Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of hypotonic solution-induced calcium mobilization by F... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195055
(CHEMBL3954949)Show SMILES CC1CCCC(C)N1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 Show InChI InChI=1S/C21H25N5OS2/c1-12-6-5-7-13(2)26(12)20(27)16-8-9-18(22-10-16)25-21-24-17(11-28-21)19-14(3)23-15(4)29-19/h8-13H,5-7H2,1-4H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195058
(CHEMBL3979286)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)Nc2ccc(Cl)cc2)n1 Show InChI InChI=1S/C20H16ClN5OS2/c1-11-18(29-12(2)23-11)16-10-28-20(25-16)26-17-8-3-13(9-22-17)19(27)24-15-6-4-14(21)5-7-15/h3-10H,1-2H3,(H,24,27)(H,22,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM65888
((2',4'-Dimethyl-[4,5']bithiazolyl-2-yl...)Show InChI InChI=1S/C13H12N4S2/c1-8-12(19-9(2)15-8)10-7-18-13(16-10)17-11-5-3-4-6-14-11/h3-7H,1-2H3,(H,14,16,17) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195059
(CHEMBL3932523)Show InChI InChI=1S/C16H16N4O2S2/c1-4-22-15(21)11-5-6-13(17-7-11)20-16-19-12(8-23-16)14-9(2)18-10(3)24-14/h5-8H,4H2,1-3H3,(H,17,19,20) | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195141
(CHEMBL3900585)Show InChI InChI=1S/C14H11N5S2/c1-8-13(21-9(2)17-8)11-7-20-14(18-11)19-12-4-3-10(5-15)6-16-12/h3-4,6-7H,1-2H3,(H,16,18,19) | PDB
UniProtKB/SwissProt
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PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195142
(CHEMBL3925315)Show InChI InChI=1S/C14H14N4OS2/c1-8-13(21-9(2)15-8)10-7-20-14(16-10)18-11-5-4-6-12(17-11)19-3/h4-7H,1-3H3,(H,16,17,18) | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192802
(CHEMBL3927993)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O2S2/c1-11-19(30-12(2)23-11)17-10-29-21(24-17)25-18-6-3-13(9-22-18)20(28)26-14-4-5-15(26)8-16(27)7-14/h3,6,9-10,14-15H,4-5,7-8H2,1-2H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195056
(CHEMBL3975583)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)NC2CCCCC2)n1 Show InChI InChI=1S/C20H23N5OS2/c1-12-18(28-13(2)22-12)16-11-27-20(24-16)25-17-9-8-14(10-21-17)19(26)23-15-6-4-3-5-7-15/h8-11,15H,3-7H2,1-2H3,(H,23,26)(H,21,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195092
(CHEMBL3977499)Show InChI InChI=1S/C14H13N3S2/c1-9-13(19-10(2)15-9)12-8-18-14(17-12)16-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,16,17) | PDB
UniProtKB/SwissProt
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CHEMBL
MCE
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| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195220
(CHEMBL424708)Show InChI InChI=1S/C14H12BrN3S2/c1-8-13(20-9(2)16-8)12-7-19-14(18-12)17-11-5-3-10(15)4-6-11/h3-7H,1-2H3,(H,17,18) | PDB
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CHEMBL
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195061
(CHEMBL3944251)Show InChI InChI=1S/C14H14N4OS2/c1-8-13(21-9(2)16-8)11-7-20-14(17-11)18-12-5-4-10(19-3)6-15-12/h4-7H,1-3H3,(H,15,17,18) | PDB
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UniChem
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PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195139
(CHEMBL3946266)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2CCCCC2)n1 Show InChI InChI=1S/C19H21N5OS2/c1-12-17(27-13(2)21-12)15-11-26-19(22-15)23-16-7-6-14(10-20-16)18(25)24-8-4-3-5-9-24/h6-7,10-11H,3-5,8-9H2,1-2H3,(H,20,22,23) | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
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| Article
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50194946
(CHEMBL3900878)Show SMILES CC1CC(=O)CC(C)N1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 Show InChI InChI=1S/C21H23N5O2S2/c1-11-7-16(27)8-12(2)26(11)20(28)15-5-6-18(22-9-15)25-21-24-17(10-29-21)19-13(3)23-14(4)30-19/h5-6,9-12H,7-8H2,1-4H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195137
(CHEMBL3971104)Show SMILES CN(C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H18ClN5OS2/c1-12-19(30-13(2)24-12)17-11-29-21(25-17)26-18-9-4-14(10-23-18)20(28)27(3)16-7-5-15(22)6-8-16/h4-11H,1-3H3,(H,23,25,26) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192821
(CHEMBL2133556)Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33) | PDB
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Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50194948
(CHEMBL3960032)Show InChI InChI=1S/C14H11N5S2/c1-8-13(21-9(2)16-8)11-7-20-14(18-11)19-12-5-3-4-10(6-15)17-12/h3-5,7H,1-2H3,(H,17,18,19) | PDB
UniProtKB/SwissProt
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UniChem
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| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195057
(CHEMBL3950242)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)NCc2ccc(Cl)cc2)n1 Show InChI InChI=1S/C21H18ClN5OS2/c1-12-19(30-13(2)25-12)17-11-29-21(26-17)27-18-8-5-15(10-23-18)20(28)24-9-14-3-6-16(22)7-4-14/h3-8,10-11H,9H2,1-2H3,(H,24,28)(H,23,26,27) | PDB
UniProtKB/SwissProt
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UniChem
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| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195221
(CHEMBL3971734)Show InChI InChI=1S/C14H11N5S2/c1-8-13(21-9(2)17-8)11-7-20-14(18-11)19-12-5-10(6-15)3-4-16-12/h3-5,7H,1-2H3,(H,16,18,19) | PDB
UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50194949
(CHEMBL3898828)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(NS(=O)(=O)c3ccc(Cl)cc3)cn2)n1 Show InChI InChI=1S/C19H16ClN5O2S3/c1-11-18(29-12(2)22-11)16-10-28-19(23-16)24-17-8-5-14(9-21-17)25-30(26,27)15-6-3-13(20)4-7-15/h3-10,25H,1-2H3,(H,21,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50194947
(CHEMBL3970031)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)S(=O)(=O)Nc2ccc(Cl)cc2)n1 Show InChI InChI=1S/C19H16ClN5O2S3/c1-11-18(29-12(2)22-11)16-10-28-19(23-16)24-17-8-7-15(9-21-17)30(26,27)25-14-5-3-13(20)4-6-14/h3-10,25H,1-2H3,(H,21,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195062
(CHEMBL3916322)Show InChI InChI=1S/C14H14N4OS2/c1-8-13(21-9(2)16-8)11-7-20-14(17-11)18-12-6-10(19-3)4-5-15-12/h4-7H,1-3H3,(H,15,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195054
(CHEMBL1374508)Show InChI InChI=1S/C13H12N4S2/c1-8-12(19-9(2)15-8)11-7-18-13(17-11)16-10-4-3-5-14-6-10/h3-7H,1-2H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195053
(CHEMBL3983567)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2CCC(=O)CC2)n1 Show InChI InChI=1S/C19H19N5O2S2/c1-11-17(28-12(2)21-11)15-10-27-19(22-15)23-16-4-3-13(9-20-16)18(26)24-7-5-14(25)6-8-24/h3-4,9-10H,5-8H2,1-2H3,(H,20,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Rattus norvegicus) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 300 nM 4alphaPDD-induced calcium mobilization by FLIPR... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195063
(CHEMBL3948261)Show InChI InChI=1S/C13H12N4S2/c1-8-12(19-9(2)15-8)11-7-18-13(17-11)16-10-3-5-14-6-4-10/h3-7H,1-2H3,(H,14,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195060
(CHEMBL3953003)Show InChI InChI=1S/C14H11N5S2/c1-8-12(21-9(2)17-8)11-7-20-14(18-11)19-13-10(6-15)4-3-5-16-13/h3-5,7H,1-2H3,(H,16,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195052
(CHEMBL3919377)Show InChI InChI=1S/C12H11N5S2/c1-7-10(19-8(2)15-7)9-6-18-12(16-9)17-11-13-4-3-5-14-11/h3-6H,1-2H3,(H,13,14,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195051
(CHEMBL3941505)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(NC(=O)c3ccc(Cl)cc3)cn2)n1 Show InChI InChI=1S/C20H16ClN5OS2/c1-11-18(29-12(2)23-11)16-10-28-20(25-16)26-17-8-7-15(9-22-17)24-19(27)13-3-5-14(21)6-4-13/h3-10H,1-2H3,(H,24,27)(H,22,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as blockade of 100 nM capsaicin-induced calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195136
(CHEMBL3972736)Show InChI InChI=1S/C14H14N4OS2/c1-8-12(21-9(2)16-8)10-7-20-14(17-10)18-13-11(19-3)5-4-6-15-13/h4-7H,1-3H3,(H,15,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195140
(CHEMBL3923579)Show InChI InChI=1S/C16H17N5OS2/c1-4-17-15(22)11-5-6-13(18-7-11)21-16-20-12(8-23-16)14-9(2)19-10(3)24-14/h5-8H,4H2,1-3H3,(H,17,22)(H,18,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50195064
(CHEMBL3951293)Show InChI InChI=1S/C14H12N4O2S2/c1-7-12(22-8(2)16-7)10-6-21-14(17-10)18-11-4-3-9(5-15-11)13(19)20/h3-6H,1-2H3,(H,19,20)(H,15,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this
Ligand-Target Pair | |
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