Found 99 hits Enz. Inhib. hit(s) with all data for entry = 50017373 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM19387
(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2COCc2ccccc2)cc1 Show InChI InChI=1S/C26H27N5O3S/c1-35(32,33)22-13-7-18(8-14-22)15-29-21-11-9-20(10-12-21)24-23(30-26(28)31-25(24)27)17-34-16-19-5-3-2-4-6-19/h2-14,29H,15-17H2,1H3,(H4,27,28,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181180
(CHEMBL377514 | N-(3,5-dimethylbenzyl)-3-(5-(4-(4-(...)Show SMILES Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(cc3)S(C)(=O)=O)cc2)c1 Show InChI InChI=1S/C30H34N6O3S/c1-19-14-20(2)16-22(15-19)18-34-27(37)13-12-26-28(29(31)36-30(32)35-26)23-6-8-24(9-7-23)33-17-21-4-10-25(11-5-21)40(3,38)39/h4-11,14-16,33H,12-13,17-18H2,1-3H3,(H,34,37)(H4,31,32,35,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181184
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((3-...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#8]-[#6]-c1nc(-[#7])nc(-[#7])c1-c1ccc(-[#7]-[#6]-c2ccc(cc2)S([#6])(=O)=O)cc1 Show InChI InChI=1S/C24H29N5O3S/c1-16(2)12-13-32-15-21-22(23(25)29-24(26)28-21)18-6-8-19(9-7-18)27-14-17-4-10-20(11-5-17)33(3,30)31/h4-12,27H,13-15H2,1-3H3,(H4,25,26,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181214
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((4-...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CNc2ccc(F)cc2)cc1 Show InChI InChI=1S/C25H25FN6O2S/c1-35(33,34)21-12-2-16(3-13-21)14-29-19-8-4-17(5-9-19)23-22(31-25(28)32-24(23)27)15-30-20-10-6-18(26)7-11-20/h2-13,29-30H,14-15H2,1H3,(H4,27,28,31,32) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181184
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((3-...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#8]-[#6]-c1nc(-[#7])nc(-[#7])c1-c1ccc(-[#7]-[#6]-c2ccc(cc2)S([#6])(=O)=O)cc1 Show InChI InChI=1S/C24H29N5O3S/c1-16(2)12-13-32-15-21-22(23(25)29-24(26)28-21)18-6-8-19(9-7-18)27-14-17-4-10-20(11-5-17)33(3,30)31/h4-12,27H,13-15H2,1-3H3,(H4,25,26,28,29) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181191
(CHEMBL205711 | N-(3-chlorobenzyl)-3-(5-(4-(4-(meth...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CCC(=O)NCc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C28H29ClN6O3S/c1-39(37,38)23-11-5-18(6-12-23)16-32-22-9-7-20(8-10-22)26-24(34-28(31)35-27(26)30)13-14-25(36)33-17-19-3-2-4-21(29)15-19/h2-12,15,32H,13-14,16-17H2,1H3,(H,33,36)(H4,30,31,34,35) | PDB
Reactome pathway
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UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181217
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((me...)Show SMILES CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1)c1ccccc1 Show InChI InChI=1S/C26H28N6O2S/c1-32(21-6-4-3-5-7-21)17-23-24(25(27)31-26(28)30-23)19-10-12-20(13-11-19)29-16-18-8-14-22(15-9-18)35(2,33)34/h3-15,29H,16-17H2,1-2H3,(H4,27,28,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181182
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((fu...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2COCc2ccco2)cc1 Show InChI InChI=1S/C24H25N5O4S/c1-34(30,31)20-10-4-16(5-11-20)13-27-18-8-6-17(7-9-18)22-21(28-24(26)29-23(22)25)15-32-14-19-3-2-12-33-19/h2-12,27H,13-15H2,1H3,(H4,25,26,28,29) | PDB
Reactome pathway
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181201
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(iso...)Show SMILES CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C24H31N5O3S/c1-16(2)12-13-32-15-21-22(23(25)29-24(26)28-21)18-6-8-19(9-7-18)27-14-17-4-10-20(11-5-17)33(3,30)31/h4-11,16,27H,12-15H2,1-3H3,(H4,25,26,28,29) | PDB
Reactome pathway
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181180
(CHEMBL377514 | N-(3,5-dimethylbenzyl)-3-(5-(4-(4-(...)Show SMILES Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(cc3)S(C)(=O)=O)cc2)c1 Show InChI InChI=1S/C30H34N6O3S/c1-19-14-20(2)16-22(15-19)18-34-27(37)13-12-26-28(29(31)36-30(32)35-26)23-6-8-24(9-7-23)33-17-21-4-10-25(11-5-21)40(3,38)39/h4-11,14-16,33H,12-13,17-18H2,1-3H3,(H,34,37)(H4,31,32,35,36) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181229
(5-[4-(4-methanesulfonyl-benzylamino)-phenyl]-6-(5-...)Show SMILES Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(cc3)S(C)(=O)=O)cc2)o1 Show InChI InChI=1S/C25H27N5O4S/c1-16-3-10-20(34-16)14-33-15-22-23(24(26)30-25(27)29-22)18-6-8-19(9-7-18)28-13-17-4-11-21(12-5-17)35(2,31)32/h3-12,28H,13-15H2,1-2H3,(H4,26,27,29,30) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181225
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((be...)Show SMILES CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C27H30N6O2S/c1-33(17-20-6-4-3-5-7-20)18-24-25(26(28)32-27(29)31-24)21-10-12-22(13-11-21)30-16-19-8-14-23(15-9-19)36(2,34)35/h3-15,30H,16-18H2,1-2H3,(H4,28,29,31,32) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181192
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-octy...)Show SMILES CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C26H35N5O2S/c1-3-4-5-6-7-8-9-23-24(25(27)31-26(28)30-23)20-12-14-21(15-13-20)29-18-19-10-16-22(17-11-19)34(2,32)33/h10-17,29H,3-9,18H2,1-2H3,(H4,27,28,30,31) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181191
(CHEMBL205711 | N-(3-chlorobenzyl)-3-(5-(4-(4-(meth...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CCC(=O)NCc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C28H29ClN6O3S/c1-39(37,38)23-11-5-18(6-12-23)16-32-22-9-7-20(8-10-22)26-24(34-28(31)35-27(26)30)13-14-25(36)33-17-19-3-2-4-21(29)15-19/h2-12,15,32H,13-14,16-17H2,1H3,(H,33,36)(H4,30,31,34,35) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181204
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-isop...)Show SMILES CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H25N5O2S/c1-13(2)19-18(20(22)26-21(23)25-19)15-6-8-16(9-7-15)24-12-14-4-10-17(11-5-14)29(3,27)28/h4-11,13,24H,12H2,1-3H3,(H4,22,23,25,26) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181179
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((ph...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CNc2ccccc2)cc1 Show InChI InChI=1S/C25H26N6O2S/c1-34(32,33)21-13-7-17(8-14-21)15-28-20-11-9-18(10-12-20)23-22(30-25(27)31-24(23)26)16-29-19-5-3-2-4-6-19/h2-14,28-29H,15-16H2,1H3,(H4,26,27,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181176
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-hept...)Show SMILES CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C25H33N5O2S/c1-3-4-5-6-7-8-22-23(24(26)30-25(27)29-22)19-11-13-20(14-12-19)28-17-18-9-15-21(16-10-18)33(2,31)32/h9-16,28H,3-8,17H2,1-2H3,(H4,26,27,29,30) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181181
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-hexy...)Show SMILES CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C24H31N5O2S/c1-3-4-5-6-7-21-22(23(25)29-24(26)28-21)18-10-12-19(13-11-18)27-16-17-8-14-20(15-9-17)32(2,30)31/h8-15,27H,3-7,16H2,1-2H3,(H4,25,26,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181201
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(iso...)Show SMILES CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C24H31N5O3S/c1-16(2)12-13-32-15-21-22(23(25)29-24(26)28-21)18-6-8-19(9-7-18)27-14-17-4-10-20(11-5-17)33(3,30)31/h4-11,16,27H,12-15H2,1-3H3,(H4,25,26,28,29) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM19387
(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2COCc2ccccc2)cc1 Show InChI InChI=1S/C26H27N5O3S/c1-35(32,33)22-13-7-18(8-14-22)15-29-21-11-9-20(10-12-21)24-23(30-26(28)31-25(24)27)17-34-16-19-5-3-2-4-6-19/h2-14,29H,15-17H2,1H3,(H4,27,28,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
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UniChem
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PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181185
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(met...)Show SMILES COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C20H23N5O3S/c1-28-12-17-18(19(21)25-20(22)24-17)14-5-7-15(8-6-14)23-11-13-3-9-16(10-4-13)29(2,26)27/h3-10,23H,11-12H2,1-2H3,(H4,21,22,24,25) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181217
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((me...)Show SMILES CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1)c1ccccc1 Show InChI InChI=1S/C26H28N6O2S/c1-32(21-6-4-3-5-7-21)17-23-24(25(27)31-26(28)30-23)19-10-12-20(13-11-19)29-16-18-8-14-22(15-9-18)35(2,33)34/h3-15,29H,16-17H2,1-2H3,(H4,27,28,30,31) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181179
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((ph...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CNc2ccccc2)cc1 Show InChI InChI=1S/C25H26N6O2S/c1-34(32,33)21-13-7-17(8-14-21)15-28-20-11-9-18(10-12-20)23-22(30-25(27)31-24(23)26)16-29-19-5-3-2-4-6-19/h2-14,28-29H,15-16H2,1H3,(H4,26,27,30,31) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181182
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((fu...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2COCc2ccco2)cc1 Show InChI InChI=1S/C24H25N5O4S/c1-34(30,31)20-10-4-16(5-11-20)13-27-18-8-6-17(7-9-18)22-21(28-24(26)29-23(22)25)15-32-14-19-3-2-12-33-19/h2-12,27H,13-15H2,1H3,(H4,25,26,28,29) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM19351
(2,4-diaminopyrimidine-based antagonist, 4c | 6-eth...)Show SMILES CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C20H23N5O2S/c1-3-17-18(19(21)25-20(22)24-17)14-6-8-15(9-7-14)23-12-13-4-10-16(11-5-13)28(2,26)27/h4-11,23H,3,12H2,1-2H3,(H4,21,22,24,25) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181229
(5-[4-(4-methanesulfonyl-benzylamino)-phenyl]-6-(5-...)Show SMILES Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(cc3)S(C)(=O)=O)cc2)o1 Show InChI InChI=1S/C25H27N5O4S/c1-16-3-10-20(34-16)14-33-15-22-23(24(26)30-25(27)29-22)18-6-8-19(9-7-18)28-13-17-4-11-21(12-5-17)35(2,31)32/h3-12,28H,13-15H2,1-2H3,(H4,26,27,29,30) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181193
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-isob...)Show SMILES CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H27N5O2S/c1-14(2)12-19-20(21(23)27-22(24)26-19)16-6-8-17(9-7-16)25-13-15-4-10-18(11-5-15)30(3,28)29/h4-11,14,25H,12-13H2,1-3H3,(H4,23,24,26,27) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181210
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(((4...)Show SMILES CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1)c1ccc(F)cc1 Show InChI InChI=1S/C26H27FN6O2S/c1-33(21-11-7-19(27)8-12-21)16-23-24(25(28)32-26(29)31-23)18-5-9-20(10-6-18)30-15-17-3-13-22(14-4-17)36(2,34)35/h3-14,30H,15-16H2,1-2H3,(H4,28,29,31,32) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181211
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-tert...)Show SMILES CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H27N5O2S/c1-22(2,3)19-18(20(23)27-21(24)26-19)15-7-9-16(10-8-15)25-13-14-5-11-17(12-6-14)30(4,28)29/h5-12,25H,13H2,1-4H3,(H4,23,24,26,27) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181206
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-buty...)Show SMILES CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H27N5O2S/c1-3-4-5-19-20(21(23)27-22(24)26-19)16-8-10-17(11-9-16)25-14-15-6-12-18(13-7-15)30(2,28)29/h6-13,25H,3-5,14H2,1-2H3,(H4,23,24,26,27) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181214
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((4-...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CNc2ccc(F)cc2)cc1 Show InChI InChI=1S/C25H25FN6O2S/c1-35(33,34)21-12-2-16(3-13-21)14-29-19-8-4-17(5-9-19)23-22(31-25(28)32-24(23)27)15-30-20-10-6-18(26)7-11-20/h2-13,29-30H,14-15H2,1H3,(H4,27,28,31,32) | PDB
Reactome pathway
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181209
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(ind...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CN2CCc3ccccc23)cc1 Show InChI InChI=1S/C27H28N6O2S/c1-36(34,35)22-12-6-18(7-13-22)16-30-21-10-8-20(9-11-21)25-23(31-27(29)32-26(25)28)17-33-15-14-19-4-2-3-5-24(19)33/h2-13,30H,14-17H2,1H3,(H4,28,29,31,32) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181188
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-cycl...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2C2CCC2)cc1 Show InChI InChI=1S/C22H25N5O2S/c1-30(28,29)18-11-5-14(6-12-18)13-25-17-9-7-15(8-10-17)19-20(16-3-2-4-16)26-22(24)27-21(19)23/h5-12,16,25H,2-4,13H2,1H3,(H4,23,24,26,27) | PDB
Reactome pathway
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UniChem
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181204
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-isop...)Show SMILES CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H25N5O2S/c1-13(2)19-18(20(22)26-21(23)25-19)15-6-8-16(9-7-15)24-12-14-4-10-17(11-5-14)29(3,27)28/h4-11,13,24H,12H2,1-3H3,(H4,22,23,25,26) | PDB
Reactome pathway
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UniChem
Similars
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PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181196
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((cy...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CNCC2CCCC2)cc1 Show InChI InChI=1S/C25H32N6O2S/c1-34(32,33)21-12-6-18(7-13-21)15-29-20-10-8-19(9-11-20)23-22(30-25(27)31-24(23)26)16-28-14-17-4-2-3-5-17/h6-13,17,28-29H,2-5,14-16H2,1H3,(H4,26,27,30,31) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181207
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-cycl...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2C2CC2)cc1 Show InChI InChI=1S/C21H23N5O2S/c1-29(27,28)17-10-2-13(3-11-17)12-24-16-8-6-14(7-9-16)18-19(15-4-5-15)25-21(23)26-20(18)22/h2-3,6-11,15,24H,4-5,12H2,1H3,(H4,22,23,25,26) | PDB
Reactome pathway
KEGG
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UniChem
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181177
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-pent...)Show SMILES CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C23H29N5O2S/c1-3-4-5-6-20-21(22(24)28-23(25)27-20)17-9-11-18(12-10-17)26-15-16-7-13-19(14-8-16)31(2,29)30/h7-14,26H,3-6,15H2,1-2H3,(H4,24,25,27,28) | PDB
Reactome pathway
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| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181215
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-cycl...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2C2CCCC2)cc1 Show InChI InChI=1S/C23H27N5O2S/c1-31(29,30)19-12-6-15(7-13-19)14-26-18-10-8-16(9-11-18)20-21(17-4-2-3-5-17)27-23(25)28-22(20)24/h6-13,17,26H,2-5,14H2,1H3,(H4,24,25,27,28) | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181206
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-buty...)Show SMILES CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H27N5O2S/c1-3-4-5-19-20(21(23)27-22(24)26-19)16-8-10-17(11-9-16)25-14-15-6-12-18(13-7-15)30(2,28)29/h6-13,25H,3-5,14H2,1-2H3,(H4,23,24,26,27) | PDB
Reactome pathway
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181203
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(iso...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CN2Cc3ccccc3C2)cc1 Show InChI InChI=1S/C27H28N6O2S/c1-36(34,35)23-12-6-18(7-13-23)14-30-22-10-8-19(9-11-22)25-24(31-27(29)32-26(25)28)17-33-15-20-4-2-3-5-21(20)16-33/h2-13,30H,14-17H2,1H3,(H4,28,29,31,32) | PDB
Reactome pathway
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| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181224
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-cycl...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2C2CCCCC2)cc1 Show InChI InChI=1S/C24H29N5O2S/c1-32(30,31)20-13-7-16(8-14-20)15-27-19-11-9-17(10-12-19)21-22(18-5-3-2-4-6-18)28-24(26)29-23(21)25/h7-14,18,27H,2-6,15H2,1H3,(H4,25,26,28,29) | PDB
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181198
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-ethy...)Show SMILES CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H25N5O2S/c1-4-18-19(20(23-2)26-21(22)25-18)15-7-9-16(10-8-15)24-13-14-5-11-17(12-6-14)29(3,27)28/h5-12,24H,4,13H2,1-3H3,(H3,22,23,25,26) | PDB
Reactome pathway
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM19351
(2,4-diaminopyrimidine-based antagonist, 4c | 6-eth...)Show SMILES CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C20H23N5O2S/c1-3-17-18(19(21)25-20(22)24-17)14-6-8-15(9-7-14)23-12-13-4-10-16(11-5-13)28(2,26)27/h4-11,23H,3,12H2,1-2H3,(H4,21,22,24,25) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181220
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(2,3...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2C2Cc3ccccc3O2)cc1 Show InChI InChI=1S/C26H25N5O3S/c1-35(32,33)20-12-6-16(7-13-20)15-29-19-10-8-17(9-11-19)23-24(30-26(28)31-25(23)27)22-14-18-4-2-3-5-21(18)34-22/h2-13,22,29H,14-15H2,1H3,(H4,27,28,30,31) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181176
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-hept...)Show SMILES CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C25H33N5O2S/c1-3-4-5-6-7-8-22-23(24(26)30-25(27)29-22)19-11-13-20(14-12-19)28-17-18-9-15-21(16-10-18)33(2,31)32/h9-16,28H,3-8,17H2,1-2H3,(H4,26,27,29,30) | PDB
Reactome pathway
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181223
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((py...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2COCc2cccnc2)cc1 Show InChI InChI=1S/C25H26N6O3S/c1-35(32,33)21-10-4-17(5-11-21)14-29-20-8-6-19(7-9-20)23-22(30-25(27)31-24(23)26)16-34-15-18-3-2-12-28-13-18/h2-13,29H,14-16H2,1H3,(H4,26,27,30,31) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by binding assay |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181193
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-isob...)Show SMILES CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H27N5O2S/c1-14(2)12-19-20(21(23)27-22(24)26-19)16-6-8-17(9-7-16)25-13-15-4-10-18(11-5-15)30(3,28)29/h4-11,14,25H,12-13H2,1-3H3,(H4,23,24,26,27) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181227
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((3,...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CN2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C28H30N6O2S/c1-37(35,36)24-12-6-19(7-13-24)16-31-23-10-8-21(9-11-23)26-25(32-28(30)33-27(26)29)18-34-15-14-20-4-2-3-5-22(20)17-34/h2-13,31H,14-18H2,1H3,(H4,29,30,32,33) | PDB
Reactome pathway
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181199
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((be...)Show SMILES CS(=O)(=O)c1ccc(CNc2ccc(cc2)-c2c(N)nc(N)nc2CNCc2ccccc2)cc1 Show InChI InChI=1S/C26H28N6O2S/c1-35(33,34)22-13-7-19(8-14-22)16-30-21-11-9-20(10-12-21)24-23(31-26(28)32-25(24)27)17-29-15-18-5-3-2-4-6-18/h2-14,29-30H,15-17H2,1H3,(H4,27,28,31,32) | PDB
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| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50181185
(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(met...)Show SMILES COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C20H23N5O3S/c1-28-12-17-18(19(21)25-20(22)24-17)14-5-7-15(8-6-14)23-11-13-3-9-16(10-4-13)29(2,26)27/h3-10,23H,11-12H2,1-2H3,(H4,21,22,24,25) | PDB
Reactome pathway
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human GHS receptor by FLIPR |
Bioorg Med Chem Lett 16: 1864-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.012
BindingDB Entry DOI: 10.7270/Q2610ZW2 |
More data for this
Ligand-Target Pair | |
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