Compile Data Set for Download or QSAR

Found 52 hits Enz. Inhib. hit(s) with all data for entry = 50025895   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261646 ((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...) Show SMILES COC[C@@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H21F3N6O3/c1-12(11-34-2)28-22-30-16(13-6-8-14(9-7-13)23(24,25)26)10-18(31-22)35-17-5-3-4-15-19(17)32-20(27)21(33)29-15/h3-10,12H,11H2,1-2H3,(H2,27,32)(H,29,33)(H,28,30,31)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261646 ((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...) Show SMILES COC[C@@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H21F3N6O3/c1-12(11-34-2)28-22-30-16(13-6-8-14(9-7-13)23(24,25)26)10-18(31-22)35-17-5-3-4-15-19(17)32-20(27)21(33)29-15/h3-10,12H,11H2,1-2H3,(H2,27,32)(H,29,33)(H,28,30,31)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20557 (AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20554 (3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-17(23)18(28)26-12/h1-9H,(H2,23,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20557 (AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of low pH-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261150 (3-Amino-5-(2-(2-methoxyethylamino)-6-(4-(trifluoro...) Show SMILES COCCNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H19F3N6O3/c1-33-10-9-27-21-29-15(12-5-7-13(8-6-12)22(23,24)25)11-17(30-21)34-16-4-2-3-14-18(16)31-19(26)20(32)28-14/h2-8,11H,9-10H2,1H3,(H2,26,31)(H,28,32)(H,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20554 (3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-17(23)18(28)26-12/h1-9H,(H2,23,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261295 (3-Amino-5-(6-(2-(2-methoxyethylamino)-6-(trifluoro...) Show SMILES COCCNc1nc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C21H18F3N7O3/c1-33-8-7-26-19-11(5-6-15(30-19)21(22,23)24)13-9-16(28-10-27-13)34-14-4-2-3-12-17(14)31-18(25)20(32)29-12/h2-6,9-10H,7-8H2,1H3,(H2,25,31)(H,26,30)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261266 (CHEMBL466743 | N-(2-(6-(3-Amino-2-oxo-1,2-dihydroq...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)c3ccccn3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C25H16F3N7O3/c26-25(27,28)13-7-8-14(18(10-13)34-23(36)16-4-1-2-9-30-16)17-11-20(32-12-31-17)38-19-6-3-5-15-21(19)35-22(29)24(37)33-15/h1-12H,(H2,29,35)(H,33,37)(H,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261295 (3-Amino-5-(6-(2-(2-methoxyethylamino)-6-(trifluoro...) Show SMILES COCCNc1nc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C21H18F3N7O3/c1-33-8-7-26-19-11(5-6-15(30-19)21(22,23)24)13-9-16(28-10-27-13)34-14-4-2-3-12-17(14)31-18(25)20(32)29-12/h2-6,9-10H,7-8H2,1H3,(H2,25,31)(H,26,30)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261266 (CHEMBL466743 | N-(2-(6-(3-Amino-2-oxo-1,2-dihydroq...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)c3ccccn3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C25H16F3N7O3/c26-25(27,28)13-7-8-14(18(10-13)34-23(36)16-4-1-2-9-30-16)17-11-20(32-12-31-17)38-19-6-3-5-15-21(19)35-22(29)24(37)33-15/h1-12H,(H2,29,35)(H,33,37)(H,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20557 (AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261149 ((S)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...) Show SMILES COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H21F3N6O3/c1-12(11-34-2)28-22-30-16(13-6-8-14(9-7-13)23(24,25)26)10-18(31-22)35-17-5-3-4-15-19(17)32-20(27)21(33)29-15/h3-10,12H,11H2,1-2H3,(H2,27,32)(H,29,33)(H,28,30,31)/t12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261150 (3-Amino-5-(2-(2-methoxyethylamino)-6-(4-(trifluoro...) Show SMILES COCCNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H19F3N6O3/c1-33-10-9-27-21-29-15(12-5-7-13(8-6-12)22(23,24)25)11-17(30-21)34-16-4-2-3-14-18(16)31-19(26)20(32)28-14/h2-8,11H,9-10H2,1H3,(H2,26,31)(H,28,32)(H,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261294 (3-Amino-5-(6-(2-amino-6-(trifluoromethyl)pyridin-3...) Show SMILES Nc1nc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C18H12F3N7O2/c19-18(20,21)12-5-4-8(15(22)27-12)10-6-13(25-7-24-10)30-11-3-1-2-9-14(11)28-16(23)17(29)26-9/h1-7H,(H2,22,27)(H2,23,28)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261296 (3-Amino-5-(6-(2-((R)-tetrahydrofuran-3-ylamino)-6-...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3N[C@@H]3CCCO3)C(F)(F)F)cccc2[nH]c1=O |r| Show InChI InChI=1S/C22H18F3N7O3/c23-22(24,25)15-7-6-11(20(30-15)31-16-5-2-8-34-16)13-9-17(28-10-27-13)35-14-4-1-3-12-18(14)32-19(26)21(33)29-12/h1,3-4,6-7,9-10,16H,2,5,8H2,(H2,26,32)(H,29,33)(H,30,31)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20557 (AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261317 (3-Amino-5-(6-(2-((1-isobutylpiperidin-2-yl)methyla...) Show SMILES CC(C)CN1CCCCC1CNc1nc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C28H31F3N8O2/c1-16(2)14-39-11-4-3-6-17(39)13-33-26-18(9-10-22(37-26)28(29,30)31)20-12-23(35-15-34-20)41-21-8-5-7-19-24(21)38-25(32)27(40)36-19/h5,7-10,12,15-17H,3-4,6,11,13-14H2,1-2H3,(H2,32,38)(H,33,37)(H,36,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261149 ((S)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...) Show SMILES COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H21F3N6O3/c1-12(11-34-2)28-22-30-16(13-6-8-14(9-7-13)23(24,25)26)10-18(31-22)35-17-5-3-4-15-19(17)32-20(27)21(33)29-15/h3-10,12H,11H2,1-2H3,(H2,27,32)(H,29,33)(H,28,30,31)/t12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261296 (3-Amino-5-(6-(2-((R)-tetrahydrofuran-3-ylamino)-6-...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3N[C@@H]3CCCO3)C(F)(F)F)cccc2[nH]c1=O |r| Show InChI InChI=1S/C22H18F3N7O3/c23-22(24,25)15-7-6-11(20(30-15)31-16-5-2-8-34-16)13-9-17(28-10-27-13)35-14-4-1-3-12-18(14)32-19(26)21(33)29-12/h1,3-4,6-7,9-10,16H,2,5,8H2,(H2,26,32)(H,29,33)(H,30,31)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261263 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)py...) Show SMILES Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C19H13F3N6O2/c20-19(21,22)9-4-5-10(11(23)6-9)13-7-15(26-8-25-13)30-14-3-1-2-12-16(14)28-17(24)18(29)27-12/h1-8H,23H2,(H2,24,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261317 (3-Amino-5-(6-(2-((1-isobutylpiperidin-2-yl)methyla...) Show SMILES CC(C)CN1CCCCC1CNc1nc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C28H31F3N8O2/c1-16(2)14-39-11-4-3-6-17(39)13-33-26-18(9-10-22(37-26)28(29,30)31)20-12-23(35-15-34-20)41-21-8-5-7-19-24(21)38-25(32)27(40)36-19/h5,7-10,12,15-17H,3-4,6,11,13-14H2,1-2H3,(H2,32,38)(H,33,37)(H,36,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261152 (3-amino-5-(2-((1-neopentylpiperidin-2-yl)methylami...) Show SMILES CC(C)(C)CN1CCCCC1CNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C30H34F3N7O2/c1-29(2,3)17-40-14-5-4-7-20(40)16-35-28-37-22(18-10-12-19(13-11-18)30(31,32)33)15-24(38-28)42-23-9-6-8-21-25(23)39-26(34)27(41)36-21/h6,8-13,15,20H,4-5,7,14,16-17H2,1-3H3,(H2,34,39)(H,36,41)(H,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261152 (3-amino-5-(2-((1-neopentylpiperidin-2-yl)methylami...) Show SMILES CC(C)(C)CN1CCCCC1CNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C30H34F3N7O2/c1-29(2,3)17-40-14-5-4-7-20(40)16-35-28-37-22(18-10-12-19(13-11-18)30(31,32)33)15-24(38-28)42-23-9-6-8-21-25(23)39-26(34)27(41)36-21/h6,8-13,15,20H,4-5,7,14,16-17H2,1-3H3,(H2,34,39)(H,36,41)(H,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261316 (3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(triflu...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3NCCN3CCOCC3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C24H23F3N8O3/c25-24(26,27)18-5-4-14(22(33-18)29-6-7-35-8-10-37-11-9-35)16-12-19(31-13-30-16)38-17-3-1-2-15-20(17)34-21(28)23(36)32-15/h1-5,12-13H,6-11H2,(H2,28,34)(H,29,33)(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261264 (1-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimi...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)NC(C)(C)C)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H23F3N6O3S/c1-13(35)31-23-33-21-18(6-5-7-19(21)38-23)37-20-11-16(29-12-30-20)15-9-8-14(25(26,27)28)10-17(15)32-22(36)34-24(2,3)4/h5-12H,1-4H3,(H,31,33,35)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261645 (4-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)-6-...) Show SMILES Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H13F3N6O2/c20-19(21,22)10-6-4-9(5-7-10)12-8-14(27-18(24)26-12)30-13-3-1-2-11-15(13)28-16(23)17(29)25-11/h1-8H,(H2,23,28)(H,25,29)(H2,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261319 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2...) Show SMILES COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1N)C(F)(F)F |r| Show InChI InChI=1S/C23H22F3N7O3/c1-11(10-35-2)29-22-31-16(13-7-6-12(8-14(13)27)23(24,25)26)9-18(32-22)36-17-5-3-4-15-19(17)33-20(28)21(34)30-15/h3-9,11H,10,27H2,1-2H3,(H2,28,33)(H,30,34)(H,29,31,32)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261294 (3-Amino-5-(6-(2-amino-6-(trifluoromethyl)pyridin-3...) Show SMILES Nc1nc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C18H12F3N7O2/c19-18(20,21)12-5-4-8(15(22)27-12)10-6-13(25-7-24-10)30-11-3-1-2-9-14(11)28-16(23)17(29)26-9/h1-7H,(H2,22,27)(H2,23,28)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261153 (3-Amino-5-(2-(1-(pyridin-2-yl)ethylamino)-6-(4-(tr...) Show SMILES CC(Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F)c1ccccn1 Show InChI InChI=1S/C26H20F3N7O2/c1-14(17-5-2-3-12-31-17)32-25-34-19(15-8-10-16(11-9-15)26(27,28)29)13-21(35-25)38-20-7-4-6-18-22(20)36-23(30)24(37)33-18/h2-14H,1H3,(H2,30,36)(H,33,37)(H,32,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261293 (CHEMBL467964 | N-(2-(6-(3-Amino-2-oxo-1,2-dihydroq...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)c3ccncc3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C25H16F3N7O3/c26-25(27,28)14-4-5-15(18(10-14)34-23(36)13-6-8-30-9-7-13)17-11-20(32-12-31-17)38-19-3-1-2-16-21(19)35-22(29)24(37)33-16/h1-12H,(H2,29,35)(H,33,37)(H,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261293 (CHEMBL467964 | N-(2-(6-(3-Amino-2-oxo-1,2-dihydroq...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)c3ccncc3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C25H16F3N7O3/c26-25(27,28)14-4-5-15(18(10-14)34-23(36)13-6-8-30-9-7-13)17-11-20(32-12-31-17)38-19-3-1-2-16-21(19)35-22(29)24(37)33-16/h1-12H,(H2,29,35)(H,33,37)(H,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261191 (CHEMBL495673 | N-(4-(6-(2-Amino-4-(trifluoromethyl...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3N)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)27-19-28-18-15(3-2-4-16(18)31-19)30-17-8-14(25-9-26-17)12-6-5-11(7-13(12)24)20(21,22)23/h2-9H,24H2,1H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261645 (4-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)-6-...) Show SMILES Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H13F3N6O2/c20-19(21,22)10-6-4-9(5-7-10)12-8-14(27-18(24)26-12)30-13-3-1-2-11-15(13)28-16(23)17(29)25-11/h1-8H,(H2,23,28)(H,25,29)(H2,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261319 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2...) Show SMILES COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1N)C(F)(F)F |r| Show InChI InChI=1S/C23H22F3N7O3/c1-11(10-35-2)29-22-31-16(13-7-6-12(8-14(13)27)23(24,25)26)9-18(32-22)36-17-5-3-4-15-19(17)33-20(28)21(34)30-15/h3-9,11H,10,27H2,1-2H3,(H2,28,33)(H,30,34)(H,29,31,32)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261263 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)py...) Show SMILES Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C19H13F3N6O2/c20-19(21,22)9-4-5-10(11(23)6-9)13-7-15(26-8-25-13)30-14-3-1-2-12-16(14)28-17(24)18(29)27-12/h1-8H,23H2,(H2,24,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261265 (1-(2-(6-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-ylo...) Show SMILES CC(C)(C)NC(=O)Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C24H22F3N7O3/c1-23(2,3)34-22(36)32-16-9-12(24(25,26)27)7-8-13(16)15-10-18(30-11-29-15)37-17-6-4-5-14-19(17)33-20(28)21(35)31-14/h4-11H,1-3H3,(H2,28,33)(H,31,35)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261318 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2...) Show SMILES COCCNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1N)C(F)(F)F Show InChI InChI=1S/C22H20F3N7O3/c1-34-8-7-28-21-30-15(12-6-5-11(9-13(12)26)22(23,24)25)10-17(31-21)35-16-4-2-3-14-18(16)32-19(27)20(33)29-14/h2-6,9-10H,7-8,26H2,1H3,(H2,27,32)(H,29,33)(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261346 (3-amino-5-(6-(2-amino-6-(trifluoromethyl)pyridin-3...) Show SMILES COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(nc1N)C(F)(F)F |r| Show InChI InChI=1S/C22H21F3N8O3/c1-10(9-35-2)28-21-30-13(11-6-7-15(22(23,24)25)31-18(11)26)8-16(32-21)36-14-5-3-4-12-17(14)33-19(27)20(34)29-12/h3-8,10H,9H2,1-2H3,(H2,26,31)(H2,27,33)(H,29,34)(H,28,30,32)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50225024 (CHEMBL398410 | N-(4-(2-amino-6-(4-(trifluoromethyl...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(N)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)25-19-28-17-14(3-2-4-15(17)31-19)30-16-9-13(26-18(24)27-16)11-5-7-12(8-6-11)20(21,22)23/h2-9H,1H3,(H2,24,26,27)(H,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261265 (1-(2-(6-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-ylo...) Show SMILES CC(C)(C)NC(=O)Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C24H22F3N7O3/c1-23(2,3)34-22(36)32-16-9-12(24(25,26)27)7-8-13(16)15-10-18(30-11-29-15)37-17-6-4-5-14-19(17)33-20(28)21(35)31-14/h4-11H,1-3H3,(H2,28,33)(H,31,35)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261153 (3-Amino-5-(2-(1-(pyridin-2-yl)ethylamino)-6-(4-(tr...) Show SMILES CC(Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F)c1ccccn1 Show InChI InChI=1S/C26H20F3N7O2/c1-14(17-5-2-3-12-31-17)32-25-34-19(15-8-10-16(11-9-15)26(27,28)29)13-21(35-25)38-20-7-4-6-18-22(20)36-23(30)24(37)33-18/h2-14H,1H3,(H2,30,36)(H,33,37)(H,32,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261318 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2...) Show SMILES COCCNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1N)C(F)(F)F Show InChI InChI=1S/C22H20F3N7O3/c1-34-8-7-28-21-30-15(12-6-5-11(9-13(12)26)22(23,24)25)10-17(31-21)35-16-4-2-3-14-18(16)32-19(27)20(33)29-14/h2-6,9-10H,7-8,26H2,1H3,(H2,27,32)(H,29,33)(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261264 (1-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimi...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)NC(C)(C)C)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H23F3N6O3S/c1-13(35)31-23-33-21-18(6-5-7-19(21)38-23)37-20-11-16(29-12-30-20)15-9-8-14(25(26,27)28)10-17(15)32-22(36)34-24(2,3)4/h5-12H,1-4H3,(H,31,33,35)(H2,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261346 (3-amino-5-(6-(2-amino-6-(trifluoromethyl)pyridin-3...) Show SMILES COC[C@H](C)Nc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(nc1N)C(F)(F)F |r| Show InChI InChI=1S/C22H21F3N8O3/c1-10(9-35-2)28-21-30-13(11-6-7-15(22(23,24)25)31-18(11)26)8-16(32-21)36-14-5-3-4-12-17(14)33-19(27)20(34)29-12/h3-8,10H,9H2,1-2H3,(H2,26,31)(H2,27,33)(H,29,34)(H,28,30,32)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261151 (3-amino-5-(2-(3-hydroxybutylamino)-6-(4-(trifluoro...) Show SMILES CC(O)CCNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H21F3N6O3/c1-12(33)9-10-28-22-30-16(13-5-7-14(8-6-13)23(24,25)26)11-18(31-22)35-17-4-2-3-15-19(17)32-20(27)21(34)29-15/h2-8,11-12,33H,9-10H2,1H3,(H2,27,32)(H,29,34)(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50225024 (CHEMBL398410 | N-(4-(2-amino-6-(4-(trifluoromethyl...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(N)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)25-19-28-17-14(3-2-4-15(17)31-19)30-16-9-13(26-18(24)27-16)11-5-7-12(8-6-11)20(21,22)23/h2-9H,1H3,(H2,24,26,27)(H,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261151 (3-amino-5-(2-(3-hydroxybutylamino)-6-(4-(trifluoro...) Show SMILES CC(O)CCNc1nc(Oc2cccc3[nH]c(=O)c(N)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H21F3N6O3/c1-12(33)9-10-28-22-30-16(13-5-7-14(8-6-13)23(24,25)26)11-18(31-22)35-17-4-2-3-15-19(17)32-20(27)21(34)29-15/h2-8,11-12,33H,9-10H2,1H3,(H2,27,32)(H,29,34)(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261191 (CHEMBL495673 | N-(4-(6-(2-Amino-4-(trifluoromethyl...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3N)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)27-19-28-18-15(3-2-4-16(18)31-19)30-17-8-14(25-9-26-17)12-6-5-11(7-13(12)24)20(21,22)23/h2-9H,24H2,1H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50261316 (3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(triflu...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3NCCN3CCOCC3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C24H23F3N8O3/c25-24(26,27)18-5-4-14(22(33-18)29-6-7-35-8-10-37-11-9-35)16-12-19(31-13-30-16)38-17-3-1-2-15-20(17)34-21(28)23(36)32-15/h1-5,12-13H,6-11H2,(H2,28,34)(H,29,33)(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair

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