Found 121 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069135
(CHEMBL3402459)Show SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2OCCN(C)C)-c2cn[nH]c2)c1 Show InChI InChI=1S/C23H29N5O3/c1-27(2)10-11-31-22-13-18(19-14-24-25-15-19)8-9-21(22)26-23(29)28(3)16-17-6-5-7-20(12-17)30-4/h5-9,12-15H,10-11,16H2,1-4H3,(H,24,25)(H,26,29) | PDB
MMDB
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AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431137
(CHEMBL2332060)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1O[C@H]1CCN(C)C1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C25H31N5O3/c1-4-30(16-18-6-5-7-21(12-18)32-3)25(31)28-23-9-8-19(20-14-26-27-15-20)13-24(23)33-22-10-11-29(2)17-22/h5-9,12-15,22H,4,10-11,16-17H2,1-3H3,(H,26,27)(H,28,31)/t22-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069307
(CHEMBL2332067)Show SMILES COc1cccc(CN(CCN)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C20H23N5O2/c1-27-19-4-2-3-15(11-19)14-25(10-9-21)20(26)24-18-7-5-16(6-8-18)17-12-22-23-13-17/h2-8,11-13H,9-10,14,21H2,1H3,(H,22,23)(H,24,26) | PDB
MMDB
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431134
(CHEMBL2332068)Show SMILES COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C22H27N5O2/c1-26(2)11-12-27(16-17-5-4-6-21(13-17)29-3)22(28)25-20-9-7-18(8-10-20)19-14-23-24-15-19/h4-10,13-15H,11-12,16H2,1-3H3,(H,23,24)(H,25,28) | PDB
MMDB
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PC cid
PC sid
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| Article
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431145
(CHEMBL2332098)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C20H22N4O2/c1-3-24(14-15-5-4-6-19(11-15)26-2)20(25)23-18-9-7-16(8-10-18)17-12-21-22-13-17/h4-13H,3,14H2,1-2H3,(H,21,22)(H,23,25) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069234
(CHEMBL3402455)Show InChI InChI=1S/C18H17FN4O2/c1-25-15-4-2-3-12(7-15)9-20-18(24)23-17-6-5-13(8-16(17)19)14-10-21-22-11-14/h2-8,10-11H,9H2,1H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
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| CHEMBL
MMDB
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431144
(CHEMBL2332099)Show SMILES COc1cccc(CN(C2CC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C21H22N4O2/c1-27-20-4-2-3-15(11-20)14-25(19-9-10-19)21(26)24-18-7-5-16(6-8-18)17-12-22-23-13-17/h2-8,11-13,19H,9-10,14H2,1H3,(H,22,23)(H,24,26) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431138
(CHEMBL2332097)Show SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C19H20N4O2/c1-23(13-14-4-3-5-18(10-14)25-2)19(24)22-17-8-6-15(7-9-17)16-11-20-21-12-16/h3-12H,13H2,1-2H3,(H,20,21)(H,22,24) | PDB
MMDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069139
(CHEMBL3402463)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1OCCN1CCCC1)-c1cn[nH]c1 Show InChI InChI=1S/C26H33N5O3/c1-3-31(19-20-7-6-8-23(15-20)33-2)26(32)29-24-10-9-21(22-17-27-28-18-22)16-25(24)34-14-13-30-11-4-5-12-30/h6-10,15-18H,3-5,11-14,19H2,1-2H3,(H,27,28)(H,29,32) | PDB
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PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069232
(CHEMBL3402453)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2OC)-c2cn[nH]c2)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-16-5-3-4-13(8-16)10-20-19(24)23-17-7-6-14(9-18(17)26-2)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069233
(CHEMBL3402454)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2Cl)-c2cn[nH]c2)c1 Show InChI InChI=1S/C18H17ClN4O2/c1-25-15-4-2-3-12(7-15)9-20-18(24)23-17-6-5-13(8-16(17)19)14-10-21-22-11-14/h2-8,10-11H,9H2,1H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069238
(CHEMBL3402456)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2OCCN(C)C)-c2cn[nH]c2)c1 Show InChI InChI=1S/C22H27N5O3/c1-27(2)9-10-30-21-12-17(18-14-24-25-15-18)7-8-20(21)26-22(28)23-13-16-5-4-6-19(11-16)29-3/h4-8,11-12,14-15H,9-10,13H2,1-3H3,(H,24,25)(H2,23,26,28) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431135
(CHEMBL2332065)Show SMILES COc1cccc(CN(CCO)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C20H22N4O3/c1-27-19-4-2-3-15(11-19)14-24(9-10-25)20(26)23-18-7-5-16(6-8-18)17-12-21-22-13-17/h2-8,11-13,25H,9-10,14H2,1H3,(H,21,22)(H,23,26) | PDB
MMDB
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431138
(CHEMBL2332097)Show SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C19H20N4O2/c1-23(13-14-4-3-5-18(10-14)25-2)19(24)22-17-8-6-15(7-9-17)16-11-20-21-12-16/h3-12H,13H2,1-2H3,(H,20,21)(H,22,24) | PDB
MMDB
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069240
(CHEMBL3402457)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2OCCN2CCCC2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H29N5O3/c1-31-21-6-4-5-18(13-21)15-25-24(30)28-22-8-7-19(20-16-26-27-17-20)14-23(22)32-12-11-29-9-2-3-10-29/h4-8,13-14,16-17H,2-3,9-12,15H2,1H3,(H,26,27)(H2,25,28,30) | PDB
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069309
(CHEMBL3402471)Show SMILES OCCOc1cc(ccc1NC(=O)N(CCO)Cc1ccccc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H24N4O4/c26-9-8-25(15-16-4-2-1-3-5-16)21(28)24-19-7-6-17(18-13-22-23-14-18)12-20(19)29-11-10-27/h1-7,12-14,26-27H,8-11,15H2,(H,22,23)(H,24,28) | PDB
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431134
(CHEMBL2332068)Show SMILES COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C22H27N5O2/c1-26(2)11-12-27(16-17-5-4-6-21(13-17)29-3)22(28)25-20-9-7-18(8-10-20)19-14-23-24-15-19/h4-10,13-15H,11-12,16H2,1-3H3,(H,23,24)(H,25,28) | PDB
MMDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431143
(CHEMBL2332057)Show InChI InChI=1S/C19H20N4O2/c24-11-10-18(15-4-2-1-3-5-15)23-19(25)22-17-8-6-14(7-9-17)16-12-20-21-13-16/h1-9,12-13,18,24H,10-11H2,(H,20,21)(H2,22,23,25) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069231
(CHEMBL3402452)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2N(C)C)-c2cn[nH]c2)c1 Show InChI InChI=1S/C20H23N5O2/c1-25(2)19-10-15(16-12-22-23-13-16)7-8-18(19)24-20(26)21-11-14-5-4-6-17(9-14)27-3/h4-10,12-13H,11H2,1-3H3,(H,22,23)(H2,21,24,26) | PDB
MMDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431144
(CHEMBL2332099)Show SMILES COc1cccc(CN(C2CC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C21H22N4O2/c1-27-20-4-2-3-15(11-20)14-25(19-9-10-19)21(26)24-18-7-5-16(6-8-18)17-12-22-23-13-17/h2-8,11-13,19H,9-10,14H2,1H3,(H,22,23)(H,24,26) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431143
(CHEMBL2332057)Show InChI InChI=1S/C19H20N4O2/c24-11-10-18(15-4-2-1-3-5-15)23-19(25)22-17-8-6-14(7-9-17)16-12-20-21-13-16/h1-9,12-13,18,24H,10-11H2,(H,20,21)(H2,22,23,25) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431135
(CHEMBL2332065)Show SMILES COc1cccc(CN(CCO)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C20H22N4O3/c1-27-19-4-2-3-15(11-19)14-24(9-10-25)20(26)23-18-7-5-16(6-8-18)17-12-21-22-13-17/h2-8,11-13,25H,9-10,14H2,1H3,(H,21,22)(H,23,26) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431145
(CHEMBL2332098)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C20H22N4O2/c1-3-24(14-15-5-4-6-19(11-15)26-2)20(25)23-18-9-7-16(8-10-18)17-12-21-22-13-17/h4-13H,3,14H2,1-2H3,(H,21,22)(H,23,25) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431137
(CHEMBL2332060)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1O[C@H]1CCN(C)C1)-c1cn[nH]c1 |r| Show InChI InChI=1S/C25H31N5O3/c1-4-30(16-18-6-5-7-21(12-18)32-3)25(31)28-23-9-8-19(20-14-26-27-15-20)13-24(23)33-22-10-11-29(2)17-22/h5-9,12-15,22H,4,10-11,16-17H2,1-3H3,(H,26,27)(H,28,31)/t22-/m0/s1 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069134
(CHEMBL3402458)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2N(C)CCN(C)C)-c2cn[nH]c2)c1 Show InChI InChI=1S/C23H30N6O2/c1-28(2)10-11-29(3)22-13-18(19-15-25-26-16-19)8-9-21(22)27-23(30)24-14-17-6-5-7-20(12-17)31-4/h5-9,12-13,15-16H,10-11,14H2,1-4H3,(H,25,26)(H2,24,27,30) | PDB
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069136
(CHEMBL3402460)Show SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2OCCN2CCCC2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O3/c1-29(18-19-6-5-7-22(14-19)32-2)25(31)28-23-9-8-20(21-16-26-27-17-21)15-24(23)33-13-12-30-10-3-4-11-30/h5-9,14-17H,3-4,10-13,18H2,1-2H3,(H,26,27)(H,28,31) | PDB
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431131
(CHEMBL2332056)Show SMILES OCCC(NC(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(F)c1 Show InChI InChI=1S/C19H19FN4O2/c20-16-3-1-2-14(10-16)18(8-9-25)24-19(26)23-17-6-4-13(5-7-17)15-11-21-22-12-15/h1-7,10-12,18,25H,8-9H2,(H,21,22)(H2,23,24,26) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431133
(CHEMBL2332059)Show SMILES CN(C)CCC(NC(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccccc1 Show InChI InChI=1S/C21H25N5O/c1-26(2)13-12-20(17-6-4-3-5-7-17)25-21(27)24-19-10-8-16(9-11-19)18-14-22-23-15-18/h3-11,14-15,20H,12-13H2,1-2H3,(H,22,23)(H2,24,25,27) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431133
(CHEMBL2332059)Show SMILES CN(C)CCC(NC(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccccc1 Show InChI InChI=1S/C21H25N5O/c1-26(2)13-12-20(17-6-4-3-5-7-17)25-21(27)24-19-10-8-16(9-11-19)18-14-22-23-15-18/h3-11,14-15,20H,12-13H2,1-2H3,(H,22,23)(H2,24,25,27) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431131
(CHEMBL2332056)Show SMILES OCCC(NC(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(F)c1 Show InChI InChI=1S/C19H19FN4O2/c20-16-3-1-2-14(10-16)18(8-9-25)24-19(26)23-17-6-4-13(5-7-17)15-11-21-22-12-15/h1-7,10-12,18,25H,8-9H2,(H,21,22)(H2,23,24,26) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431129
(CHEMBL2332076)Show SMILES COc1cccc(c1)C(CCO)NC(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C20H22N4O3/c1-27-18-4-2-3-15(11-18)19(9-10-25)24-20(26)23-17-7-5-14(6-8-17)16-12-21-22-13-16/h2-8,11-13,19,25H,9-10H2,1H3,(H,21,22)(H2,23,24,26) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069209
(CHEMBL3402447)Show InChI InChI=1S/C19H20N4O2/c1-13-18(12-21-23-13)15-6-8-16(9-7-15)22-19(24)20-11-14-4-3-5-17(10-14)25-2/h3-10,12H,11H2,1-2H3,(H,21,23)(H2,20,22,24) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431129
(CHEMBL2332076)Show SMILES COc1cccc(c1)C(CCO)NC(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C20H22N4O3/c1-27-18-4-2-3-15(11-18)19(9-10-25)24-20(26)23-17-7-5-14(6-8-17)16-12-21-22-13-16/h2-8,11-13,19,25H,9-10H2,1H3,(H,21,22)(H2,23,24,26) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431142
(CHEMBL2332058)Show InChI InChI=1S/C18H18N4O2/c23-12-17(14-4-2-1-3-5-14)22-18(24)21-16-8-6-13(7-9-16)15-10-19-20-11-15/h1-11,17,23H,12H2,(H,19,20)(H2,21,22,24) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069305
(CHEMBL3402466)Show InChI InChI=1S/C18H18N4O2/c1-24-17-4-2-3-13(9-17)10-19-18(23)22-16-7-5-14(6-8-16)15-11-20-21-12-15/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069305
(CHEMBL3402466)Show InChI InChI=1S/C18H18N4O2/c1-24-17-4-2-3-13(9-17)10-19-18(23)22-16-7-5-14(6-8-16)15-11-20-21-12-15/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069209
(CHEMBL3402447)Show InChI InChI=1S/C19H20N4O2/c1-13-18(12-21-23-13)15-6-8-16(9-7-15)22-19(24)20-11-14-4-3-5-17(10-14)25-2/h3-10,12H,11H2,1-2H3,(H,21,23)(H2,20,22,24) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431142
(CHEMBL2332058)Show InChI InChI=1S/C18H18N4O2/c23-12-17(14-4-2-1-3-5-14)22-18(24)21-16-8-6-13(7-9-16)15-10-19-20-11-15/h1-11,17,23H,12H2,(H,19,20)(H2,21,22,24) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431126
(CHEMBL2332069)Show SMILES COc1cccc(CN(CCN2CCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H29N5O2/c1-31-23-6-4-5-19(15-23)18-29(14-13-28-11-2-3-12-28)24(30)27-22-9-7-20(8-10-22)21-16-25-26-17-21/h4-10,15-17H,2-3,11-14,18H2,1H3,(H,25,26)(H,27,30) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431141
(CHEMBL2332064)Show SMILES COc1cccc(CN(C(C)C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C21H24N4O2/c1-15(2)25(14-16-5-4-6-20(11-16)27-3)21(26)24-19-9-7-17(8-10-19)18-12-22-23-13-18/h4-13,15H,14H2,1-3H3,(H,22,23)(H,24,26) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431126
(CHEMBL2332069)Show SMILES COc1cccc(CN(CCN2CCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H29N5O2/c1-31-23-6-4-5-19(15-23)18-29(14-13-28-11-2-3-12-28)24(30)27-22-9-7-20(8-10-22)21-16-25-26-17-21/h4-10,15-17H,2-3,11-14,18H2,1H3,(H,25,26)(H,27,30) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431141
(CHEMBL2332064)Show SMILES COc1cccc(CN(C(C)C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C21H24N4O2/c1-15(2)25(14-16-5-4-6-20(11-16)27-3)21(26)24-19-9-7-17(8-10-19)18-12-22-23-13-18/h4-13,15H,14H2,1-3H3,(H,22,23)(H,24,26) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069208
(CHEMBL3402446)Show InChI InChI=1S/C17H15FN4O/c18-15-3-1-2-12(8-15)9-19-17(23)22-16-6-4-13(5-7-16)14-10-20-21-11-14/h1-8,10-11H,9H2,(H,20,21)(H2,19,22,23) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069208
(CHEMBL3402446)Show InChI InChI=1S/C17H15FN4O/c18-15-3-1-2-12(8-15)9-19-17(23)22-16-6-4-13(5-7-16)14-10-20-21-11-14/h1-8,10-11H,9H2,(H,20,21)(H2,19,22,23) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069207
(CHEMBL3402444)Show InChI InChI=1S/C17H17N5O/c18-15-3-1-2-12(8-15)9-19-17(23)22-16-6-4-13(5-7-16)14-10-20-21-11-14/h1-8,10-11H,9,18H2,(H,20,21)(H2,19,22,23) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069207
(CHEMBL3402444)Show InChI InChI=1S/C17H17N5O/c18-15-3-1-2-12(8-15)9-19-17(23)22-16-6-4-13(5-7-16)14-10-20-21-11-14/h1-8,10-11H,9,18H2,(H,20,21)(H2,19,22,23) | PDB
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UniChem
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069138
(CHEMBL3402462)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 Show InChI InChI=1S/C24H31N5O3/c1-5-29(17-18-7-6-8-21(13-18)31-4)24(30)27-22-10-9-19(20-15-25-26-16-20)14-23(22)32-12-11-28(2)3/h6-10,13-16H,5,11-12,17H2,1-4H3,(H,25,26)(H,27,30) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069138
(CHEMBL3402462)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 Show InChI InChI=1S/C24H31N5O3/c1-5-29(17-18-7-6-8-21(13-18)31-4)24(30)27-22-10-9-19(20-15-25-26-16-20)14-23(22)32-12-11-28(2)3/h6-10,13-16H,5,11-12,17H2,1-4H3,(H,25,26)(H,27,30) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431139
(CHEMBL2332074)Show SMILES COc1cccc(CN(CCCN2CCCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C26H33N5O2/c1-33-25-8-5-7-21(17-25)20-31(16-6-15-30-13-3-2-4-14-30)26(32)29-24-11-9-22(10-12-24)23-18-27-28-19-23/h5,7-12,17-19H,2-4,6,13-16,20H2,1H3,(H,27,28)(H,29,32) | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431140
(CHEMBL2332072)Show SMILES COc1cccc(CN(CCCN2CCOCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O3/c1-32-24-5-2-4-20(16-24)19-30(11-3-10-29-12-14-33-15-13-29)25(31)28-23-8-6-21(7-9-23)22-17-26-27-18-22/h2,4-9,16-18H,3,10-15,19H2,1H3,(H,26,27)(H,28,31) | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431139
(CHEMBL2332074)Show SMILES COc1cccc(CN(CCCN2CCCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C26H33N5O2/c1-33-25-8-5-7-21(17-25)20-31(16-6-15-30-13-3-2-4-14-30)26(32)29-24-11-9-22(10-12-24)23-18-27-28-19-23/h5,7-12,17-19H,2-4,6,13-16,20H2,1H3,(H,27,28)(H,29,32) | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431140
(CHEMBL2332072)Show SMILES COc1cccc(CN(CCCN2CCOCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O3/c1-32-24-5-2-4-20(16-24)19-30(11-3-10-29-12-14-33-15-13-29)25(31)28-23-8-6-21(7-9-23)22-17-26-27-18-22/h2,4-9,16-18H,3,10-15,19H2,1H3,(H,26,27)(H,28,31) | PDB
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PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431124
(CHEMBL2332073)Show SMILES COc1cccc(CN(CCN2CCCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O2/c1-32-24-7-5-6-20(16-24)19-30(15-14-29-12-3-2-4-13-29)25(31)28-23-10-8-21(9-11-23)22-17-26-27-18-22/h5-11,16-18H,2-4,12-15,19H2,1H3,(H,26,27)(H,28,31) | PDB
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PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431136
(CHEMBL2332070)Show SMILES COc1cccc(CN(CCCN2CCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O2/c1-32-24-7-4-6-20(16-24)19-30(15-5-14-29-12-2-3-13-29)25(31)28-23-10-8-21(9-11-23)22-17-26-27-18-22/h4,6-11,16-18H,2-3,5,12-15,19H2,1H3,(H,26,27)(H,28,31) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069178
(CHEMBL3402448)Show InChI InChI=1S/C20H19N3O2/c1-25-19-4-2-3-15(13-19)14-22-20(24)23-18-7-5-16(6-8-18)17-9-11-21-12-10-17/h2-13H,14H2,1H3,(H2,22,23,24) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069178
(CHEMBL3402448)Show InChI InChI=1S/C20H19N3O2/c1-25-19-4-2-3-15(13-19)14-22-20(24)23-18-7-5-16(6-8-18)17-9-11-21-12-10-17/h2-13H,14H2,1H3,(H2,22,23,24) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431124
(CHEMBL2332073)Show SMILES COc1cccc(CN(CCN2CCCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O2/c1-32-24-7-5-6-20(16-24)19-30(15-14-29-12-3-2-4-13-29)25(31)28-23-10-8-21(9-11-23)22-17-26-27-18-22/h5-11,16-18H,2-4,12-15,19H2,1H3,(H,26,27)(H,28,31) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431136
(CHEMBL2332070)Show SMILES COc1cccc(CN(CCCN2CCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C25H31N5O2/c1-32-24-7-4-6-20(16-24)19-30(15-5-14-29-12-2-3-13-29)25(31)28-23-10-8-21(9-11-23)22-17-26-27-18-22/h4,6-11,16-18H,2-3,5,12-15,19H2,1H3,(H,26,27)(H,28,31) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069185
(CHEMBL3402473)Show SMILES CN(C)CCSc1cc(ccc1NC(=O)NCc1ccccc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H25N5OS/c1-26(2)10-11-28-20-12-17(18-14-23-24-15-18)8-9-19(20)25-21(27)22-13-16-6-4-3-5-7-16/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,23,24)(H2,22,25,27) | PDB
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UniChem
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PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069140
(CHEMBL3402464)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1N(C)CCN(C)C)-c1cn[nH]c1 Show InChI InChI=1S/C25H34N6O2/c1-6-31(18-19-8-7-9-22(14-19)33-5)25(32)28-23-11-10-20(21-16-26-27-17-21)15-24(23)30(4)13-12-29(2)3/h7-11,14-17H,6,12-13,18H2,1-5H3,(H,26,27)(H,28,32) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069140
(CHEMBL3402464)Show SMILES CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1N(C)CCN(C)C)-c1cn[nH]c1 Show InChI InChI=1S/C25H34N6O2/c1-6-31(18-19-8-7-9-22(14-19)33-5)25(32)28-23-11-10-20(21-16-26-27-17-21)15-24(23)30(4)13-12-29(2)3/h7-11,14-17H,6,12-13,18H2,1-5H3,(H,26,27)(H,28,32) | PDB
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069184
(CHEMBL3402475)Show SMILES CC(C)N(Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C20H22N4O/c1-15(2)24(14-16-6-4-3-5-7-16)20(25)23-19-10-8-17(9-11-19)18-12-21-22-13-18/h3-13,15H,14H2,1-2H3,(H,21,22)(H,23,25) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069137
(CHEMBL3402461)Show SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2N(C)CCN(C)C)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H32N6O2/c1-28(2)11-12-29(3)23-14-19(20-15-25-26-16-20)9-10-22(23)27-24(31)30(4)17-18-7-6-8-21(13-18)32-5/h6-10,13-16H,11-12,17H2,1-5H3,(H,25,26)(H,27,31) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069137
(CHEMBL3402461)Show SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2N(C)CCN(C)C)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H32N6O2/c1-28(2)11-12-29(3)23-14-19(20-15-25-26-16-20)9-10-22(23)27-24(31)30(4)17-18-7-6-8-21(13-18)32-5/h6-10,13-16H,11-12,17H2,1-5H3,(H,25,26)(H,27,31) | PDB
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069306
(CHEMBL3402474)Show SMILES CN(C)CCN(C)c1cc(ccc1NC(=O)NCc1ccccc1)-c1cn[nH]c1 Show InChI InChI=1S/C22H28N6O/c1-27(2)11-12-28(3)21-13-18(19-15-24-25-16-19)9-10-20(21)26-22(29)23-14-17-7-5-4-6-8-17/h4-10,13,15-16H,11-12,14H2,1-3H3,(H,24,25)(H2,23,26,29) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431128
(CHEMBL2331562)Show InChI InChI=1S/C19H20N4O2/c24-11-10-23(14-15-4-2-1-3-5-15)19(25)22-18-8-6-16(7-9-18)17-12-20-21-13-17/h1-9,12-13,24H,10-11,14H2,(H,20,21)(H,22,25) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431128
(CHEMBL2331562)Show InChI InChI=1S/C19H20N4O2/c24-11-10-23(14-15-4-2-1-3-5-15)19(25)22-18-8-6-16(7-9-18)17-12-20-21-13-17/h1-9,12-13,24H,10-11,14H2,(H,20,21)(H,22,25) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431127
(CHEMBL2332071)Show SMILES COc1cccc(CN(CCN2CCOCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H29N5O3/c1-31-23-4-2-3-19(15-23)18-29(10-9-28-11-13-32-14-12-28)24(30)27-22-7-5-20(6-8-22)21-16-25-26-17-21/h2-8,15-17H,9-14,18H2,1H3,(H,25,26)(H,27,30) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431127
(CHEMBL2332071)Show SMILES COc1cccc(CN(CCN2CCOCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H29N5O3/c1-31-23-4-2-3-19(15-23)18-29(10-9-28-11-13-32-14-12-28)24(30)27-22-7-5-20(6-8-22)21-16-25-26-17-21/h2-8,15-17H,9-14,18H2,1H3,(H,25,26)(H,27,30) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069210
(CHEMBL3402449)Show InChI InChI=1S/C19H19N5O2/c1-26-16-4-2-3-13(11-16)12-22-19(25)23-15-7-5-14(6-8-15)17-9-10-21-18(20)24-17/h2-11H,12H2,1H3,(H2,20,21,24)(H2,22,23,25) | PDB
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PC sid
UniChem
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PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069210
(CHEMBL3402449)Show InChI InChI=1S/C19H19N5O2/c1-26-16-4-2-3-13(11-16)12-22-19(25)23-15-7-5-14(6-8-15)17-9-10-21-18(20)24-17/h2-11H,12H2,1H3,(H2,20,21,24)(H2,22,23,25) | PDB
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UniChem
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PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431125
(CHEMBL2332075)Show SMILES OCCN(Cc1ccccc1)C(=O)Nc1ccc(cc1F)-c1cn[nH]c1 Show InChI InChI=1S/C19H19FN4O2/c20-17-10-15(16-11-21-22-12-16)6-7-18(17)23-19(26)24(8-9-25)13-14-4-2-1-3-5-14/h1-7,10-12,25H,8-9,13H2,(H,21,22)(H,23,26) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431125
(CHEMBL2332075)Show SMILES OCCN(Cc1ccccc1)C(=O)Nc1ccc(cc1F)-c1cn[nH]c1 Show InChI InChI=1S/C19H19FN4O2/c20-17-10-15(16-11-21-22-12-16)6-7-18(17)23-19(26)24(8-9-25)13-14-4-2-1-3-5-14/h1-7,10-12,25H,8-9,13H2,(H,21,22)(H,23,26) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069182
(CHEMBL3402445)Show InChI InChI=1S/C17H15ClN4O/c18-15-3-1-2-12(8-15)9-19-17(23)22-16-6-4-13(5-7-16)14-10-20-21-11-14/h1-8,10-11H,9H2,(H,20,21)(H2,19,22,23) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431123
(CHEMBL2332066)Show SMILES COCCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H24N4O3/c1-27-11-10-25(15-16-4-3-5-20(12-16)28-2)21(26)24-19-8-6-17(7-9-19)18-13-22-23-14-18/h3-9,12-14H,10-11,15H2,1-2H3,(H,22,23)(H,24,26) | PDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069182
(CHEMBL3402445)Show InChI InChI=1S/C17H15ClN4O/c18-15-3-1-2-12(8-15)9-19-17(23)22-16-6-4-13(5-7-16)14-10-20-21-11-14/h1-8,10-11H,9H2,(H,20,21)(H2,19,22,23) | PDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431123
(CHEMBL2332066)Show SMILES COCCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C21H24N4O3/c1-27-11-10-25(15-16-4-3-5-20(12-16)28-2)21(26)24-19-8-6-17(7-9-19)18-13-22-23-14-18/h3-9,12-14H,10-11,15H2,1-2H3,(H,22,23)(H,24,26) | PDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069303
(CHEMBL3402465)Show InChI InChI=1S/C17H16N4O/c22-17(18-10-13-4-2-1-3-5-13)21-16-8-6-14(7-9-16)15-11-19-20-12-15/h1-9,11-12H,10H2,(H,19,20)(H2,18,21,22) | PDB
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UniChem
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PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069303
(CHEMBL3402465)Show InChI InChI=1S/C17H16N4O/c22-17(18-10-13-4-2-1-3-5-13)21-16-8-6-14(7-9-16)15-11-19-20-12-15/h1-9,11-12H,10H2,(H,19,20)(H2,18,21,22) | PDB
MMDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069187
(CHEMBL3402441)Show InChI InChI=1S/C18H18N4O2/c1-24-17-5-3-2-4-14(17)10-19-18(23)22-16-8-6-13(7-9-16)15-11-20-21-12-15/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069187
(CHEMBL3402441)Show InChI InChI=1S/C18H18N4O2/c1-24-17-5-3-2-4-14(17)10-19-18(23)22-16-8-6-13(7-9-16)15-11-20-21-12-15/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069188
(CHEMBL3402443)Show InChI InChI=1S/C18H18N4O/c1-13-3-2-4-14(9-13)10-19-18(23)22-17-7-5-15(6-8-17)16-11-20-21-12-16/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069188
(CHEMBL3402443)Show InChI InChI=1S/C18H18N4O/c1-13-3-2-4-14(9-13)10-19-18(23)22-17-7-5-15(6-8-17)16-11-20-21-12-16/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069211
(CHEMBL3402450)Show InChI InChI=1S/C20H20N4O2/c1-26-18-4-2-3-14(11-18)13-23-20(25)24-17-7-5-15(6-8-17)16-9-10-22-19(21)12-16/h2-12H,13H2,1H3,(H2,21,22)(H2,23,24,25) | PDB
MMDB
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069211
(CHEMBL3402450)Show InChI InChI=1S/C20H20N4O2/c1-26-18-4-2-3-14(11-18)13-23-20(25)24-17-7-5-15(6-8-17)16-9-10-22-19(21)12-16/h2-12H,13H2,1H3,(H2,21,22)(H2,23,24,25) | PDB
MMDB
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069308
(CHEMBL3402467)Show InChI InChI=1S/C12H14N4O/c1-13-12(17)16(2)11-5-3-9(4-6-11)10-7-14-15-8-10/h3-8H,1-2H3,(H,13,17)(H,14,15) | PDB
MMDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069308
(CHEMBL3402467)Show InChI InChI=1S/C12H14N4O/c1-13-12(17)16(2)11-5-3-9(4-6-11)10-7-14-15-8-10/h3-8H,1-2H3,(H,13,17)(H,14,15) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431163
(CHEMBL2332078)Show InChI InChI=1S/C18H18N4O/c23-18(19-11-10-14-4-2-1-3-5-14)22-17-8-6-15(7-9-17)16-12-20-21-13-16/h1-9,12-13H,10-11H2,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431163
(CHEMBL2332078)Show InChI InChI=1S/C18H18N4O/c23-18(19-11-10-14-4-2-1-3-5-14)22-17-8-6-15(7-9-17)16-12-20-21-13-16/h1-9,12-13H,10-11H2,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069186
(CHEMBL3402472)Show SMILES CN(C)CCOc1cc(ccc1NC(=O)N(CCN(C)C)Cc1ccccc1)-c1cn[nH]c1 Show InChI InChI=1S/C25H34N6O2/c1-29(2)12-13-31(19-20-8-6-5-7-9-20)25(32)28-23-11-10-21(22-17-26-27-18-22)16-24(23)33-15-14-30(3)4/h5-11,16-18H,12-15,19H2,1-4H3,(H,26,27)(H,28,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069186
(CHEMBL3402472)Show SMILES CN(C)CCOc1cc(ccc1NC(=O)N(CCN(C)C)Cc1ccccc1)-c1cn[nH]c1 Show InChI InChI=1S/C25H34N6O2/c1-29(2)12-13-31(19-20-8-6-5-7-9-20)25(32)28-23-11-10-21(22-17-26-27-18-22)16-24(23)33-15-14-30(3)4/h5-11,16-18H,12-15,19H2,1-4H3,(H,26,27)(H,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069142
(CHEMBL3402451)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2)C2=NC=NC3NC=CC23)c1 |c:21,25,t:19| Show InChI InChI=1S/C21H21N5O2/c1-28-17-4-2-3-14(11-17)12-23-21(27)26-16-7-5-15(6-8-16)19-18-9-10-22-20(18)25-13-24-19/h2-11,13,18,20,22H,12H2,1H3,(H2,23,26,27) | PDB
MMDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 188 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069142
(CHEMBL3402451)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2)C2=NC=NC3NC=CC23)c1 |c:21,25,t:19| Show InChI InChI=1S/C21H21N5O2/c1-28-17-4-2-3-14(11-17)12-23-21(27)26-16-7-5-15(6-8-16)19-18-9-10-22-20(18)25-13-24-19/h2-11,13,18,20,22H,12H2,1H3,(H2,23,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 188 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431161
(CHEMBL2332085)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1OC Show InChI InChI=1S/C19H20N4O3/c1-25-17-5-3-4-14(18(17)26-2)10-20-19(24)23-16-8-6-13(7-9-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431161
(CHEMBL2332085)Show SMILES COc1cccc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1OC Show InChI InChI=1S/C19H20N4O3/c1-25-17-5-3-4-14(18(17)26-2)10-20-19(24)23-16-8-6-13(7-9-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431160
(CHEMBL2332083)Show InChI InChI=1S/C19H18N4O/c24-19(23-10-9-14-3-1-2-4-16(14)13-23)22-18-7-5-15(6-8-18)17-11-20-21-12-17/h1-8,11-12H,9-10,13H2,(H,20,21)(H,22,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431160
(CHEMBL2332083)Show InChI InChI=1S/C19H18N4O/c24-19(23-10-9-14-3-1-2-4-16(14)13-23)22-18-7-5-15(6-8-18)17-11-20-21-12-17/h1-8,11-12H,9-10,13H2,(H,20,21)(H,22,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431159
(CHEMBL2332090)Show SMILES COc1cc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)cc(OC)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-7-13(8-18(9-17)26-2)10-20-19(24)23-16-5-3-14(4-6-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 281 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431159
(CHEMBL2332090)Show SMILES COc1cc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)cc(OC)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-7-13(8-18(9-17)26-2)10-20-19(24)23-16-5-3-14(4-6-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 281 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431157
(CHEMBL2332086)Show SMILES COc1ccc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)c(OC)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-8-5-14(18(9-17)26-2)10-20-19(24)23-16-6-3-13(4-7-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 331 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431157
(CHEMBL2332086)Show SMILES COc1ccc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)c(OC)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-8-5-14(18(9-17)26-2)10-20-19(24)23-16-6-3-13(4-7-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 331 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431156
(CHEMBL2332091)Show InChI InChI=1S/C18H17FN4O2/c1-25-17-7-2-12(8-16(17)19)9-20-18(24)23-15-5-3-13(4-6-15)14-10-21-22-11-14/h2-8,10-11H,9H2,1H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 357 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431156
(CHEMBL2332091)Show InChI InChI=1S/C18H17FN4O2/c1-25-17-7-2-12(8-16(17)19)9-20-18(24)23-15-5-3-13(4-6-15)14-10-21-22-11-14/h2-8,10-11H,9H2,1H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 357 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431155
(CHEMBL2332089)Show SMILES COc1ccc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)cc1OC Show InChI InChI=1S/C19H20N4O3/c1-25-17-8-3-13(9-18(17)26-2)10-20-19(24)23-16-6-4-14(5-7-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
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B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 425 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431155
(CHEMBL2332089)Show SMILES COc1ccc(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)cc1OC Show InChI InChI=1S/C19H20N4O3/c1-25-17-8-3-13(9-18(17)26-2)10-20-19(24)23-16-6-4-14(5-7-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 425 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431154
(CHEMBL2332087)Show SMILES COc1ccc(OC)c(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-7-8-18(26-2)14(9-17)10-20-19(24)23-16-5-3-13(4-6-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431154
(CHEMBL2332087)Show SMILES COc1ccc(OC)c(CNC(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-7-8-18(26-2)14(9-17)10-20-19(24)23-16-5-3-13(4-6-16)15-11-21-22-12-15/h3-9,11-12H,10H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431152
(CHEMBL2332084)Show InChI InChI=1S/C17H22N4O/c22-17(18-10-13-4-2-1-3-5-13)21-16-8-6-14(7-9-16)15-11-19-20-12-15/h6-9,11-13H,1-5,10H2,(H,19,20)(H2,18,21,22) | PDB
MMDB
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 751 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069304
(CHEMBL3402468)Show InChI InChI=1S/C13H16N4O2/c1-14-13(19)17(6-7-18)12-4-2-10(3-5-12)11-8-15-16-9-11/h2-5,8-9,18H,6-7H2,1H3,(H,14,19)(H,15,16) | PDB
MMDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 751 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431152
(CHEMBL2332084)Show InChI InChI=1S/C17H22N4O/c22-17(18-10-13-4-2-1-3-5-13)21-16-8-6-14(7-9-16)15-11-19-20-12-15/h6-9,11-13H,1-5,10H2,(H,19,20)(H2,18,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 752 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069304
(CHEMBL3402468)Show InChI InChI=1S/C13H16N4O2/c1-14-13(19)17(6-7-18)12-4-2-10(3-5-12)11-8-15-16-9-11/h2-5,8-9,18H,6-7H2,1H3,(H,14,19)(H,15,16) | PDB
MMDB
KEGG
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B.MOAD
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 752 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431151
(CHEMBL2332088)Show SMILES COc1cccc(OC)c1CNC(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-4-3-5-18(26-2)16(17)12-20-19(24)23-15-8-6-13(7-9-15)14-10-21-22-11-14/h3-11H,12H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
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B.MOAD
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 924 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431151
(CHEMBL2332088)Show SMILES COc1cccc(OC)c1CNC(=O)Nc1ccc(cc1)-c1cn[nH]c1 Show InChI InChI=1S/C19H20N4O3/c1-25-17-4-3-5-18(26-2)16(17)12-20-19(24)23-15-8-6-13(7-9-15)14-10-21-22-11-14/h3-11H,12H2,1-2H3,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 925 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431150
(CHEMBL2332079)Show InChI InChI=1S/C19H20N4O/c24-19(20-12-4-7-15-5-2-1-3-6-15)23-18-10-8-16(9-11-18)17-13-21-22-14-17/h1-3,5-6,8-11,13-14H,4,7,12H2,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50431150
(CHEMBL2332079)Show InChI InChI=1S/C19H20N4O/c24-19(20-12-4-7-15-5-2-1-3-6-15)23-18-10-8-16(9-11-18)17-13-21-22-14-17/h1-3,5-6,8-11,13-14H,4,7,12H2,(H,21,22)(H2,20,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069183
(CHEMBL3402442)Show InChI InChI=1S/C18H18N4O2/c1-24-17-8-2-13(3-9-17)10-19-18(23)22-16-6-4-14(5-7-16)15-11-20-21-12-15/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069183
(CHEMBL3402442)Show InChI InChI=1S/C18H18N4O2/c1-24-17-8-2-13(3-9-17)10-19-18(23)22-16-6-4-14(5-7-16)15-11-20-21-12-15/h2-9,11-12H,10H2,1H3,(H,20,21)(H2,19,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069141
(CHEMBL3402469)Show InChI InChI=1S/C15H21N5O/c1-16-15(21)20(9-8-19(2)3)14-6-4-12(5-7-14)13-10-17-18-11-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,21)(H,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069141
(CHEMBL3402469)Show InChI InChI=1S/C15H21N5O/c1-16-15(21)20(9-8-19(2)3)14-6-4-12(5-7-14)13-10-17-18-11-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,21)(H,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069302
(CHEMBL3402470)Show InChI InChI=1S/C16H23N5O/c1-17-16(22)21(10-4-9-20(2)3)15-7-5-13(6-8-15)14-11-18-19-12-14/h5-8,11-12H,4,9-10H2,1-3H3,(H,17,22)(H,18,19) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 3.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50069302
(CHEMBL3402470)Show InChI InChI=1S/C16H23N5O/c1-17-16(22)21(10-4-9-20(2)3)15-7-5-13(6-8-15)14-11-18-19-12-14/h5-8,11-12H,4,9-10H2,1-3H3,(H,17,22)(H,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Technology
Curated by ChEMBL
| Assay Description
Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF mode |
Bioorg Med Chem 23: 2505-17 (2015)
Article DOI: 10.1016/j.bmc.2015.03.047
BindingDB Entry DOI: 10.7270/Q2ZP47SX |
More data for this
Ligand-Target Pair | |
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