Found 52 hits Enz. Inhib. hit(s) with all data for entry = 50046193 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098793
(CHEMBL3593342)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098792
(CHEMBL3593343)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)c(F)c(F)c1)\C#N Show InChI InChI=1S/C16H13F3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098713
(CHEMBL3593335)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098719
(CHEMBL3593329)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098793
(CHEMBL3593342)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098719
(CHEMBL3593329)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098712
(CHEMBL3593336)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098787
(CHEMBL3593468)Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)c1 Show InChI InChI=1S/C18H16Cl2N4O2/c19-12-6-13(20)8-14(7-12)22-23-16(10-21)18(25)15-9-17(26-24-15)11-4-2-1-3-5-11/h6-9,11,22H,1-5H2/b23-16+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098709
(CHEMBL3593338)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(F)c(Cl)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-11(18)10(17)6-9/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098748
(CHEMBL3593339)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6-,8+,9?,10?/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098718
(CHEMBL3593330)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-10(17)11(18)6-9/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098797
(CHEMBL3593471)Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)cc(Cl)c1Cl Show InChI InChI=1S/C18H15Cl3N4O2/c19-12-6-11(7-13(20)17(12)21)23-24-15(9-22)18(26)14-8-16(27-25-14)10-4-2-1-3-5-10/h6-8,10,23H,1-5H2/b24-15+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098794
(CHEMBL3593341)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(c(Cl)c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-9-4-5-10(11(18)6-9)17(19,20)21/h4-7,23H,1-3H3/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098797
(CHEMBL3593471)Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)cc(Cl)c1Cl Show InChI InChI=1S/C18H15Cl3N4O2/c19-12-6-11(7-13(20)17(12)21)23-24-15(9-22)18(26)14-8-16(27-25-14)10-4-2-1-3-5-10/h6-8,10,23H,1-5H2/b24-15+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098796
(CHEMBL3593470)Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)cc(Cl)c1Cl Show InChI InChI=1S/C15H9Cl3N4O2/c16-9-3-8(4-10(17)14(9)18)20-21-12(6-19)15(23)11-5-13(24-22-11)7-1-2-7/h3-5,7,20H,1-2H2/b21-12+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098710
(CHEMBL3593337)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(F)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-10(17)11(18)6-9/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098794
(CHEMBL3593341)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(c(Cl)c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-9-4-5-10(11(18)6-9)17(19,20)21/h4-7,23H,1-3H3/b24-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50011360
(CHEMBL3260990)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at EPAC2 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098787
(CHEMBL3593468)Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)c1 Show InChI InChI=1S/C18H16Cl2N4O2/c19-12-6-13(20)8-14(7-12)22-23-16(10-21)18(25)15-9-17(26-24-15)11-4-2-1-3-5-11/h6-9,11,22H,1-5H2/b23-16+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098714
(CHEMBL3593334)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(F)c1)\C#N Show InChI InChI=1S/C16H14F2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098788
(CHEMBL3593467)Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)c1 Show InChI InChI=1S/C15H10Cl2N4O2/c16-9-3-10(17)5-11(4-9)19-20-13(7-18)15(22)12-6-14(23-21-12)8-1-2-8/h3-6,8,19H,1-2H2/b20-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098716
(CHEMBL3593332)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N Show InChI InChI=1S/C18H14F6N4O2/c1-16(2,3)14-7-12(28-30-14)15(29)13(8-25)27-26-11-5-9(17(19,20)21)4-10(6-11)18(22,23)24/h4-7,26H,1-3H3/b27-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098713
(CHEMBL3593335)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098715
(CHEMBL3593333)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14F4N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098716
(CHEMBL3593332)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N Show InChI InChI=1S/C18H14F6N4O2/c1-16(2,3)14-7-12(28-30-14)15(29)13(8-25)27-26-11-5-9(17(19,20)21)4-10(6-11)18(22,23)24/h4-7,26H,1-3H3/b27-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098795
(CHEMBL3593340)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(F)c(F)c1)\C#N Show InChI InChI=1S/C16H14F2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-10(17)11(18)6-9/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098720
(CHEMBL3593328)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)ccc1Cl)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-6-9(17)4-5-10(11)18/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098709
(CHEMBL3593338)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(F)c(Cl)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-11(18)10(17)6-9/h4-7,20H,1-3H3/b21-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098796
(CHEMBL3593470)Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)cc(Cl)c1Cl Show InChI InChI=1S/C15H9Cl3N4O2/c16-9-3-8(4-10(17)14(9)18)20-21-12(6-19)15(23)11-5-13(24-22-11)7-1-2-7/h3-5,7,20H,1-2H2/b21-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50011360
(CHEMBL3260990)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098792
(CHEMBL3593343)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)c(F)c(F)c1)\C#N Show InChI InChI=1S/C16H13F3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50011360
(CHEMBL3260990)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098748
(CHEMBL3593339)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6-,8+,9?,10?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50011360
(CHEMBL3260990)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at EPAC1 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50011360
(CHEMBL3260990)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098789
(CHEMBL3593465)Show SMILES Clc1cccc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)c1 Show InChI InChI=1S/C18H17ClN4O2/c19-13-7-4-8-14(9-13)21-22-16(11-20)18(24)15-10-17(25-23-15)12-5-2-1-3-6-12/h4,7-10,12,21H,1-3,5-6H2/b22-16+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 3
(Homo sapiens (Human)) | BDBM50098712
(CHEMBL3593336)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098725
(CHEMBL3594321)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H15F3N4O2/c1-16(2,3)14-8-12(24-26-14)15(25)13(9-21)23-22-11-6-4-5-10(7-11)17(18,19)20/h4-8,22H,1-3H3/b23-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098727
(CHEMBL3594319)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Br)c1)\C#N Show InChI InChI=1S/C16H15BrN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098791
(CHEMBL3593344)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1c(Cl)cc(Cl)cc1Cl)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)21-22-14-9(18)4-8(17)5-10(14)19/h4-6,22H,1-3H3/b21-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098798
(CHEMBL3593480)Show InChI InChI=1S/C13H8Cl2N4O2/c1-7-2-11(19-21-7)13(20)12(6-16)18-17-10-4-8(14)3-9(15)5-10/h2-5,17H,1H3/b18-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098726
(CHEMBL3594320)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(F)c1)\C#N Show InChI InChI=1S/C16H15FN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098721
(CHEMBL3593327)Show SMILES Cc1cccc(N\N=C(/C#N)C(=O)c2cc(on2)C(C)(C)C)c1 Show InChI InChI=1S/C17H18N4O2/c1-11-6-5-7-12(8-11)19-20-14(10-18)16(22)13-9-15(23-21-13)17(2,3)4/h5-9,19H,1-4H3/b20-14+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098728
(CHEMBL3594318)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)cc1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-10(17)5-7-11/h4-8,19H,1-3H3/b20-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098786
(CHEMBL3593469)Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccccc2)c1 Show InChI InChI=1S/C18H10Cl2N4O2/c19-12-6-13(20)8-14(7-12)22-23-16(10-21)18(25)15-9-17(26-24-15)11-4-2-1-3-5-11/h1-9,22H/b23-16+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098729
(CHEMBL3594317)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccccc1Cl)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-7-5-4-6-10(11)17/h4-8,19H,1-3H3/b20-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098724
(CHEMBL3594322)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(c1)[N+]([O-])=O)\C#N Show InChI InChI=1S/C16H15N5O4/c1-16(2,3)14-8-12(20-25-14)15(22)13(9-17)19-18-10-5-4-6-11(7-10)21(23)24/h4-8,18H,1-3H3/b19-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098717
(CHEMBL3593331)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1Cl)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)13-7-11(22-24-13)15(23)12(8-19)21-20-10-6-4-5-9(17)14(10)18/h4-7,20H,1-3H3/b21-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098730
(CHEMBL3594316)Show InChI InChI=1S/C16H16N4O2/c1-16(2,3)14-9-12(20-22-14)15(21)13(10-17)19-18-11-7-5-4-6-8-11/h4-9,18H,1-3H3/b19-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098790
(CHEMBL3593346)Show InChI InChI=1S/C15H11ClN4O2/c16-10-2-1-3-11(6-10)18-19-13(8-17)15(21)12-7-14(22-20-12)9-4-5-9/h1-3,6-7,9,18H,4-5H2/b19-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |