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Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with all data for entry = 50032474   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417191
PNG
(CHEMBL1272136)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3c(F)cccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H19ClFN3O2/c1-2-14-6-3-7-15(12-14)24-21(28)25-19-10-5-11-26(20(19)27)13-16-17(22)8-4-9-18(16)23/h3-12H,2,13H2,1H3,(H2,24,25,28)
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 6.31n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50329821
PNG
(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3c(F)cccc3Cl)c2=O)c1
Show InChI InChI=1S/C20H17ClFN3O3/c1-28-14-6-2-5-13(11-14)23-20(27)24-18-9-4-10-25(19(18)26)12-15-16(21)7-3-8-17(15)22/h2-11H,12H2,1H3,(H2,23,24,27)
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 25.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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 50.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417206
PNG
(CHEMBL1271527)
Show SMILES CC(C)c1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C22H22ClN3O2/c1-15(2)16-8-5-9-18(13-16)24-22(28)25-20-11-6-12-26(21(20)27)14-17-7-3-4-10-19(17)23/h3-13,15H,14H2,1-2H3,(H2,24,25,28)
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 63.1n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417190
PNG
(CHEMBL1272086)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3F)c2=O)c1
Show InChI InChI=1S/C21H20FN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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 100n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417195
PNG
(CHEMBL1272083)
Show SMILES Clc1ccccc1Cn1cccc(NC(=O)Nc2ccccc2Cl)c1=O
Show InChI InChI=1S/C19H15Cl2N3O2/c20-14-7-2-1-6-13(14)12-24-11-5-10-17(18(24)25)23-19(26)22-16-9-4-3-8-15(16)21/h1-11H,12H2,(H2,22,23,26)
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 126n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417188
PNG
(CHEMBL1272030)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(C)n(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C22H22ClN3O2/c1-3-16-7-6-9-18(13-16)24-22(28)25-20-12-11-15(2)26(21(20)27)14-17-8-4-5-10-19(17)23/h4-13H,3,14H2,1-2H3,(H2,24,25,28)
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 126n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417189
PNG
(CHEMBL1272085)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccc(F)cc3Cl)c2=O)c1
Show InChI InChI=1S/C21H19ClFN3O2/c1-2-14-5-3-6-17(11-14)24-21(28)25-19-7-4-10-26(20(19)27)13-15-8-9-16(23)12-18(15)22/h3-12H,2,13H2,1H3,(H2,24,25,28)
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 126n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(RAT)		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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 158n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of rat EP3 receptor

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417209
PNG
(CHEMBL1271634)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C20H18ClN3O3/c1-27-16-8-4-7-15(12-16)22-20(26)23-18-10-5-11-24(19(18)25)13-14-6-2-3-9-17(14)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 158n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417194
PNG
(CHEMBL1272029)
Show SMILES Fc1ccccc1NC(=O)Nc1cccn(Cc2ccccc2Cl)c1=O
Show InChI InChI=1S/C19H15ClFN3O2/c20-14-7-2-1-6-13(14)12-24-11-5-10-17(18(24)25)23-19(26)22-16-9-4-3-8-15(16)21/h1-11H,12H2,(H2,22,23,26)
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 158n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417186
PNG
(CHEMBL1271918)
Show SMILES CCc1cccc(NC(=O)Nc2cc(C)cn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C22H22ClN3O2/c1-3-16-7-6-9-18(12-16)24-22(28)25-20-11-15(2)13-26(21(20)27)14-17-8-4-5-10-19(17)23/h4-13H,3,14H2,1-2H3,(H2,24,25,28)
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 200n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417228
PNG
(CHEMBL1272031)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3cccc(c3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O2/c1-2-15-6-4-9-18(13-15)26-21(30)27-19-10-5-11-28(20(19)29)14-16-7-3-8-17(12-16)22(23,24)25/h3-13H,2,14H2,1H3,(H2,26,27,30)
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 200n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417205
PNG
(CHEMBL1271475)
Show SMILES Cc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C20H18ClN3O2/c1-14-6-4-8-16(12-14)22-20(26)23-18-10-5-11-24(19(18)25)13-15-7-2-3-9-17(15)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 251n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417211
PNG
(CHEMBL1271687)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Br)c2=O)c1
Show InChI InChI=1S/C20H18BrN3O3/c1-27-16-8-4-7-15(12-16)22-20(26)23-18-10-5-11-24(19(18)25)13-14-6-2-3-9-17(14)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 316n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417217
PNG
(CHEMBL1271972)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccc(F)cc3Cl)c2=O)c1
Show InChI InChI=1S/C20H17ClFN3O3/c1-28-16-5-2-4-15(11-16)23-20(27)24-18-6-3-9-25(19(18)26)12-13-7-8-14(22)10-17(13)21/h2-11H,12H2,1H3,(H2,23,24,27)
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 398n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417213
PNG
(CHEMBL1271802)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3cccc(Cl)c3)c2=O)c1
Show InChI InChI=1S/C20H18ClN3O3/c1-27-17-8-3-7-16(12-17)22-20(26)23-18-9-4-10-24(19(18)25)13-14-5-2-6-15(21)11-14/h2-12H,13H2,1H3,(H2,22,23,26)
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 398n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417203
PNG
(CHEMBL1272295)
Show SMILES Clc1ccccc1Cn1cccc(NC(=O)Nc2cccc(I)c2)c1=O
Show InChI InChI=1S/C19H15ClIN3O2/c20-16-8-2-1-5-13(16)12-24-10-4-9-17(18(24)25)23-19(26)22-15-7-3-6-14(21)11-15/h1-11H,12H2,(H2,22,23,26)
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 398n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417227
PNG
(CHEMBL1271973)
Show SMILES CCc1cccc(NC(=O)Nc2cc(Cl)cn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H19Cl2N3O2/c1-2-14-6-5-8-17(10-14)24-21(28)25-19-11-16(22)13-26(20(19)27)12-15-7-3-4-9-18(15)23/h3-11,13H,2,12H2,1H3,(H2,24,25,28)
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 501n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417210
PNG
(CHEMBL1271686)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccccc3F)c2=O)c1
Show InChI InChI=1S/C20H18FN3O3/c1-27-16-8-4-7-15(12-16)22-20(26)23-18-10-5-11-24(19(18)25)13-14-6-2-3-9-17(14)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 501n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417199
PNG
(CHEMBL1272185)
Show SMILES COc1ccccc1NC(=O)Nc1cccn(Cc2ccccc2Cl)c1=O
Show InChI InChI=1S/C20H18ClN3O3/c1-27-18-11-5-4-9-16(18)22-20(26)23-17-10-6-12-24(19(17)25)13-14-7-2-3-8-15(14)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 631n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417197
PNG
(CHEMBL1272133)
Show SMILES Cc1ccccc1NC(=O)Nc1cccn(Cc2ccccc2Cl)c1=O
Show InChI InChI=1S/C20H18ClN3O2/c1-14-7-2-5-10-17(14)22-20(26)23-18-11-6-12-24(19(18)25)13-15-8-3-4-9-16(15)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 794n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417222
PNG
(CHEMBL1271971)
Show SMILES COc1ccc(Cn2cccc(NC(=O)Nc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C21H21N3O4/c1-27-17-10-8-15(9-11-17)14-24-12-4-7-19(20(24)25)23-21(26)22-16-5-3-6-18(13-16)28-2/h3-13H,14H2,1-2H3,(H2,22,23,26)
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 794n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417193
PNG
(CHEMBL1272028)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3cc(F)ccc3Cl)c2=O)c1
Show InChI InChI=1S/C20H17ClFN3O3/c1-28-16-5-2-4-15(11-16)23-20(27)24-18-6-3-9-25(19(18)26)12-13-10-14(22)7-8-17(13)21/h2-11H,12H2,1H3,(H2,23,24,27)
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 794n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417218
PNG
(CHEMBL1271635)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccccc3)c2=O)c1
Show InChI InChI=1S/C20H19N3O3/c1-26-17-10-5-9-16(13-17)21-20(25)22-18-11-6-12-23(19(18)24)14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H2,21,22,25)
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 1.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417221
PNG
(CHEMBL1271915)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C20H18ClN3O3/c1-27-17-5-2-4-16(12-17)22-20(26)23-18-6-3-11-24(19(18)25)13-14-7-9-15(21)10-8-14/h2-12H,13H2,1H3,(H2,22,23,26)
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 1.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417202
PNG
(CHEMBL1272241)
Show SMILES Clc1ccccc1Cn1cccc(NC(=O)Nc2cccc(Br)c2)c1=O
Show InChI InChI=1S/C19H15BrClN3O2/c20-14-6-3-7-15(11-14)22-19(26)23-17-9-4-10-24(18(17)25)12-13-5-1-2-8-16(13)21/h1-11H,12H2,(H2,22,23,26)
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 1.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417201
PNG
(CHEMBL1272240)
Show SMILES Clc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C19H15Cl2N3O2/c20-14-6-3-7-15(11-14)22-19(26)23-17-9-4-10-24(18(17)25)12-13-5-1-2-8-16(13)21/h1-11H,12H2,(H2,22,23,26)
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 1.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417212
PNG
(CHEMBL1271743)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3cccc(F)c3)c2=O)c1
Show InChI InChI=1S/C20H18FN3O3/c1-27-17-8-3-7-16(12-17)22-20(26)23-18-9-4-10-24(19(18)25)13-14-5-2-6-15(21)11-14/h2-12H,13H2,1H3,(H2,22,23,26)
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 1.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417215
PNG
(CHEMBL1271859)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccc(F)cc3)c2=O)c1
Show InChI InChI=1S/C20H18FN3O3/c1-27-17-5-2-4-16(12-17)22-20(26)23-18-6-3-11-24(19(18)25)13-14-7-9-15(21)10-8-14/h2-12H,13H2,1H3,(H2,22,23,26)
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 1.26E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417187
PNG
(CHEMBL1271974)
Show SMILES COc1cccc(NC(=O)Nc2ccc(C)n(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-11-19(20(26)25(14)13-15-6-3-4-9-18(15)22)24-21(27)23-16-7-5-8-17(12-16)28-2/h3-12H,13H2,1-2H3,(H2,23,24,27)
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 1.26E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417229
PNG
(CHEMBL1271917)
Show SMILES COc1cccc(NC(=O)Nc2cc(C)cn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-19(24-21(27)23-16-7-5-8-17(11-16)28-2)20(26)25(12-14)13-15-6-3-4-9-18(15)22/h3-12H,13H2,1-2H3,(H2,23,24,27)
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 1.26E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417220
PNG
(CHEMBL1271803)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3cccc(C)c3)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-6-3-7-16(12-15)14-24-11-5-10-19(20(24)25)23-21(26)22-17-8-4-9-18(13-17)27-2/h3-13H,14H2,1-2H3,(H2,22,23,26)
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 1.26E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417200
PNG
(CHEMBL1272186)
Show SMILES Fc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C19H15ClFN3O2/c20-16-8-2-1-5-13(16)12-24-10-4-9-17(18(24)25)23-19(26)22-15-7-3-6-14(21)11-15/h1-11H,12H2,(H2,22,23,26)
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 1.58E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417214
PNG
(CHEMBL1271858)
Show SMILES COc1cccc(Cn2cccc(NC(=O)Nc3cccc(OC)c3)c2=O)c1
Show InChI InChI=1S/C21H21N3O4/c1-27-17-8-3-6-15(12-17)14-24-11-5-10-19(20(24)25)23-21(26)22-16-7-4-9-18(13-16)28-2/h3-13H,14H2,1-2H3,(H2,22,23,26)
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 2.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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 2.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417219
PNG
(CHEMBL1271742)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccccc3C)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-7-3-4-8-16(15)14-24-12-6-11-19(20(24)25)23-21(26)22-17-9-5-10-18(13-17)27-2/h3-13H,14H2,1-2H3,(H2,22,23,26)
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 2.51E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417216
PNG
(CHEMBL1271916)
Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-8-10-16(11-9-15)14-24-12-4-7-19(20(24)25)23-21(26)22-17-5-3-6-18(13-17)27-2/h3-13H,14H2,1-2H3,(H2,22,23,26)
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 3.16E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417181
PNG
(CHEMBL1271688)
Show SMILES Cc1ccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C20H18ClN3O2/c1-14-8-10-16(11-9-14)22-20(26)23-18-7-4-12-24(19(18)25)13-15-5-2-3-6-17(15)21/h2-12H,13H2,1H3,(H2,22,23,26)
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 3.16E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417198
PNG
(CHEMBL1272134)
Show SMILES CCc1ccccc1NC(=O)Nc1cccn(Cc2ccccc2Cl)c1=O
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-8-4-6-11-18(15)23-21(27)24-19-12-7-13-25(20(19)26)14-16-9-3-5-10-17(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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 3.98E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417196
PNG
(CHEMBL1272084)
Show SMILES Clc1ccccc1Cn1cccc(NC(=O)Nc2ccccc2I)c1=O
Show InChI InChI=1S/C19H15ClIN3O2/c20-14-7-2-1-6-13(14)12-24-11-5-10-17(18(24)25)23-19(26)22-16-9-4-3-8-15(16)21/h1-11H,12H2,(H2,22,23,26)
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 5.01E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radioligand from human EP1 receptor

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radioligand from human EP4 receptor

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radioligand from human EP2 receptor

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radioligand from human FP receptor

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Thromboxane A2 receptor


(Homo sapiens (Human))		BDBM50417192
PNG
(CHEMBL1271476)
Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radioligand from human TP receptor

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417183
PNG
(CHEMBL1269038)
Show SMILES COc1ccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C20H18ClN3O3/c1-27-16-10-8-15(9-11-16)22-20(26)23-18-7-4-12-24(19(18)25)13-14-5-2-3-6-17(14)21/h2-12H,13H2,1H3,(H2,22,23,26)
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>2.51E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417225
PNG
(CHEMBL1271805)
Show SMILES COc1cccc(c1)C(=O)Nc1cccn(Cc2ccccc2Cl)c1=O
Show InChI InChI=1S/C20H17ClN2O3/c1-26-16-8-4-7-14(12-16)19(24)22-18-10-5-11-23(20(18)25)13-15-6-2-3-9-17(15)21/h2-12H,13H2,1H3,(H,22,24)
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>2.51E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50417224
PNG
(CHEMBL1271744)
Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C20H15ClF3N3O2/c21-16-5-2-1-4-13(16)12-27-11-3-6-17(18(27)28)26-19(29)25-15-9-7-14(8-10-15)20(22,23)24/h1-11H,12H2,(H2,25,26,29)
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>2.51E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...

Bioorg Med Chem Lett 20: 6744-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8
More data for this
Ligand-Target Pair
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