The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28591512 |
114 |
Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. |
Glaxosmithkline |
| 28337332 |
41 |
BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. |
Bristol-Myers Squibb |
| 28169167 |
137 |
Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 2157007 |
9 |
Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets. |
Ohio State University |
| 7120280 |
9 |
Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. |
TBA |
| 27958732 |
93 |
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. |
Bristol-Myers Squibb |
| 27876250 |
60 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH |
Jagiellonian University Medical College |
| 27939174 |
84 |
Challenges in the development of an M |
Vanderbilt University Medical Center |
| 28105289 |
51 |
Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] asa7 Nicotinic Receptor Agonists. |
Bristol-Myers Squibb Research and Development |
| 27839919 |
192 |
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples. |
University of Kansas |
| 27933810 |
166 |
Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 26876931 |
36 |
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket. |
Abbott Healthcare Products |
| 26988801 |
55 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. |
Jagiellonian University Medical College |
| 26700945 |
68 |
Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. |
National Institute of Biological Sciences, Beijing |
| 26475518 |
19 |
Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor. |
City University of New York |
| 25127461 |
36 |
Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression. |
Yonsei University |
| 24901260 |
12 |
Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors. |
University of Illinois At Chicago |
| 24881566 |
140 |
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
Glaxosmithkline |
| 24755431 |
59 |
The discovery of diazepinone-based 5-HT3 receptor partial agonists. |
Amri |
| 24050653 |
59 |
Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. |
The Johns Hopkins University School of Medicine |
| 24582985 |
1 |
5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor. |
Virginia Commonwealth University |
| 24365159 |
35 |
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds. |
University of Missouri |
| 24128816 |
10 |
Design of fluorinated 5-HT(4)R antagonists: influence of the basicity and lipophilicity toward the 5-HT(4)R binding affinities. |
University of Southampton |
| 24128813 |
8 |
Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. |
Universit£ |
| 24147864 |
6 |
Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1). |
National Institute of Mental Health |
| 24084296 |
9 |
In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model. |
University of Mississippi |
| 24035337 |
10 |
2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character. |
Virginia Commonwealth University |
| 24611085 |
101 |
Discovery of ML314, a Brain Penetrant Non-Peptidic?-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. |
Sanford-Burnham Medical Research Institute |
| 23756062 |
25 |
Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties. |
Theravance |
| 23707254 |
7 |
Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems. |
Dalhousie University |
| 23602445 |
23 |
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. |
Ucl School of Pharmacy |
| 23582449 |
20 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. |
Institute of Organic Synthesis |
| 23466604 |
36 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. |
Universit£ |
| 23403082 |
28 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. |
Broad Institute of Mit and Harvard |
| 23414838 |
33 |
Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 23265874 |
1 |
Near native binding of a fluorescent serotonin conjugate to serotonin type 3 receptors. |
Washington State University |
| 22468936 |
49 |
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). |
Siena Biotech |
| 21782429 |
18 |
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A. |
Vu University Amsterdam |
| 20724042 |
2 |
Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors. |
University of Modena and Reggio Emilia |
| 20591663 |
23 |
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods. |
Glaxosmithkline |
| 9191957 |
210 |
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
Universit£ |
| 7752204 |
98 |
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. |
Merck Sharp & Dohme Research Laboratories |
| 23084435 |
17 |
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors. |
Savannah State University |
| 21486038 |
177 |
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. |
H. Lundbeck |
| 23126648 |
213 |
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. |
Targacept |
| 23102207 |
122 |
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers. |
Universit£ |
| 23083093 |
25 |
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate. |
Siena Biotech |
| 23006002 |
35 |
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists. |
Suven Life Sciences |
| 22793665 |
190 |
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. |
Targacept |
| 23006041 |
32 |
Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands. |
Vu University Amsterdam |
| 21919481 |
114 |
Discovery and development ofa7 nicotinic acetylcholine receptor modulators. |
Targacept |
| 22313227 |
78 |
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype. |
National Institute of Mental Health |
| 21726069 |
98 |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. |
University of Namur |
| 21207959 |
69 |
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. |
National Institute of Mental Health |
| 20931963 |
112 |
Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome. |
Aska Pharmaceutical |
| 20684563 |
176 |
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. |
H. Lundbeck |
| 20146481 |
16 |
Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. |
University of Warwick |
| 19963380 |
38 |
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. |
Hunter College and The Graduate Center of The City University of New York |
| 19700325 |
46 |
mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). |
Sepracor |
| 19576766 |
86 |
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
Pfizer |
| 19447040 |
31 |
Quinazolindione derivatives as potent 5-HT3A receptor antagonists. |
Konkuk University |
| 18468904 |
48 |
High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand. |
Purdue University |
| 18033297 |
3 |
An antidepressant that extends lifespan in adult Caenorhabditis elegans. |
Howard Hughes Medical Institute |
| 17483457 |
58 |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. |
Abbott Laboratories |
| 18023344 |
77 |
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration. |
F. Hoffmann-La Roche |
| 17998160 |
101 |
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. |
F. Hoffmann-La Roche |
| 18181565 |
71 |
Multi-target-directed ligands to combat neurodegenerative diseases. |
University of Bologna |
| 17722904 |
146 |
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. |
University of Copenhagen |
| 16198561 |
99 |
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. |
Novartis Institutes For Biomedical Research |
| 16165358 |
26 |
High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor. |
Eli Lilly |
| 12540230 |
18 |
5-HT4 receptor ligands: applications and new prospects. |
Paris-Sud University |
| 12954071 |
109 |
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
Alcon Research |
| 12825922 |
207 |
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). |
Virginia Commonwealth University |
| 11170628 |
37 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties. |
Universidad Complutense |
| 9083484 |
84 |
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands. |
Cooperation Pharmaceutique Fran�Aise |
| 2145434 |
11 |
An initial three-component pharmacophore for specific serotonin-3 receptor ligands. |
Pfizer |
| 2213824 |
20 |
Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists. |
Pfizer |
| 22107017 |
47 |
Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H3 receptor antagonists with potent cognition enhancing activity. |
Cephalon |
| 22189135 |
15 |
High-affinity fluorescent ligands for the 5-HT(3) receptor. |
University of Bern |
| 21866910 |
66 |
N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT6R) antagonists with unique structural features. |
Abbott Healthcare Products |
| 21195614 |
56 |
Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. |
Pfizer |
| 21146988 |
26 |
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome. |
Amri |
| 20889341 |
59 |
Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists. |
Amri |
| 20812727 |
157 |
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. |
National Institute of Mental Health |
| 20813948 |
63 |
Spiroindolones, a potent compound class for the treatment of malaria. |
Swiss Tropical and Public Health Institute |
| 20709559 |
16 |
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. |
Purdue University |
| 20591666 |
66 |
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. |
Università |
| 20465311 |
36 |
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914). |
Siena Biotech |
| 20384344 |
42 |
Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice. |
Meiji Seika Kaisha |
| 20043678 |
92 |
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. |
Pfizer |
| 19646882 |
72 |
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. |
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj |
| 19646865 |
45 |
Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence. |
Pfizer |
| 9182127 |
9 |
Perhydrogenation of tabersonine, ans Aspidiosperma indole alkaloid. |
UniversitÉ |
| | 21 |
Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamides |
TBA |
| | 44 |
5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists |
TBA |
| 19329329 |
183 |
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. |
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz |
| 19282174 |
85 |
Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. |
Pfizer |
| 19261477 |
43 |
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. |
Université |
| 19231180 |
81 |
Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. |
Roche Palo Alto |
| 19208472 |
52 |
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. |
Novartis Institutes For Biomedical Research |
| 19119012 |
20 |
New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents. |
Washington University |
| 17067154 |
27 |
Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. |
Uppsala University |
| 16971122 |
4 |
Inhibitors of unactivated p38 MAP kinase. |
Johnson and Johnson Pharmaceutical Research and Development |
| 16821801 |
35 |
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. |
Pfizer |
| 16361098 |
70 |
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists. |
F. Hoffmann-La Roche |
| 16055331 |
45 |
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. |
Carlsson Research |
| 15267230 |
50 |
Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists. |
Uppsala University |
| 12482441 |
45 |
Development of a presynaptic 5-HT1A antagonist. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12361399 |
17 |
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding. |
Universita Di Camerino |
| 11784148 |
81 |
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. |
Pharmazeutisches Institut Der UniversitäT Freiburg |
| 11514154 |
9 |
5-HT(3)R binding of lerisetron: an interdisciplinary approach to drug-Receptor interactions. |
The University of Louisiana At Monroe |
| 10715164 |
57 |
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. |
Virginia Commonwealth University |
| 10543880 |
63 |
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies. |
Universita' Degli Studi Di Salerno |
| 10464021 |
59 |
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents. |
Knoll Pharmaceuticals |
| 9357515 |
55 |
Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
Merck Sharp and Dohme Research Laboratories |
| 8831767 |
60 |
Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors. |
Virginia Commonwealth University |
| 1652026 |
43 |
Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity. |
Virginia Commonwealth University |
| 24108128 |
2 |
Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis. |
University of Wuerzburg |
| 26833890 |
18 |
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. |
Yogi Vemana University |
| 27064299 |
8 |
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. |
Broad Institute |
| 26851737 |
36 |
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies. |
University of Karachi |
| 26469307 |
7 |
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. |
University of Leipzig |
| 19351152 |
34 |
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. |
University of Leeds |
| 17154490 |
10 |
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. |
Karo Bio |
| 16686531 |
26 |
Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. |
Mgi Pharma |
| 12941317 |
25 |
Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and X-ray crystallographic analysis. |
Glaxosmithkline |
| 10698450 |
21 |
Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation. |
Medivir |
| | 4 |
Molecular Origins of the Slow Streptavidin-Biotin Dissociation Kinetics |
University of Washington |
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