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PubMed code 8784448

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052869
PNG
((R)-6-Methyl-11-phenyl-5,6,6a,7-tetrahydro-4H-dibe...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(-c2ccccc2)c-31
Show InChI InChI=1S/C23H21N/c1-24-14-13-17-9-5-12-20-22-18(15-21(24)23(17)20)10-6-11-19(22)16-7-3-2-4-8-16/h2-12,21H,13-15H2,1H3/t21-/m1/s1
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 1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052864
PNG
((R)-11-Ethyl-6-methyl-5,6,6a,7-tetrahydro-4H-diben...)
Show SMILES CCc1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C19H21N/c1-3-13-6-4-8-15-12-17-19-14(10-11-20(17)2)7-5-9-16(19)18(13)15/h4-9,17H,3,10-12H2,1-2H3/t17-/m1/s1
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 4.5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016007
PNG
((R)-11-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES COc1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C18H19NO/c1-19-10-9-12-5-3-7-14-17(12)15(19)11-13-6-4-8-16(20-2)18(13)14/h3-8,15H,9-11H2,1-2H3/t15-/m1/s1
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 5.10n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052873
PNG
((R)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1...)
Show SMILES Oc1cccc2C[C@H]3NCCc4cccc(c34)-c12
Show InChI InChI=1S/C16H15NO/c18-14-6-2-4-11-9-13-15-10(7-8-17-13)3-1-5-12(15)16(11)14/h1-6,13,17-18H,7-9H2/t13-/m1/s1
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 5.70n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052863
PNG
((R)-6-Methyl-11-vinyl-5,6,6a,7-tetrahydro-4H-diben...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C=C)c-31
Show InChI InChI=1S/C19H19N/c1-3-13-6-4-8-15-12-17-19-14(10-11-20(17)2)7-5-9-16(19)18(13)15/h3-9,17H,1,10-12H2,2H3/t17-/m1/s1
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 6n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052875
PNG
(CHEMBL333836 | Trifluoro-methanesulfonic acid (R)-...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c-31
Show InChI InChI=1S/C18H16F3NO3S/c1-22-9-8-11-4-2-6-13-16(11)14(22)10-12-5-3-7-15(17(12)13)25-26(23,24)18(19,20)21/h2-7,14H,8-10H2,1H3/t14-/m1/s1
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 7.70n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052871
PNG
((R)-11-Methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES COc1cccc2C[C@H]3NCCc4cccc(c34)-c12
Show InChI InChI=1S/C17H17NO/c1-19-15-7-3-5-12-10-14-16-11(8-9-18-14)4-2-6-13(16)17(12)15/h2-7,14,18H,8-10H2,1H3/t14-/m1/s1
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 8.30n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016013
PNG
((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C17H17NO/c1-18-9-8-11-4-2-6-13-16(11)14(18)10-12-5-3-7-15(19)17(12)13/h2-7,14,19H,8-10H2,1H3/t14-/m1/s1
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 9.60n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM84636
PNG
(CHEMBL27559 | NPA-11-OH-R,(+))
Show SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31 |r|
Show InChI InChI=1S/C19H21NO/c1-2-10-20-11-9-13-5-3-7-15-18(13)16(20)12-14-6-4-8-17(21)19(14)15/h3-8,16,21H,2,9-12H2,1H3/t16-/m1/s1
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 12.7n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052867
PNG
((R)-6,11-Dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[d...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C)c-31
Show InChI InChI=1S/C18H19N/c1-12-5-3-7-14-11-16-18-13(9-10-19(16)2)6-4-8-15(18)17(12)14/h3-8,16H,9-11H2,1-2H3/t16-/m1/s1
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 14.4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50016013
PNG
((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C17H17NO/c1-18-9-8-11-4-2-6-13-16(11)14(18)10-12-5-3-7-15(19)17(12)13/h2-7,14,19H,8-10H2,1H3/t14-/m1/s1
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 20.4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052870
PNG
((R)-11-(2-Methoxy-phenyl)-6-methyl-5,6,6a,7-tetrah...)
Show SMILES COc1ccccc1-c1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C24H23NO/c1-25-14-13-16-7-5-11-20-23-17(15-21(25)24(16)20)8-6-10-19(23)18-9-3-4-12-22(18)26-2/h3-12,21H,13-15H2,1-2H3/t21-/m1/s1
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 26.9n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052876
PNG
((R)-11-Methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(OC)c-31
Show InChI InChI=1S/C20H23NO/c1-3-11-21-12-10-14-6-4-8-16-19(14)17(21)13-15-7-5-9-18(22-2)20(15)16/h4-9,17H,3,10-13H2,1-2H3/t17-/m1/s1
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 31.3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM84636
PNG
(CHEMBL27559 | NPA-11-OH-R,(+))
Show SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31 |r|
Show InChI InChI=1S/C19H21NO/c1-2-10-20-11-9-13-5-3-7-15-18(13)16(20)12-14-6-4-8-17(21)19(14)15/h3-8,16,21H,2,9-12H2,1H3/t16-/m1/s1
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 39.5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052877
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C#N)c-31
Show InChI InChI=1S/C18H16N2/c1-20-9-8-12-4-3-7-15-17-13(10-16(20)18(12)15)5-2-6-14(17)11-19/h2-7,16H,8-10H2,1H3/t16-/m1/s1
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 41.1n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 |r|
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 41.9n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052879
PNG
(1-((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C(C)=O)c-31
Show InChI InChI=1S/C19H19NO/c1-12(21)15-7-4-6-14-11-17-19-13(9-10-20(17)2)5-3-8-16(19)18(14)15/h3-8,17H,9-11H2,1-2H3/t17-/m1/s1
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 57.1n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50016013
PNG
((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C17H17NO/c1-18-9-8-11-4-2-6-13-16(11)14(18)10-12-5-3-7-15(19)17(12)13/h2-7,14,19H,8-10H2,1H3/t14-/m1/s1
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 58.5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052864
PNG
((R)-11-Ethyl-6-methyl-5,6,6a,7-tetrahydro-4H-diben...)
Show SMILES CCc1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C19H21N/c1-3-13-6-4-8-15-12-17-19-14(10-11-20(17)2)7-5-9-16(19)18(13)15/h4-9,17H,3,10-12H2,1-2H3/t17-/m1/s1
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 79.2n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052865
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc3-c4ccccc4C[C@@H]1c23
Show InChI InChI=1S/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3/t16-/m1/s1
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 80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052863
PNG
((R)-6-Methyl-11-vinyl-5,6,6a,7-tetrahydro-4H-diben...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C=C)c-31
Show InChI InChI=1S/C19H19N/c1-3-13-6-4-8-15-12-17-19-14(10-11-20(17)2)7-5-9-16(19)18(13)15/h3-9,17H,1,10-12H2,2H3/t17-/m1/s1
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 177n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052877
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C#N)c-31
Show InChI InChI=1S/C18H16N2/c1-20-9-8-12-4-3-7-15-17-13(10-16(20)18(12)15)5-2-6-14(17)11-19/h2-7,16H,8-10H2,1H3/t16-/m1/s1
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 183n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052875
PNG
(CHEMBL333836 | Trifluoro-methanesulfonic acid (R)-...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c-31
Show InChI InChI=1S/C18H16F3NO3S/c1-22-9-8-11-4-2-6-13-16(11)14(22)10-12-5-3-7-15(17(12)13)25-26(23,24)18(19,20)21/h2-7,14H,8-10H2,1H3/t14-/m1/s1
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 195n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052868
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C(N)=O)c-31
Show InChI InChI=1S/C18H18N2O/c1-20-9-8-11-4-2-6-13-16-12(10-15(20)17(11)13)5-3-7-14(16)18(19)21/h2-7,15H,8-10H2,1H3,(H2,19,21)/t15-/m1/s1
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 198n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052867
PNG
((R)-6,11-Dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[d...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C)c-31
Show InChI InChI=1S/C18H19N/c1-12-5-3-7-14-11-16-18-13(9-10-19(16)2)6-4-8-15(18)17(12)14/h3-8,16H,9-11H2,1-2H3/t16-/m1/s1
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 201n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052869
PNG
((R)-6-Methyl-11-phenyl-5,6,6a,7-tetrahydro-4H-dibe...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(-c2ccccc2)c-31
Show InChI InChI=1S/C23H21N/c1-24-14-13-17-9-5-12-20-22-18(15-21(24)23(17)20)10-6-11-19(22)16-7-3-2-4-8-16/h2-12,21H,13-15H2,1H3/t21-/m1/s1
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 233n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 |r|
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 236n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D(1A) dopamine receptor


(RAT)		BDBM50052864
PNG
((R)-11-Ethyl-6-methyl-5,6,6a,7-tetrahydro-4H-diben...)
Show SMILES CCc1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C19H21N/c1-3-13-6-4-8-15-12-17-19-14(10-11-20(17)2)7-5-9-16(19)18(13)15/h4-9,17H,3,10-12H2,1-2H3/t17-/m1/s1
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 270n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052877
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C#N)c-31
Show InChI InChI=1S/C18H16N2/c1-20-9-8-12-4-3-7-15-17-13(10-16(20)18(12)15)5-2-6-14(17)11-19/h2-7,16H,8-10H2,1H3/t16-/m1/s1
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 279n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 |r|
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 296n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052879
PNG
(1-((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C(C)=O)c-31
Show InChI InChI=1S/C19H19NO/c1-12(21)15-7-4-6-14-11-17-19-13(9-10-20(17)2)5-3-8-16(19)18(14)15/h3-8,17H,9-11H2,1-2H3/t17-/m1/s1
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 311n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052878
PNG
((R)-6-Isopropyl-11-methoxy-5,6,6a,7-tetrahydro-4H-...)
Show SMILES COc1cccc2C[C@H]3N(CCc4cccc(c34)-c12)C(C)C
Show InChI InChI=1S/C20H23NO/c1-13(2)21-11-10-14-6-4-8-16-19(14)17(21)12-15-7-5-9-18(22-3)20(15)16/h4-9,13,17H,10-12H2,1-3H3/t17-/m1/s1
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 375n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052875
PNG
(CHEMBL333836 | Trifluoro-methanesulfonic acid (R)-...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c-31
Show InChI InChI=1S/C18H16F3NO3S/c1-22-9-8-11-4-2-6-13-16(11)14(22)10-12-5-3-7-15(17(12)13)25-26(23,24)18(19,20)21/h2-7,14H,8-10H2,1H3/t14-/m1/s1
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 386n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052872
PNG
((R)-6-Isopropyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,...)
Show SMILES CC(C)N1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C19H21NO/c1-12(2)20-10-9-13-5-3-7-15-18(13)16(20)11-14-6-4-8-17(21)19(14)15/h3-8,12,16,21H,9-11H2,1-2H3/t16-/m1/s1
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 437n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052865
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc3-c4ccccc4C[C@@H]1c23
Show InChI InChI=1S/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3/t16-/m1/s1
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 527n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50016007
PNG
((R)-11-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES COc1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C18H19NO/c1-19-10-9-12-5-3-7-14-17(12)15(19)11-13-6-4-8-16(20-2)18(13)14/h3-8,15H,9-11H2,1-2H3/t15-/m1/s1
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 551n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50016007
PNG
((R)-11-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES COc1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C18H19NO/c1-19-10-9-12-5-3-7-14-17(12)15(19)11-13-6-4-8-16(20-2)18(13)14/h3-8,15H,9-11H2,1-2H3/t15-/m1/s1
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 606n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052867
PNG
((R)-6,11-Dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[d...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C)c-31
Show InChI InChI=1S/C18H19N/c1-12-5-3-7-14-11-16-18-13(9-10-19(16)2)6-4-8-15(18)17(12)14/h3-8,16H,9-11H2,1-2H3/t16-/m1/s1
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 700n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052865
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc3-c4ccccc4C[C@@H]1c23
Show InChI InChI=1S/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3/t16-/m1/s1
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 717n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052863
PNG
((R)-6-Methyl-11-vinyl-5,6,6a,7-tetrahydro-4H-diben...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C=C)c-31
Show InChI InChI=1S/C19H19N/c1-3-13-6-4-8-15-12-17-19-14(10-11-20(17)2)7-5-9-16(19)18(13)15/h3-9,17H,1,10-12H2,2H3/t17-/m1/s1
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 720n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052876
PNG
((R)-11-Methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(OC)c-31
Show InChI InChI=1S/C20H23NO/c1-3-11-21-12-10-14-6-4-8-16-19(14)17(21)13-15-7-5-9-18(22-2)20(15)16/h4-9,17H,3,10-13H2,1-2H3/t17-/m1/s1
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 826n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052874
PNG
((R)-6-Benzyl-11-methoxy-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES COc1cccc2C[C@H]3N(Cc4ccccc4)CCc4cccc(c34)-c12
Show InChI InChI=1S/C24H23NO/c1-26-22-12-6-10-19-15-21-23-18(9-5-11-20(23)24(19)22)13-14-25(21)16-17-7-3-2-4-8-17/h2-12,21H,13-16H2,1H3/t21-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052866
PNG
((R)-6-Benzyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES Oc1cccc2C[C@H]3N(Cc4ccccc4)CCc4cccc(c34)-c12
Show InChI InChI=1S/C23H21NO/c25-21-11-5-9-18-14-20-22-17(8-4-10-19(22)23(18)21)12-13-24(20)15-16-6-2-1-3-7-16/h1-11,20,25H,12-15H2/t20-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052871
PNG
((R)-11-Methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES COc1cccc2C[C@H]3NCCc4cccc(c34)-c12
Show InChI InChI=1S/C17H17NO/c1-19-15-7-3-5-12-10-14-16-11(8-9-18-14)4-2-6-13(16)17(12)15/h2-7,14,18H,8-10H2,1H3/t14-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052873
PNG
((R)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1...)
Show SMILES Oc1cccc2C[C@H]3NCCc4cccc(c34)-c12
Show InChI InChI=1S/C16H15NO/c18-14-6-2-4-11-9-13-15-10(7-8-17-13)3-1-5-12(15)16(11)14/h1-6,13,17-18H,7-9H2/t13-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052878
PNG
((R)-6-Isopropyl-11-methoxy-5,6,6a,7-tetrahydro-4H-...)
Show SMILES COc1cccc2C[C@H]3N(CCc4cccc(c34)-c12)C(C)C
Show InChI InChI=1S/C20H23NO/c1-13(2)21-11-10-14-6-4-8-16-19(14)17(21)12-15-7-5-9-18(22-3)20(15)16/h4-9,13,17H,10-12H2,1-3H3/t17-/m1/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human Dopamine receptor D2A

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052872
PNG
((R)-6-Isopropyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,...)
Show SMILES CC(C)N1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C19H21NO/c1-12(2)20-10-9-13-5-3-7-15-18(13)16(20)11-14-6-4-8-17(21)19(14)15/h3-8,12,16,21H,9-11H2,1-2H3/t16-/m1/s1
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 1.01E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM84636
PNG
(CHEMBL27559 | NPA-11-OH-R,(+))
Show SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31 |r|
Show InChI InChI=1S/C19H21NO/c1-2-10-20-11-9-13-5-3-7-15-18(13)16(20)12-14-6-4-8-17(21)19(14)15/h3-8,16,21H,2,9-12H2,1H3/t16-/m1/s1
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 1.09E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052873
PNG
((R)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1...)
Show SMILES Oc1cccc2C[C@H]3NCCc4cccc(c34)-c12
Show InChI InChI=1S/C16H15NO/c18-14-6-2-4-11-9-13-15-10(7-8-17-13)3-1-5-12(15)16(11)14/h1-6,13,17-18H,7-9H2/t13-/m1/s1
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 1.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052870
PNG
((R)-11-(2-Methoxy-phenyl)-6-methyl-5,6,6a,7-tetrah...)
Show SMILES COc1ccccc1-c1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C24H23NO/c1-25-14-13-16-7-5-11-20-23-17(15-21(25)24(16)20)8-6-10-19(23)18-9-3-4-12-22(18)26-2/h3-12,21H,13-15H2,1-2H3/t21-/m1/s1
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 1.33E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052870
PNG
((R)-11-(2-Methoxy-phenyl)-6-methyl-5,6,6a,7-tetrah...)
Show SMILES COc1ccccc1-c1cccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Show InChI InChI=1S/C24H23NO/c1-25-14-13-16-7-5-11-20-23-17(15-21(25)24(16)20)8-6-10-19(23)18-9-3-4-12-22(18)26-2/h3-12,21H,13-15H2,1-2H3/t21-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052866
PNG
((R)-6-Benzyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES Oc1cccc2C[C@H]3N(Cc4ccccc4)CCc4cccc(c34)-c12
Show InChI InChI=1S/C23H21NO/c25-21-11-5-9-18-14-20-22-17(8-4-10-19(22)23(18)21)12-13-24(20)15-16-6-2-1-3-7-16/h1-11,20,25H,12-15H2/t20-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052874
PNG
((R)-6-Benzyl-11-methoxy-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES COc1cccc2C[C@H]3N(Cc4ccccc4)CCc4cccc(c34)-c12
Show InChI InChI=1S/C24H23NO/c1-26-22-12-6-10-19-15-21-23-18(9-5-11-20(23)24(19)22)13-14-25(21)16-17-7-3-2-4-8-17/h2-12,21H,13-16H2,1H3/t21-/m1/s1
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 3.22E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052869
PNG
((R)-6-Methyl-11-phenyl-5,6,6a,7-tetrahydro-4H-dibe...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(-c2ccccc2)c-31
Show InChI InChI=1S/C23H21N/c1-24-14-13-17-9-5-12-20-22-18(15-21(24)23(17)20)10-6-11-19(22)16-7-3-2-4-8-16/h2-12,21H,13-15H2,1H3/t21-/m1/s1
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 3.63E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052868
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C(N)=O)c-31
Show InChI InChI=1S/C18H18N2O/c1-20-9-8-11-4-2-6-13-16-12(10-15(20)17(11)13)5-3-7-14(16)18(19)21/h2-7,15H,8-10H2,1H3,(H2,19,21)/t15-/m1/s1
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>4.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052879
PNG
(1-((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C(C)=O)c-31
Show InChI InChI=1S/C19H19NO/c1-12(21)15-7-4-6-14-11-17-19-13(9-10-20(17)2)5-3-8-16(19)18(14)15/h3-8,17H,9-11H2,1-2H3/t17-/m1/s1
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 4.69E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052876
PNG
((R)-11-Methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(OC)c-31
Show InChI InChI=1S/C20H23NO/c1-3-11-21-12-10-14-6-4-8-16-19(14)17(21)13-15-7-5-9-18(22-2)20(15)16/h4-9,17H,3,10-13H2,1-2H3/t17-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052871
PNG
((R)-11-Methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES COc1cccc2C[C@H]3NCCc4cccc(c34)-c12
Show InChI InChI=1S/C17H17NO/c1-19-15-7-3-5-12-10-14-16-11(8-9-18-14)4-2-6-13(16)17(12)15/h2-7,14,18H,8-10H2,1H3/t14-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50052866
PNG
((R)-6-Benzyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES Oc1cccc2C[C@H]3N(Cc4ccccc4)CCc4cccc(c34)-c12
Show InChI InChI=1S/C23H21NO/c25-21-11-5-9-18-14-20-22-17(8-4-10-19(22)23(18)21)12-13-24(20)15-16-6-2-1-3-7-16/h1-11,20,25H,12-15H2/t20-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052878
PNG
((R)-6-Isopropyl-11-methoxy-5,6,6a,7-tetrahydro-4H-...)
Show SMILES COc1cccc2C[C@H]3N(CCc4cccc(c34)-c12)C(C)C
Show InChI InChI=1S/C20H23NO/c1-13(2)21-11-10-14-6-4-8-16-19(14)17(21)12-15-7-5-9-18(22-3)20(15)16/h4-9,13,17H,10-12H2,1-3H3/t17-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052872
PNG
((R)-6-Isopropyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,...)
Show SMILES CC(C)N1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C19H21NO/c1-12(2)20-10-9-13-5-3-7-15-18(13)16(20)11-14-6-4-8-17(21)19(14)15/h3-8,12,16,21H,9-11H2,1-2H3/t16-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50052868
PNG
((R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(C(N)=O)c-31
Show InChI InChI=1S/C18H18N2O/c1-20-9-8-11-4-2-6-13-16-12(10-15(20)17(11)13)5-3-7-14(16)18(19)21/h2-7,15H,8-10H2,1H3,(H2,19,21)/t15-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride fromd human Dopamine receptor D2A expressed in LtK- cells

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50052874
PNG
((R)-6-Benzyl-11-methoxy-5,6,6a,7-tetrahydro-4H-dib...)
Show SMILES COc1cccc2C[C@H]3N(Cc4ccccc4)CCc4cccc(c34)-c12
Show InChI InChI=1S/C24H23NO/c1-26-22-12-6-10-19-15-21-23-18(9-5-11-20(23)24(19)22)13-14-25(21)16-17-7-3-2-4-8-17/h2-12,21H,13-16H2,1H3/t21-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1

J Med Chem 39: 3503-13 (1996)


Article DOI: 10.1021/jm960189i
BindingDB Entry DOI: 10.7270/Q2T43S6S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%