| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase beta |
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| Ligand | BDBM50164648 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1661124 (CHEMBL4010736) |
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| IC50 | 1400±n/a nM |
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| Citation |  Kirschberg, TA; Metobo, S; Clarke, MO; Aktoudianakis, V; Babusis, D; Barauskas, O; Birkus, G; Butler, T; Byun, D; Chin, G; Doerffler, E; Edwards, TE; Fenaux, M; Lee, R; Lew, W; Mish, MR; Murakami, E; Park, Y; Squires, NH; Tirunagari, N; Wang, T; Whitcomb, M; Xu, J; Yang, H; Ye, H; Zhang, L; Appleby, TC; Feng, JY; Ray, AS; Cho, A; Kim, CU Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorg Med Chem Lett27:1840-1847 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase beta |
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| Name: | DNA polymerase beta |
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| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
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| Type: | Protein |
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| Mol. Mass.: | 38188.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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| BDBM50164648 |
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| n/a |
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| Name | BDBM50164648 |
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| Synonyms: | 2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL363559 | dTTP | dThd5'PPP | deoxy-TTP | pppdT | thymidine 5'-(tetrahydrogen triphosphate) | thymidine 5'-triphosphate |
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| Type | Small organic molecule |
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| Emp. Form. | C10H17N2O14P3 |
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| Mol. Mass. | 482.1683 |
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| SMILES | Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| |
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| Structure | 
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