Found 19 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246540
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C28H36N8O5S/c1-5-23-24-25(33-36(23)17-20-9-7-8-10-29-20)27(37)32-26(31-24)22-15-21(16-30-28(22)41-19(3)18-40-4)42(38,39)35-13-11-34(6-2)12-14-35/h7-10,15-16,19H,5-6,11-14,17-18H2,1-4H3,(H,31,32,37)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246541
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C25H37N7O6S/c1-6-20-21-22(29-32(20)12-13-36-4)24(33)28-23(27-21)19-14-18(15-26-25(19)38-17(3)16-37-5)39(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246483
(3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-pro...)Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C27H34N8O4S/c1-4-15-39-27-21(16-20(17-29-27)40(37,38)34-13-11-33(6-3)12-14-34)25-30-23-22(5-2)35(32-24(23)26(36)31-25)18-19-9-7-8-10-28-19/h7-10,16-17H,4-6,11-15,18H2,1-3H3,(H,30,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14392
(3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 Show InChI InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)18-19-8-6-7-9-28-19)26(36)31-25(30-23)21-16-20(17-29-27(21)40-15-14-39-3)41(37,38)34-12-10-33(5-2)11-13-34/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50245798
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)c2ccccn2)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C26H32N8O4S/c1-5-21-22-23(31-32(21)4)25(35)30-24(29-22)19-15-18(39(36,37)34-13-11-33(6-2)12-14-34)16-28-26(19)38-17(3)20-9-7-8-10-27-20/h7-10,15-17H,5-6,11-14H2,1-4H3,(H,29,30,35)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246538
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C23H33N7O5S/c1-6-18-19-20(27-28(18)4)22(31)26-21(25-19)17-12-16(13-24-23(17)35-15(3)14-34-5)36(32,33)30-10-8-29(7-2)9-11-30/h12-13,15H,6-11,14H2,1-5H3,(H,25,26,31)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246539
((R)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-pr...)Show SMILES CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C24H35N7O5S/c1-6-8-30-9-11-31(12-10-30)37(33,34)17-13-18(24(25-14-17)36-16(3)15-35-5)22-26-20-19(7-2)29(4)28-21(20)23(32)27-22/h13-14,16H,6-12,15H2,1-5H3,(H,26,27,32)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246484
(5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-(2-methoxye...)Show SMILES CCCc1n(C)nc2c1nc([nH]c2=O)-c1cc(cnc1OCCOC)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H33N7O5S/c1-5-7-18-19-20(27-28(18)3)22(31)26-21(25-19)17-14-16(15-24-23(17)35-13-12-34-4)36(32,33)30-10-8-29(6-2)9-11-30/h14-15H,5-13H2,1-4H3,(H,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50245799
((S)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C23H33N7O5S/c1-6-18-19-20(27-28(18)4)22(31)26-21(25-19)17-12-16(13-24-23(17)35-15(3)14-34-5)36(32,33)30-10-8-29(7-2)9-11-30/h12-13,15H,6-11,14H2,1-5H3,(H,25,26,31)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50245858
((S)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@@H](C)COC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C25H37N7O6S/c1-6-20-21-22(29-32(20)12-13-36-4)24(33)28-23(27-21)19-14-18(15-26-25(19)38-17(3)16-37-5)39(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50245800
((S)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-pr...)Show SMILES CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C24H35N7O5S/c1-6-8-30-9-11-31(12-10-30)37(33,34)17-13-18(24(25-14-17)36-16(3)15-35-5)22-26-20-19(7-2)29(4)28-21(20)23(32)27-22/h13-14,16H,6-12,15H2,1-5H3,(H,26,27,32)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50245801
((S)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@@H](C)COC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C28H36N8O5S/c1-5-23-24-25(33-36(23)17-20-9-7-8-10-29-20)27(37)32-26(31-24)22-15-21(16-30-28(22)41-19(3)18-40-4)42(38,39)35-13-11-34(6-2)12-14-35/h7-10,15-16,19H,5-6,11-14,17-18H2,1-4H3,(H,31,32,37)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50245955
((S)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@@H](C)c2ccccn2)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C26H32N8O4S/c1-5-21-22-23(31-32(21)4)25(35)30-24(29-22)19-15-18(39(36,37)34-13-11-33(6-2)12-14-34)16-28-26(19)38-17(3)20-9-7-8-10-27-20/h7-10,15-17H,5-6,11-14H2,1-4H3,(H,29,30,35)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
(Canis familiaris) | BDBM50246541
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C25H37N7O6S/c1-6-20-21-22(29-32(20)12-13-36-4)24(33)28-23(27-21)19-14-18(15-26-25(19)38-17(3)16-37-5)39(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 734 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of canine retina PDE6 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
(Canis familiaris) | BDBM50246539
((R)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-pr...)Show SMILES CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C24H35N7O5S/c1-6-8-30-9-11-31(12-10-30)37(33,34)17-13-18(24(25-14-17)36-16(3)15-35-5)22-26-20-19(7-2)29(4)28-21(20)23(32)27-22/h13-14,16H,6-12,15H2,1-5H3,(H,26,27,32)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of canine retina PDE6 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
(Canis familiaris) | BDBM50246540
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C28H36N8O5S/c1-5-23-24-25(33-36(23)17-20-9-7-8-10-29-20)27(37)32-26(31-24)22-15-21(16-30-28(22)41-19(3)18-40-4)42(38,39)35-13-11-34(6-2)12-14-35/h7-10,15-16,19H,5-6,11-14,17-18H2,1-4H3,(H,31,32,37)/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of canine retina PDE6 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
(Canis familiaris) | BDBM50246538
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C23H33N7O5S/c1-6-18-19-20(27-28(18)4)22(31)26-21(25-19)17-12-16(13-24-23(17)35-15(3)14-34-5)36(32,33)30-10-8-29(7-2)9-11-30/h12-13,15H,6-11,14H2,1-5H3,(H,25,26,31)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of canine retina PDE6 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
(Canis familiaris) | BDBM50245798
((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)c2ccccn2)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C26H32N8O4S/c1-5-21-22-23(31-32(21)4)25(35)30-24(29-22)19-15-18(39(36,37)34-13-11-33(6-2)12-14-34)16-28-26(19)38-17(3)20-9-7-8-10-27-20/h7-10,15-17H,5-6,11-14H2,1-4H3,(H,29,30,35)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of canine retina PDE6 by scintillation proximity assay |
Bioorg Med Chem Lett 18: 6033-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.037
BindingDB Entry DOI: 10.7270/Q2H131WT |
More data for this
Ligand-Target Pair | |
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