Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with all data for entry = 50031468   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313846 ((R)-5-(4-fluorophenyl)-5-((5-hydroxy-1-oxoisoindol...) Show SMILES Oc1ccc2C(=O)N(C[C@]3(NC(=O)NC3=O)c3ccc(F)cc3)Cc2c1 |r| Show InChI InChI=1S/C18H14FN3O4/c19-12-3-1-11(2-4-12)18(16(25)20-17(26)21-18)9-22-8-10-7-13(23)5-6-14(10)15(22)24/h1-7,23H,8-9H2,(H2,20,21,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313842 ((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...) Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3cnccn3)C(=O)c2c1 |r| Show InChI InChI=1S/C17H15N5O4/c1-26-11-3-2-10-8-22(14(23)12(10)6-11)9-17(13-7-18-4-5-19-13)15(24)20-16(25)21-17/h2-7H,8-9H2,1H3,(H2,20,21,24,25)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313843 ((R)-5-(furan-2-yl)-5-((6-methoxy-1-oxoisoindolin-2...) Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccco3)C(=O)c2c1 |r| Show InChI InChI=1S/C17H15N3O5/c1-24-11-5-4-10-8-20(14(21)12(10)7-11)9-17(13-3-2-6-25-13)15(22)18-16(23)19-17/h2-7H,8-9H2,1H3,(H2,18,19,22,23)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313841 ((R)-5-(4-fluorophenyl)-5-((6-methoxy-1-oxoisoindol...) Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(F)cc3)C(=O)c2c1 |r| Show InChI InChI=1S/C19H16FN3O4/c1-27-14-7-2-11-9-23(16(24)15(11)8-14)10-19(17(25)21-18(26)22-19)12-3-5-13(20)6-4-12/h2-8H,9-10H2,1H3,(H2,21,22,25,26)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313844 ((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...) Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3cnn(C)c3)C(=O)c2c1 |r| Show InChI InChI=1S/C17H17N5O4/c1-21-8-11(6-18-21)17(15(24)19-16(25)20-17)9-22-7-10-3-4-12(26-2)5-13(10)14(22)23/h3-6,8H,7,9H2,1-2H3,(H2,19,20,24,25)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313838 ((R)-5-(4-hydroxyphenyl)-5-((6-methoxy-1-oxoisoindo...) Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(O)cc3)C(=O)c2c1 |r| Show InChI InChI=1S/C19H17N3O5/c1-27-14-7-2-11-9-22(16(24)15(11)8-14)10-19(17(25)20-18(26)21-19)12-3-5-13(23)6-4-12/h2-8,23H,9-10H2,1H3,(H2,20,21,25,26)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313851 ((+/-)-5-(4-fluorophenyl)-5-((5-((2-methylquinolin-...) Show SMILES Cc1cc(COc2ccc3C(=O)N(CC4(NC(=O)NC4=O)c4ccc(F)cc4)Cc3c2)c2ccccc2n1 Show InChI InChI=1S/C29H23FN4O4/c1-17-12-19(23-4-2-3-5-25(23)31-17)15-38-22-10-11-24-18(13-22)14-34(26(24)35)16-29(27(36)32-28(37)33-29)20-6-8-21(30)9-7-20/h2-13H,14-16H2,1H3,(H2,32,33,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313848 ((R)-5-((5-(cyclopropylmethoxy)-1-oxoisoindolin-2-y...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3cc(OCC4CC4)ccc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C22H20FN3O4/c23-16-5-3-15(4-6-16)22(20(28)24-21(29)25-22)12-26-10-14-9-17(30-11-13-1-2-13)7-8-18(14)19(26)27/h3-9,13H,1-2,10-12H2,(H2,24,25,28,29)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313845 ((+/-)-5-((5-methoxy-1-oxoisoindolin-2-yl)methyl)-5...) Show SMILES COc1ccc2C(=O)N(CC3(NC(=O)NC3=O)c3ccccc3)Cc2c1 Show InChI InChI=1S/C19H17N3O4/c1-26-14-7-8-15-12(9-14)10-22(16(15)23)11-19(13-5-3-2-4-6-13)17(24)20-18(25)21-19/h2-9H,10-11H2,1H3,(H2,20,21,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313835 ((+/-)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5...) Show SMILES COc1ccc2CN(CC3(NC(=O)NC3=O)c3ccccc3)C(=O)c2c1 Show InChI InChI=1S/C19H17N3O4/c1-26-14-8-7-12-10-22(16(23)15(12)9-14)11-19(13-5-3-2-4-6-13)17(24)20-18(25)21-19/h2-9H,10-11H2,1H3,(H2,20,21,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313825 ((+/-)-5-(4-fluorophenyl)-5-((1-oxoisoindolin-2-yl)...) Show SMILES Fc1ccc(cc1)C1(CN2Cc3ccccc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C18H14FN3O3/c19-13-7-5-12(6-8-13)18(16(24)20-17(25)21-18)10-22-9-11-3-1-2-4-14(11)15(22)23/h1-8H,9-10H2,(H2,20,21,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313831 ((+/-)-5-(4-fluorophenyl)-5-((6-methoxy-1-oxo-1H-py...) Show SMILES COc1cc2C(=O)N(CC3(NC(=O)NC3=O)c3ccc(F)cc3)Cc2cn1 Show InChI InChI=1S/C18H15FN4O4/c1-27-14-6-13-10(7-20-14)8-23(15(13)24)9-18(16(25)21-17(26)22-18)11-2-4-12(19)5-3-11/h2-7H,8-9H2,1H3,(H2,21,22,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313840 ((+/-)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-...) Show SMILES Fc1ccc(c(F)c1)C1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C18H12ClF2N3O3/c19-10-2-1-9-7-24(15(25)12(9)5-10)8-18(16(26)22-17(27)23-18)13-4-3-11(20)6-14(13)21/h1-6H,7-8H2,(H2,22,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313824 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(NC(=O)NC3=O)c3ccccc3)c(=O)c2c1 Show InChI InChI=1S/C18H16N4O4/c1-26-12-7-8-14-13(9-12)15(23)22(21-14)10-18(11-5-3-2-4-6-11)16(24)19-17(25)20-18/h2-9,21H,10H2,1H3,(H2,19,20,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313847 ((+/-)-5-((5-chloro-1-oxoisoindolin-2-yl)methyl)-5-...) Show SMILES Fc1ccc(cc1)C1(CN2Cc3cc(Cl)ccc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C18H13ClFN3O3/c19-12-3-6-14-10(7-12)8-23(15(14)24)9-18(16(25)21-17(26)22-18)11-1-4-13(20)5-2-11/h1-7H,8-9H2,(H2,21,22,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313849 ((+/-)-5-(4-fluorophenyl)-5-((1-oxo-5-(pyridin-4-yl...) Show SMILES Fc1ccc(cc1)C1(CN2Cc3cc(OCc4ccncc4)ccc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C24H19FN4O4/c25-18-3-1-17(2-4-18)24(22(31)27-23(32)28-24)14-29-12-16-11-19(5-6-20(16)21(29)30)33-13-15-7-9-26-10-8-15/h1-11H,12-14H2,(H2,27,28,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313836 ((+/-)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)-5-...) Show SMILES Oc1ccccc1C1(CN2Cc3ccc(F)cc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C18H14FN3O4/c19-11-6-5-10-8-22(15(24)12(10)7-11)9-18(16(25)20-17(26)21-18)13-3-1-2-4-14(13)23/h1-7,23H,8-9H2,(H2,20,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313832 ((+/-)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5...) Show SMILES COc1ccc2CN(CC3(C)NC(=O)NC3=O)C(=O)c2c1 Show InChI InChI=1S/C14H15N3O4/c1-14(12(19)15-13(20)16-14)7-17-6-8-3-4-9(21-2)5-10(8)11(17)18/h3-5H,6-7H2,1-2H3,(H2,15,16,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313837 ((+/-)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-...) Show SMILES Oc1cccc(c1)C1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C18H14ClN3O4/c19-12-5-4-10-8-22(15(24)14(10)7-12)9-18(16(25)20-17(26)21-18)11-2-1-3-13(23)6-11/h1-7,23H,8-9H2,(H2,20,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313819 (5-((6-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2c(c1)[nH]n(CC1(C)NC(=O)NC1=O)c2=O Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-4-3-7(21-2)5-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313823 (5-((5,6-dimethoxy-3-oxo-1H-indazol-2(3H)-yl)methyl...) Show SMILES COc1cc2[nH]n(CC3(NC(=O)NC3=O)c3ccccc3)c(=O)c2cc1OC Show InChI InChI=1S/C19H18N4O5/c1-27-14-8-12-13(9-15(14)28-2)22-23(16(12)24)10-19(11-6-4-3-5-7-11)17(25)20-18(26)21-19/h3-9,22H,10H2,1-2H3,(H2,20,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313833 ((R)-5-ethyl-5-((6-methoxy-1-oxoisoindolin-2-yl)met...) Show SMILES CC[C@]1(CN2Cc3ccc(OC)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C15H17N3O4/c1-3-15(13(20)16-14(21)17-15)8-18-7-9-4-5-10(22-2)6-11(9)12(18)19/h4-6H,3,7-8H2,1-2H3,(H2,16,17,20,21)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313822 (5-((6-(benzyloxy)-3-oxo-1H-indazol-2(3H)-yl)methyl...) Show SMILES CC1(Cn2[nH]c3cc(OCc4ccccc4)ccc3c2=O)NC(=O)NC1=O Show InChI InChI=1S/C19H18N4O4/c1-19(17(25)20-18(26)21-19)11-23-16(24)14-8-7-13(9-15(14)22-23)27-10-12-5-3-2-4-6-12/h2-9,22H,10-11H2,1H3,(H2,20,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	176	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313820 (5-((5-ethoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-m...) Show SMILES CCOc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C14H16N4O4/c1-3-22-8-4-5-10-9(6-8)11(19)18(17-10)7-14(2)12(20)15-13(21)16-14/h4-6,17H,3,7H2,1-2H3,(H2,15,16,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	209	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	245	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of ADAM10				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313850 ((R)-5-((5-(2-cyclohexylethoxy)-1-oxoisoindolin-2-y...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3cc(OCCC4CCCCC4)ccc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C26H28FN3O4/c27-20-8-6-19(7-9-20)26(24(32)28-25(33)29-26)16-30-15-18-14-21(10-11-22(18)23(30)31)34-13-12-17-4-2-1-3-5-17/h6-11,14,17H,1-5,12-13,15-16H2,(H2,28,29,32,33)/t26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	332	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313821 (5-((5-(benzyloxy)-3-oxo-1H-indazol-2(3H)-yl)methyl...) Show SMILES CC1(Cn2[nH]c3ccc(OCc4ccccc4)cc3c2=O)NC(=O)NC1=O Show InChI InChI=1S/C19H18N4O4/c1-19(17(25)20-18(26)21-19)11-23-16(24)14-9-13(7-8-15(14)22-23)27-10-12-5-3-2-4-6-12/h2-9,22H,10-11H2,1H3,(H2,20,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	391	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313834 ((R)-5-benzyl-5-((6-methoxy-1-oxoisoindolin-2-yl)me...) Show SMILES COc1ccc2CN(C[C@@]3(Cc4ccccc4)NC(=O)NC3=O)C(=O)c2c1 |r| Show InChI InChI=1S/C20H19N3O4/c1-27-15-8-7-14-11-23(17(24)16(14)9-15)12-20(18(25)21-19(26)22-20)10-13-5-3-2-4-6-13/h2-9H,10-12H2,1H3,(H2,21,22,25,26)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313826 ((+/-)-5-(1,1-Dioxo-1,3-dihydro-1lambda*6*-benzo[d]...) Show SMILES Fc1ccc(cc1)C1(CN2Cc3ccccc3S2(=O)=O)NC(=O)NC1=O Show InChI InChI=1S/C17H14FN3O4S/c18-13-7-5-12(6-8-13)17(15(22)19-16(23)20-17)10-21-9-11-3-1-2-4-14(11)26(21,24)25/h1-8H,9-10H2,(H2,19,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP14				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313827 ((+/-)-5-(4-fluorophenyl)-5-((3-oxotetrahydroimidaz...) Show SMILES Fc1ccc(cc1)C1(CN2CC3CCCCN3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C17H19FN4O3/c18-12-6-4-11(5-7-12)17(14(23)19-15(24)20-17)10-21-9-13-3-1-2-8-22(13)16(21)25/h4-7,13H,1-3,8-10H2,(H2,19,20,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313829 ((+/-)-5-methyl-5-((7-oxo-5H-pyrrolo[3,4-b]pyridin-...) Show SMILES CC1(CN2Cc3cccnc3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C12H12N4O3/c1-12(10(18)14-11(19)15-12)6-16-5-7-3-2-4-13-8(7)9(16)17/h2-4H,5-6H2,1H3,(H2,14,15,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.82E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of ADAM9				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP13				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313830 ((+/-)-5-methyl-5-((5-oxo-5H-pyrrolo[3,4-b]pyridin-...) Show SMILES CC1(Cn2cc3[nH]cccc3c2=O)NC(=O)NC1=O Show InChI InChI=1S/C12H12N4O3/c1-12(10(18)14-11(19)15-12)6-16-5-8-7(9(16)17)3-2-4-13-8/h2-5,13H,6H2,1H3,(H2,14,15,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.49E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.19E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP14				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP9				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP7				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50313839 ((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...) Show SMILES Fc1ccc(cc1)[C@]1(CN2Cc3ccc(Cl)cc3C2=O)NC(=O)NC1=O |r| Show InChI InChI=1S/C18H13ClFN3O3/c19-12-4-1-10-8-23(15(24)14(10)7-12)9-18(16(25)21-17(26)22-18)11-2-5-13(20)6-3-11/h1-7H,8-9H2,(H2,21,22,25,26)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP13				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50313828 ((+/-)-5-(4-fluorophenyl)-5-((3-oxo-1H-pyrrolo[1,2-...) Show SMILES Fc1ccc(cc1)C1(CN2CC3CCCN3C2=O)NC(=O)NC1=O Show InChI InChI=1S/C16H17FN4O3/c17-11-5-3-10(4-6-11)16(13(22)18-14(23)19-16)9-20-8-12-2-1-7-21(12)15(20)24/h3-6,12H,1-2,7-9H2,(H2,18,19,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE by FRET assay				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50313818 (5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...) Show SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1 Show InChI InChI=1S/C13H14N4O4/c1-13(11(19)14-12(20)15-13)6-17-10(18)8-5-7(21-2)3-4-9(8)16-17/h3-5,16H,6H2,1-2H3,(H2,14,15,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of MMP9				Bioorg Med Chem Lett 20: 1877-80 (2010) Article DOI: 10.1016/j.bmcl.2010.01.148 BindingDB Entry DOI: 10.7270/Q2F76CQ9
					More data for this Ligand-Target Pair