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USPatent US9206198

Compile data set for download or QSAR
Found 113 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195013
PNG
(US9206198, 78 | US9206198, 79)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3Cl)CC2)C1=O |t:1|
Show InChI InChI=1S/C23H25ClN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
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n/an/a 3n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194963
PNG
(US9206198, 18)
Show SMILES CO[C@@H](CN1CC2CCC(C1)CC1(CCN(C3=CC(=O)OC3)C1=O)C2)c1ccc2C(=O)OCc2c1C |r,t:17,TLB:22:12:7.8:5.10.4,THB:3:4:7.8:11.24.12|
Show InChI InChI=1S/C28H34N2O6/c1-17-21(5-6-22-23(17)16-36-26(22)32)24(34-2)14-29-12-18-3-4-19(13-29)11-28(10-18)7-8-30(27(28)33)20-9-25(31)35-15-20/h5-6,9,18-19,24H,3-4,7-8,10-16H2,1-2H3/t18?,19?,24-,28?/m0/s1
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n/an/a 4n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194951
PNG
(US9206198, 5)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:23|
Show InChI InChI=1S/C23H26N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,10,19,26H,4-9,11-13H2,1H3/t19-/m0/s1
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n/an/a 4n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194967
PNG
(US9206198, 22)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(F)C(=O)OC2)CC1 |r,c:26|
Show InChI InChI=1S/C23H25FN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1
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n/an/a 4n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194968
PNG
(US9206198, 23)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:24|
Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)29)20(27)12-25-9-6-24(7-10-25)5-2-8-26(23(24)30)16-11-21(28)31-13-16/h3-4,11,20,27H,2,5-10,12-14H2,1H3/t20-/m0/s1
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194956
PNG
(US9206198, 9)
Show SMILES CC1=C(COC1=O)N1CCCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)13-32-23(18)30)21(28)12-26-10-7-25(8-11-26)6-3-9-27(24(25)31)20-14-33-22(29)16(20)2/h4-5,21,28H,3,6-14H2,1-2H3/t21-/m0/s1
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195012
PNG
(US9206198, 76 | US9206198, 77)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3C3CC3)CC2)C1=O |t:1|
Show InChI InChI=1S/C26H30N2O6/c1-15-20(14-34-23(15)30)28-11-8-26(25(28)32)6-9-27(10-7-26)12-21(29)18-5-4-17-19(13-33-24(17)31)22(18)16-2-3-16/h4-5,16,21,29H,2-3,6-14H2,1H3
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194992
PNG
(US9206198, 53C)
Show SMILES C[C@H]([C@@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27|
Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21-/m1/s1
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195014
PNG
(US9206198, 80 | US9206198, 81)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3F)CC2)C1=O |t:1|
Show InChI InChI=1S/C23H25FN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194954
PNG
(US9206198, 7)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H28N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,20,27H,5-13H2,1-2H3/t20-/m0/s1
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195030
PNG
(US9206198, 53A)
Show SMILES C[C@@H]([C@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27|
Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21-/m0/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194947
PNG
(US9206198, 1)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CCc3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1|
Show InChI InChI=1S/C24H28N2O5/c1-15-17(3-4-18-19(15)13-30-22(18)28)5-9-25-10-6-24(7-11-25)8-12-26(23(24)29)20-14-31-21(27)16(20)2/h3-4H,5-14H2,1-2H3
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195005
PNG
(US9206198, 66)
Show SMILES CCC1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m0/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194992
PNG
(US9206198, 53C)
Show SMILES C[C@H]([C@@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27|
Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21-/m1/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194970
PNG
(US9206198, 25)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(Cl)C(=O)OC2)CC1 |r,c:26|
Show InChI InChI=1S/C23H25ClN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194953
PNG
(US9206198, 6B)
Show SMILES C[C@H]1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:30|
Show InChI InChI=1S/C24H28N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9,14,20,27H,5-8,10-13H2,1-2H3/t14-,20-/m0/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194970
PNG
(US9206198, 25)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(Cl)C(=O)OC2)CC1 |r,c:26|
Show InChI InChI=1S/C23H25ClN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195011
PNG
(US9206198, 74 | US9206198, 75)
Show SMILES CCc1c2COC(=O)c2ccc1C(O)CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |c:27|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-17(4-5-18-19(16)13-32-23(18)30)21(28)12-26-9-6-25(7-10-26)8-11-27(24(25)31)20-14-33-22(29)15(20)2/h4-5,21,28H,3,6-14H2,1-2H3
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195012
PNG
(US9206198, 76 | US9206198, 77)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3C3CC3)CC2)C1=O |t:1|
Show InChI InChI=1S/C26H30N2O6/c1-15-20(14-34-23(15)30)28-11-8-26(25(28)32)6-9-27(10-7-26)12-21(29)18-5-4-17-19(13-33-24(17)31)22(18)16-2-3-16/h4-5,16,21,29H,2-3,6-14H2,1H3
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n/an/a 10n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194965
PNG
(US9206198, 20)
Show SMILES CO[C@@H](CN1C2CCC1CC1(CCN(C1=O)C1=C(C)C(=O)OC1)C2)c1ccc2C(=O)OCc2c1C |r,c:18,THB:11:10:6.7:4|
Show InChI InChI=1S/C27H32N2O6/c1-15-19(6-7-20-21(15)13-34-25(20)31)23(33-3)12-29-17-4-5-18(29)11-27(10-17)8-9-28(26(27)32)22-14-35-24(30)16(22)2/h6-7,17-18,23H,4-5,8-14H2,1-3H3/t17?,18?,23-,27?/m0/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195018
PNG
(US9206198, 85A | US9206198, 85B)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC2)C(C)(C)C(O)c2ccc3C(=O)OCc3c2C)C1=O |t:1|
Show InChI InChI=1S/C26H32N2O6/c1-15-17(5-6-18-19(15)13-33-23(18)31)21(29)25(3,4)27-10-7-26(8-11-27)9-12-28(24(26)32)20-14-34-22(30)16(20)2/h5-6,21,29H,7-14H2,1-4H3
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195013
PNG
(US9206198, 78 | US9206198, 79)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3Cl)CC2)C1=O |t:1|
Show InChI InChI=1S/C23H25ClN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194956
PNG
(US9206198, 9)
Show SMILES CC1=C(COC1=O)N1CCCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)13-32-23(18)30)21(28)12-26-10-7-25(8-11-26)6-3-9-27(24(25)31)20-14-33-22(29)16(20)2/h4-5,21,28H,3,6-14H2,1-2H3/t21-/m0/s1
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n/an/a 10n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194987
PNG
(US9206198, 48)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](F)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H27FN2O5/c1-14-16(3-4-17-18(14)12-31-22(17)29)19(25)11-26-8-5-24(6-9-26)7-10-27(23(24)30)20-13-32-21(28)15(20)2/h3-4,19H,5-13H2,1-2H3/t19-/m1/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195006
PNG
(US9206198, 69)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CC(C3CC3)N(C3=CC(=O)OC3)C2=O)CC1 |r,t:27|
Show InChI InChI=1S/C26H30N2O6/c1-15-18(4-5-19-20(15)14-34-24(19)31)22(29)12-27-8-6-26(7-9-27)11-21(16-2-3-16)28(25(26)32)17-10-23(30)33-13-17/h4-5,10,16,21-22,29H,2-3,6-9,11-14H2,1H3/t21?,22-/m0/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194990
PNG
(US9206198, 51)
Show SMILES CO[C@@H](CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1)c1ccc2C(=O)OCc2c1C |r,t:11|
Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)28)20(30-2)12-25-8-5-24(6-9-25)7-10-26(23(24)29)16-11-21(27)31-13-16/h3-4,11,20H,5-10,12-14H2,1-2H3/t20-/m0/s1
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n/an/a 20n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194980
PNG
(US9206198, 39 | US9206198, 42)
Show SMILES CC1CC2(CC3CCC(C2)N3C[C@H](O)c2ccc3C(=O)OCc3c2C)C(=O)N1C1=CC(=O)OC1 |r,wD:12.14,t:33,TLB:2:3:6.7:10,11:10:6.7:9.4.3,(5.93,1.35,;5.06,.08,;3.52,.03,;3.09,-1.45,;1.39,-1.37,;.23,-.26,;.75,1.19,;1.13,-.04,;.51,-1.74,;1.69,-2.65,;-1.46,-1.13,;-2.79,-.36,;-4.13,-1.13,;-4.13,-2.67,;-5.46,-.36,;-5.46,1.18,;-6.79,1.95,;-8.13,1.18,;-9.59,1.66,;-10.36,2.99,;-10.5,.41,;-9.59,-.83,;-8.13,-.36,;-6.79,-1.13,;-6.79,-2.67,;4.36,-2.32,;3.23,1.13,;5.58,-1.37,;6.79,.09,;7.7,1.34,;9.16,.86,;10.5,1.63,;9.16,-.68,;7.7,-1.16,)|
Show InChI InChI=1S/C26H30N2O6/c1-14-8-26(25(32)28(14)18-7-23(30)33-12-18)9-16-3-4-17(10-26)27(16)11-22(29)19-5-6-20-21(15(19)2)13-34-24(20)31/h5-7,14,16-17,22,29H,3-4,8-13H2,1-2H3/t14?,16?,17?,22-,26?/m0/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195026
PNG
(US9206198, 30)
Show SMILES CC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=C(C)C(=O)OC1 |r,c:30|
Show InChI InChI=1S/C25H30N2O6/c1-14-10-25(24(31)27(14)20-13-33-22(29)16(20)3)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m1/s1
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n/an/a 20n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195026
PNG
(US9206198, 30)
Show SMILES CC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=C(C)C(=O)OC1 |r,c:30|
Show InChI InChI=1S/C25H30N2O6/c1-14-10-25(24(31)27(14)20-13-33-22(29)16(20)3)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m1/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195033
PNG
(US9206198, 67)
Show SMILES CCC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m1/s1
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n/an/a 20n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194963
PNG
(US9206198, 18)
Show SMILES CO[C@@H](CN1CC2CCC(C1)CC1(CCN(C3=CC(=O)OC3)C1=O)C2)c1ccc2C(=O)OCc2c1C |r,t:17,TLB:22:12:7.8:5.10.4,THB:3:4:7.8:11.24.12|
Show InChI InChI=1S/C28H34N2O6/c1-17-21(5-6-22-23(17)16-36-26(22)32)24(34-2)14-29-12-18-3-4-19(13-29)11-28(10-18)7-8-30(27(28)33)20-9-25(31)35-15-20/h5-6,9,18-19,24H,3-4,7-8,10-16H2,1-2H3/t18?,19?,24-,28?/m0/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195033
PNG
(US9206198, 67)
Show SMILES CCC1CC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m1/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195022
PNG
(US9206198, 6A)
Show SMILES C[C@@H]1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:30|
Show InChI InChI=1S/C24H28N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9,14,20,27H,5-8,10-13H2,1-2H3/t14-,20+/m1/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195005
PNG
(US9206198, 66)
Show SMILES CCC1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:31|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-11-25(24(31)27(16)17-10-22(29)32-13-17)6-8-26(9-7-25)12-21(28)18-4-5-19-20(15(18)2)14-33-23(19)30/h4-5,10,16,21,28H,3,6-9,11-14H2,1-2H3/t16?,21-/m0/s1
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n/an/a 20n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194968
PNG
(US9206198, 23)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:24|
Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)29)20(27)12-25-9-6-24(7-10-25)5-2-8-26(23(24)30)16-11-21(28)31-13-16/h3-4,11,20,27H,2,5-10,12-14H2,1H3/t20-/m0/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194962
PNG
(US9206198, 17)
Show SMILES CCC1=C(COC1=O)N1CCC2(CCN(C[C@H](OC)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:2|
Show InChI InChI=1S/C26H32N2O6/c1-4-17-21(15-34-23(17)29)28-12-9-26(25(28)31)7-10-27(11-8-26)13-22(32-3)18-5-6-19-20(16(18)2)14-33-24(19)30/h5-6,22H,4,7-15H2,1-3H3/t22-/m0/s1
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n/an/a 20n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194958
PNG
(US9206198, 11)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,t:14|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)14-32-23(18)29)21(31-3)13-26-9-6-25(7-10-26)8-11-27(24(25)30)20-12-22(28)33-16(20)2/h4-5,12,16,21H,6-11,13-14H2,1-3H3/t16?,21-/m0/s1
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n/an/a 20n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194981
PNG
(US9206198, 40 | US9206198, 41)
Show SMILES CC1CC2(CC3CCC(C2)N3C[C@@H](O)c2ccc3C(=O)OCc3c2C)C(=O)N1C1=CC(=O)OC1 |r,wU:12.14,t:33,TLB:2:3:6.7:10,11:10:6.7:9.4.3,(5.93,1.35,;5.06,.08,;3.52,.03,;3.09,-1.45,;1.39,-1.37,;.23,-.26,;.75,1.19,;1.13,-.04,;.51,-1.74,;1.69,-2.65,;-1.46,-1.13,;-2.79,-.36,;-4.13,-1.13,;-4.13,-2.67,;-5.46,-.36,;-5.46,1.18,;-6.79,1.95,;-8.13,1.18,;-9.59,1.66,;-10.36,2.99,;-10.5,.41,;-9.59,-.83,;-8.13,-.36,;-6.79,-1.13,;-6.79,-2.67,;4.36,-2.32,;3.23,1.13,;5.58,-1.37,;6.79,.09,;7.7,1.34,;9.16,.86,;10.5,1.63,;9.16,-.68,;7.7,-1.16,)|
Show InChI InChI=1S/C26H30N2O6/c1-14-8-26(25(32)28(14)18-7-23(30)33-12-18)9-16-3-4-17(10-26)27(16)11-22(29)19-5-6-20-21(15(19)2)13-34-24(20)31/h5-7,14,16-17,22,29H,3-4,8-13H2,1-2H3/t14?,16?,17?,22-,26?/m1/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194979
PNG
(US9206198, 38)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3cc4COC(=O)c4cc3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H28N2O6/c1-14-9-18-16(12-31-22(18)29)10-17(14)20(27)11-25-6-3-24(4-7-25)5-8-26(23(24)30)19-13-32-21(28)15(19)2/h9-10,20,27H,3-8,11-13H2,1-2H3/t20-/m0/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194954
PNG
(US9206198, 7)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H28N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,20,27H,5-13H2,1-2H3/t20-/m0/s1
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n/an/a 20n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194952
PNG
(US9206198, 6)
Show SMILES CC1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:30|
Show InChI InChI=1S/C24H28N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9,14,20,27H,5-8,10-13H2,1-2H3/t14?,20-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195011
PNG
(US9206198, 74 | US9206198, 75)
Show SMILES CCc1c2COC(=O)c2ccc1C(O)CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |c:27|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-17(4-5-18-19(16)13-32-23(18)30)21(28)12-26-9-6-25(7-10-26)8-11-27(24(25)31)20-14-33-22(29)15(20)2/h4-5,21,28H,3,6-14H2,1-2H3
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194989
PNG
(US9206198, 50)
Show SMILES CCO[C@@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,c:15|
Show InChI InChI=1S/C26H32N2O6/c1-4-32-22(18-5-6-19-20(16(18)2)14-33-24(19)30)13-27-10-7-26(8-11-27)9-12-28(25(26)31)21-15-34-23(29)17(21)3/h5-6,22H,4,7-15H2,1-3H3/t22-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194978
PNG
(US9206198, 37)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](O)c3cc4COC(=O)c4cc3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H28N2O6/c1-14-9-18-16(12-31-22(18)29)10-17(14)20(27)11-25-6-3-24(4-7-25)5-8-26(23(24)30)19-13-32-21(28)15(19)2/h9-10,20,27H,3-8,11-13H2,1-2H3/t20-/m1/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194967
PNG
(US9206198, 22)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(F)C(=O)OC2)CC1 |r,c:26|
Show InChI InChI=1S/C23H25FN2O6/c1-13-14(2-3-15-16(13)11-31-20(15)28)18(27)10-25-7-4-23(5-8-25)6-9-26(22(23)30)17-12-32-21(29)19(17)24/h2-3,18,27H,4-12H2,1H3/t18-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195006
PNG
(US9206198, 69)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CC(C3CC3)N(C3=CC(=O)OC3)C2=O)CC1 |r,t:27|
Show InChI InChI=1S/C26H30N2O6/c1-15-18(4-5-19-20(15)14-34-24(19)31)22(29)12-27-8-6-26(7-9-27)11-21(16-2-3-16)28(25(26)32)17-10-23(30)33-13-17/h4-5,10,16,21-22,29H,2-3,6-9,11-14H2,1H3/t21?,22-/m0/s1
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n/an/a 30n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194957
PNG
(US9206198, 10)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2)C2=CC(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,t:13|
Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)28)21(29-2)12-25-8-5-24(6-9-25)7-10-26(15-24)17-11-22(27)30-13-17/h3-4,11,21H,5-10,12-15H2,1-2H3/t21-/m0/s1
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n/an/a 30n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195009
PNG
(US9206198, 72)
Show SMILES CC1=CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:1,30|
Show InChI InChI=1S/C24H26N2O6/c1-14-10-24(23(30)26(14)16-9-21(28)31-12-16)5-7-25(8-6-24)11-20(27)17-3-4-18-19(15(17)2)13-32-22(18)29/h3-4,9-10,20,27H,5-8,11-13H2,1-2H3/t20-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194951
PNG
(US9206198, 5)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:23|
Show InChI InChI=1S/C23H26N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,10,19,26H,4-9,11-13H2,1H3/t19-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194977
PNG
(US9206198, 36)
Show SMILES CC1=C(COC1=O)N1CC(=O)C2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H26N2O7/c1-13-15(3-4-16-17(13)11-32-22(16)30)19(27)9-25-7-5-24(6-8-25)20(28)10-26(23(24)31)18-12-33-21(29)14(18)2/h3-4,19,27H,5-12H2,1-2H3/t19-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195023
PNG
(US9206198, 12)
Show SMILES CO[C@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,t:14|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)14-32-23(18)29)21(31-3)13-26-9-6-25(7-10-26)8-11-27(24(25)30)20-12-22(28)33-16(20)2/h4-5,12,16,21H,6-11,13-14H2,1-3H3/t16?,21-/m1/s1
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n/an/a 30n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194982
PNG
(US9206198, 43)
Show SMILES CC1=C(COC1=O)N1C=CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,c:9,t:1|
Show InChI InChI=1S/C24H26N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,7,10,20,27H,5-6,8-9,11-13H2,1-2H3/t20-/m0/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194955
PNG
(US9206198, 8)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H28N2O6/c1-14-16(3-4-17-18(14)12-31-22(17)29)20(27)11-25-8-5-24(6-9-25)7-10-26(23(24)30)19-13-32-21(28)15(19)2/h3-4,20,27H,5-13H2,1-2H3/t20-/m1/s1
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n/an/a 30n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194983
PNG
(US9206198, 44)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CC1)C=CN(C1=CC(=O)OC1)C2=O |r,c:23,t:26|
Show InChI InChI=1S/C23H24N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,6,9-10,19,26H,4-5,7-8,11-13H2,1H3/t19-/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194988
PNG
(US9206198, 49)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,c:14|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)13-32-23(18)29)21(31-3)12-26-9-6-25(7-10-26)8-11-27(24(25)30)20-14-33-22(28)16(20)2/h4-5,21H,6-14H2,1-3H3/t21-/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195016
PNG
(US9206198, 83)
Show SMILES COC1CN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CCC11CCN(C2=C(C)C(=O)OC2)C1=O |r,c:28|
Show InChI InChI=1S/C25H30N2O7/c1-14-16(4-5-17-18(14)12-33-23(17)30)20(28)10-26-8-6-25(21(11-26)32-3)7-9-27(24(25)31)19-13-34-22(29)15(19)2/h4-5,20-21,28H,6-13H2,1-3H3/t20-,21?,25?/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195004
PNG
(US9206198, 65)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CC1)C(=O)N(C1=CC(=O)OC1)c1ccccc21 |r,t:26|
Show InChI InChI=1S/C27H26N2O6/c1-16-18(6-7-19-20(16)15-35-25(19)32)23(30)13-28-10-8-27(9-11-28)21-4-2-3-5-22(21)29(26(27)33)17-12-24(31)34-14-17/h2-7,12,23,30H,8-11,13-15H2,1H3/t23-/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194986
PNG
(US9206198, 47)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](F)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Show InChI InChI=1S/C24H27FN2O5/c1-14-16(3-4-17-18(14)12-31-22(17)29)19(25)11-26-8-5-24(6-9-26)7-10-27(23(24)30)20-13-32-21(28)15(20)2/h3-4,19H,5-13H2,1-2H3/t19-/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194974
PNG
(US9206198, 31)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)C2=C(C3CC3)C(=O)OC2)CC1 |r,c:26|
Show InChI InChI=1S/C26H30N2O6/c1-15-17(4-5-18-19(15)13-33-23(18)30)21(29)12-27-9-6-26(7-10-27)8-11-28(25(26)32)20-14-34-24(31)22(20)16-2-3-16/h4-5,16,21,29H,2-3,6-14H2,1H3/t21-/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194964
PNG
(US9206198, 19)
Show SMILES CC1=C(COC1=O)N1CCC2(CC3CCC(CN(C[C@H](O)c4ccc5C(=O)OCc5c4C)C3)C2)C1=O |r,t:1,TLB:34:10:13.14:32.16.17,18:17:13.14:33.11.10,THB:9:10:13.14:32.16.17|
Show InChI InChI=1S/C28H34N2O6/c1-16-20(5-6-21-22(16)14-35-26(21)33)24(31)13-29-11-18-3-4-19(12-29)10-28(9-18)7-8-30(27(28)34)23-15-36-25(32)17(23)2/h5-6,18-19,24,31H,3-4,7-15H2,1-2H3/t18?,19?,24-,28?/m0/s1
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n/an/a 40n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194948
PNG
(US9206198, 2)
Show SMILES CO[C@@H](CN1CCC2(C[C@H](C)N(C3=CC(=O)OC3)C2=O)CC1)c1ccc2C(=O)OCc2c1C |r,t:12|
Show InChI InChI=1S/C25H30N2O6/c1-15-11-25(24(30)27(15)17-10-22(28)32-13-17)6-8-26(9-7-25)12-21(31-3)18-4-5-19-20(16(18)2)14-33-23(19)29/h4-5,10,15,21H,6-9,11-14H2,1-3H3/t15-,21-/m0/s1
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n/an/a 50n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195031
PNG
(US9206198, 53B)
Show SMILES C[C@H]([C@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27|
Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21+/m1/s1
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n/an/a 50n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195016
PNG
(US9206198, 83)
Show SMILES COC1CN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CCC11CCN(C2=C(C)C(=O)OC2)C1=O |r,c:28|
Show InChI InChI=1S/C25H30N2O7/c1-14-16(4-5-17-18(14)12-33-23(17)30)20(28)10-26-8-6-25(21(11-26)32-3)7-9-27(24(25)31)19-13-34-22(29)15(19)2/h4-5,20-21,28H,6-13H2,1-3H3/t20-,21?,25?/m0/s1
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n/an/a 50n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194960
PNG
(US9206198, 15)
Show SMILES CO[C@@H](CN1CCC2(CN(C(=O)C2)C2=CC(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,t:14|
Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)13-32-23(18)29)20(30-2)11-25-7-5-24(6-8-25)10-21(27)26(14-24)16-9-22(28)31-12-16/h3-4,9,20H,5-8,10-14H2,1-2H3/t20-/m0/s1
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n/an/a 50n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195014
PNG
(US9206198, 80 | US9206198, 81)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3F)CC2)C1=O |t:1|
Show InChI InChI=1S/C23H25FN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
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n/an/a 50n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194959
PNG
(US9206198, 13)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,c:14|
Show InChI InChI=1S/C26H32N2O6/c1-15-18(5-6-19-20(15)14-33-24(19)30)21(32-4)13-27-10-7-26(8-11-27)9-12-28(25(26)31)22-16(2)23(29)34-17(22)3/h5-6,17,21H,7-14H2,1-4H3/t17?,21-/m0/s1
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n/an/a 60n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195017
PNG
(US9206198, 84A | US9206198, 84B)
Show SMILES CC1=C(COC1)N1CCC2(CCN(CC2)C(CO)Cc2ccc3C(=O)OCc3c2C)C1=O |t:1|
Show InChI InChI=1S/C25H32N2O5/c1-16-13-31-15-22(16)27-10-7-25(24(27)30)5-8-26(9-6-25)19(12-28)11-18-3-4-20-21(17(18)2)14-32-23(20)29/h3-4,19,28H,5-15H2,1-2H3
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n/an/a 60n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194991
PNG
(US9206198, 52)
Show SMILES O=C1OCC(=C1)N1CCC2(CCN(CC3OCCc4c5COC(=O)c5ccc34)CC2)C1=O |c:4|
Show InChI InChI=1S/C24H26N2O6/c27-21-11-15(13-31-21)26-9-6-24(23(26)29)4-7-25(8-5-24)12-20-17-1-2-18-19(14-32-22(18)28)16(17)3-10-30-20/h1-2,11,20H,3-10,12-14H2
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n/an/a 60n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195032
PNG
(US9206198, 53D)
Show SMILES C[C@@H]([C@@H](O)c1ccc2C(=O)OCc2c1C)N1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,c:27|
Show InChI InChI=1S/C25H30N2O6/c1-14-17(4-5-18-19(14)12-32-23(18)30)21(28)16(3)26-9-6-25(7-10-26)8-11-27(24(25)31)20-13-33-22(29)15(20)2/h4-5,16,21,28H,6-13H2,1-3H3/t16-,21+/m0/s1
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n/an/a 70n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195027
PNG
(US9206198, 35)
Show SMILES CC1CN(C(=O)C11CCN(C[C@@H](O)c2ccc3C(=O)OCc3c2C)CC1)C1=C(C)C(=O)OC1 |r,c:30|
Show InChI InChI=1S/C25H30N2O6/c1-14-10-27(20-13-33-22(29)16(20)3)24(31)25(14)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m1/s1
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n/an/a 70n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195008
PNG
(US9206198, 71)
Show SMILES COCC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:3|
Show InChI InChI=1S/C25H30N2O7/c1-15-16(3-4-17-18(15)13-33-22(17)29)21(28)11-26-8-5-25(6-9-26)7-10-27(24(25)31)20-14-34-23(30)19(20)12-32-2/h3-4,21,28H,5-14H2,1-2H3/t21-/m0/s1
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n/an/a 70n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194973
PNG
(US9206198, 29)
Show SMILES CC1CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C(=O)N1C1=C(C)C(=O)OC1 |r,c:30|
Show InChI InChI=1S/C25H30N2O6/c1-14-10-25(24(31)27(14)20-13-33-22(29)16(20)3)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m0/s1
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n/an/a 70n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194949
PNG
(US9206198, 3)
Show SMILES O=C1OCC(=C1)N1CCC2(CCN(CCc3ccc4C(=O)OCc4c3)CC2)C1=O |c:4|
Show InChI InChI=1S/C22H24N2O5/c25-19-12-17(14-28-19)24-10-6-22(21(24)27)4-8-23(9-5-22)7-3-15-1-2-18-16(11-15)13-29-20(18)26/h1-2,11-12H,3-10,13-14H2
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n/an/a 70n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195017
PNG
(US9206198, 84A | US9206198, 84B)
Show SMILES CC1=C(COC1)N1CCC2(CCN(CC2)C(CO)Cc2ccc3C(=O)OCc3c2C)C1=O |t:1|
Show InChI InChI=1S/C25H32N2O5/c1-16-13-31-15-22(16)27-10-7-25(24(27)30)5-8-26(9-6-25)19(12-28)11-18-3-4-20-21(17(18)2)14-32-23(20)29/h3-4,19,28H,5-15H2,1-2H3
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n/an/a 70n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194962
PNG
(US9206198, 17)
Show SMILES CCC1=C(COC1=O)N1CCC2(CCN(C[C@H](OC)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:2|
Show InChI InChI=1S/C26H32N2O6/c1-4-17-21(15-34-23(17)29)28-12-9-26(25(28)31)7-10-27(11-8-26)13-22(32-3)18-5-6-19-20(16(18)2)14-33-24(19)30/h5-6,22H,4,7-15H2,1-3H3/t22-/m0/s1
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n/an/a 80n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195010
PNG
(US9206198, 73)
Show SMILES CC1=CN(C(=O)C11CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1)C1=C(C)C(=O)OC1 |r,c:30,t:1|
Show InChI InChI=1S/C25H28N2O6/c1-14-10-27(20-13-33-22(29)16(20)3)24(31)25(14)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,10,21,28H,6-9,11-13H2,1-3H3/t21-/m0/s1
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n/an/a 80n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194976
PNG
(US9206198, 34)
Show SMILES CC1CN(C(=O)C11CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1)C1=C(C)C(=O)OC1 |r,c:30|
Show InChI InChI=1S/C25H30N2O6/c1-14-10-27(20-13-33-22(29)16(20)3)24(31)25(14)6-8-26(9-7-25)11-21(28)17-4-5-18-19(15(17)2)12-32-23(18)30/h4-5,14,21,28H,6-13H2,1-3H3/t14?,21-/m0/s1
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n/an/a 90n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194980
PNG
(US9206198, 39 | US9206198, 42)
Show SMILES CC1CC2(CC3CCC(C2)N3C[C@H](O)c2ccc3C(=O)OCc3c2C)C(=O)N1C1=CC(=O)OC1 |r,wD:12.14,t:33,TLB:2:3:6.7:10,11:10:6.7:9.4.3,(5.93,1.35,;5.06,.08,;3.52,.03,;3.09,-1.45,;1.39,-1.37,;.23,-.26,;.75,1.19,;1.13,-.04,;.51,-1.74,;1.69,-2.65,;-1.46,-1.13,;-2.79,-.36,;-4.13,-1.13,;-4.13,-2.67,;-5.46,-.36,;-5.46,1.18,;-6.79,1.95,;-8.13,1.18,;-9.59,1.66,;-10.36,2.99,;-10.5,.41,;-9.59,-.83,;-8.13,-.36,;-6.79,-1.13,;-6.79,-2.67,;4.36,-2.32,;3.23,1.13,;5.58,-1.37,;6.79,.09,;7.7,1.34,;9.16,.86,;10.5,1.63,;9.16,-.68,;7.7,-1.16,)|
Show InChI InChI=1S/C26H30N2O6/c1-14-8-26(25(32)28(14)18-7-23(30)33-12-18)9-16-3-4-17(10-26)27(16)11-22(29)19-5-6-20-21(15(19)2)13-34-24(20)31/h5-7,14,16-17,22,29H,3-4,8-13H2,1-2H3/t14?,16?,17?,22-,26?/m0/s1
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n/an/a 100n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195024
PNG
(US9206198, 14)
Show SMILES CO[C@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,c:14|
Show InChI InChI=1S/C26H32N2O6/c1-15-18(5-6-19-20(15)14-33-24(19)30)21(32-4)13-27-10-7-26(8-11-27)9-12-28(25(26)31)22-16(2)23(29)34-17(22)3/h5-6,17,21H,7-14H2,1-4H3/t17?,21-/m1/s1
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n/an/a 100n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194999
PNG
(US9206198, 60)
Show SMILES CNC(CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |c:14|
Show InChI InChI=1S/C25H31N3O5/c1-15-17(4-5-18-19(15)13-32-23(18)30)20(26-3)12-27-9-6-25(7-10-27)8-11-28(24(25)31)21-14-33-22(29)16(21)2/h4-5,20,26H,6-14H2,1-3H3
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n/an/a 100n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194961
PNG
(US9206198, 16)
Show SMILES CO[C@@H](CN1CCC2(CN(C(=O)C2)C2=C(C)C(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,c:14|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)12-32-24(18)30)21(31-3)11-26-8-6-25(7-9-26)10-22(28)27(14-25)20-13-33-23(29)16(20)2/h4-5,21H,6-14H2,1-3H3/t21-/m0/s1
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n/an/a 110n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194958
PNG
(US9206198, 11)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,t:14|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)14-32-23(18)29)21(31-3)13-26-9-6-25(7-10-26)8-11-27(24(25)30)20-12-22(28)33-16(20)2/h4-5,12,16,21H,6-11,13-14H2,1-3H3/t16?,21-/m0/s1
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n/an/a 120n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195018
PNG
(US9206198, 85A | US9206198, 85B)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC2)C(C)(C)C(O)c2ccc3C(=O)OCc3c2C)C1=O |t:1|
Show InChI InChI=1S/C26H32N2O6/c1-15-17(5-6-18-19(15)13-33-23(18)31)21(29)25(3,4)27-10-7-26(8-11-27)9-12-28(24(26)32)20-14-34-22(30)16(20)2/h5-6,21,29H,7-14H2,1-4H3
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n/an/a 120n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194985
PNG
(US9206198, 46)
Show SMILES CN1CC2CC3(CCN(C3=O)C3=C(C)C(=O)OC3)CC(C1)N2C[C@@H](O)c1ccc2C(=O)OCc2c1C |r,c:12,TLB:0:1:21:18.4.5,9:5:21:2.1.20,THB:6:5:21:2.1.20,22:21:2.1.20:18.4.5|
Show InChI InChI=1S/C27H33N3O6/c1-15-19(4-5-20-21(15)13-35-25(20)33)23(31)12-30-17-8-27(9-18(30)11-28(3)10-17)6-7-29(26(27)34)22-14-36-24(32)16(22)2/h4-5,17-18,23,31H,6-14H2,1-3H3/t17?,18?,23-,27?/m1/s1
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n/an/a 140n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195023
PNG
(US9206198, 12)
Show SMILES CO[C@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,t:14|
Show InChI InChI=1S/C25H30N2O6/c1-15-17(4-5-18-19(15)14-32-23(18)29)21(31-3)13-26-9-6-25(7-10-26)8-11-27(24(25)30)20-12-22(28)33-16(20)2/h4-5,12,16,21H,6-11,13-14H2,1-3H3/t16?,21-/m1/s1
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n/an/a 140n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194993
PNG
(US9206198, 54)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(NC3CC3)c3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1|
Show InChI InChI=1S/C27H33N3O5/c1-16-19(5-6-20-21(16)14-34-25(20)32)22(28-18-3-4-18)13-29-10-7-27(8-11-29)9-12-30(26(27)33)23-15-35-24(31)17(23)2/h5-6,18,22,28H,3-4,7-15H2,1-2H3
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n/an/a 150n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194984
PNG
(US9206198, 45)
Show SMILES CN1CC2CC3(CCN(C3=O)C3=C(C)C(=O)OC3)CC(C1)N2C[C@H](O)c1ccc2C(=O)OCc2c1C |r,c:12,TLB:0:1:21:18.4.5,9:5:21:2.1.20,THB:6:5:21:2.1.20,22:21:2.1.20:18.4.5|
Show InChI InChI=1S/C27H33N3O6/c1-15-19(4-5-20-21(15)13-35-25(20)33)23(31)12-30-17-8-27(9-18(30)11-28(3)10-17)6-7-29(26(27)34)22-14-36-24(32)16(22)2/h4-5,17-18,23,31H,6-14H2,1-3H3/t17?,18?,23-,27?/m0/s1
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n/an/a 160n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194960
PNG
(US9206198, 15)
Show SMILES CO[C@@H](CN1CCC2(CN(C(=O)C2)C2=CC(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,t:14|
Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)13-32-23(18)29)20(30-2)11-25-7-5-24(6-8-25)10-21(27)26(14-24)16-9-22(28)31-12-16/h3-4,9,20H,5-8,10-14H2,1-2H3/t20-/m0/s1
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n/an/a 170n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195015
PNG
(US9206198, 82)
Show SMILES CC1=C(COC1=O)N1CCC2(CC3COCC(C2)N3C[C@H](O)c2ccc3C(=O)OCc3c2C)C1=O |r,t:1,TLB:9:10:18:13.15.14,19:18:13.15.14:17.11.10,THB:33:10:18:13.15.14|
Show InChI InChI=1S/C26H30N2O7/c1-14-18(3-4-19-20(14)12-34-24(19)31)22(29)9-28-16-7-26(8-17(28)11-33-10-16)5-6-27(25(26)32)21-13-35-23(30)15(21)2/h3-4,16-17,22,29H,5-13H2,1-2H3/t16?,17?,22-,26?/m0/s1
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n/an/a 180n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195014
PNG
(US9206198, 80 | US9206198, 81)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3F)CC2)C1=O |t:1|
Show InChI InChI=1S/C23H25FN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
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n/an/a 190n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195025
PNG
(US9206198, 28)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2F)C1=O |r,t:1|
Show InChI InChI=1S/C24H27FN2O6/c1-13-15(3-4-16-17(13)11-32-22(16)30)19(28)9-26-7-5-24(20(25)10-26)6-8-27(23(24)31)18-12-33-21(29)14(18)2/h3-4,19-20,28H,5-12H2,1-2H3/t19-,20?,24?/m1/s1
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n/an/a 190n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194957
PNG
(US9206198, 10)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2)C2=CC(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |r,t:13|
Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)28)21(29-2)12-25-8-5-24(6-9-25)7-10-26(15-24)17-11-22(27)30-13-17/h3-4,11,21H,5-10,12-15H2,1-2H3/t21-/m0/s1
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n/an/a 200n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195011
PNG
(US9206198, 74 | US9206198, 75)
Show SMILES CCc1c2COC(=O)c2ccc1C(O)CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |c:27|
Show InChI InChI=1S/C25H30N2O6/c1-3-16-17(4-5-18-19(16)13-32-23(18)30)21(28)12-26-9-6-25(7-10-26)8-11-27(24(25)31)20-14-33-22(29)15(20)2/h4-5,21,28H,3,6-14H2,1-2H3
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n/an/a 200n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194998
PNG
(US9206198, 59)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(NCC[N+]#[C-])c3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1|
Show InChI InChI=1S/C27H32N4O5/c1-17-19(4-5-20-21(17)15-35-25(20)33)22(29-10-9-28-3)14-30-11-6-27(7-12-30)8-13-31(26(27)34)23-16-36-24(32)18(23)2/h4-5,22,29H,6-16H2,1-2H3
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n/an/a 210n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194972
PNG
(US9206198, 27)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2F)C1=O |r,t:1|
Show InChI InChI=1S/C24H27FN2O6/c1-13-15(3-4-16-17(13)11-32-22(16)30)19(28)9-26-7-5-24(20(25)10-26)6-8-27(23(24)31)18-12-33-21(29)14(18)2/h3-4,19-20,28H,5-12H2,1-2H3/t19-,20?,24?/m0/s1
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n/an/a 210n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194997
PNG
(US9206198, 58)
Show SMILES COCCNC(CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1)c1ccc2C(=O)OCc2c1C |c:17|
Show InChI InChI=1S/C27H35N3O6/c1-17-19(4-5-20-21(17)15-35-25(20)32)22(28-9-13-34-3)14-29-10-6-27(7-11-29)8-12-30(26(27)33)23-16-36-24(31)18(23)2/h4-5,22,28H,6-16H2,1-3H3
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n/an/a 220n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194971
PNG
(US9206198, 26)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2O)C1=O |r,t:1|
Show InChI InChI=1S/C24H28N2O7/c1-13-15(3-4-16-17(13)11-32-22(16)30)19(27)9-25-7-5-24(20(28)10-25)6-8-26(23(24)31)18-12-33-21(29)14(18)2/h3-4,19-20,27-28H,5-12H2,1-2H3/t19-,20?,24?/m0/s1
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n/an/a 230n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194969
PNG
(US9206198, 24)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C2)C2=CC(=O)OC2)CC1 |r,t:26|
Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)29)21(27)12-25-9-6-24(7-10-25)5-2-8-26(15-24)17-11-22(28)30-13-17/h3-4,11,21,27H,2,5-10,12-15H2,1H3/t21-/m0/s1
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n/an/a 240n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195012
PNG
(US9206198, 76 | US9206198, 77)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3C3CC3)CC2)C1=O |t:1|
Show InChI InChI=1S/C26H30N2O6/c1-15-20(14-34-23(15)30)28-11-8-26(25(28)32)6-9-27(10-7-26)12-21(29)18-5-4-17-19(13-33-24(17)31)22(18)16-2-3-16/h4-5,16,21,29H,2-3,6-14H2,1H3
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n/an/a 240n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194981
PNG
(US9206198, 40 | US9206198, 41)
Show SMILES CC1CC2(CC3CCC(C2)N3C[C@@H](O)c2ccc3C(=O)OCc3c2C)C(=O)N1C1=CC(=O)OC1 |r,wU:12.14,t:33,TLB:2:3:6.7:10,11:10:6.7:9.4.3,(5.93,1.35,;5.06,.08,;3.52,.03,;3.09,-1.45,;1.39,-1.37,;.23,-.26,;.75,1.19,;1.13,-.04,;.51,-1.74,;1.69,-2.65,;-1.46,-1.13,;-2.79,-.36,;-4.13,-1.13,;-4.13,-2.67,;-5.46,-.36,;-5.46,1.18,;-6.79,1.95,;-8.13,1.18,;-9.59,1.66,;-10.36,2.99,;-10.5,.41,;-9.59,-.83,;-8.13,-.36,;-6.79,-1.13,;-6.79,-2.67,;4.36,-2.32,;3.23,1.13,;5.58,-1.37,;6.79,.09,;7.7,1.34,;9.16,.86,;10.5,1.63,;9.16,-.68,;7.7,-1.16,)|
Show InChI InChI=1S/C26H30N2O6/c1-14-8-26(25(32)28(14)18-7-23(30)33-12-18)9-16-3-4-17(10-26)27(16)11-22(29)19-5-6-20-21(15(19)2)13-34-24(20)31/h5-7,14,16-17,22,29H,3-4,8-13H2,1-2H3/t14?,16?,17?,22-,26?/m1/s1
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n/an/a 240n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194994
PNG
(US9206198, 55)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(NCC(F)F)c3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1|
Show InChI InChI=1S/C26H31F2N3O5/c1-15-17(3-4-18-19(15)13-35-24(18)33)20(29-11-22(27)28)12-30-8-5-26(6-9-30)7-10-31(25(26)34)21-14-36-23(32)16(21)2/h3-4,20,22,29H,5-14H2,1-2H3
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n/an/a 250n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195013
PNG
(US9206198, 78 | US9206198, 79)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(O)c3ccc4C(=O)OCc4c3Cl)CC2)C1=O |t:1|
Show InChI InChI=1S/C23H25ClN2O6/c1-13-17(12-32-20(13)28)26-9-6-23(22(26)30)4-7-25(8-5-23)10-18(27)15-3-2-14-16(19(15)24)11-31-21(14)29/h2-3,18,27H,4-12H2,1H3
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n/an/a 270n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194949
PNG
(US9206198, 3)
Show SMILES O=C1OCC(=C1)N1CCC2(CCN(CCc3ccc4C(=O)OCc4c3)CC2)C1=O |c:4|
Show InChI InChI=1S/C22H24N2O5/c25-19-12-17(14-28-19)24-10-6-22(21(24)27)4-8-23(9-5-22)7-3-15-1-2-18-16(11-15)13-29-20(18)26/h1-2,11-12H,3-10,13-14H2
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n/an/a 290n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194990
PNG
(US9206198, 51)
Show SMILES CO[C@@H](CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1)c1ccc2C(=O)OCc2c1C |r,t:11|
Show InChI InChI=1S/C24H28N2O6/c1-15-17(3-4-18-19(15)14-32-22(18)28)20(30-2)12-25-8-5-24(6-9-25)7-10-26(23(24)29)16-11-21(27)31-13-16/h3-4,11,20H,5-10,12-14H2,1-2H3/t20-/m0/s1
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n/an/a 310n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194996
PNG
(US9206198, 57)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(N3CCC3)c3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1|
Show InChI InChI=1S/C27H33N3O5/c1-17-19(4-5-20-21(17)15-34-25(20)32)22(29-9-3-10-29)14-28-11-6-27(7-12-28)8-13-30(26(27)33)23-16-35-24(31)18(23)2/h4-5,22H,3,6-16H2,1-2H3
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n/an/a 320n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195007
PNG
(US9206198, 70)
Show SMILES CC1=C(COC1=O)N1C(CC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O)C1CC1 |r,t:1|
Show InChI InChI=1S/C27H32N2O6/c1-15-18(5-6-19-20(15)13-34-25(19)32)23(30)12-28-9-7-27(8-10-28)11-21(17-3-4-17)29(26(27)33)22-14-35-24(31)16(22)2/h5-6,17,21,23,30H,3-4,7-14H2,1-2H3/t21?,23-/m0/s1
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n/an/a 340n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194991
PNG
(US9206198, 52)
Show SMILES O=C1OCC(=C1)N1CCC2(CCN(CC3OCCc4c5COC(=O)c5ccc34)CC2)C1=O |c:4|
Show InChI InChI=1S/C24H26N2O6/c27-21-11-15(13-31-21)26-9-6-24(23(26)29)4-7-25(8-5-24)12-20-17-1-2-18-19(14-32-22(18)28)16(17)3-10-30-20/h1-2,11,20H,3-10,12-14H2
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n/an/a 350n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194995
PNG
(US9206198, 56)
Show SMILES CC1=C(COC1=O)N1CCC2(CCN(CC(NC3CCC3)c3ccc4C(=O)OCc4c3C)CC2)C1=O |t:1|
Show InChI InChI=1S/C28H35N3O5/c1-17-20(6-7-21-22(17)15-35-26(21)33)23(29-19-4-3-5-19)14-30-11-8-28(9-12-30)10-13-31(27(28)34)24-16-36-25(32)18(24)2/h6-7,19,23,29H,3-5,8-16H2,1-2H3
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n/an/a 370n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194966
PNG
(US9206198, 21)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:23|
Show InChI InChI=1S/C23H26N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,10,19,26H,4-9,11-13H2,1H3/t19-/m1/s1
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n/an/a 370n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195024
PNG
(US9206198, 14)
Show SMILES CO[C@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,c:14|
Show InChI InChI=1S/C26H32N2O6/c1-15-18(5-6-19-20(15)14-33-24(19)30)21(32-4)13-27-10-7-26(8-11-27)9-12-28(25(26)31)22-16(2)23(29)34-17(22)3/h5-6,17,21H,7-14H2,1-4H3/t17?,21-/m1/s1
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US Patent
n/an/a 380n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194966
PNG
(US9206198, 21)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2(CCN(C3=CC(=O)OC3)C2=O)CC1 |r,t:23|
Show InChI InChI=1S/C23H26N2O6/c1-14-16(2-3-17-18(14)13-31-21(17)28)19(26)11-24-7-4-23(5-8-24)6-9-25(22(23)29)15-10-20(27)30-12-15/h2-3,10,19,26H,4-9,11-13H2,1H3/t19-/m1/s1
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n/an/a 390n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194959
PNG
(US9206198, 13)
Show SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C |r,c:14|
Show InChI InChI=1S/C26H32N2O6/c1-15-18(5-6-19-20(15)14-33-24(19)30)21(32-4)13-27-10-7-26(8-11-27)9-12-28(25(26)31)22-16(2)23(29)34-17(22)3/h5-6,17,21H,7-14H2,1-4H3/t17?,21-/m0/s1
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n/an/a 490n/an/an/an/an/a37



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM194969
PNG
(US9206198, 24)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C2)C2=CC(=O)OC2)CC1 |r,t:26|
Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)29)21(27)12-25-9-6-24(7-10-25)5-2-8-26(15-24)17-11-22(28)30-13-17/h3-4,11,21,27H,2,5-10,12-15H2,1H3/t21-/m0/s1
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n/an/a 620n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...

US Patent US9206198 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86FH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%