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PubMed code 15686891

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160633
PNG
(2-methyl-6-[(5-phenylpyridin-3-yl)ethynyl]pyridine...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1ccccc1
Show InChI InChI=1S/C19H14N2/c1-15-6-5-9-19(21-15)11-10-16-12-18(14-20-13-16)17-7-3-2-4-8-17/h2-9,12-14H,1H3
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 1.70n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160627
PNG
(2-{[5-(2-furyl)pyridin-3-yl]ethynyl}-6-methylpyrid...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1ccco1
Show InChI InChI=1S/C17H12N2O/c1-13-4-2-5-16(19-13)8-7-14-10-15(12-18-11-14)17-6-3-9-20-17/h2-6,9-12H,1H3
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 6.5n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160624
PNG
(6-Methyl-5''-(6-methyl-pyridin-2-ylethynyl)-[2,3''...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1cccc(C)n1
Show InChI InChI=1S/C19H15N3/c1-14-5-3-7-18(21-14)10-9-16-11-17(13-20-12-16)19-8-4-6-15(2)22-19/h3-8,11-13H,1-2H3
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 13n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160640
PNG
(2-(3-Furan-2-yl-phenylethynyl)-6-methyl-pyridine |...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)-c1ccco1
Show InChI InChI=1S/C18H13NO/c1-14-5-2-8-17(19-14)11-10-15-6-3-7-16(13-15)18-9-4-12-20-18/h2-9,12-13H,1H3
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 36n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160631
PNG
(2-{[5-(3-methoxyphenyl)pyridin-3-yl]ethynyl}-6-met...)
Show SMILES COc1cccc(c1)-c1cncc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C20H16N2O/c1-15-5-3-7-19(22-15)10-9-16-11-18(14-21-13-16)17-6-4-8-20(12-17)23-2/h3-8,11-14H,1-2H3
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 74n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160622
PNG
(2-Methyl-6-(3-thiophen-2-yl-phenylethynyl)-pyridin...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)-c1cccs1
Show InChI InChI=1S/C18H13NS/c1-14-5-2-8-17(19-14)11-10-15-6-3-7-16(13-15)18-9-4-12-20-18/h2-9,12-13H,1H3
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 147n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160623
PNG
(2-methyl-6-[(5-thien-2-ylpyridin-3-yl)ethynyl]pyri...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1cccs1
Show InChI InChI=1S/C17H12N2S/c1-13-4-2-5-16(19-13)8-7-14-10-15(12-18-11-14)17-6-3-9-20-17/h2-6,9-12H,1H3
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 155n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160621
PNG
(2-Biphenyl-3-ylethynyl-6-methyl-pyridine | CHEMBL1...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H15N/c1-16-7-5-12-20(21-16)14-13-17-8-6-11-19(15-17)18-9-3-2-4-10-18/h2-12,15H,1H3
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 993n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160630
PNG
(2-(3''-Methoxy-biphenyl-3-ylethynyl)-6-methyl-pyri...)
Show SMILES COc1cccc(c1)-c1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C21H17NO/c1-16-6-3-10-20(22-16)13-12-17-7-4-8-18(14-17)19-9-5-11-21(15-19)23-2/h3-11,14-15H,1-2H3
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 2.36E+3n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160632
PNG
(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)C#N
Show InChI InChI=1S/C15H10N2/c1-12-4-2-7-15(17-12)9-8-13-5-3-6-14(10-13)11-16/h2-7,10H,1H3
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n/an/a 5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50123005
PNG
(2-(3-Methoxy-phenylethynyl)-6-methyl-pyridine | 2-...)
Show SMILES COc1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C15H13NO/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-2/h3-8,11H,1-2H3
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n/an/a 8n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160625
PNG
(2-Methyl-6-(3-nitro-phenylethynyl)-pyridine | CHEM...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H10N2O2/c1-11-4-2-6-13(15-11)9-8-12-5-3-7-14(10-12)16(17)18/h2-7,10H,1H3
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n/an/a 13n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160633
PNG
(2-methyl-6-[(5-phenylpyridin-3-yl)ethynyl]pyridine...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1ccccc1
Show InChI InChI=1S/C19H14N2/c1-15-6-5-9-19(21-15)11-10-16-12-18(14-20-13-16)17-7-3-2-4-8-17/h2-9,12-14H,1H3
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n/an/a 20n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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n/an/a 36n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160634
PNG
(1-[3-(6-Methyl-pyridin-2-ylethynyl)-phenyl]-ethano...)
Show SMILES CC(=O)c1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C16H13NO/c1-12-5-3-8-16(17-12)10-9-14-6-4-7-15(11-14)13(2)18/h3-8,11H,1-2H3
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n/an/a 146n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160635
PNG
(CHEMBL183793 | Methanesulfonic acid 3-(6-methyl-py...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OS(C)(=O)=O)c1
Show InChI InChI=1S/C15H13NO3S/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)19-20(2,17)18/h3-8,11H,1-2H3
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n/an/a 180n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160648
PNG
(3-(6-Methyl-pyridin-2-ylethynyl)-phenylamine | CHE...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(N)c1
Show InChI InChI=1S/C14H12N2/c1-11-4-2-7-14(16-11)9-8-12-5-3-6-13(15)10-12/h2-7,10H,15H2,1H3
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n/an/a 188n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160627
PNG
(2-{[5-(2-furyl)pyridin-3-yl]ethynyl}-6-methylpyrid...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1ccco1
Show InChI InChI=1S/C17H12N2O/c1-13-4-2-5-16(19-13)8-7-14-10-15(12-18-11-14)17-6-3-9-20-17/h2-6,9-12H,1H3
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n/an/a 205n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160639
PNG
(3-(6-Methyl-pyridin-2-ylethynyl)-benzoic acid meth...)
Show SMILES COC(=O)c1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C16H13NO2/c1-12-5-3-8-15(17-12)10-9-13-6-4-7-14(11-13)16(18)19-2/h3-8,11H,1-2H3
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n/an/a 208n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160624
PNG
(6-Methyl-5''-(6-methyl-pyridin-2-ylethynyl)-[2,3''...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1cccc(C)n1
Show InChI InChI=1S/C19H15N3/c1-14-5-3-7-18(21-14)10-9-16-11-17(13-20-12-16)19-8-4-6-15(2)22-19/h3-8,11-13H,1-2H3
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n/an/a 257n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160623
PNG
(2-methyl-6-[(5-thien-2-ylpyridin-3-yl)ethynyl]pyri...)
Show SMILES Cc1cccc(n1)C#Cc1cncc(c1)-c1cccs1
Show InChI InChI=1S/C17H12N2S/c1-13-4-2-5-16(19-13)8-7-14-10-15(12-18-11-14)17-6-3-9-20-17/h2-6,9-12H,1H3
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n/an/a 271n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160631
PNG
(2-{[5-(3-methoxyphenyl)pyridin-3-yl]ethynyl}-6-met...)
Show SMILES COc1cccc(c1)-c1cncc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C20H16N2O/c1-15-5-3-7-19(22-15)10-9-16-11-18(14-21-13-16)17-6-4-8-20(12-17)23-2/h3-8,11-14H,1-2H3
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n/an/a 282n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160650
PNG
(2-(3-Allyloxy-phenylethynyl)-6-methyl-pyridine | C...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCC=C)c1
Show InChI InChI=1S/C17H15NO/c1-3-12-19-17-9-5-7-15(13-17)10-11-16-8-4-6-14(2)18-16/h3-9,13H,1,12H2,2H3
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n/an/a 290n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160640
PNG
(2-(3-Furan-2-yl-phenylethynyl)-6-methyl-pyridine |...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)-c1ccco1
Show InChI InChI=1S/C18H13NO/c1-14-5-2-8-17(19-14)11-10-15-6-3-7-16(13-15)18-9-4-12-20-18/h2-9,12-13H,1H3
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n/an/a 371n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160641
PNG
(2-(3-Cyclopropylmethoxy-phenylethynyl)-6-methyl-py...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C18H17NO/c1-14-4-2-6-17(19-14)11-10-15-5-3-7-18(12-15)20-13-16-8-9-16/h2-7,12,16H,8-9,13H2,1H3
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n/an/a 420n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160630
PNG
(2-(3''-Methoxy-biphenyl-3-ylethynyl)-6-methyl-pyri...)
Show SMILES COc1cccc(c1)-c1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C21H17NO/c1-16-6-3-10-20(22-16)13-12-17-7-4-8-18(14-17)19-9-5-11-21(15-19)23-2/h3-11,14-15H,1-2H3
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n/an/a 493n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160621
PNG
(2-Biphenyl-3-ylethynyl-6-methyl-pyridine | CHEMBL1...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H15N/c1-16-7-5-12-20(21-16)14-13-17-8-6-11-19(15-17)18-9-3-2-4-10-18/h2-12,15H,1H3
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n/an/a 629n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160622
PNG
(2-Methyl-6-(3-thiophen-2-yl-phenylethynyl)-pyridin...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)-c1cccs1
Show InChI InChI=1S/C18H13NS/c1-14-5-2-8-17(19-14)11-10-15-6-3-7-16(13-15)18-9-4-12-20-18/h2-9,12-13H,1H3
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n/an/a 656n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160643
PNG
(CHEMBL182911 | Phenyl-acetic acid 3-(6-methyl-pyri...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C22H17NO2/c1-17-7-5-11-20(23-17)14-13-19-10-6-12-21(15-19)25-22(24)16-18-8-3-2-4-9-18/h2-12,15H,16H2,1H3
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n/an/a 740n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160649
PNG
(3-Phenyl-propionic acid 3-(6-methyl-pyridin-2-ylet...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)CCc2ccccc2)c1
Show InChI InChI=1S/C23H19NO2/c1-18-7-5-11-21(24-18)15-13-20-10-6-12-22(17-20)26-23(25)16-14-19-8-3-2-4-9-19/h2-12,17H,14,16H2,1H3
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n/an/a 890n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160653
PNG
(CHEMBL446620 | Furan-2-carboxylic acid 3-(6-methyl...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)c2ccco2)c1
Show InChI InChI=1S/C19H13NO3/c1-14-5-2-7-16(20-14)11-10-15-6-3-8-17(13-15)23-19(21)18-9-4-12-22-18/h2-9,12-13H,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160620
PNG
(3-Iodo-benzoic acid 3-(6-methyl-pyridin-2-ylethyny...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)c2cccc(I)c2)c1
Show InChI InChI=1S/C21H14INO2/c1-15-5-2-9-19(23-15)12-11-16-6-3-10-20(13-16)25-21(24)17-7-4-8-18(22)14-17/h2-10,13-14H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160637
PNG
(2-Methyl-6-[3-(4-phenyl-butoxy)-phenylethynyl]-pyr...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCCCCc2ccccc2)c1
Show InChI InChI=1S/C24H23NO/c1-20-9-7-14-23(25-20)17-16-22-13-8-15-24(19-22)26-18-6-5-12-21-10-3-2-4-11-21/h2-4,7-11,13-15,19H,5-6,12,18H2,1H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160628
PNG
(4-Phenyl-butyric acid 3-(6-methyl-pyridin-2-ylethy...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)CCCc2ccccc2)c1
Show InChI InChI=1S/C24H21NO2/c1-19-8-5-13-22(25-19)17-16-21-12-6-14-23(18-21)27-24(26)15-7-11-20-9-3-2-4-10-20/h2-6,8-10,12-14,18H,7,11,15H2,1H3
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n/an/a 1.17E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160626
PNG
(2-Methyl-6-[3-(3-phenyl-propoxy)-phenylethynyl]-py...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCCCc2ccccc2)c1
Show InChI InChI=1S/C23H21NO/c1-19-8-5-13-22(24-19)16-15-21-11-6-14-23(18-21)25-17-7-12-20-9-3-2-4-10-20/h2-6,8-11,13-14,18H,7,12,17H2,1H3
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n/an/a 1.19E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160645
PNG
(2-[3-(3-Methoxy-benzyloxy)-phenylethynyl]-6-methyl...)
Show SMILES COc1cccc(COc2cccc(c2)C#Cc2cccc(C)n2)c1
Show InChI InChI=1S/C22H19NO2/c1-17-6-3-9-20(23-17)13-12-18-7-4-11-22(14-18)25-16-19-8-5-10-21(15-19)24-2/h3-11,14-15H,16H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160638
PNG
(Benzoic acid 3-(6-methyl-pyridin-2-ylethynyl)-phen...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15NO2/c1-16-7-5-11-19(22-16)14-13-17-8-6-12-20(15-17)24-21(23)18-9-3-2-4-10-18/h2-12,15H,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160651
PNG
(2-Methyl-6-(3-phenethyloxy-phenylethynyl)-pyridine...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCCc2ccccc2)c1
Show InChI InChI=1S/C22H19NO/c1-18-7-5-11-21(23-18)14-13-20-10-6-12-22(17-20)24-16-15-19-8-3-2-4-9-19/h2-12,17H,15-16H2,1H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160644
PNG
(3-Methoxy-benzoic acid 3-(6-methyl-pyridin-2-yleth...)
Show SMILES COc1cccc(c1)C(=O)Oc1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C22H17NO3/c1-16-6-3-9-19(23-16)13-12-17-7-4-11-21(14-17)26-22(24)18-8-5-10-20(15-18)25-2/h3-11,14-15H,1-2H3
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n/an/a 1.72E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160636
PNG
(2-(3-Benzyloxy-phenylethynyl)-6-methyl-pyridine | ...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C21H17NO/c1-17-7-5-11-20(22-17)14-13-18-10-6-12-21(15-18)23-16-19-8-3-2-4-9-19/h2-12,15H,16H2,1H3
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n/an/a 1.84E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160647
PNG
(2-[3-(3-Iodo-benzyloxy)-phenylethynyl]-6-methyl-py...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCc2cccc(I)c2)c1
Show InChI InChI=1S/C21H16INO/c1-16-5-2-9-20(23-16)12-11-17-6-4-10-21(14-17)24-15-18-7-3-8-19(22)13-18/h2-10,13-14H,15H2,1H3
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n/an/a 1.98E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160646
PNG
(2-{3-[2-(4-Fluoro-phenyl)-ethoxy]-phenylethynyl}-6...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OCCc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H18FNO/c1-17-4-2-6-21(24-17)13-10-19-5-3-7-22(16-19)25-15-14-18-8-11-20(23)12-9-18/h2-9,11-12,16H,14-15H2,1H3
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n/an/a 2.05E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160652
PNG
(CHEMBL435699 | [3-(6-Methyl-pyridin-2-ylethynyl)-p...)
Show SMILES COC(=O)COc1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C17H15NO3/c1-13-5-3-7-15(18-13)10-9-14-6-4-8-16(11-14)21-12-17(19)20-2/h3-8,11H,12H2,1-2H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160642
PNG
(4-Bromo-butyric acid 3-(6-methyl-pyridin-2-ylethyn...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(OC(=O)CCCBr)c1
Show InChI InChI=1S/C18H16BrNO2/c1-14-5-2-7-16(20-14)11-10-15-6-3-8-17(13-15)22-18(21)9-4-12-19/h2-3,5-8,13H,4,9,12H2,1H3
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Article
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n/an/a 3.35E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50160629
PNG
(CHEMBL182620 | Toluene-4-sulfonic acid 3-(6-methyl...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1cccc(c1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C21H17NO3S/c1-16-9-13-21(14-10-16)26(23,24)25-20-8-4-6-18(15-20)11-12-19-7-3-5-17(2)22-19/h3-10,13-15H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay

Bioorg Med Chem Lett 15: 945-9 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.047
BindingDB Entry DOI: 10.7270/Q2QN6681
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%