08,;-11.66,2.48,;-11.26,3.96,;-9.78,4.36,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;5.49,-4.29,;2.83,-4.29,;4.16,-5.06,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)| Show InChI InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50064349
(1-tert-Butyl-3-{6-(2,6-dichloro-phenyl)-2-[4-(2-di...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(c(NC(=O)NC(C)(C)C)nc3n2)-c2c(Cl)cccc2Cl)cc1 |(2.14,-2.63,;2.14,-4.18,;.81,-4.94,;-.53,-4.18,;-.53,-2.63,;.81,-6.47,;2.14,-7.25,;2.15,-8.79,;3.48,-9.56,;3.48,-11.11,;4.81,-11.87,;6.14,-11.1,;7.47,-11.87,;8.8,-11.1,;8.8,-9.56,;10.13,-8.78,;11.47,-9.55,;12.8,-8.78,;14.14,-9.55,;14.14,-11.1,;15.47,-11.87,;15.47,-13.41,;14.13,-14.18,;16.8,-14.19,;16.79,-15.73,;18.13,-16.5,;15.45,-16.49,;17.89,-14.64,;12.8,-11.87,;11.46,-11.09,;10.13,-11.87,;15.47,-8.79,;15.47,-7.26,;14.14,-6.49,;16.8,-6.49,;18.15,-7.26,;18.13,-8.8,;16.8,-9.57,;16.8,-11.11,;6.14,-9.56,;4.81,-8.79,)| Show InChI InChI=1S/C30H35Cl2N7O2/c1-6-39(7-2)15-16-41-21-13-11-20(12-14-21)34-28-33-18-19-17-22(25-23(31)9-8-10-24(25)32)27(35-26(19)36-28)37-29(40)38-30(3,4)5/h8-14,17-18H,6-7,15-16H2,1-5H3,(H3,33,34,35,36,37,38,40) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3071
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-6.81,-2.74,;-6.81,-4.28,;-8.14,-5.05,;-9.48,-4.29,;-9.48,-2.75,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C20H14Cl2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h2-11H,1H3,(H,23,24,25) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3487
(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)Show SMILES COc1ccc(NC(=O)Nc2nc3nc(NCCCN4CCN(C)CC4)ncc3cc2-c2c(Cl)cccc2Cl)cc1 |(30.19,-24.55,;28.88,-23.74,;28.93,-22.2,;27.62,-21.39,;27.67,-19.85,;29.03,-19.12,;29.03,-17.58,;27.69,-16.81,;26.36,-17.58,;27.69,-15.27,;26.36,-14.5,;25.03,-15.27,;23.69,-14.5,;22.36,-15.27,;21.03,-14.5,;19.69,-15.27,;18.36,-14.5,;16.87,-14.9,;15.78,-13.81,;14.29,-14.21,;13,-13.38,;11.63,-14.08,;11.56,-15.62,;10.23,-16.39,;12.86,-16.45,;14.22,-15.75,;21.03,-12.96,;22.36,-12.19,;23.69,-12.96,;25.03,-12.19,;26.36,-12.96,;27.69,-12.19,;27.69,-10.65,;26.36,-9.88,;29.03,-9.88,;30.36,-10.65,;30.36,-12.19,;29.03,-12.96,;29.03,-14.5,;30.34,-19.93,;30.29,-21.47,)| Show InChI InChI=1S/C29H32Cl2N8O2/c1-38-13-15-39(16-14-38)12-4-11-32-28-33-18-19-17-22(25-23(30)5-3-6-24(25)31)27(35-26(19)36-28)37-29(40)34-20-7-9-21(41-2)10-8-20/h3,5-10,17-18H,4,11-16H2,1-2H3,(H3,32,33,34,35,36,37,40) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3473
(1-benzyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methyl...)Show SMILES CN1CCN(CCCNc2ncc3cc(c(NC(=O)NCc4ccccc4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.83,-4.29,;1.49,-3.52,;.16,-4.29,;.16,-5.83,;1.49,-6.6,;2.83,-5.83,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| Show InChI InChI=1S/C29H32Cl2N8O/c1-38-13-15-39(16-14-38)12-6-11-32-28-33-19-21-17-22(25-23(30)9-5-10-24(25)31)27(35-26(21)36-28)37-29(40)34-18-20-7-3-2-4-8-20/h2-5,7-10,17,19H,6,11-16,18H2,1H3,(H3,32,33,34,35,36,37,40) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3474
(1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-me...)Show SMILES CN1CCN(CCCNc2ncc3cc(c(NC(=O)NC4CCCCC4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.8,-4.24,;2.74,-5.78,;4.04,-6.6,;5.4,-5.88,;5.46,-4.34,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| Show InChI InChI=1S/C28H36Cl2N8O/c1-37-13-15-38(16-14-37)12-6-11-31-27-32-18-19-17-21(24-22(29)9-5-10-23(24)30)26(34-25(19)35-27)36-28(39)33-20-7-3-2-4-8-20/h5,9-10,17-18,20H,2-4,6-8,11-16H2,1H3,(H3,31,32,33,34,35,36,39) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3104
(2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H...)Show SMILES Cn1c2nc(Nc3ccc(CC(O)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-9.48,-2.74,;-9.48,-4.28,;-8.15,-5.05,;-8.15,-6.59,;-7.38,-7.93,;-5.84,-7.93,;-8.15,-9.26,;-6.82,-4.28,;-6.82,-2.74,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C22H16Cl2N4O3/c1-28-20-13(10-15(21(28)31)19-16(23)3-2-4-17(19)24)11-25-22(27-20)26-14-7-5-12(6-8-14)9-18(29)30/h2-8,10-11H,9H2,1H3,(H,29,30)(H,25,26,27) | MMDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3071
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-6.81,-2.74,;-6.81,-4.28,;-8.14,-5.05,;-9.48,-4.29,;-9.48,-2.75,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C20H14Cl2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h2-11H,1H3,(H,23,24,25) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3096
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31) | MMDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3095
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 62 | 6-(2,...)Show SMILES CCN(CC)CCOc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-13.08,-10.99,;-11.59,-10.59,;-10.82,-9.26,;-9.48,-10.03,;-8.4,-8.94,;-11.59,-7.93,;-10.82,-6.59,;-10.82,-5.05,;-9.48,-4.28,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)12-13-35-19-9-6-8-18(15-19)30-26-29-16-17-14-20(25(34)32(3)24(17)31-26)23-21(27)10-7-11-22(23)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,29,30,31) | MMDB
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Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3101
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 68 | 6-(2,...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.03,-11.21,;-8.03,-9.67,;-9.39,-8.95,;-9.45,-7.41,;-8.15,-6.59,;-6.79,-7.31,;-6.73,-8.85,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C25H24Cl2N6O/c1-31-10-12-33(13-11-31)18-8-6-17(7-9-18)29-25-28-15-16-14-19(24(34)32(2)23(16)30-25)22-20(26)4-3-5-21(22)27/h3-9,14-15H,10-13H2,1-2H3,(H,28,29,30) | MMDB
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Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3064
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 31 | 6-(2,...)Show SMILES CN1CCN(CCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)CC1 |(-10.37,-10.59,;-9.97,-9.1,;-8.49,-8.7,;-8.09,-7.22,;-9.18,-6.13,;-8.52,-4.79,;-8.92,-3.31,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-10.66,-6.53,;-11.06,-8.01,)| Show InChI InChI=1S/C22H26Cl2N6O/c1-28-9-11-30(12-10-28)8-4-7-25-22-26-14-15-13-16(21(31)29(2)20(15)27-22)19-17(23)5-3-6-18(19)24/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,25,26,27) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3050
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3474
(1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-me...)Show SMILES CN1CCN(CCCNc2ncc3cc(c(NC(=O)NC4CCCCC4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.8,-4.24,;2.74,-5.78,;4.04,-6.6,;5.4,-5.88,;5.46,-4.34,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| Show InChI InChI=1S/C28H36Cl2N8O/c1-37-13-15-38(16-14-37)12-6-11-31-27-32-18-19-17-21(24-22(29)9-5-10-23(24)30)26(34-25(19)35-27)36-28(39)33-20-7-3-2-4-8-20/h5,9-10,17-18,20H,2-4,6-8,11-16H2,1H3,(H3,31,32,33,34,35,36,39) | MMDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3071
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-6.81,-2.74,;-6.81,-4.28,;-8.14,-5.05,;-9.48,-4.29,;-9.48,-2.75,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C20H14Cl2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h2-11H,1H3,(H,23,24,25) | MMDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3096
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31) | PDB
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Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3451
(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl |(-13.55,.59,;-13.15,2.08,;-11.66,2.48,;-11.26,3.96,;-9.78,4.36,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;5.49,-4.29,;2.83,-4.29,;4.16,-5.06,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)| Show InChI InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36) | MMDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3451
(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl |(-13.55,.59,;-13.15,2.08,;-11.66,2.48,;-11.26,3.96,;-9.78,4.36,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;5.49,-4.29,;2.83,-4.29,;4.16,-5.06,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)| Show InChI InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3063
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 30 | 6-(2,...)Show SMILES Cn1c2nc(NCCCN3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-8.92,-3.31,;-8.52,-4.79,;-9.18,-6.13,;-8.09,-7.22,;-8.49,-8.7,;-9.97,-9.1,;-11.06,-8.01,;-10.66,-6.53,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C21H23Cl2N5O2/c1-27-19-14(12-15(20(27)29)18-16(22)4-2-5-17(18)23)13-25-21(26-19)24-6-3-7-28-8-10-30-11-9-28/h2,4-5,12-13H,3,6-11H2,1H3,(H,24,25,26) | PDB
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| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3487
(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)Show SMILES COc1ccc(NC(=O)Nc2nc3nc(NCCCN4CCN(C)CC4)ncc3cc2-c2c(Cl)cccc2Cl)cc1 |(30.19,-24.55,;28.88,-23.74,;28.93,-22.2,;27.62,-21.39,;27.67,-19.85,;29.03,-19.12,;29.03,-17.58,;27.69,-16.81,;26.36,-17.58,;27.69,-15.27,;26.36,-14.5,;25.03,-15.27,;23.69,-14.5,;22.36,-15.27,;21.03,-14.5,;19.69,-15.27,;18.36,-14.5,;16.87,-14.9,;15.78,-13.81,;14.29,-14.21,;13,-13.38,;11.63,-14.08,;11.56,-15.62,;10.23,-16.39,;12.86,-16.45,;14.22,-15.75,;21.03,-12.96,;22.36,-12.19,;23.69,-12.96,;25.03,-12.19,;26.36,-12.96,;27.69,-12.19,;27.69,-10.65,;26.36,-9.88,;29.03,-9.88,;30.36,-10.65,;30.36,-12.19,;29.03,-12.96,;29.03,-14.5,;30.34,-19.93,;30.29,-21.47,)| Show InChI InChI=1S/C29H32Cl2N8O2/c1-38-13-15-39(16-14-38)12-4-11-32-28-33-18-19-17-22(25-23(30)5-3-6-24(25)31)27(35-26(19)36-28)37-29(40)34-20-7-9-21(41-2)10-8-20/h3,5-10,17-18H,4,11-16H2,1-2H3,(H3,32,33,34,35,36,37,40) | PDB
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| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3487
(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)Show SMILES COc1ccc(NC(=O)Nc2nc3nc(NCCCN4CCN(C)CC4)ncc3cc2-c2c(Cl)cccc2Cl)cc1 |(30.19,-24.55,;28.88,-23.74,;28.93,-22.2,;27.62,-21.39,;27.67,-19.85,;29.03,-19.12,;29.03,-17.58,;27.69,-16.81,;26.36,-17.58,;27.69,-15.27,;26.36,-14.5,;25.03,-15.27,;23.69,-14.5,;22.36,-15.27,;21.03,-14.5,;19.69,-15.27,;18.36,-14.5,;16.87,-14.9,;15.78,-13.81,;14.29,-14.21,;13,-13.38,;11.63,-14.08,;11.56,-15.62,;10.23,-16.39,;12.86,-16.45,;14.22,-15.75,;21.03,-12.96,;22.36,-12.19,;23.69,-12.96,;25.03,-12.19,;26.36,-12.96,;27.69,-12.19,;27.69,-10.65,;26.36,-9.88,;29.03,-9.88,;30.36,-10.65,;30.36,-12.19,;29.03,-12.96,;29.03,-14.5,;30.34,-19.93,;30.29,-21.47,)| Show InChI InChI=1S/C29H32Cl2N8O2/c1-38-13-15-39(16-14-38)12-4-11-32-28-33-18-19-17-22(25-23(30)5-3-6-24(25)31)27(35-26(19)36-28)37-29(40)34-20-7-9-21(41-2)10-8-20/h3,5-10,17-18H,4,11-16H2,1-2H3,(H3,32,33,34,35,36,37,40) | MMDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3474
(1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-me...)Show SMILES CN1CCN(CCCNc2ncc3cc(c(NC(=O)NC4CCCCC4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.8,-4.24,;2.74,-5.78,;4.04,-6.6,;5.4,-5.88,;5.46,-4.34,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| Show InChI InChI=1S/C28H36Cl2N8O/c1-37-13-15-38(16-14-37)12-6-11-31-27-32-18-19-17-21(24-22(29)9-5-10-23(24)30)26(34-25(19)35-27)36-28(39)33-20-7-3-2-4-8-20/h5,9-10,17-18,20H,2-4,6-8,11-16H2,1H3,(H3,31,32,33,34,35,36,39) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3062
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 29 | 6-(2,...)Show SMILES CCN(CC)CCCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-6.72,-6.82,;-8.2,-7.22,;-9.29,-6.13,;-10.38,-7.22,;-11.71,-6.45,;-8.52,-4.79,;-8.92,-3.31,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C21H25Cl2N5O/c1-4-28(5-2)11-7-10-24-21-25-13-14-12-15(20(29)27(3)19(14)26-21)18-16(22)8-6-9-17(18)23/h6,8-9,12-13H,4-5,7,10-11H2,1-3H3,(H,24,25,26) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3473
(1-benzyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methyl...)Show SMILES CN1CCN(CCCNc2ncc3cc(c(NC(=O)NCc4ccccc4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.83,-4.29,;1.49,-3.52,;.16,-4.29,;.16,-5.83,;1.49,-6.6,;2.83,-5.83,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| Show InChI InChI=1S/C29H32Cl2N8O/c1-38-13-15-39(16-14-38)12-6-11-32-28-33-19-21-17-22(25-23(30)9-5-10-24(25)31)27(35-26(21)36-28)37-29(40)34-18-20-7-3-2-4-8-20/h2-5,7-10,17,19H,6,11-16,18H2,1H3,(H3,32,33,34,35,36,37,40) | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50064349
(1-tert-Butyl-3-{6-(2,6-dichloro-phenyl)-2-[4-(2-di...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(c(NC(=O)NC(C)(C)C)nc3n2)-c2c(Cl)cccc2Cl)cc1 |(2.14,-2.63,;2.14,-4.18,;.81,-4.94,;-.53,-4.18,;-.53,-2.63,;.81,-6.47,;2.14,-7.25,;2.15,-8.79,;3.48,-9.56,;3.48,-11.11,;4.81,-11.87,;6.14,-11.1,;7.47,-11.87,;8.8,-11.1,;8.8,-9.56,;10.13,-8.78,;11.47,-9.55,;12.8,-8.78,;14.14,-9.55,;14.14,-11.1,;15.47,-11.87,;15.47,-13.41,;14.13,-14.18,;16.8,-14.19,;16.79,-15.73,;18.13,-16.5,;15.45,-16.49,;17.89,-14.64,;12.8,-11.87,;11.46,-11.09,;10.13,-11.87,;15.47,-8.79,;15.47,-7.26,;14.14,-6.49,;16.8,-6.49,;18.15,-7.26,;18.13,-8.8,;16.8,-9.57,;16.8,-11.11,;6.14,-9.56,;4.81,-8.79,)| Show InChI InChI=1S/C30H35Cl2N7O2/c1-6-39(7-2)15-16-41-21-13-11-20(12-14-21)34-28-33-18-19-17-22(25-23(31)9-8-10-24(25)32)27(35-26(19)36-28)37-29(40)38-30(3,4)5/h8-14,17-18H,6-7,15-16H2,1-5H3,(H3,33,34,35,36,37,38,40) | MMDB
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Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3062
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 29 | 6-(2,...)Show SMILES CCN(CC)CCCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-6.72,-6.82,;-8.2,-7.22,;-9.29,-6.13,;-10.38,-7.22,;-11.71,-6.45,;-8.52,-4.79,;-8.92,-3.31,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C21H25Cl2N5O/c1-4-28(5-2)11-7-10-24-21-25-13-14-12-15(20(29)27(3)19(14)26-21)18-16(22)8-6-9-17(18)23/h6,8-9,12-13H,4-5,7,10-11H2,1-3H3,(H,24,25,26) | PDB
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| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3473
(1-benzyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methyl...)Show SMILES CN1CCN(CCCNc2ncc3cc(c(NC(=O)NCc4ccccc4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.83,-4.29,;1.49,-3.52,;.16,-4.29,;.16,-5.83,;1.49,-6.6,;2.83,-5.83,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| Show InChI InChI=1S/C29H32Cl2N8O/c1-38-13-15-39(16-14-38)12-6-11-32-28-33-19-21-17-22(25-23(30)9-5-10-24(25)31)27(35-26(21)36-28)37-29(40)34-18-20-7-3-2-4-8-20/h2-5,7-10,17,19H,6,11-16,18H2,1H3,(H3,32,33,34,35,36,37,40) | MMDB
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| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3064
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 31 | 6-(2,...)Show SMILES CN1CCN(CCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)CC1 |(-10.37,-10.59,;-9.97,-9.1,;-8.49,-8.7,;-8.09,-7.22,;-9.18,-6.13,;-8.52,-4.79,;-8.92,-3.31,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-10.66,-6.53,;-11.06,-8.01,)| Show InChI InChI=1S/C22H26Cl2N6O/c1-28-9-11-30(12-10-28)8-4-7-25-22-26-14-15-13-16(21(31)29(2)20(15)27-22)19-17(23)5-3-6-18(19)24/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,25,26,27) | MMDB
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3050
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19) | MMDB
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| n/a | n/a | 4.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3050
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19) | PDB
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| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3063
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 30 | 6-(2,...)Show SMILES Cn1c2nc(NCCCN3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-8.92,-3.31,;-8.52,-4.79,;-9.18,-6.13,;-8.09,-7.22,;-8.49,-8.7,;-9.97,-9.1,;-11.06,-8.01,;-10.66,-6.53,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C21H23Cl2N5O2/c1-27-19-14(12-15(20(27)29)18-16(22)4-2-5-17(18)23)13-25-21(26-19)24-6-3-7-28-8-10-30-11-9-28/h2,4-5,12-13H,3,6-11H2,1H3,(H,24,25,26) | MMDB
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| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3064
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 31 | 6-(2,...)Show SMILES CN1CCN(CCCNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)CC1 |(-10.37,-10.59,;-9.97,-9.1,;-8.49,-8.7,;-8.09,-7.22,;-9.18,-6.13,;-8.52,-4.79,;-8.92,-3.31,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-10.66,-6.53,;-11.06,-8.01,)| Show InChI InChI=1S/C22H26Cl2N6O/c1-28-9-11-30(12-10-28)8-4-7-25-22-26-14-15-13-16(21(31)29(2)20(15)27-22)19-17(23)5-3-6-18(19)24/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,25,26,27) | PDB
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| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3062
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 29 | 6-(2,...)Show SMILES CCN(CC)CCCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-6.72,-6.82,;-8.2,-7.22,;-9.29,-6.13,;-10.38,-7.22,;-11.71,-6.45,;-8.52,-4.79,;-8.92,-3.31,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C21H25Cl2N5O/c1-4-28(5-2)11-7-10-24-21-25-13-14-12-15(20(29)27(3)19(14)26-21)18-16(22)8-6-9-17(18)23/h6,8-9,12-13H,4-5,7,10-11H2,1-3H3,(H,24,25,26) | MMDB
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| n/a | n/a | 8.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50064347
(6-(2,6-Dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]p...)Show SMILES Cn1c2ncncc2cc(-c2c(Cl)cccc2Cl)c1=O |(4.31,-8.43,;4.32,-6.89,;2.98,-6.1,;1.65,-6.89,;.32,-6.12,;.32,-4.57,;1.65,-3.79,;2.99,-4.57,;4.32,-3.79,;5.66,-4.57,;6.99,-3.81,;6.99,-2.28,;5.66,-1.5,;8.32,-1.5,;9.67,-2.28,;9.65,-3.82,;8.32,-4.59,;8.32,-6.12,;5.66,-6.12,;6.99,-6.89,)| Show InChI InChI=1S/C14H9Cl2N3O/c1-19-13-8(6-17-7-18-13)5-9(14(19)20)12-10(15)3-2-4-11(12)16/h2-7H,1H3 | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50064348
(2-Amino-6-(3,5-dimethoxy-phenyl)-8-methyl-8H-pyrid...)Show InChI InChI=1S/C16H16N4O3/c1-20-14-10(8-18-16(17)19-14)6-13(15(20)21)9-4-11(22-2)7-12(5-9)23-3/h4-8H,1-3H3,(H2,17,18,19) | MMDB
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| n/a | n/a | 4.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3061
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 28 | 6-(2,...)Show SMILES CN(C)c1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-8.15,-1.97,;-8.15,-.43,;-9.48,.34,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C16H14Cl2N4O/c1-21(2)16-19-8-9-7-10(15(23)22(3)14(9)20-16)13-11(17)5-4-6-12(13)18/h4-8H,1-3H3 | PDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM4831
(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C20H18F6N6O/c1-18(2,3)32-17(33)31-15-13(6-10-8-28-16(27)30-14(10)29-15)9-4-11(19(21,22)23)7-12(5-9)20(24,25)26/h4-8H,1-3H3,(H4,27,28,29,30,31,32,33) | MMDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM4850
(1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...)Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31) | PDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM4831
(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C20H18F6N6O/c1-18(2,3)32-17(33)31-15-13(6-10-8-28-16(27)30-14(10)29-15)9-4-11(19(21,22)23)7-12(5-9)20(24,25)26/h4-8H,1-3H3,(H4,27,28,29,30,31,32,33) | PDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3443
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) | PDB
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| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of human epidermal growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3443
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) | MMDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM4849
(1-[2-amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyri...)Show SMILES CCOc1cc(OCC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C Show InChI InChI=1S/C22H28N6O3/c1-6-30-15-8-13(9-16(11-15)31-7-2)17-10-14-12-24-20(23)26-18(14)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29) | MMDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3061
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 28 | 6-(2,...)Show SMILES CN(C)c1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-8.15,-1.97,;-8.15,-.43,;-9.48,.34,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C16H14Cl2N4O/c1-21(2)16-19-8-9-7-10(15(23)22(3)14(9)20-16)13-11(17)5-4-6-12(13)18/h4-8H,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM3052
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 19 | 6-(2,...)Show SMILES Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C15H11Cl2N3O/c1-8-18-7-9-6-10(15(21)20(2)14(9)19-8)13-11(16)4-3-5-12(13)17/h3-7H,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM3052
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 19 | 6-(2,...)Show SMILES Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1 |(-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,)| Show InChI InChI=1S/C15H11Cl2N3O/c1-8-18-7-9-6-10(15(21)20(2)14(9)19-8)13-11(16)4-3-5-12(13)17/h3-7H,1-2H3 | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50064348
(2-Amino-6-(3,5-dimethoxy-phenyl)-8-methyl-8H-pyrid...)Show InChI InChI=1S/C16H16N4O3/c1-20-14-10(8-18-16(17)19-14)6-13(15(20)21)9-4-11(22-2)7-12(5-9)23-3/h4-8H,1-3H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of chicken c-Src tyrosine kinase |
J Med Chem 41: 1752-63 (1998)
Article DOI: 10.1021/jm970634p
BindingDB Entry DOI: 10.7270/Q26T0KQ6 |
More data for this
Ligand-Target Pair | |
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