Reaction Details | |||
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Target | Cyclin-dependent kinase 4 | ||
Ligand | BDBM50420305 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Activity Assay | ||
pH | 7.5±0 | ||
IC50 | 12±n/a nM | ||
Citation | Howard, S; Mortenson, PN; Hiscock, SD; Woolford, AJ; Woodhead, AJ; Chessari, G; O'Reilly, M; Congreve, MS; Dagostin, C; Cho, YS; Yang, F; Chen, CH; Brain, CT; Lagu, B; Wang, Y; Kim, S; Giraldes, J; Luzzio, MJ; Perez, LB Imidazole derivatives and their use as modulators of cyclin dependent kinases US Patent US8598217 Publication Date 12/3/2013 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Cyclin-dependent kinase 4 | |||
Name: | Cyclin-dependent kinase 4 | ||
Synonyms: | Cyclin-dependent kinase 4 (CDK4) | ||
Type: | Enzyme | ||
Mol. Mass.: | 21063.86 | ||
Organism: | Oryctolagus cuniculus (Rabbit) | ||
Description: | Q0GMK6 | ||
Residue: | 189 | ||
Sequence: |
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BDBM50420305 | |||
n/a | |||
Name | BDBM50420305 | ||
Synonyms: | CHEMBL2089057 | US8598217, 173 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30N8O | ||
Mol. Mass. | 482.5801 | ||
SMILES | CN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccc(C#N)c(c1)-c1c(C)nn(C)c1C |(10.17,-39.75,;9.4,-38.41,;10.17,-37.08,;7.86,-38.41,;7.09,-39.74,;5.55,-39.75,;4.79,-38.41,;5.54,-37.08,;7.09,-37.08,;3.25,-38.42,;2.47,-37.08,;.94,-37.09,;.18,-38.42,;-1.32,-38.74,;-1.49,-40.28,;-.07,-40.9,;.95,-39.75,;2.48,-39.75,;-2.82,-41.05,;-2.82,-42.59,;-4.15,-40.28,;-5.49,-41.06,;-6.83,-40.29,;-6.82,-38.74,;-8.16,-37.97,;-9.5,-37.2,;-5.49,-37.97,;-4.16,-38.73,;-5.51,-36.43,;-6.76,-35.53,;-8.22,-36.01,;-6.29,-34.06,;-4.75,-34.06,;-3.85,-32.81,;-4.27,-35.52,;-2.8,-35.99,)| | ||
Structure |