Reaction Details |
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Target | Glucocorticoid receptor |
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Ligand | BDBM19202 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304255 (CHEMBL829726) |
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EC50 | 5.2±n/a nM |
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Citation | Thompson, CF; Quraishi, N; Ali, A; Tata, JR; Hammond, ML; Balkovec, JM; Einstein, M; Ge, L; Harris, G; Kelly, TM; Mazur, P; Pandit, S; Santoro, J; Sitlani, A; Wang, C; Williamson, J; Miller, DK; Yamin, TT; Thompson, CM; O'Neill, EA; Zaller, D; Forrest, MJ; Carballo-Jane, E; Luell, S Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy. Bioorg Med Chem Lett15:2163-7 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucocorticoid receptor |
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Name: | Glucocorticoid receptor |
Synonyms: | GCR_MOUSE | Glucocorticoid | Glucocorticoid receptor | Grl | Grl1 | Nr3c1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 86050.26 |
Organism: | MOUSE |
Description: | Glucocorticoid 0 MOUSE::P06537 |
Residue: | 783 |
Sequence: | MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQ
RILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLG
LSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRK
SQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGED
DPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVI
KQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFN
VIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTA
TGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNC
PACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVS
LLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMT
LLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQ
RLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQR
FYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLF
HQK
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BDBM19202 |
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n/a |
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Name | BDBM19202 |
Synonyms: | (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(thiophen-3-yl)ethan-1-ol | CHEMBL310570 | N-Arylpyrazolo[3,2-c]-Based Ligand, 25 |
Type | Small organic molecule |
Emp. Form. | C24H25FN2OS |
Mol. Mass. | 408.532 |
SMILES | [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@](C)(O)c1ccsc1 |r,t:5| |
Structure |
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