The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28218840 |
38 |
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. |
East China University of Science and Technology |
28065501 |
38 |
Synthesis, docking, cytotoxicity, and LTA |
Mansoura University |
27651294 |
25 |
Thermodynamic properties of leukotriene A |
Goethe-University Frankfurt |
24125851 |
48 |
Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation. |
University of Mansoura |
23260350 |
49 |
Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. |
Janssen Research and Development |
23220644 |
50 |
Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase. |
Peking University |
23127888 |
56 |
Azabenzthiazole inhibitors of leukotriene A4 hydrolase. |
Janssen Research and Development |
22796349 |
34 |
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors. |
Universit£ |
12139459 |
74 |
Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. |
Pfizer |
10691697 |
133 |
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. |
Searle Research and Development |
| 38 |
Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase |
TBA |
| 8 |
Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity |
TBA |
22059882 |
206 |
5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. |
Amira Pharmaceuticals |
21542630 |
135 |
Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase. |
Peking University |
21377770 |
26 |
Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors. |
Gyeongsang National University (Gnu) |
21292493 |
23 |
Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13. |
Merck Sharpe and Dohme |
20371179 |
37 |
Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. |
Decode Chemistry |
19950900 |
18 |
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. |
Decode Chemistry |
19618939 |
36 |
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. |
Decode Biostructures |
8904845 |
3 |
Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus. |
Searle Research and Development |
19090779 |
12 |
Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. |
Peking University |
18952425 |
8 |
Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. |
Peking University |
18674901 |
32 |
Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors. |
Santen Pharmaceutical |
18590959 |
61 |
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors. |
Berlex Biosciences |
18586492 |
81 |
Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase. |
Berlex Biosciences |
12643929 |
18 |
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase. |
Pfizer |
12419366 |
27 |
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase. |
Pharmacia |
32551007 |
19 |
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase. |
Goethe-University |
31751136 |
6 |
Effect of Modifier Structure on the Activation of Leukotriene A |
George Mason University |
32184960 |
34 |
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA |
Goethe University Frankfurt |
30846252 |
23 |
Recent developments in the synthesis and applications of phosphinic peptide analogs. |
Wroclaw University of Technology |
8423594 |
39 |
Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. |
Scripps Research Institute |
29630364 |
63 |
Design of Aminopeptidase N Inhibitors as Anti-cancer Agents. |
Jadavpur University |
10926521 |
15 |
Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design. |
Max-Planck-Institut Fuer Biochemie |