Found 50 hits Enz. Inhib. hit(s) with all data for entry = 50034961 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Inhibition of the dual specificity kinase MEK-2 |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Inhibition of the dual specificity kinase MEK-1 |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description AP-1 suppression activity using freshly prepared DMSO stock |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description AP-1 suppression activity using one month old DMSO stock |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072154
(2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...)Show InChI InChI=1S/C18H14N4O2S2/c19-9-11(17(21)25-15-7-3-1-5-13(15)23)12(10-20)18(22)26-16-8-4-2-6-14(16)24/h1-8,11-12,21-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072163
(2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...)Show InChI InChI=1S/C14H10N4S4/c15-7-9(13(17)21-11-3-1-5-19-11)10(8-16)14(18)22-12-4-2-6-20-12/h1-6,9-10,17-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description AP-1 suppression activity using one week old DMSO stock |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072154
(2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...)Show InChI InChI=1S/C18H14N4O2S2/c19-9-11(17(21)25-15-7-3-1-5-13(15)23)12(10-20)18(22)26-16-8-4-2-6-14(16)24/h1-8,11-12,21-24H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072166
(2,3-Bis-[1-amino-1-(4-hydroxy-phenylsulfanyl)-meth...)Show SMILES Oc1ccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2ccc(O)cc2)cc1 Show InChI InChI=1S/C18H14N4O2S2/c19-9-15(17(21)25-13-5-1-11(23)2-6-13)16(10-20)18(22)26-14-7-3-12(24)4-8-14/h1-8,15-16,21-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072151
(2,3-Bis-[1-amino-1-(4-amino-phenylsulfanyl)-meth-(...)Show SMILES Nc1ccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2ccc(N)cc2)cc1 Show InChI InChI=1S/C18H16N6S2/c19-9-15(17(23)25-13-5-1-11(21)2-6-13)16(10-20)18(24)26-14-7-3-12(22)4-8-14/h1-8,15-16,23-24H,21-22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description AP-1 suppression activity using two months old DMSO stock |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072148
(2,3-Bis-[3H-benzothiazol-(2Z)-ylidene]-succinonitr...)Show InChI InChI=1S/C18H10N4S2/c19-9-11(17-21-13-5-1-3-7-15(13)23-17)12(10-20)18-22-14-6-2-4-8-16(14)24-18/h1-8,11-12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072162
(2,3-Bis-[1-amino-1-(2-chloro-phenylsulfanyl)-meth-...)Show SMILES Clc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1Cl Show InChI InChI=1S/C18H12Cl2N4S2/c19-13-5-1-3-7-15(13)25-17(23)11(9-21)12(10-22)18(24)26-16-8-4-2-6-14(16)20/h1-8,11-12,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072164
(2,3-Bis-[1-amino-1-phenylsulfanyl-meth-(Z)-ylidene...)Show InChI InChI=1S/C18H14N4S2/c19-11-15(17(21)23-13-7-3-1-4-8-13)16(12-20)18(22)24-14-9-5-2-6-10-14/h1-10,15-16,21-22H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072156
(2,3-Bis-[1-amino-1-(2-fluoro-phenylsulfanyl)-meth-...)Show InChI InChI=1S/C18H12F2N4S2/c19-13-5-1-3-7-15(13)25-17(23)11(9-21)12(10-22)18(24)26-16-8-4-2-6-14(16)20/h1-8,11-12,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072150
(2,3-Bis-[1-amino-1-(2-bromo-phenylsulfanyl)-meth-(...)Show SMILES Brc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1Br Show InChI InChI=1S/C18H12Br2N4S2/c19-13-5-1-3-7-15(13)25-17(23)11(9-21)12(10-22)18(24)26-16-8-4-2-6-14(16)20/h1-8,11-12,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072163
(2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...)Show InChI InChI=1S/C14H10N4S4/c15-7-9(13(17)21-11-3-1-5-19-11)10(8-16)14(18)22-12-4-2-6-20-12/h1-6,9-10,17-18H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072144
(2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4...)Show InChI InChI=1S/C16H10N4S/c17-8-13-14(9-18)16(20-15(13)19)21-12-6-5-10-3-1-2-4-11(10)7-12/h1-7,20H,19H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072157
(2,3-Bis-[1-amino-1-(3-chloro-phenylsulfanyl)-meth-...)Show SMILES Clc1cccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2cccc(Cl)c2)c1 Show InChI InChI=1S/C18H12Cl2N4S2/c19-11-3-1-5-13(7-11)25-17(23)15(9-21)16(10-22)18(24)26-14-6-2-4-12(20)8-14/h1-8,15-16,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072146
(CHEMBL316635 | N-[3,4-Dicyano-5-(naphthalen-2-ylsu...)Show SMILES O=S(=O)(Nc1[nH]c(Sc2ccc3ccccc3c2)c(C#N)c1C#N)c1ccccc1 Show InChI InChI=1S/C22H14N4O2S2/c23-13-19-20(14-24)22(29-17-11-10-15-6-4-5-7-16(15)12-17)25-21(19)26-30(27,28)18-8-2-1-3-9-18/h1-12,25-26H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072161
(2,3-Bis-[1-amino-1-o-tolylsulfanyl-meth-(Z)-yliden...)Show InChI InChI=1S/C20H18N4S2/c1-13-7-3-5-9-17(13)25-19(23)15(11-21)16(12-22)20(24)26-18-10-6-4-8-14(18)2/h3-10,15-16,23-24H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072160
(2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-d...)Show SMILES N#Cc1c(Sc2ccc3ccccc3c2)[nH]c(Sc2ccc3ccccc3c2)c1C#N Show InChI InChI=1S/C26H15N3S2/c27-15-23-24(16-28)26(31-22-12-10-18-6-2-4-8-20(18)14-22)29-25(23)30-21-11-9-17-5-1-3-7-19(17)13-21/h1-14,29H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072158
(2,3-Bis-[1-amino-1-(1-amino-naphthalen-2-ylsulfany...)Show SMILES Nc1c(SC(=N)C(C#N)C(C#N)C(=N)Sc2ccc3ccccc3c2N)ccc2ccccc12 Show InChI InChI=1S/C26H20N6S2/c27-13-19(25(31)33-21-11-9-15-5-1-3-7-17(15)23(21)29)20(14-28)26(32)34-22-12-10-16-6-2-4-8-18(16)24(22)30/h1-12,19-20,31-32H,29-30H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072152
(2,3-Bis-[1-amino-1-(4-chloro-phenylsulfanyl)-meth-...)Show SMILES Clc1ccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C18H12Cl2N4S2/c19-11-1-5-13(6-2-11)25-17(23)15(9-21)16(10-22)18(24)26-14-7-3-12(20)4-8-14/h1-8,15-16,23-24H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Inhibition of the dual specificity kinase MEK-1 |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072159
(2,3-Bis-[1-amino-1-(2,6-dichloro-phenylsulfanyl)-m...)Show SMILES Clc1cccc(Cl)c1SC(=N)C(C#N)C(C#N)C(=N)Sc1c(Cl)cccc1Cl Show InChI InChI=1S/C18H10Cl4N4S2/c19-11-3-1-4-12(20)15(11)27-17(25)9(7-23)10(8-24)18(26)28-16-13(21)5-2-6-14(16)22/h1-6,9-10,25-26H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072165
(2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-yli...)Show InChI InChI=1S/C18H13N5S2/c19-9-11(17(22)24-15-7-3-1-5-13(15)21)12(10-20)18-23-14-6-2-4-8-16(14)25-18/h1-8,11-12,22H,21H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072155
(2,3-Bis-[1-amino-1-(2-methoxy-phenylsulfanyl)-meth...)Show SMILES COc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1OC Show InChI InChI=1S/C20H18N4O2S2/c1-25-15-7-3-5-9-17(15)27-19(23)13(11-21)14(12-22)20(24)28-18-10-6-4-8-16(18)26-2/h3-10,13-14,23-24H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072149
(2,3-Bis-[1-amino-1-(3-amino-phenylsulfanyl)-meth-(...)Show SMILES Nc1cccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2cccc(N)c2)c1 Show InChI InChI=1S/C18H16N6S2/c19-9-15(17(23)25-13-5-1-3-11(21)7-13)16(10-20)18(24)26-14-6-2-4-12(22)8-14/h1-8,15-16,23-24H,21-22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072159
(2,3-Bis-[1-amino-1-(2,6-dichloro-phenylsulfanyl)-m...)Show SMILES Clc1cccc(Cl)c1SC(=N)C(C#N)C(C#N)C(=N)Sc1c(Cl)cccc1Cl Show InChI InChI=1S/C18H10Cl4N4S2/c19-11-3-1-4-12(20)15(11)27-17(25)9(7-23)10(8-24)18(26)28-16-13(21)5-2-6-14(16)22/h1-6,9-10,25-26H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072162
(2,3-Bis-[1-amino-1-(2-chloro-phenylsulfanyl)-meth-...)Show SMILES Clc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1Cl Show InChI InChI=1S/C18H12Cl2N4S2/c19-13-5-1-3-7-15(13)25-17(23)11(9-21)12(10-22)18(24)26-16-8-4-2-6-14(16)20/h1-8,11-12,23-24H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072156
(2,3-Bis-[1-amino-1-(2-fluoro-phenylsulfanyl)-meth-...)Show InChI InChI=1S/C18H12F2N4S2/c19-13-5-1-3-7-15(13)25-17(23)11(9-21)12(10-22)18(24)26-16-8-4-2-6-14(16)20/h1-8,11-12,23-24H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072150
(2,3-Bis-[1-amino-1-(2-bromo-phenylsulfanyl)-meth-(...)Show SMILES Brc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1Br Show InChI InChI=1S/C18H12Br2N4S2/c19-13-5-1-3-7-15(13)25-17(23)11(9-21)12(10-22)18(24)26-16-8-4-2-6-14(16)20/h1-8,11-12,23-24H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072146
(CHEMBL316635 | N-[3,4-Dicyano-5-(naphthalen-2-ylsu...)Show SMILES O=S(=O)(Nc1[nH]c(Sc2ccc3ccccc3c2)c(C#N)c1C#N)c1ccccc1 Show InChI InChI=1S/C22H14N4O2S2/c23-13-19-20(14-24)22(29-17-11-10-15-6-4-5-7-16(15)12-17)25-21(19)26-30(27,28)18-8-2-1-3-9-18/h1-12,25-26H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072151
(2,3-Bis-[1-amino-1-(4-amino-phenylsulfanyl)-meth-(...)Show SMILES Nc1ccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2ccc(N)cc2)cc1 Show InChI InChI=1S/C18H16N6S2/c19-9-15(17(23)25-13-5-1-11(21)2-6-13)16(10-20)18(24)26-14-7-3-12(22)4-8-14/h1-8,15-16,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072164
(2,3-Bis-[1-amino-1-phenylsulfanyl-meth-(Z)-ylidene...)Show InChI InChI=1S/C18H14N4S2/c19-11-15(17(21)23-13-7-3-1-4-8-13)16(12-20)18(22)24-14-9-5-2-6-10-14/h1-10,15-16,21-22H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072161
(2,3-Bis-[1-amino-1-o-tolylsulfanyl-meth-(Z)-yliden...)Show InChI InChI=1S/C20H18N4S2/c1-13-7-3-5-9-17(13)25-19(23)15(11-21)16(12-22)20(24)26-18-10-6-4-8-14(18)2/h3-10,15-16,23-24H,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50072145
(2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-...)Show InChI InChI=1S/C12H9N5S/c13-5-7-8(6-14)12(17-11(7)16)18-10-4-2-1-3-9(10)15/h1-4,17H,15-16H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Non-competitive inhibition of the dual specificity kinase MEK |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072155
(2,3-Bis-[1-amino-1-(2-methoxy-phenylsulfanyl)-meth...)Show SMILES COc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1OC Show InChI InChI=1S/C20H18N4O2S2/c1-25-15-7-3-5-9-17(15)27-19(23)13(11-21)14(12-22)20(24)28-18-10-6-4-8-16(18)26-2/h3-10,13-14,23-24H,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Inhibition of the dual specificity kinase MEK-1 |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072149
(2,3-Bis-[1-amino-1-(3-amino-phenylsulfanyl)-meth-(...)Show SMILES Nc1cccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2cccc(N)c2)c1 Show InChI InChI=1S/C18H16N6S2/c19-9-15(17(23)25-13-5-1-3-11(21)7-13)16(10-20)18(24)26-14-6-2-4-12(22)8-14/h1-8,15-16,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072157
(2,3-Bis-[1-amino-1-(3-chloro-phenylsulfanyl)-meth-...)Show SMILES Clc1cccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2cccc(Cl)c2)c1 Show InChI InChI=1S/C18H12Cl2N4S2/c19-11-3-1-5-13(7-11)25-17(23)15(9-21)16(10-22)18(24)26-14-6-2-4-12(20)8-14/h1-8,15-16,23-24H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072165
(2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-yli...)Show InChI InChI=1S/C18H13N5S2/c19-9-11(17(22)24-15-7-3-1-5-13(15)21)12(10-20)18-23-14-6-2-4-8-16(14)25-18/h1-8,11-12,22H,21H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072152
(2,3-Bis-[1-amino-1-(4-chloro-phenylsulfanyl)-meth-...)Show SMILES Clc1ccc(SC(=N)C(C#N)C(C#N)C(=N)Sc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C18H12Cl2N4S2/c19-11-1-5-13(6-2-11)25-17(23)15(9-21)16(10-22)18(24)26-14-7-3-12(20)4-8-14/h1-8,15-16,23-24H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072147
((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)Show InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8,11-12,23-24H,21-22H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description AP-1 suppression activity using six months old DMSO stock |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072144
(2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4...)Show InChI InChI=1S/C16H10N4S/c17-8-13-14(9-18)16(20-15(13)19)21-12-6-5-10-3-1-2-4-11(10)7-12/h1-7,20H,19H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072145
(2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-...)Show InChI InChI=1S/C12H9N5S/c13-5-7-8(6-14)12(17-11(7)16)18-10-4-2-1-3-9(10)15/h1-4,17H,15-16H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072160
(2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-d...)Show SMILES N#Cc1c(Sc2ccc3ccccc3c2)[nH]c(Sc2ccc3ccccc3c2)c1C#N Show InChI InChI=1S/C26H15N3S2/c27-15-23-24(16-28)26(31-22-12-10-18-6-2-4-8-20(18)14-22)29-25(23)30-21-11-9-17-5-1-3-7-19(17)13-21/h1-14,29H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 2.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human)) | BDBM50072148
(2,3-Bis-[3H-benzothiazol-(2Z)-ylidene]-succinonitr...)Show InChI InChI=1S/C18H10N4S2/c19-9-11(17-21-13-5-1-3-7-15(13)23-17)12(10-20)18-22-14-6-2-4-8-16(14)24-18/h1-8,11-12H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description Ability to antagonise AP-1 transcriptional activity |
Bioorg Med Chem Lett 8: 2839-44 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2HNN |
More data for this Ligand-Target Pair | |