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PubMed code 22464130

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383459
PNG
(CHEMBL2031619)
Show SMILES O=c1ccnc2c(cccn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-17-6-9-21-18-16(5-4-12-26(17)18)19-22-23-20(28-19)25-13-7-15(8-14-25)24-10-2-1-3-11-24/h4-6,9,12,15H,1-3,7-8,10-11,13-14H2
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PubMed
 2.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383442
PNG
(CHEMBL2031602)
Show SMILES Cc1nnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25N7S/c1-14-20-21-17-6-5-15(13-26(14)17)18-22-23-19(27-18)25-11-7-16(8-12-25)24-9-3-2-4-10-24/h5-6,13,16H,2-4,7-12H2,1H3
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 2.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383459
PNG
(CHEMBL2031619)
Show SMILES O=c1ccnc2c(cccn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-17-6-9-21-18-16(5-4-12-26(17)18)19-22-23-20(28-19)25-13-7-15(8-14-25)24-10-2-1-3-11-24/h4-6,9,12,15H,1-3,7-8,10-11,13-14H2
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 2.60n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383444
PNG
(CHEMBL2031604)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2ccnn12
Show InChI InChI=1S/C19H24N6S/c1-2-11-23(12-3-1)15-8-13-24(14-9-15)19-22-21-18(26-19)17-6-4-5-16-7-10-20-25(16)17/h4-7,10,15H,1-3,8-9,11-14H2
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 3.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383442
PNG
(CHEMBL2031602)
Show SMILES Cc1nnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25N7S/c1-14-20-21-17-6-5-15(13-26(14)17)18-22-23-19(27-18)25-11-7-16(8-12-25)24-9-3-2-4-10-24/h5-6,13,16H,2-4,7-12H2,1H3
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 3.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383448
PNG
(CHEMBL2031608)
Show SMILES O=C(N1CCC1)c1cccc(n1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H28N6OS/c28-20(26-12-5-13-26)18-7-4-6-17(22-18)19-23-24-21(29-19)27-14-8-16(9-15-27)25-10-2-1-3-11-25/h4,6-7,16H,1-3,5,8-15H2
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 4.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383445
PNG
(CHEMBL2031605)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2cccnc12
Show InChI InChI=1S/C21H25N5S/c1-2-12-25(13-3-1)17-9-14-26(15-10-17)21-24-23-20(27-21)18-8-4-6-16-7-5-11-22-19(16)18/h4-8,11,17H,1-3,9-10,12-15H2
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 4.60n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383445
PNG
(CHEMBL2031605)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2cccnc12
Show InChI InChI=1S/C21H25N5S/c1-2-12-25(13-3-1)17-9-14-26(15-10-17)21-24-23-20(27-21)18-8-4-6-16-7-5-11-22-19(16)18/h4-8,11,17H,1-3,9-10,12-15H2
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 7.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383453
PNG
(CHEMBL2031613)
Show SMILES O=c1ccc2cc(ccc2[nH]1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H25N5OS/c27-19-7-5-15-14-16(4-6-18(15)22-19)20-23-24-21(28-20)26-12-8-17(9-13-26)25-10-2-1-3-11-25/h4-7,14,17H,1-3,8-13H2,(H,22,27)
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 10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383456
PNG
(CHEMBL2031616)
Show SMILES O=c1ccoc2ccc(cc12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H24N4O2S/c26-18-8-13-27-19-5-4-15(14-17(18)19)20-22-23-21(28-20)25-11-6-16(7-12-25)24-9-2-1-3-10-24/h4-5,8,13-14,16H,1-3,6-7,9-12H2
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 12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383450
PNG
(CHEMBL2031610)
Show SMILES O=c1cccnn1-c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C22H26N6OS/c29-20-8-5-11-23-28(20)19-7-4-6-17(16-19)21-24-25-22(30-21)27-14-9-18(10-15-27)26-12-2-1-3-13-26/h4-8,11,16,18H,1-3,9-10,12-15H2
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 12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383456
PNG
(CHEMBL2031616)
Show SMILES O=c1ccoc2ccc(cc12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H24N4O2S/c26-18-8-13-27-19-5-4-15(14-17(18)19)20-22-23-21(28-20)25-11-6-16(7-12-25)24-9-2-1-3-10-24/h4-5,8,13-14,16H,1-3,6-7,9-12H2
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 12.7n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383458
PNG
(CHEMBL2031618)
Show SMILES O=c1ccnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-18-6-9-21-17-5-4-15(14-26(17)18)19-22-23-20(28-19)25-12-7-16(8-13-25)24-10-2-1-3-11-24/h4-6,9,14,16H,1-3,7-8,10-13H2
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 13n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383449
PNG
(CHEMBL2031609)
Show SMILES CC(=O)Nc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H27N5OS/c1-15(26)21-17-7-5-6-16(14-17)19-22-23-20(27-19)25-12-8-18(9-13-25)24-10-3-2-4-11-24/h5-7,14,18H,2-4,8-13H2,1H3,(H,21,26)
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 16.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383441
PNG
(CHEMBL2031601)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1cccc2cnccc12
Show InChI InChI=1S/C21H25N5S/c1-2-11-25(12-3-1)17-8-13-26(14-9-17)21-24-23-20(27-21)19-6-4-5-16-15-22-10-7-18(16)19/h4-7,10,15,17H,1-3,8-9,11-14H2
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 17.8n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383455
PNG
(CHEMBL2031615)
Show SMILES O=c1ccc2c(cccc2[nH]1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H25N5OS/c27-19-8-7-16-17(5-4-6-18(16)22-19)20-23-24-21(28-20)26-13-9-15(10-14-26)25-11-2-1-3-12-25/h4-8,15H,1-3,9-14H2,(H,22,27)
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 20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383452
PNG
(CHEMBL2031612)
Show SMILES O=C1COc2ccc(cc2N1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H25N5O2S/c26-18-13-27-17-5-4-14(12-16(17)21-18)19-22-23-20(28-19)25-10-6-15(7-11-25)24-8-2-1-3-9-24/h4-5,12,15H,1-3,6-11,13H2,(H,21,26)
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 22.1n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383440
PNG
(CHEMBL2031600)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H26N6OS/c1-15-22-23-19(28-15)16-6-5-7-17(14-16)20-24-25-21(29-20)27-12-8-18(9-13-27)26-10-3-2-4-11-26/h5-7,14,18H,2-4,8-13H2,1H3
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 22.8n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383443
PNG
(CHEMBL2031603)
Show SMILES Cc1nc2cc(ccc2o1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H25N5OS/c1-14-21-17-13-15(5-6-18(17)26-14)19-22-23-20(27-19)25-11-7-16(8-12-25)24-9-3-2-4-10-24/h5-6,13,16H,2-4,7-12H2,1H3
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 24.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383458
PNG
(CHEMBL2031618)
Show SMILES O=c1ccnc2ccc(cn12)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H24N6OS/c27-18-6-9-21-17-5-4-15(14-26(17)18)19-22-23-20(28-19)25-12-7-16(8-13-25)24-10-2-1-3-11-24/h4-6,9,14,16H,1-3,7-8,10-13H2
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 25n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383439
PNG
(CHEMBL2031599)
Show SMILES CC(O)c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H28N4OS/c1-15(25)16-6-5-7-17(14-16)19-21-22-20(26-19)24-12-8-18(9-13-24)23-10-3-2-4-11-23/h5-7,14-15,18,25H,2-4,8-13H2,1H3
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 29n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383454
PNG
(CHEMBL2031614)
Show SMILES O=c1ccc2ccc(cc2[nH]1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H25N5OS/c27-19-7-6-15-4-5-16(14-18(15)22-19)20-23-24-21(28-20)26-12-8-17(9-13-26)25-10-2-1-3-11-25/h4-7,14,17H,1-3,8-13H2,(H,22,27)
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 35.9n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)		BDBM50383440
PNG
(CHEMBL2031600)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H26N6OS/c1-15-22-23-19(28-15)16-6-5-7-17(14-16)20-24-25-21(29-20)27-12-8-18(9-13-27)26-10-3-2-4-11-26/h5-7,14,18H,2-4,8-13H2,1H3
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 40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from mouse histamine H3 receptor

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383451
PNG
(CHEMBL2031611)
Show SMILES O=C1Cc2cc(ccc2N1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H25N5OS/c26-18-13-15-12-14(4-5-17(15)21-18)19-22-23-20(27-19)25-10-6-16(7-11-25)24-8-2-1-3-9-24/h4-5,12,16H,1-3,6-11,13H2,(H,21,26)
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 64.4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383447
PNG
(CHEMBL2031607)
Show SMILES O=C(N1CCC1)c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C22H29N5OS/c28-21(26-12-5-13-26)18-7-4-6-17(16-18)20-23-24-22(29-20)27-14-8-19(9-15-27)25-10-2-1-3-11-25/h4,6-7,16,19H,1-3,5,8-15H2
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 78.9n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383457
PNG
(CHEMBL2031617)
Show SMILES Cc1cc(=O)c2cc(ccc2o1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C22H26N4O2S/c1-15-13-19(27)18-14-16(5-6-20(18)28-15)21-23-24-22(29-21)26-11-7-17(8-12-26)25-9-3-2-4-10-25/h5-6,13-14,17H,2-4,7-12H2,1H3
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 82.8n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383446
PNG
(CHEMBL2031606)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C21H29N5OS/c1-24(2)20(27)17-8-6-7-16(15-17)19-22-23-21(28-19)26-13-9-18(10-14-26)25-11-4-3-5-12-25/h6-8,15,18H,3-5,9-14H2,1-2H3
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 192n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK cell membranes after 30 mins by scintillati...

Bioorg Med Chem Lett 22: 3354-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.076
BindingDB Entry DOI: 10.7270/Q2DN462S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%