Found 1667 hits Enz. Inhib. hit(s) with Target = 'Casein kinase II alpha/beta' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214466
(CHEMBL398149 | N-(3-(8-cyano-4-(cyclopropylamino)p...)Show SMILES CC(=O)Nc1cccc(Nc2nc(NC3CC3)n3ncc(C#N)c3n2)c1 Show InChI InChI=1S/C17H16N8O/c1-10(26)20-13-3-2-4-14(7-13)21-16-23-15-11(8-18)9-19-25(15)17(24-16)22-12-5-6-12/h2-4,7,9,12H,5-6H2,1H3,(H,20,26)(H2,21,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214473
(CHEMBL230354 | N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZO...)Show SMILES CC(=O)Nc1cccc(Nc2nc(Nc3ccccc3)n3ncc(C#N)c3n2)c1 Show InChI InChI=1S/C20H16N8O/c1-13(29)23-16-8-5-9-17(10-16)24-19-26-18-14(11-21)12-22-28(18)20(27-19)25-15-6-3-2-4-7-15/h2-10,12H,1H3,(H,23,29)(H2,24,25,26,27) | PDB
UniProtKB/SwissProt
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Similars
| Article PubMed
| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiography |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214454
(CHEMBL230462 | N-(3-(8-cyano-4-(cyclobutylamino)py...)Show SMILES CC(=O)Nc1cccc(Nc2nc(NC3CCC3)n3ncc(C#N)c3n2)c1 Show InChI InChI=1S/C18H18N8O/c1-11(27)21-14-6-3-7-15(8-14)22-17-24-16-12(9-19)10-20-26(16)18(25-17)23-13-4-2-5-13/h3,6-8,10,13H,2,4-5H2,1H3,(H,21,27)(H2,22,23,24,25) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214444
(2-(p-toluidino)-4-(phenylamino)pyrazolo[1,5-a][1,3...)Show InChI InChI=1S/C19H15N7/c1-13-7-9-16(10-8-13)22-18-24-17-14(11-20)12-21-26(17)19(25-18)23-15-5-3-2-4-6-15/h2-10,12H,1H3,(H2,22,23,24,25) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214465
(2-(4-chlorobenzylamino)-4-(phenylamino)pyrazolo[1,...)Show SMILES Clc1ccc(CNc2nc(Nc3ccccc3)n3ncc(C#N)c3n2)cc1 Show InChI InChI=1S/C19H14ClN7/c20-15-8-6-13(7-9-15)11-22-18-25-17-14(10-21)12-23-27(17)19(26-18)24-16-4-2-1-3-5-16/h1-9,12H,11H2,(H2,22,24,25,26) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214477
(4-(phenylamino)-2-(4-(pyridin-2-yl)piperazin-1-yl)...)Show SMILES N#Cc1cnn2c(Nc3ccccc3)nc(nc12)N1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C21H19N9/c22-14-16-15-24-30-19(16)26-20(27-21(30)25-17-6-2-1-3-7-17)29-12-10-28(11-13-29)18-8-4-5-9-23-18/h1-9,15H,10-13H2,(H,25,26,27) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50508987
(CHEMBL4465651)Show InChI InChI=1S/C13H7BrO4/c14-11-10(16)4-3-8-7-2-1-6(15)5-9(7)13(17)18-12(8)11/h1-5,15-16H | PDB
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214460
(2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[...)Show InChI InChI=1S/C19H21N7/c20-11-15-13-22-26-17(15)24-18(21-12-14-7-3-1-4-8-14)25-19(26)23-16-9-5-2-6-10-16/h2,5-6,9-10,13-14H,1,3-4,7-8,12H2,(H2,21,23,24,25) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214474
(CHEMBL230353 | N-(3-(8-cyano-4-(phenethylamino)pyr...)Show SMILES CC(=O)Nc1cccc(Nc2nc(NCCc3ccccc3)n3ncc(C#N)c3n2)c1 Show InChI InChI=1S/C22H20N8O/c1-15(31)26-18-8-5-9-19(12-18)27-21-28-20-17(13-23)14-25-30(20)22(29-21)24-11-10-16-6-3-2-4-7-16/h2-9,12,14H,10-11H2,1H3,(H,26,31)(H2,24,27,28,29) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214448
(2-(3,4-dimethoxyphenylamino)-4-(phenylamino)pyrazo...)Show SMILES COc1ccc(Nc2nc(Nc3ccccc3)n3ncc(C#N)c3n2)cc1OC Show InChI InChI=1S/C20H17N7O2/c1-28-16-9-8-15(10-17(16)29-2)23-19-25-18-13(11-21)12-22-27(18)20(26-19)24-14-6-4-3-5-7-14/h3-10,12H,1-2H3,(H2,23,24,25,26) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214464
(CHEMBL230568 | N-(3-(8-methyl-4-(phenylamino)pyraz...)Show SMILES CC(=O)Nc1cccc(Nc2nc(Nc3ccccc3)n3ncc(C)c3n2)c1 Show InChI InChI=1S/C20H19N7O/c1-13-12-21-27-18(13)25-19(26-20(27)24-15-7-4-3-5-8-15)23-17-10-6-9-16(11-17)22-14(2)28/h3-12H,1-2H3,(H,22,28)(H2,23,24,25,26) | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214450
(2-(3,4-dihydroisoquinolin-2(1H)-yl)-4-(phenylamino...)Show SMILES N#Cc1cnn2c(Nc3ccccc3)nc(nc12)N1CCc2ccccc2C1 Show InChI InChI=1S/C21H17N7/c22-12-17-13-23-28-19(17)25-20(26-21(28)24-18-8-2-1-3-9-18)27-11-10-15-6-4-5-7-16(15)14-27/h1-9,13H,10-11,14H2,(H,24,25,26) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214457
(2-(2,3-dihydro-1H-inden-2-ylamino)-4-(phenylamino)...)Show SMILES N#Cc1cnn2c(Nc3ccccc3)nc(NC3Cc4ccccc4C3)nc12 Show InChI InChI=1S/C21H17N7/c22-12-16-13-23-28-19(16)26-20(27-21(28)25-17-8-2-1-3-9-17)24-18-10-14-6-4-5-7-15(14)11-18/h1-9,13,18H,10-11H2,(H2,24,25,26,27) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214453
(2-(isopentylamino)-4-(phenylamino)pyrazolo[1,5-a][...)Show InChI InChI=1S/C17H19N7/c1-12(2)8-9-19-16-22-15-13(10-18)11-20-24(15)17(23-16)21-14-6-4-3-5-7-14/h3-7,11-12H,8-9H2,1-2H3,(H2,19,21,22,23) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359842
(CHEMBL1928905)Show InChI InChI=1S/C10H6Br4N2O2S/c1-16-9-7(14)5(12)4(11)6(13)8(9)15-10(16)19-2-3(17)18/h2H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214468
(4-(phenylamino)-2-(pyrrolidin-1-yl)pyrazolo[1,5-a]...)Show InChI InChI=1S/C16H15N7/c17-10-12-11-18-23-14(12)20-15(22-8-4-5-9-22)21-16(23)19-13-6-2-1-3-7-13/h1-3,6-7,11H,4-5,8-9H2,(H,19,20,21) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214446
(2,4-bis(phenylamino)pyrazolo[1,5-a][1,3,5]triazine...)Show InChI InChI=1S/C18H13N7/c19-11-13-12-20-25-16(13)23-17(21-14-7-3-1-4-8-14)24-18(25)22-15-9-5-2-6-10-15/h1-10,12H,(H2,21,22,23,24) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214443
(CHEMBL230673 | N-(3-(8-bromo-4-(cyclopropylamino)p...)Show SMILES CC(=O)Nc1cccc(Nc2nc(NC3CC3)n3ncc(Br)c3n2)c1 Show InChI InChI=1S/C16H16BrN7O/c1-9(25)19-11-3-2-4-12(7-11)20-15-22-14-13(17)8-18-24(14)16(23-15)21-10-5-6-10/h2-4,7-8,10H,5-6H2,1H3,(H,19,25)(H2,20,21,22,23) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214471
(2-(4-(diethylamino)phenylamino)-4-(phenylamino)pyr...)Show SMILES CCN(CC)c1ccc(Nc2nc(Nc3ccccc3)n3ncc(C#N)c3n2)cc1 Show InChI InChI=1S/C22H22N8/c1-3-29(4-2)19-12-10-18(11-13-19)25-21-27-20-16(14-23)15-24-30(20)22(28-21)26-17-8-6-5-7-9-17/h5-13,15H,3-4H2,1-2H3,(H2,25,26,27,28) | PDB
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| Article PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214452
(2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[...)Show InChI InChI=1S/C18H20N8/c1-2-24-8-10-25(11-9-24)17-22-16-14(12-19)13-20-26(16)18(23-17)21-15-6-4-3-5-7-15/h3-7,13H,2,8-11H2,1H3,(H,21,22,23) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50420549
(CHEMBL2087008)Show SMILES COc1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C17H13N3O4S/c1-24-13-8-6-10(7-9-13)14(21)18-17-20-19-15(25-17)11-2-4-12(5-3-11)16(22)23/h2-9H,1H3,(H,22,23)(H,18,20,21) | PDB
UniProtKB/SwissProt
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiography |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214451
(CHEMBL230463 | N-(3-(4-(cyclopropylamino)-8-methyl...)Show InChI InChI=1S/C17H19N7O/c1-10-9-18-24-15(10)22-16(23-17(24)21-12-6-7-12)20-14-5-3-4-13(8-14)19-11(2)25/h3-5,8-9,12H,6-7H2,1-2H3,(H,19,25)(H2,20,21,22,23) | PDB
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156670
(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)Show InChI InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15) | PDB
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warsaw University of Technology
Curated by ChEMBL
| Assay Description Binding affinity to CK2alpha (unknown origin) |
Eur J Med Chem 84: 364-74 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.019 BindingDB Entry DOI: 10.7270/Q2N29ZKT |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156669
(4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...)Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13) | PDB
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha in human PLC1 cells using (Arg)3(Glu)3Thr(Glu)3 as substrate after 24 hrs in presence of [32P]gammaGTP |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM34038
(4,5,6,7-tetraiodobenzimidazole (TIBI), 1a)Show InChI InChI=1S/C7H2I4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13) | PDB
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156669
(4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...)Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13) | PDB
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| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado State University
Curated by ChEMBL
| Assay Description Inhibition of human wild type CK2alpha |
J Med Chem 59: 1655-70 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00997 BindingDB Entry DOI: 10.7270/Q24T6M70 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214470
(2-(1H-imidazol-2-ylamino)-4-(phenylamino)pyrazolo[...)Show InChI InChI=1S/C15H11N9/c16-8-10-9-19-24-12(10)21-14(22-13-17-6-7-18-13)23-15(24)20-11-4-2-1-3-5-11/h1-7,9H,(H3,17,18,20,21,22,23) | PDB
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| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214478
(2-(benzyl(methyl)amino)-4-(phenylamino)pyrazolo[1,...)Show InChI InChI=1S/C20H17N7/c1-26(14-15-8-4-2-5-9-15)19-24-18-16(12-21)13-22-27(18)20(25-19)23-17-10-6-3-7-11-17/h2-11,13H,14H2,1H3,(H,23,24,25) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50508989
(CHEMBL273101)Show InChI InChI=1S/C10H6Br2O3/c1-4-5-2-3-6(13)8(12)9(5)15-10(14)7(4)11/h2-3,13H,1H3 | PDB
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| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50041419
(1,2,5,8-tetrahydroxy-9,10-anthracenedione | 1,2,5,...)Show InChI InChI=1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H | PDB
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| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156368
(CHEMBL608394)Show InChI InChI=1S/C7H2Br4N2S/c8-1-2(9)4(11)6-5(3(1)10)12-7(14)13-6/h(H2,12,13,14) | PDB
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| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado State University
Curated by ChEMBL
| Assay Description Inhibition of human wild type CK2alpha |
J Med Chem 59: 1655-70 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00997 BindingDB Entry DOI: 10.7270/Q24T6M70 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50347922
(CHEMBL270724)Show InChI InChI=1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+ | PDB
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiography |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359841
(CHEMBL1928904)Show InChI InChI=1S/C11H8Br4N2O2S/c12-5-6(13)8(15)10-9(7(5)14)16-11(17-10)20-3-1-2-4(18)19/h1-3H2,(H,16,17)(H,18,19) | PDB
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM34053
(iodinated benzimidazole, 16)Show InChI InChI=1S/C9H4I4N2O2S/c10-3-4(11)6(13)8-7(5(3)12)14-9(15-8)18-1-2(16)17/h1H2,(H,14,15)(H,16,17) | PDB
UniProtKB/SwissProt
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| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359846
(CHEMBL1233807)Show InChI InChI=1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20) | PDB
UniProtKB/SwissProt
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| 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359844
(CHEMBL1928907)Show InChI InChI=1S/C12H10Br4N2O2S/c1-18-11-9(16)7(14)6(13)8(15)10(11)17-12(18)21-4-2-3-5(19)20/h2-4H2,1H3,(H,19,20) | PDB
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| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359846
(CHEMBL1233807)Show InChI InChI=1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20) | PDB
UniProtKB/SwissProt
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| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214445
(3-(2-(3-acetamidophenylamino)-8-cyanopyrazolo[1,5-...)Show SMILES CC(=O)Nc1cccc(Nc2nc(Nc3cccc(c3)C(O)=O)n3ncc(C#N)c3n2)c1 Show InChI InChI=1S/C21H16N8O3/c1-12(30)24-16-6-3-7-17(9-16)25-20-27-18-14(10-22)11-23-29(18)21(28-20)26-15-5-2-4-13(8-15)19(31)32/h2-9,11H,1H3,(H,24,30)(H,31,32)(H2,25,26,27,28) | PDB
UniProtKB/SwissProt
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| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156670
(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)Show InChI InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15) | PDB
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| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156673
(((4,5,6,7-tetrabromo-1H-benzimidazol-2-yl)sulfanyl...)Show InChI InChI=1S/C9H4Br4N2O2S/c10-3-4(11)6(13)8-7(5(3)12)14-9(15-8)18-1-2(16)17/h1H2,(H,14,15)(H,16,17) | PDB
UniProtKB/SwissProt
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| 106 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM34053
(iodinated benzimidazole, 16)Show InChI InChI=1S/C9H4I4N2O2S/c10-3-4(11)6(13)8-7(5(3)12)14-9(15-8)18-1-2(16)17/h1H2,(H,14,15)(H,16,17) | PDB
UniProtKB/SwissProt
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| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359843
(CHEMBL1928906)Show InChI InChI=1S/C11H8Br4N2O2S/c1-17-10-8(15)6(13)5(12)7(14)9(10)16-11(17)20-3-2-4(18)19/h2-3H2,1H3,(H,18,19) | PDB
UniProtKB/SwissProt
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| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359840
(CHEMBL1928903)Show InChI InChI=1S/C10H6Br4N2O2S/c11-4-5(12)7(14)9-8(6(4)13)15-10(16-9)19-2-1-3(17)18/h1-2H2,(H,15,16)(H,17,18) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214479
(2-(1H-imidazol-1-yl)-4-(phenylamino)pyrazolo[1,5-a...)Show InChI InChI=1S/C15H10N8/c16-8-11-9-18-23-13(11)20-14(22-7-6-17-10-22)21-15(23)19-12-4-2-1-3-5-12/h1-7,9-10H,(H,19,20,21) | PDB
UniProtKB/SwissProt
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214456
(2-(p-toluidino)-4-(phenethylamino)pyrazolo[1,5-a][...)Show SMILES Cc1ccc(Nc2nc(NCCc3ccccc3)n3ncc(C#N)c3n2)cc1 Show InChI InChI=1S/C21H19N7/c1-15-7-9-18(10-8-15)25-20-26-19-17(13-22)14-24-28(19)21(27-20)23-12-11-16-5-3-2-4-6-16/h2-10,14H,11-12H2,1H3,(H2,23,25,26,27) | PDB
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Similars
| Article PubMed
| 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50214475
(4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)...)Show InChI InChI=1S/C17H15N9/c18-8-12-9-22-26-15(12)24-16(23-13-4-2-1-3-5-13)25-17(26)20-7-6-14-10-19-11-21-14/h1-5,9-11H,6-7H2,(H,19,21)(H2,20,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polaris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha |
Bioorg Med Chem Lett 17: 4191-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.041 BindingDB Entry DOI: 10.7270/Q23778D9 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50359843
(CHEMBL1928906)Show InChI InChI=1S/C11H8Br4N2O2S/c1-17-10-8(15)6(13)5(12)7(14)9(10)16-11(17)20-3-2-4(18)19/h2-3H2,1H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50156670
(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)Show InChI InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 139 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The John Paul II Catholic University of Lublin
Curated by ChEMBL
| Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s... |
Eur J Med Chem 47: 345-50 (2012)
Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944 |
More data for this Ligand-Target Pair | |