BindingDB logo
myBDB logout

Patent code US10759799

Compile Data Set for Download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459183
PNG
(US10759799, Compound 4)
Show SMILES O=C1CCc2cccc(c2)-c2ccnc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-7-4-15-2-1-3-17(10-15)20-8-9-29-26-24(20)31-27(32-26)25-21-12-16(5-6-22(21)33-34-25)18-11-19(30-23)14-28-13-18/h1-3,5-6,8-14H,4,7H2,(H,30,35)(H,33,34)(H,29,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 204n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459194
PNG
(US10759799, Compound 51)
Show SMILES CN1CCCCN(C)c2nccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(C1)c2
Show InChI InChI=1S/C25H26N8/c1-32-9-3-4-10-33(2)25-23-21(7-8-27-25)28-24(29-23)22-19-12-17(5-6-20(19)30-31-22)18-11-16(15-32)13-26-14-18/h5-8,11-14H,3-4,9-10,15H2,1-2H3,(H,28,29)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459194
PNG
(US10759799, Compound 51)
Show SMILES CN1CCCCN(C)c2nccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(C1)c2
Show InChI InChI=1S/C25H26N8/c1-32-9-3-4-10-33(2)25-23-21(7-8-27-25)28-24(29-23)22-19-12-17(5-6-20(19)30-31-22)18-11-16(15-32)13-26-14-18/h5-8,11-14H,3-4,9-10,15H2,1-2H3,(H,28,29)(H,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459197
PNG
(US10759799, Compound 71)
Show SMILES O=C1CCCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C29H22N6O/c36-26-9-2-5-17-4-1-6-19(12-17)22-7-3-8-25-27(22)33-29(32-25)28-23-14-18(10-11-24(23)34-35-28)20-13-21(31-26)16-30-15-20/h1,3-4,6-8,10-16H,2,5,9H2,(H,31,36)(H,32,33)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 14n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459184
PNG
(US10759799, Compound 5)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ncc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-8-7-15-3-1-4-16(9-15)20-5-2-6-22-24(20)32-27(31-22)25-21-11-18(13-29-26(21)34-33-25)17-10-19(30-23)14-28-12-17/h1-6,9-14H,7-8H2,(H,30,35)(H,31,32)(H,29,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 48n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459181
PNG
(US10759799, Compound 2)
Show SMILES O=C1CCc2cccc(c2)-c2nccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-7-4-15-2-1-3-17(10-15)24-26-22(8-9-29-24)31-27(32-26)25-20-12-16(5-6-21(20)33-34-25)18-11-19(30-23)14-28-13-18/h1-3,5-6,8-14H,4,7H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459182
PNG
(US10759799, Compound 3)
Show SMILES O=C1CCc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-24-7-4-15-2-1-3-17(8-15)21-13-29-14-23-25(21)32-27(31-23)26-20-10-16(5-6-22(20)33-34-26)18-9-19(30-24)12-28-11-18/h1-3,5-6,8-14H,4,7H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459181
PNG
(US10759799, Compound 2)
Show SMILES O=C1CCc2cccc(c2)-c2nccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-7-4-15-2-1-3-17(10-15)24-26-22(8-9-29-24)31-27(32-26)25-20-12-16(5-6-21(20)33-34-25)18-11-19(30-23)14-28-13-18/h1-3,5-6,8-14H,4,7H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459187
PNG
(US10759799, Compound 8)
Show SMILES C1NCc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(cncc5[nH]4)-c4cccc1c4)c3c2
Show InChI InChI=1S/C26H19N7/c1-2-15-6-18(3-1)21-13-29-14-23-24(21)31-26(30-23)25-20-8-17(4-5-22(20)32-33-25)19-7-16(10-27-9-15)11-28-12-19/h1-8,11-14,27H,9-10H2,(H,30,31)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459192
PNG
(US10759799, Compound 38)
Show SMILES O=C1COc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C26H17N7O2/c34-23-13-35-18-3-1-2-15(7-18)20-11-28-12-22-24(20)31-26(30-22)25-19-8-14(4-5-21(19)32-33-25)16-6-17(29-23)10-27-9-16/h1-12H,13H2,(H,29,34)(H,30,31)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459185
PNG
(US10759799, Compound 6)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3cnc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-24-8-7-15-3-1-4-16(9-15)19-5-2-6-21-25(19)32-27(31-21)26-20-11-22(29-14-23(20)33-34-26)17-10-18(30-24)13-28-12-17/h1-6,9-14H,7-8H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 96n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459186
PNG
(US10759799, Compound 7)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(nc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-10-7-15-3-1-4-16(11-15)19-5-2-6-21-24(19)32-27(31-21)26-25-22(33-34-26)9-8-20(30-25)17-12-18(29-23)14-28-13-17/h1-6,8-9,11-14H,7,10H2,(H,29,35)(H,31,32)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459191
PNG
(US10759799, Compound 29)
Show SMILES CN1Cc2c(cnn2C)-c2ccc3[nH]nc(-c4nc5c(cccc5[nH]4)-c4cccc(C1)c4)c3c2
Show InChI InChI=1S/C27H23N7/c1-33-14-16-5-3-6-17(11-16)19-7-4-8-23-25(19)30-27(29-23)26-20-12-18(9-10-22(20)31-32-26)21-13-28-34(2)24(21)15-33/h3-13H,14-15H2,1-2H3,(H,29,30)(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 15n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459198
PNG
(US10759799, Compound 97)
Show SMILES O=C1CCc2cccc(c2)-c2cncc(NC(=O)c3n[nH]c4ccc(cc34)-c3cncc(CN1)c3)c2
Show InChI InChI=1S/C28H22N6O2/c35-26-7-4-17-2-1-3-19(8-17)22-10-23(16-30-15-22)32-28(36)27-24-11-20(5-6-25(24)33-34-27)21-9-18(13-31-26)12-29-14-21/h1-3,5-6,8-12,14-16H,4,7,13H2,(H,31,35)(H,32,36)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459188
PNG
(US10759799, Compound 10)
Show SMILES C1NCc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(cccc5[nH]4)-c4cccc1c4)c3c2
Show InChI InChI=1S/C27H20N6/c1-3-16-9-19(4-1)21-5-2-6-24-25(21)31-27(30-24)26-22-11-18(7-8-23(22)32-33-26)20-10-17(13-28-12-16)14-29-15-20/h1-11,14-15,28H,12-13H2,(H,30,31)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 18n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459180
PNG
(US10759799, Compound 1)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C28H20N6O/c35-25-10-7-16-3-1-4-18(11-16)21-5-2-6-24-26(21)32-28(31-24)27-22-13-17(8-9-23(22)33-34-27)19-12-20(30-25)15-29-14-19/h1-6,8-9,11-15H,7,10H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459183
PNG
(US10759799, Compound 4)
Show SMILES O=C1CCc2cccc(c2)-c2ccnc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-7-4-15-2-1-3-17(10-15)20-8-9-29-26-24(20)31-27(32-26)25-21-12-16(5-6-22(21)33-34-25)18-11-19(30-23)14-28-13-18/h1-3,5-6,8-14H,4,7H2,(H,30,35)(H,33,34)(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 494n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459187
PNG
(US10759799, Compound 8)
Show SMILES C1NCc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(cncc5[nH]4)-c4cccc1c4)c3c2
Show InChI InChI=1S/C26H19N7/c1-2-15-6-18(3-1)21-13-29-14-23-24(21)31-26(30-23)25-20-8-17(4-5-22(20)32-33-25)19-7-16(10-27-9-15)11-28-12-19/h1-8,11-14,27H,9-10H2,(H,30,31)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459189
PNG
(US10759799, Compound 15)
Show SMILES Cn1ncc-2c1CNCc1cccc(c1)-c1cccc3[nH]c(nc13)-c1n[nH]c3ccc-2cc13
Show InChI InChI=1S/C26H21N7/c1-33-23-14-27-12-15-4-2-5-16(10-15)18-6-3-7-22-24(18)30-26(29-22)25-19-11-17(20(23)13-28-33)8-9-21(19)31-32-25/h2-11,13,27H,12,14H2,1H3,(H,29,30)(H,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 111n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459195
PNG
(US10759799, Compound 57)
Show SMILES C1COc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(cccc5[nH]4)-c4cccc(C1)c4)c3c2
Show InChI InChI=1S/C28H21N5O/c1-4-17-5-3-11-34-21-13-20(15-29-16-21)18-9-10-24-23(14-18)27(33-32-24)28-30-25-8-2-7-22(26(25)31-28)19(6-1)12-17/h1-2,4,6-10,12-16H,3,5,11H2,(H,30,31)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459196
PNG
(US10759799, Compound 64)
Show SMILES O=C1NC2CCC(CC2)NCc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c1cccc5[nH]4)c3c2 |(.21,1.74,;.98,3.07,;.12,4.41,;-1.34,5.18,;-2.83,5.57,;-3.61,4.25,;-4.95,3.5,;-3.47,3.1,;-2.69,4.43,;-5.35,2.01,;-4.11,1.24,;-4.16,-.18,;-5.49,-.95,;-5.49,-2.49,;-4.16,-3.26,;-2.82,-2.49,;-2.82,-.95,;-1.49,-3.26,;-1.49,-4.8,;-.15,-5.57,;1.18,-4.8,;2.64,-5.28,;3.55,-4.03,;2.64,-2.79,;3.04,-1.3,;2.07,-.1,;2.91,1.19,;2.51,2.67,;3.6,3.76,;5.09,3.36,;5.49,1.88,;4.4,.79,;4.48,-.75,;1.18,-3.26,;-.15,-2.49,)|
Show InChI InChI=1S/C27H25N7O/c35-27-20-2-1-3-23-24(20)32-26(31-23)25-21-11-16(4-9-22(21)33-34-25)17-10-15(12-28-14-17)13-29-18-5-7-19(30-27)8-6-18/h1-4,9-12,14,18-19,29H,5-8,13H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 448n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459198
PNG
(US10759799, Compound 97)
Show SMILES O=C1CCc2cccc(c2)-c2cncc(NC(=O)c3n[nH]c4ccc(cc34)-c3cncc(CN1)c3)c2
Show InChI InChI=1S/C28H22N6O2/c35-26-7-4-17-2-1-3-19(8-17)22-10-23(16-30-15-22)32-28(36)27-24-11-20(5-6-25(24)33-34-27)21-9-18(13-31-26)12-29-14-21/h1-3,5-6,8-12,14-16H,4,7,13H2,(H,31,35)(H,32,36)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 9n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459182
PNG
(US10759799, Compound 3)
Show SMILES O=C1CCc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-24-7-4-15-2-1-3-17(8-15)21-13-29-14-23-25(21)32-27(31-23)26-20-10-16(5-6-22(20)33-34-26)18-9-19(30-24)12-28-11-18/h1-3,5-6,8-14H,4,7H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459180
PNG
(US10759799, Compound 1)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C28H20N6O/c35-25-10-7-16-3-1-4-18(11-16)21-5-2-6-24-26(21)32-28(31-24)27-22-13-17(8-9-23(22)33-34-27)19-12-20(30-25)15-29-14-19/h1-6,8-9,11-15H,7,10H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 266n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459193
PNG
(US10759799, Compound 45)
Show SMILES CN1CCCn2cc(nn2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(C1)c2
Show InChI InChI=1S/C25H20N10/c1-34-5-2-6-35-14-22(31-33-35)19-11-27-12-21-23(19)29-25(28-21)24-18-8-16(3-4-20(18)30-32-24)17-7-15(13-34)9-26-10-17/h3-4,7-12,14H,2,5-6,13H2,1H3/b25-24+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459188
PNG
(US10759799, Compound 10)
Show SMILES C1NCc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(cccc5[nH]4)-c4cccc1c4)c3c2
Show InChI InChI=1S/C27H20N6/c1-3-16-9-19(4-1)21-5-2-6-24-25(21)31-27(30-24)26-22-11-18(7-8-23(22)32-33-26)20-10-17(13-28-12-16)14-29-15-20/h1-11,14-15,28H,12-13H2,(H,30,31)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459189
PNG
(US10759799, Compound 15)
Show SMILES Cn1ncc-2c1CNCc1cccc(c1)-c1cccc3[nH]c(nc13)-c1n[nH]c3ccc-2cc13
Show InChI InChI=1S/C26H21N7/c1-33-23-14-27-12-15-4-2-5-16(10-15)18-6-3-7-22-24(18)30-26(29-22)25-19-11-17(20(23)13-28-33)8-9-21(19)31-32-25/h2-11,13,27H,12,14H2,1H3,(H,29,30)(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459195
PNG
(US10759799, Compound 57)
Show SMILES C1COc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c(cccc5[nH]4)-c4cccc(C1)c4)c3c2
Show InChI InChI=1S/C28H21N5O/c1-4-17-5-3-11-34-21-13-20(15-29-16-21)18-9-10-24-23(14-18)27(33-32-24)28-30-25-8-2-7-22(26(25)31-28)19(6-1)12-17/h1-2,4,6-10,12-16H,3,5,11H2,(H,30,31)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.87E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459196
PNG
(US10759799, Compound 64)
Show SMILES O=C1NC2CCC(CC2)NCc2cncc(c2)-c2ccc3[nH]nc(-c4nc5c1cccc5[nH]4)c3c2 |(.21,1.74,;.98,3.07,;.12,4.41,;-1.34,5.18,;-2.83,5.57,;-3.61,4.25,;-4.95,3.5,;-3.47,3.1,;-2.69,4.43,;-5.35,2.01,;-4.11,1.24,;-4.16,-.18,;-5.49,-.95,;-5.49,-2.49,;-4.16,-3.26,;-2.82,-2.49,;-2.82,-.95,;-1.49,-3.26,;-1.49,-4.8,;-.15,-5.57,;1.18,-4.8,;2.64,-5.28,;3.55,-4.03,;2.64,-2.79,;3.04,-1.3,;2.07,-.1,;2.91,1.19,;2.51,2.67,;3.6,3.76,;5.09,3.36,;5.49,1.88,;4.4,.79,;4.48,-.75,;1.18,-3.26,;-.15,-2.49,)|
Show InChI InChI=1S/C27H25N7O/c35-27-20-2-1-3-23-24(20)32-26(31-23)25-21-11-16(4-9-22(21)33-34-25)17-10-15(12-28-14-17)13-29-18-5-7-19(30-27)8-6-18/h1-4,9-12,14,18-19,29H,5-8,13H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 88n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459197
PNG
(US10759799, Compound 71)
Show SMILES O=C1CCCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C29H22N6O/c36-26-9-2-5-17-4-1-6-19(12-17)22-7-3-8-25-27(22)33-29(32-25)28-23-14-18(10-11-24(23)34-35-28)20-13-21(31-26)16-30-15-20/h1,3-4,6-8,10-16H,2,5,9H2,(H,31,36)(H,32,33)(H,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 14n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459199
PNG
(US10759799, Compound 109)
Show SMILES C1COc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)n2
Show InChI InChI=1S/C26H19N7O/c1-3-15-11-17(4-1)34-10-9-28-23-14-27-13-22(29-23)16-7-8-20-19(12-16)25(33-32-20)26-30-21-6-2-5-18(15)24(21)31-26/h1-8,11-14H,9-10H2,(H,28,29)(H,30,31)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 62n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459186
PNG
(US10759799, Compound 7)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(nc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-10-7-15-3-1-4-16(11-15)19-5-2-6-21-24(19)32-27(31-21)26-25-22(33-34-26)9-8-20(30-25)17-12-18(29-23)14-28-13-17/h1-6,8-9,11-14H,7,10H2,(H,29,35)(H,31,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459190
PNG
(US10759799, Compound 22)
Show SMILES CN1Cc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(C1)c2
Show InChI InChI=1S/C28H22N6/c1-34-15-17-4-2-5-20(10-17)22-6-3-7-25-26(22)31-28(30-25)27-23-12-19(8-9-24(23)32-33-27)21-11-18(16-34)13-29-14-21/h2-14H,15-16H2,1H3,(H,30,31)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 68n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459191
PNG
(US10759799, Compound 29)
Show SMILES CN1Cc2c(cnn2C)-c2ccc3[nH]nc(-c4nc5c(cccc5[nH]4)-c4cccc(C1)c4)c3c2
Show InChI InChI=1S/C27H23N7/c1-33-14-16-5-3-6-17(11-16)19-7-4-8-23-25(19)30-27(29-23)26-20-12-18(9-10-22(20)31-32-26)21-13-28-34(2)24(21)15-33/h3-13H,14-15H2,1-2H3,(H,29,30)(H,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 412n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459192
PNG
(US10759799, Compound 38)
Show SMILES O=C1COc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C26H17N7O2/c34-23-13-35-18-3-1-2-15(7-18)20-11-28-12-22-24(20)31-26(30-22)25-19-8-14(4-5-21(19)32-33-25)16-6-17(29-23)10-27-9-16/h1-12H,13H2,(H,29,34)(H,30,31)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459199
PNG
(US10759799, Compound 109)
Show SMILES C1COc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(N1)n2
Show InChI InChI=1S/C26H19N7O/c1-3-15-11-17(4-1)34-10-9-28-23-14-27-13-22(29-23)16-7-8-20-19(12-16)25(33-32-20)26-30-21-6-2-5-18(15)24(21)31-26/h1-8,11-14H,9-10H2,(H,28,29)(H,30,31)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 96n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459185
PNG
(US10759799, Compound 6)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3cnc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-24-8-7-15-3-1-4-16(9-15)19-5-2-6-21-25(19)32-27(31-21)26-20-11-22(29-14-23(20)33-34-26)17-10-18(30-24)13-28-12-17/h1-6,9-14H,7-8H2,(H,30,35)(H,31,32)(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459190
PNG
(US10759799, Compound 22)
Show SMILES CN1Cc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(C1)c2
Show InChI InChI=1S/C28H22N6/c1-34-15-17-4-2-5-20(10-17)22-6-3-7-25-26(22)31-28(30-25)27-23-12-19(8-9-24(23)32-33-27)21-11-18(16-34)13-29-14-21/h2-14H,15-16H2,1H3,(H,30,31)(H,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 11n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM459193
PNG
(US10759799, Compound 45)
Show SMILES CN1CCCn2cc(nn2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(C1)c2
Show InChI InChI=1S/C25H20N10/c1-34-5-2-6-35-14-22(31-33-35)19-11-27-12-21-23(19)29-25(28-21)24-18-8-16(3-4-20(18)30-32-24)17-7-15(13-34)9-26-10-17/h3-4,7-12,14H,2,5-6,13H2,1H3/b25-24+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM459184
PNG
(US10759799, Compound 5)
Show SMILES O=C1CCc2cccc(c2)-c2cccc3[nH]c(nc23)-c2n[nH]c3ncc(cc23)-c2cncc(N1)c2
Show InChI InChI=1S/C27H19N7O/c35-23-8-7-15-3-1-4-16(9-15)20-5-2-6-22-24(20)32-27(31-22)25-21-11-18(13-29-26(21)34-33-25)17-10-19(30-23)14-28-12-17/h1-6,9-14H,7-8H2,(H,30,35)(H,31,32)(H,29,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 709n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...

US Patent US10759799 (2020)


BindingDB Entry DOI: 10.7270/Q2B27ZB4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%