The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28591512 |
114 |
Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. |
Glaxosmithkline |
| 27983846 |
66 |
Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. |
University of Bath |
| 28001384 |
189 |
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. |
Health & Science University |
| 27163581 |
110 |
Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. |
University of Bath |
| 26985304 |
23 |
Potential Use of Inhibitors of Tankyrases and PARP-1 as Treatment for Cancer and Other Diseases. |
Therachem Research Medilab (India) |
| 26652717 |
96 |
Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. |
Biomarin Pharmaceutical |
| 26706174 |
46 |
Development and structural analysis of adenosine site binding tankyrase inhibitors. |
University of Oulu |
| 26231158 |
29 |
Selective inhibition of PARP10 using a chemical genetics strategy. |
Oregon Health & Science University |
| 26342868 |
14 |
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation. |
China Pharmaceutical University |
| 26312434 |
1 |
Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties. |
Xinjiang Technical Institute of Physics and Chemistry |
| 26222319 |
192 |
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. |
Nerviano Medical Sciences |
| 26183543 |
87 |
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. |
University of Oulu |
| 26088338 |
50 |
Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. |
University of Malaya |
| 26026769 |
24 |
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. |
University of Bath |
| 26061013 |
55 |
Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library. |
Philochem |
| 25761096 |
17 |
Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination. |
Istituto Di Ricerche Di Biologia Molecolare |
| 25899312 |
6 |
Design, synthesis and biological evaluation of pyridazino[3,4,5-de]quinazolin-3(2H)-one as a new class of PARP-1 inhibitors. |
Peking University |
| 25847771 |
121 |
Towards small molecule inhibitors of mono-ADP-ribosyltransferases. |
Karolinska Institutet |
| 25555733 |
11 |
Synthesis and biological evaluation of isoindoloisoquinolinone, pyroloisoquinolinone and benzoquinazolinone derivatives as poly(ADP-ribose) polymerase-1 inhibitors. |
Pondicherry University |
| 25086680 |
11 |
Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. |
Beijing Institute of Pharmacology and Toxicology |
| 24922587 |
45 |
Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors. |
St. John'S University |
| 24815508 |
29 |
Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. |
Chinese Academy of Sciences |
| 24527792 |
8 |
Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. |
Universit£ |
| 24521039 |
5 |
Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells. |
National Cancer Institute-Frederick |
| 24503274 |
7 |
Synthesis, [¹8F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. |
Washington University Saint Louis |
| 24900770 |
5 |
Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. |
University of Oulu |
| 24398383 |
24 |
7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors. |
Universit£ |
| 24388690 |
48 |
Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
| 24900633 |
11 |
Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors. |
Amgen |
| 24900625 |
52 |
Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases. |
University of Bath |
| 24188023 |
32 |
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. |
Ume£ |
| 24074844 |
6 |
Identification of novel PARP-1 inhibitors by structure-based virtual screening. |
St. John'S University |
| 24116873 |
16 |
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. |
University of Oulu |
| 23879431 |
11 |
Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases. |
Novartis Institutes For Biomedical Research |
| 23844574 |
71 |
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. |
Novartis Institutes For Biomedical Research |
| 23849206 |
22 |
One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. |
University of Bath |
| 23850199 |
89 |
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors. |
Takeda California |
| 23701517 |
12 |
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. |
Amgen |
| 23672613 |
8 |
Fragment-based ligand design of novel potent inhibitors of tankyrases. |
Nanyang Technological University |
| 23522835 |
7 |
In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells. |
Sungkyunkwan [Corrected] University |
| 23481647 |
9 |
Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors. |
China Pharmaceutical University |
| 23574272 |
30 |
Screening and structural analysis of flavones inhibiting tankyrases. |
University of Oulu |
| 23473053 |
35 |
Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors. |
Chinese Academy of Sciences |
| 23316926 |
12 |
Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket. |
Amgen |
| 21413808 |
170 |
Synopsis of some recent tactical application of bioisosteres in drug design. |
Bristol-Myers Squibb Pharmaceutical Research and Development |
| 22766219 |
67 |
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. |
Abbott Laboratories |
| 22233320 |
19 |
Structural basis of selective inhibition of human tankyrases. |
Abo Akademi University |
| 22260203 |
73 |
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. |
Novartis Institutes For Biomedical Research |
| 21634396 |
55 |
Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. |
Cephalon |
| 20565110 |
7 |
Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor. |
Karolinska Institutet |
| 17074482 |
31 |
Novel poly(ADP-ribose) polymerase-1 inhibitors. |
Cephalon |
| 12825952 |
31 |
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. |
Guilford Pharmaceuticals |
| 11425538 |
29 |
Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors. |
Guilford Pharmaceuticals |
| 22365563 |
29 |
Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors. |
St. John'S University |
| 22153339 |
27 |
Novel poly(ADP-ribose) polymerase-1 inhibitors. |
Cephalon |
| 21692479 |
27 |
Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). |
University of Arizona |
| 21417348 |
48 |
5-Benzamidoisoquinolin-1-ones and 5-(κ-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). |
University of Bath |
| 21174434 |
13 |
Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. |
Cylene Pharmaceuticals |
| 20364863 |
30 |
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. |
Johns Hopkins University Brain Science Institute |
| 19873981 |
34 |
Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. |
Irbm/Merck Research Laboratories |
| 20337371 |
79 |
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. |
Abbott Laboratories |
| 20189385 |
18 |
Synthesis and evaluation of tricyclic derivatives containing a non-aromatic amide as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). |
Jeil Pharmaceutical |
| 20045315 |
26 |
Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. |
Abbott Laboratories |
| 20031401 |
54 |
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). |
Irbm/Merck Research Laboratories |
| 20022747 |
35 |
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells. |
Merck Research Laboratories |
| 20015648 |
94 |
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). |
Irbm-Merck Research Laboratories Rome |
| 20007017 |
45 |
Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors. |
Irbm-Merck Research Laboratories Rome |
| 19800803 |
16 |
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. |
Sookmyung Women'S University |
| 19888760 |
44 |
Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents. |
Abbott Laboratories |
| 19553114 |
38 |
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). |
Abbott Laboratories |
| 19553107 |
27 |
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors. |
Irbm-Merck Research Laboratories Rome |
| 19541484 |
45 |
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. |
Irbm-Merck Research Laboratories Rome |
| 19354255 |
10 |
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. |
Institutet |
| 19125579 |
58 |
Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. |
Huazhong University of Science and Technology |
| 19117416 |
18 |
Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. |
University of Bath |
| 18586490 |
40 |
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent. |
Abbott Laboratories |
| 17804225 |
33 |
Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase. |
Astellas Pharma |
| 16359865 |
22 |
Synthesis and structure-activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). |
Cephalon |
| 16290935 |
17 |
Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. |
Cephalon |
| 16290932 |
33 |
Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase. |
Kudos Pharmaceuticals |
| 16098744 |
18 |
4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. |
Fujisawa Pharmaceutical |
| 15837300 |
30 |
Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase. |
Kudos Horsham |
| 15481984 |
45 |
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase. |
Pfizer |
| 15293985 |
33 |
Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase. |
Fujisawa Pharmaceutical |
| 15109627 |
16 |
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors. |
University of Newcastle |
| 12852955 |
25 |
Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones. |
Guilford Pharmaceuticals |
| 12519059 |
10 |
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. |
Pfizer |
| 12408707 |
32 |
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure. |
Pfizer |
| 12372530 |
76 |
Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). |
Bayer |
| 11689065 |
27 |
Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis. |
Università |
| 32088129 |
19 |
Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors. |
Hefei University of Technology |
| 32511917 |
79 |
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. |
University of Oslo |
| 32435397 |
31 |
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. |
University of Naples |
| 11063605 |
36 |
Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. |
Newcastle University |
| 30684797 |
32 |
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update. |
Nirma University |
| 30996792 |
20 |
Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. |
Nerviano Medical Sciences |
| 27561983 |
22 |
Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation. |
China Pharmaceutical University |
| 27353531 |
19 |
Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors. |
China Pharmaceutical University |
| 31153806 |
11 |
Discovery of naphthacemycins as a novel class of PARP1 inhibitors. |
North China Pharmaceutical Group |
| 30883102 |
214 |
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. |
Riken |
| 31846325 |
46 |
Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy. |
TBA |
| 31442685 |
7 |
Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation. |
Suez Canal University |
| 31401008 |
34 |
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review. |
Y. B. Chavan College of Pharmacy |
| 32202790 |
160 |
Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer. |
Japanese Foundation For Cancer Research |
| 31381853 |
124 |
Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity. |
Merck Healthcare |
| 30655950 |
116 |
Rational Design of Cell-Active Inhibitors of PARP10. |
Oregon Health and Science University |
| 26546219 |
47 |
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. |
Astrazeneca |
| 26469301 |
12 |
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. |
University of Glasgow |
| 31042381 |
166 |
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. |
St. John'S University |
| 30006177 |
103 |
4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. |
University of Oulu |
| 29107427 |
13 |
Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors. |
University of Perugia |
| 30403352 |
171 |
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. |
The University of Manchester |
| 29335205 |
70 |
Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors. |
Chinese Academy of Sciences |
| 29934219 |
8 |
Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors. |
University of Salerno |
| 29456106 |
19 |
Design, synthesis and anticancer activities evaluation of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units. |
China Medical University |
| 29856625 |
43 |
Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity. |
University of Pennsylvania |
| 28763648 |
23 |
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy. |
Tsinghua University |
| 28692916 |
42 |
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. |
East China University of Science and Technology |
| 29748053 |
87 |
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14. |
Mcdaniel College |
| 28622906 |
52 |
Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors. |
Chinese Academy of Medical Sciences & Peking Union Medical College |
| 28601509 |
20 |
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy. |
Tsinghua University |
| 28445046 |
1 |
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment. |
Regina Elena National Cancer Institute |
| 29155568 |
29 |
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. |
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp) |
| 28438542 |
13 |
Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach. |
Punjabi University |
| 28340412 |
71 |
Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity. |
Chinese Academy of Medical Sciences & Peking Union Medical College |
| 28495083 |
70 |
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14. |
Mcdaniel College |
| | 4 |
Discovery of potent inhibitors of PLproCoV2 by screening a library of selenium-containing compounds |
University Ofamsterdam |
| 23488740 |
12 |
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis. |
Tokushima Bunri University |
| 21981000 |
104 |
Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis. |
Slovak University of Technology |
| 28196602 |
16 |
Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity. |
Hanoi University of Pharmacy |
| 23864660 |
3 |
Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation. |
Wageningen University |
| 26895387 |
24 |
Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. |
Stony Brook University |
| 8301582 |
57 |
Expression and pharmacological characterization of the human D3 dopamine receptor. |
Neuroscience Research Centre |
| 8169832 |
9 |
Characterization of a 5-hydroxytryptamine receptor in mouse neuroblastoma N18TG2 cells. |
University of Pennsylvania |
| 8161940 |
9 |
Melatonin receptors: localization, molecular pharmacology and physiological significance. |
Rowett Research Institute |
| 8155646 |
3 |
Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor. |
Medical University of South Carolina |
| 7908054 |
71 |
Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes. |
University of Nebraska |
| 7902811 |
5 |
Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents. |
University of North Carolina |
| 19729306 |
15 |
Structure-based design of novel human Pin1 inhibitors (I). |
Pfizer |
| 19231176 |
48 |
Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator. |
F. Hoffmann-La Roche |
| 18800822 |
40 |
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. |
Kudos Pharmaceuticals |
| 19111460 |
94 |
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design. |
Boehringer Ingelheim Pharmaceuticals |
| 16337119 |
48 |
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. |
Academy of Sciences of The Czech Republic |
| 17035017 |
25 |
2,6-Quinolinyl derivatives as potent VLA-4 antagonists. |
Ucb Pharma |
| 16806920 |
32 |
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48. |
Wyeth Research |
| 16162008 |
146 |
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. |
Abbott Laboratories |
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