Found 30 hits Enz. Inhib. hit(s) with all data for entry = 50032981 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337332
(2-(4-chlorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(Cl)cc2)[nH]n1 Show InChI InChI=1S/C22H23ClN8O/c1-15-13-19(27-26-15)24-21-18-3-2-8-31(18)28-22(25-21)30-11-9-29(10-12-30)20(32)14-16-4-6-17(23)7-5-16/h2-8,13H,9-12,14H2,1H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337333
(2-(4-fluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(F)cc2)[nH]n1 Show InChI InChI=1S/C22H23FN8O/c1-15-13-19(27-26-15)24-21-18-3-2-8-31(18)28-22(25-21)30-11-9-29(10-12-30)20(32)14-16-4-6-17(23)7-5-16/h2-8,13H,9-12,14H2,1H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337334
(2-(4-chloro-2,6-difluorophenyl)-1-(4-(4-(5-methyl-...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2c(F)cc(Cl)cc2F)[nH]n1 Show InChI InChI=1S/C22H21ClF2N8O/c1-13-9-19(29-28-13)26-21-18-3-2-4-33(18)30-22(27-21)32-7-5-31(6-8-32)20(34)12-15-16(24)10-14(23)11-17(15)25/h2-4,9-11H,5-8,12H2,1H3,(H2,26,27,28,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337336
(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(C)cc2)[nH]n1 Show InChI InChI=1S/C23H26N8O/c1-16-5-7-18(8-6-16)15-21(32)29-10-12-30(13-11-29)23-25-22(19-4-3-9-31(19)28-23)24-20-14-17(2)26-27-20/h3-9,14H,10-13,15H2,1-2H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337335
((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2S(C)(=O)=O)[nH]n1 Show InChI InChI=1S/C22H24N8O3S/c1-15-14-19(26-25-15)23-20-17-7-5-9-30(17)27-22(24-20)29-12-10-28(11-13-29)21(31)16-6-3-4-8-18(16)34(2,32)33/h3-9,14H,10-13H2,1-2H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337337
(2-(4-methoxyphenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3...)Show SMILES COc1ccc(CC(=O)N2CCN(CC2)c2nc(Nc3cc(C)n[nH]3)c3cccn3n2)cc1 Show InChI InChI=1S/C23H26N8O2/c1-16-14-20(27-26-16)24-22-19-4-3-9-31(19)28-23(25-22)30-12-10-29(11-13-30)21(32)15-17-5-7-18(33-2)8-6-17/h3-9,14H,10-13,15H2,1-2H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337338
(2-(2,6-difluoro-4-methoxyphenyl)-1-(4-(4-(5-methyl...)Show SMILES COc1cc(F)c(CC(=O)N2CCN(CC2)c2nc(Nc3cc(C)n[nH]3)c3cccn3n2)c(F)c1 Show InChI InChI=1S/C23H24F2N8O2/c1-14-10-20(29-28-14)26-22-19-4-3-5-33(19)30-23(27-22)32-8-6-31(7-9-32)21(34)13-16-17(24)11-15(35-2)12-18(16)25/h3-5,10-12H,6-9,13H2,1-2H3,(H2,26,27,28,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337339
(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)CCc2ccccc2)[nH]n1 Show InChI InChI=1S/C23H26N8O/c1-17-16-20(27-26-17)24-22-19-8-5-11-31(19)28-23(25-22)30-14-12-29(13-15-30)21(32)10-9-18-6-3-2-4-7-18/h2-8,11,16H,9-10,12-15H2,1H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337340
((2-bromophenyl)(4-(4-(5-methyl-1H-pyrazol-3-ylamin...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2Br)[nH]n1 Show InChI InChI=1S/C21H21BrN8O/c1-14-13-18(26-25-14)23-19-17-7-4-8-30(17)27-21(24-19)29-11-9-28(10-12-29)20(31)15-5-2-3-6-16(15)22/h2-8,13H,9-12H2,1H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337341
((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2)[nH]n1 Show InChI InChI=1S/C21H22N8O/c1-15-14-18(25-24-15)22-19-17-8-5-9-29(17)26-21(23-19)28-12-10-27(11-13-28)20(30)16-6-3-2-4-7-16/h2-9,14H,10-13H2,1H3,(H2,22,23,24,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337342
(2-(2,6-difluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazo...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(F)cc2F)[nH]n1 Show InChI InChI=1S/C22H22F2N8O/c1-14-11-19(28-27-14)25-21-18-3-2-6-32(18)29-22(26-21)31-9-7-30(8-10-31)20(33)12-15-4-5-16(23)13-17(15)24/h2-6,11,13H,7-10,12H2,1H3,(H2,25,26,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337343
(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2)[nH]n1 Show InChI InChI=1S/C22H24N8O/c1-16-14-19(26-25-16)23-21-18-8-5-9-30(18)27-22(24-21)29-12-10-28(11-13-29)20(31)15-17-6-3-2-4-7-17/h2-9,14H,10-13,15H2,1H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337344
((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2C)[nH]n1 Show InChI InChI=1S/C22H24N8O/c1-15-6-3-4-7-17(15)21(31)28-10-12-29(13-11-28)22-24-20(18-8-5-9-30(18)27-22)23-19-14-16(2)25-26-19/h3-9,14H,10-13H2,1-2H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337345
((2-methoxyphenyl)(4-(4-(5-methyl-1H-pyrazol-3-ylam...)Show SMILES COc1ccccc1C(=O)N1CCN(CC1)c1nc(Nc2cc(C)n[nH]2)c2cccn2n1 Show InChI InChI=1S/C22H24N8O2/c1-15-14-19(26-25-15)23-20-17-7-5-9-30(17)27-22(24-20)29-12-10-28(11-13-29)21(31)16-6-3-4-8-18(16)32-2/h3-9,14H,10-13H2,1-2H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337346
((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccc(C)cc2)[nH]n1 Show InChI InChI=1S/C22H24N8O/c1-15-5-7-17(8-6-15)21(31)28-10-12-29(13-11-28)22-24-20(18-4-3-9-30(18)27-22)23-19-14-16(2)25-26-19/h3-9,14H,10-13H2,1-2H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337347
(2-(2-fluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2F)[nH]n1 Show InChI InChI=1S/C22H23FN8O/c1-15-13-19(27-26-15)24-21-18-7-4-8-31(18)28-22(25-21)30-11-9-29(10-12-30)20(32)14-16-5-2-3-6-17(16)23/h2-8,13H,9-12,14H2,1H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337348
(4-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccc(cc2)C#N)[nH]n1 Show InChI InChI=1S/C22H21N9O/c1-15-13-19(27-26-15)24-20-18-3-2-8-31(18)28-22(25-20)30-11-9-29(10-12-30)21(32)17-6-4-16(14-23)5-7-17/h2-8,13H,9-12H2,1H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337349
(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2C)[nH]n1 Show InChI InChI=1S/C23H26N8O/c1-16-6-3-4-7-18(16)15-21(32)29-10-12-30(13-11-29)23-25-22(19-8-5-9-31(19)28-23)24-20-14-17(2)26-27-20/h3-9,14H,10-13,15H2,1-2H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337350
(2-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2C#N)[nH]n1 Show InChI InChI=1S/C22H21N9O/c1-15-13-19(27-26-15)24-20-18-7-4-8-31(18)28-22(25-20)30-11-9-29(10-12-30)21(32)17-6-3-2-5-16(17)14-23/h2-8,13H,9-12H2,1H3,(H2,24,25,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337351
((2-chlorophenyl)(4-(4-(5-methyl-1H-pyrazol-3-ylami...)Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2Cl)[nH]n1 Show InChI InChI=1S/C21H21ClN8O/c1-14-13-18(26-25-14)23-19-17-7-4-8-30(17)27-21(24-19)29-11-9-28(10-12-29)20(31)15-5-2-3-6-16(15)22/h2-8,13H,9-12H2,1H3,(H2,23,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337352
(CHEMBL1682370 | N,N-dimethyl-4-(4-(5-methyl-1H-pyr...)Show SMILES CN(C)C(=O)N1CCN(CC1)c1nc(Nc2cc(C)n[nH]2)c2cccn2n1 Show InChI InChI=1S/C17H23N9O/c1-12-11-14(21-20-12)18-15-13-5-4-6-26(13)22-16(19-15)24-7-9-25(10-8-24)17(27)23(2)3/h4-6,11H,7-10H2,1-3H3,(H2,18,19,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337353
(1-(4-(4-(5-(1-methylcyclopropyl)-1H-pyrazol-3-ylam...)Show SMILES CC1(CC1)c1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2)[nH]n1 Show InChI InChI=1S/C25H28N8O/c1-25(9-10-25)20-17-21(29-28-20)26-23-19-8-5-11-33(19)30-24(27-23)32-14-12-31(13-15-32)22(34)16-18-6-3-2-4-7-18/h2-8,11,17H,9-10,12-16H2,1H3,(H2,26,27,28,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337354
(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)Show SMILES CCC(=O)N1CCN(CC1)c1nc(Nc2cc(C)n[nH]2)c2cccn2n1 Show InChI InChI=1S/C17H22N8O/c1-3-15(26)23-7-9-24(10-8-23)17-19-16(13-5-4-6-25(13)22-17)18-14-11-12(2)20-21-14/h4-6,11H,3,7-10H2,1-2H3,(H2,18,19,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337355
(CHEMBL1682368 | N-(5-methyl-1H-pyrazol-3-yl)-2-(pi...)Show InChI InChI=1S/C14H18N8/c1-10-9-12(19-18-10)16-13-11-3-2-6-22(11)20-14(17-13)21-7-4-15-5-8-21/h2-3,6,9,15H,4-5,7-8H2,1H3,(H2,16,17,18,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337356
(2-phenyl-1-(4-(4-(thiazol-2-ylamino)pyrrolo[1,2-f]...)Show SMILES O=C(Cc1ccccc1)N1CCN(CC1)c1nc(Nc2nccs2)c2cccn2n1 Show InChI InChI=1S/C21H21N7OS/c29-18(15-16-5-2-1-3-6-16)26-10-12-27(13-11-26)20-23-19(24-21-22-8-14-30-21)17-7-4-9-28(17)25-20/h1-9,14H,10-13,15H2,(H,22,23,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337357
(1-(4-(4-(1-isopropyl-1H-imidazol-4-ylamino)pyrrolo...)Show SMILES CC(C)n1cnc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2)c1 Show InChI InChI=1S/C24H28N8O/c1-18(2)31-16-21(25-17-31)26-23-20-9-6-10-32(20)28-24(27-23)30-13-11-29(12-14-30)22(33)15-19-7-4-3-5-8-19/h3-10,16-18H,11-15H2,1-2H3,(H,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337358
(2-phenyl-1-(4-(4-(pyridin-2-ylamino)pyrrolo[1,2-f]...)Show SMILES O=C(Cc1ccccc1)N1CCN(CC1)c1nc(Nc2ccccn2)c2cccn2n1 Show InChI InChI=1S/C23H23N7O/c31-21(17-18-7-2-1-3-8-18)28-13-15-29(16-14-28)23-26-22(19-9-6-12-30(19)27-23)25-20-10-4-5-11-24-20/h1-12H,13-17H2,(H,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337359
(CHEMBL1682362 | N-cyclopropyl-3-(2-(4-(2-phenylace...)Show SMILES O=C(Cc1ccccc1)N1CCN(CC1)c1nc(Nc2cc(n[nH]2)C(=O)NC2CC2)c2cccn2n1 Show InChI InChI=1S/C25H27N9O2/c35-22(15-17-5-2-1-3-6-17)32-11-13-33(14-12-32)25-28-23(20-7-4-10-34(20)31-25)27-21-16-19(29-30-21)24(36)26-18-8-9-18/h1-7,10,16,18H,8-9,11-15H2,(H,26,36)(H2,27,28,29,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50337331
(1-(4-(4-(5-methyl-1,3,4-thiadiazol-2-ylamino)pyrro...)Show SMILES Cc1nnc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2)s1 Show InChI InChI=1S/C21H22N8OS/c1-15-24-25-21(31-15)23-19-17-8-5-9-29(17)26-20(22-19)28-12-10-27(11-13-28)18(30)14-16-6-3-2-4-7-16/h2-9H,10-14H2,1H3,(H,22,23,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50337331
(1-(4-(4-(5-methyl-1,3,4-thiadiazol-2-ylamino)pyrro...)Show SMILES Cc1nnc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccccc2)s1 Show InChI InChI=1S/C21H22N8OS/c1-15-24-25-21(31-15)23-19-17-8-5-9-29(17)26-20(22-19)28-12-10-27(11-13-28)18(30)14-16-6-3-2-4-7-16/h2-9H,10-14H2,1H3,(H,22,23,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of JAK3 after 60 mins |
Bioorg Med Chem Lett 21: 1425-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT |
More data for this Ligand-Target Pair | |