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PubMed code 15857140

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 2b


(Zea mays)		BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)
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n/an/a 7n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134805
PNG
(6,9-Dibenzyl-12-(6-oxiranyl-6-oxo-hexyl)-decahydro...)
Show SMILES O=C(CCCCC[C@@H]1NC(=O)[C@H]2CCCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C1CO1
Show InChI InChI=1S/C34H42N4O6/c39-29(30-22-44-30)18-9-3-8-16-25-31(40)36-26(20-23-12-4-1-5-13-23)32(41)37-27(21-24-14-6-2-7-15-24)34(43)38-19-11-10-17-28(38)33(42)35-25/h1-2,4-7,12-15,25-28,30H,3,8-11,16-22H2,(H,35,42)(H,36,40)(H,37,41)/t25-,26-,27-,28+,30?/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50422364
PNG
(TRAPOXIN B)
Show SMILES O=C(CCCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H]1CO1
Show InChI InChI=1S/C33H40N4O6/c38-28(29-21-43-29)17-9-3-8-15-24-30(39)35-25(19-22-11-4-1-5-12-22)31(40)36-26(20-23-13-6-2-7-14-23)33(42)37-18-10-16-27(37)32(41)34-24/h1-2,4-7,11-14,24-27,29H,3,8-10,15-21H2,(H,34,41)(H,35,39)(H,36,40)/t24-,25-,26-,27+,29-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 50n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50422363
PNG
(CHEMBL2311176)
Show SMILES C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCCCC(=O)[C@@H]2CO2)NC(=O)[C@@H](C)NC1=O
Show InChI InChI=1S/C22H34N4O6/c1-13-19(28)23-14(2)20(29)25-15(8-5-3-4-6-10-17(27)18-12-32-18)22(31)26-11-7-9-16(26)21(30)24-13/h13-16,18H,3-12H2,1-2H3,(H,23,28)(H,24,30)(H,25,29)/t13-,14+,15-,16+,18-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166158
PNG
((E)-N-Hydroxy-3-[1-methyl-4-(3-naphthalen-1-yl-3-o...)
Show SMILES Cn1cc(\C=C\C(=O)c2cccc3ccccc23)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C21H18N2O3/c1-23-14-15(13-17(23)10-12-21(25)22-26)9-11-20(24)19-8-4-6-16-5-2-3-7-18(16)19/h2-14,26H,1H3,(H,22,25)/b11-9+,12-10+
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n/an/a 200n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166156
PNG
((E)-N-Hydroxy-3-{4-[3-(2-methoxy-phenyl)-3-oxo-pro...)
Show SMILES COc1ccccc1C(=O)\C=C\c1cc(\C=C\C(=O)NO)n(C)c1
Show InChI InChI=1S/C18H18N2O4/c1-20-12-13(11-14(20)8-10-18(22)19-23)7-9-16(21)15-5-3-4-6-17(15)24-2/h3-12,23H,1-2H3,(H,19,22)/b9-7+,10-8+
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n/an/a 250n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134800
PNG
((E)-N-Hydroxy-3-[1-methyl-4-((E)-3-oxo-3-o-tolyl-p...)
Show SMILES Cc1ccccc1C(=O)C=Cc1cc(C=CC(=O)NO)n(C)c1 |w:10.11,14.14|
Show InChI InChI=1S/C18H18N2O3/c1-13-5-3-4-6-16(13)17(21)9-7-14-11-15(20(2)12-14)8-10-18(22)19-23/h3-12,23H,1-2H3,(H,19,22)
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n/an/a 270n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134804
PNG
((E)-N-Hydroxy-3-[1-methyl-4-((E)-3-oxo-3-phenyl-pr...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccccc2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H16N2O3/c1-19-12-13(11-15(19)8-10-17(21)18-22)7-9-16(20)14-5-3-2-4-6-14/h2-12,22H,1H3,(H,18,21)/b9-7+,10-8+
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n/an/a 280n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166159
PNG
((E)-3-{4-[3-(2-Bromo-phenyl)-3-oxo-propenyl]-1-met...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccccc2Br)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15BrN2O3/c1-20-11-12(10-13(20)7-9-17(22)19-23)6-8-16(21)14-4-2-3-5-15(14)18/h2-11,23H,1H3,(H,19,22)/b8-6+,9-7+
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n/an/a 360n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166168
PNG
((E)-3-[4-(2-Benzoyl-but-1-enyl)-1-methyl-1H-pyrrol...)
Show SMILES CC\C(=C/c1cc(\C=C\C(=O)NO)n(C)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C19H20N2O3/c1-3-15(19(23)16-7-5-4-6-8-16)11-14-12-17(21(2)13-14)9-10-18(22)20-24/h4-13,24H,3H2,1-2H3,(H,20,22)/b10-9+,15-11+
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n/an/a 420n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166152
PNG
((E)-N-Hydroxy-3-{4-[3-(3-methoxy-phenyl)-3-oxo-pro...)
Show SMILES COc1cccc(c1)C(=O)\C=C\c1cc(\C=C\C(=O)NO)n(C)c1
Show InChI InChI=1S/C18H18N2O4/c1-20-12-13(10-15(20)7-9-18(22)19-23)6-8-17(21)14-4-3-5-16(11-14)24-2/h3-12,23H,1-2H3,(H,19,22)/b8-6+,9-7+
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n/an/a 540n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166153
PNG
((E)-N-Hydroxy-3-{4-[3-(4-methoxy-phenyl)-3-oxo-pro...)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc(\C=C\C(=O)NO)n(C)c1
Show InChI InChI=1S/C18H18N2O4/c1-20-12-13(11-15(20)6-10-18(22)19-23)3-9-17(21)14-4-7-16(24-2)8-5-14/h3-12,23H,1-2H3,(H,19,22)/b9-3+,10-6+
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n/an/a 570n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166167
PNG
((E)-N-Hydroxy-3-[1-methyl-4-(2-methyl-3-oxo-3-phen...)
Show SMILES C\C(=C/c1cc(\C=C\C(=O)NO)n(C)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C18H18N2O3/c1-13(18(22)15-6-4-3-5-7-15)10-14-11-16(20(2)12-14)8-9-17(21)19-23/h3-12,23H,1-2H3,(H,19,21)/b9-8+,13-10+
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n/an/a 680n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166160
PNG
((E)-N-Hydroxy-3-[1-methyl-4-(3-naphthalen-2-yl-3-o...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccc3ccccc3c2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C21H18N2O3/c1-23-14-15(12-19(23)9-11-21(25)22-26)6-10-20(24)18-8-7-16-4-2-3-5-17(16)13-18/h2-14,26H,1H3,(H,22,25)/b10-6+,11-9+
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n/an/a 1.80E+3n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM22449
PNG
(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Show SMILES OCc1ccc(cc1)[C@@H]1C[C@H](CSc2nc(c(o2)-c2ccccc2)-c2ccccc2)O[C@@H](O1)c1ccc(NC(=O)CCCCCCC(=O)NO)cc1 |r|
Show InChI InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166157
PNG
((E)-3-{4-[3-(3-Bromo-phenyl)-3-oxo-propenyl]-1-met...)
Show SMILES Cn1cc(\C=C\C(=O)c2cccc(Br)c2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15BrN2O3/c1-20-11-12(9-15(20)6-8-17(22)19-23)5-7-16(21)13-3-2-4-14(18)10-13/h2-11,23H,1H3,(H,19,22)/b7-5+,8-6+
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n/an/a 2.10E+3n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134802
PNG
((E)-3-{4-[(E)-3-(2-Chloro-phenyl)-3-oxo-propenyl]-...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccccc2Cl)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15ClN2O3/c1-20-11-12(10-13(20)7-9-17(22)19-23)6-8-16(21)14-4-2-3-5-15(14)18/h2-11,23H,1H3,(H,19,22)/b8-6+,9-7+
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n/an/a 5.20E+3n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166169
PNG
((E)-3-{4-[3-(2-Fluoro-phenyl)-3-oxo-propenyl]-1-me...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccccc2F)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15FN2O3/c1-20-11-12(10-13(20)7-9-17(22)19-23)6-8-16(21)14-4-2-3-5-15(14)18/h2-11,23H,1H3,(H,19,22)/b8-6+,9-7+
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n/an/a 7.10E+3n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134795
PNG
((E)-N-Hydroxy-3-[1-methyl-4-((E)-3-oxo-3-m-tolyl-p...)
Show SMILES Cc1cccc(c1)C(=O)\C=C\c1cc(\C=C\C(=O)NO)n(C)c1
Show InChI InChI=1S/C18H18N2O3/c1-13-4-3-5-15(10-13)17(21)8-6-14-11-16(20(2)12-14)7-9-18(22)19-23/h3-12,23H,1-2H3,(H,19,22)/b8-6+,9-7+
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n/an/a 7.90E+3n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134797
PNG
((E)-N-Hydroxy-3-[1-methyl-4-((E)-3-oxo-3-p-tolyl-p...)
Show SMILES Cc1ccc(cc1)C(=O)\C=C\c1cc(\C=C\C(=O)NO)n(C)c1
Show InChI InChI=1S/C18H18N2O3/c1-13-3-6-15(7-4-13)17(21)9-5-14-11-16(20(2)12-14)8-10-18(22)19-23/h3-12,23H,1-2H3,(H,19,22)/b9-5+,10-8+
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n/an/a 1.02E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166164
PNG
((E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)...)
Show SMILES Cn1cc(\C=C\C(=O)c2cccc(F)c2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15FN2O3/c1-20-11-12(9-15(20)6-8-17(22)19-23)5-7-16(21)13-3-2-4-14(18)10-13/h2-11,23H,1H3,(H,19,22)/b7-5+,8-6+
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n/an/a 2.20E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134796
PNG
((E)-3-{4-[(E)-3-(3-Chloro-phenyl)-3-oxo-propenyl]-...)
Show SMILES Cn1cc(\C=C\C(=O)c2cccc(Cl)c2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15ClN2O3/c1-20-11-12(9-15(20)6-8-17(22)19-23)5-7-16(21)13-3-2-4-14(18)10-13/h2-11,23H,1H3,(H,19,22)/b7-5+,8-6+
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n/an/a 2.42E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50134801
PNG
((E)-3-{4-[(E)-3-(4-Chloro-phenyl)-3-oxo-propenyl]-...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccc(Cl)cc2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15ClN2O3/c1-20-11-12(10-15(20)7-9-17(22)19-23)2-8-16(21)13-3-5-14(18)6-4-13/h2-11,23H,1H3,(H,19,22)/b8-2+,9-7+
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n/an/a 2.52E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166165
PNG
((E)-3-[4-(3-Biphenyl-4-yl-3-oxo-propenyl)-1-methyl...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccc(cc2)-c2ccccc2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C23H20N2O3/c1-25-16-17(15-21(25)12-14-23(27)24-28)7-13-22(26)20-10-8-19(9-11-20)18-5-3-2-4-6-18/h2-16,28H,1H3,(H,24,27)/b13-7+,14-12+
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n/an/a 2.65E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166162
PNG
((E)-3-{4-[3-(4-Bromo-phenyl)-3-oxo-propenyl]-1-met...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccc(Br)cc2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15BrN2O3/c1-20-11-12(10-15(20)7-9-17(22)19-23)2-8-16(21)13-3-5-14(18)6-4-13/h2-11,23H,1H3,(H,19,22)/b8-2+,9-7+
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n/an/a 2.85E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166161
PNG
((E)-3-{4-[3-(4-Fluoro-phenyl)-3-oxo-propenyl]-1-me...)
Show SMILES Cn1cc(\C=C\C(=O)c2ccc(F)cc2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C17H15FN2O3/c1-20-11-12(10-15(20)7-9-17(22)19-23)2-8-16(21)13-3-5-14(18)6-4-13/h2-11,23H,1H3,(H,19,22)/b8-2+,9-7+
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n/an/a 3.53E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166154
PNG
((E)-N-Hydroxy-3-{1-methyl-4-[3-oxo-3-(3-trifluorom...)
Show SMILES Cn1cc(\C=C\C(=O)c2cccc(c2)C(F)(F)F)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C18H15F3N2O3/c1-23-11-12(9-15(23)6-8-17(25)22-26)5-7-16(24)13-3-2-4-14(10-13)18(19,20)21/h2-11,26H,1H3,(H,22,25)/b7-5+,8-6+
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n/an/a 4.90E+4n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50009834
PNG
(2-Propylvaleric acid sodium salt | CHEMBL433 | Dep...)
Show SMILES CCCC(CCC)C([O-])=O
Show InChI InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)/p-1
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n/an/a 1.28E+5n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
Histone deacetylase 2b


(Zea mays)		BDBM50166166
PNG
((E)-N-Hydroxy-3-{1-methyl-4-[3-oxo-3-(3-trifluorom...)
Show SMILES Cn1cc(\C=C\C(=O)c2cccc(OC(F)(F)F)c2)cc1\C=C\C(=O)NO
Show InChI InChI=1S/C18H15F3N2O4/c1-23-11-12(9-14(23)6-8-17(25)22-26)5-7-16(24)13-3-2-4-15(10-13)27-18(19,20)21/h2-11,26H,1H3,(H,22,25)/b7-5+,8-6+
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n/an/a 1.76E+5n/an/an/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Inhibitory concentration against maize histone deacetylase 2

J Med Chem 48: 3344-53 (2005)


Article DOI: 10.1021/jm049002a
BindingDB Entry DOI: 10.7270/Q2222VKN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%