Affinity Data by PubMed id=26985305

PubMed code 26985305

Found 34 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50265275 (4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...) Show SMILES Ic1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169081 (CHEMBL3806220) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50265311 (4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...) Show SMILES Clc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169082 (CHEMBL3805960) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169062 (CHEMBL3805194) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(N)c2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50265309 (2-(2H-tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]py...) Show SMILES Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169080 (CHEMBL3806173) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169078 (CHEMBL3804919) Show SMILES OC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50264866 (4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169079 (CHEMBL3805857) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105215 (4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...) Show SMILES NC(=O)c1cc2c(Oc3ccc(cc3)C#N)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169071 (CHEMBL3806024) Show SMILES CNC(=O)c1cc2c(Oc3ccc(I)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM50169083 (CHEMBL3805667) Show SMILES Fc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105170 (4-p-Tolyloxy-thieno[2,3-c]pyridine-2-carboxylic ac...) Show SMILES Cc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105181 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169064 (CHEMBL3806134) Show SMILES Cc1ncc(Oc2ccc(Cl)cc2)c2cc(sc12)C(N)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105159 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES CNC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50265277 (4-phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin...) Show SMILES O(c1ccccc1)c1cncc2sc(cc12)-c1nnn[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169067 (CHEMBL3805684) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(Cl)c2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169070 (CHEMBL3806182) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169068 (CHEMBL3806291) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(F)c2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105153 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES CCNC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169069 (CHEMBL3806265) Show SMILES NC(=O)c1cc2c(Oc3ccc(cc3)C(N)=O)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169076 (CHEMBL3806114) Show SMILES Clc1ccc(Oc2cncc3sc(cc23)C(=O)NC2CC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105218 (4-(4-Methoxy-phenoxy)-thieno[2,3-c]pyridine-2-carb...) Show SMILES COc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169073 (CHEMBL3805204) Show SMILES CCC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105206 (4-(4-Acetylamino-phenoxy)-thieno[2,3-c]pyridine-2-...) Show SMILES CC(=O)Nc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169074 (CHEMBL3806037) Show SMILES CC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169072 (CHEMBL3806125) Show SMILES Clc1ccc(Oc2cncc3sc(cc23)C(=O)C2CC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169077 (CHEMBL3805018) Show SMILES COC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105152 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES CN(C)C(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169075 (CHEMBL3805581) Show SMILES CC(C)NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50169062 (CHEMBL3805194) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(N)c2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK9/Cyclin T expressed in baculovirus expression system using Cdk7/9tide as substrate by adap...				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50105181 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK9/Cyclin T expressed in baculovirus expression system using Cdk7/9tide as substrate by adap...				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
Genentech, Inc Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%