Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 4

Ligand

BDBM107763

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Activity Assay

7.5±0

IC50

95±n/a nM

Citation

Howard, S; Mortenson, PN; Hiscock, SD; Woolford, AJ; Woodhead, AJ; Chessari, G; O'Reilly, M; Congreve, MS; Dagostin, C; Cho, YS; Yang, F; Chen, CH; Brain, CT; Lagu, B; Wang, Y; Kim, S; Giraldes, J; Luzzio, MJ; Perez, LB Imidazole derivatives and their use as modulators of cyclin dependent kinases US Patent US8598217 Publication Date 12/3/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Cyclin-dependent kinase 4

Name:

Cyclin-dependent kinase 4

Synonyms:

Cyclin-dependent kinase 4 (CDK4)

Type:

Enzyme

Mol. Mass.:

21063.86

Organism:

Oryctolagus cuniculus (Rabbit)

Description:

Q0GMK6

Residue:

189

Sequence:

HFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKV
TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMCQFLRGLDFLHANCIVHRDLKPENILVT
SSGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSAGCIFAEMFR
RKPLFCGNS

BDBM107763

n/a

Name

BDBM107763

Synonyms:

US8598217, 189

Type

Small organic molecule

Emp. Form.

C24H24N8O

Mol. Mass.

440.5004

SMILES

Cc1nn(C)c(C)c1-c1cc(ccc1C#N)C(=O)c1nc2nc(ccc2[nH]1)N1CCNCC1 |(-2.1,1.36,;-3.44,2.13,;-3.91,3.6,;-5.45,3.6,;-6.22,4.93,;-5.93,2.13,;-7.26,1.36,;-4.68,1.23,;-4.68,-.31,;-3.35,-1.08,;-3.35,-2.62,;-4.68,-3.39,;-6.02,-2.62,;-6.02,-1.08,;-7.35,-.31,;-8.68,.46,;-2.02,-3.39,;-2.02,-4.93,;-.68,-2.62,;.72,-3.25,;1.75,-2.1,;3.29,-2.1,;4.06,-.77,;3.29,.56,;1.75,.56,;.98,-.77,;-.52,-1.09,;5.6,-.77,;6.37,-2.1,;7.91,-2.1,;8.68,-.77,;7.91,.56,;6.37,.56,)|

Structure