BindingDB PrimarySearch

Found 57 hits with Last Name = 'blom' and Initial = 'k'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM13465 ((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition constant against protein-tyrosine phosphatase 1B by PNPP enzyme assay				J Med Chem 48: 6544-8 (2005) Article DOI: 10.1021/jm0504555 BindingDB Entry DOI: 10.7270/Q2805252
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 2 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of the dual specificity kinase MEK-2				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of the dual specificity kinase MEK-1				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM13465 ((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against T cell protein tyrosine phosphatase				J Med Chem 48: 6544-8 (2005) Article DOI: 10.1021/jm0504555 BindingDB Entry DOI: 10.7270/Q2805252
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM13465 ((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against protein-tyrosine phosphatase 1B by PNPP enzyme assay				J Med Chem 48: 6544-8 (2005) Article DOI: 10.1021/jm0504555 BindingDB Entry DOI: 10.7270/Q2805252
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description AP-1 suppression activity using freshly prepared DMSO stock				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description AP-1 suppression activity using one week old DMSO stock				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description AP-1 suppression activity using one month old DMSO stock				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072163 (2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...) Show SMILES N=C(Sc1cccs1)C(C#N)C(C#N)C(=N)Sc1cccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072154 (2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072154 (2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072166 (2,3-Bis-[1-amino-1-(4-hydroxy-phenylsulfanyl)-meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description AP-1 suppression activity using two months old DMSO stock				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072151 (2,3-Bis-[1-amino-1-(4-amino-phenylsulfanyl)-meth-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072148 (2,3-Bis-[3H-benzothiazol-(2Z)-ylidene]-succinonitr...) Show SMILES N#CC(C(C#N)c1nc2ccccc2s1)c1nc2ccccc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072156 (2,3-Bis-[1-amino-1-(2-fluoro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072162 (2,3-Bis-[1-amino-1-(2-chloro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072164 (2,3-Bis-[1-amino-1-phenylsulfanyl-meth-(Z)-ylidene...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072150 (2,3-Bis-[1-amino-1-(2-bromo-phenylsulfanyl)-meth-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072163 (2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...) Show SMILES N=C(Sc1cccs1)C(C#N)C(C#N)C(=N)Sc1cccs1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072144 (2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4...) Show SMILES Nc1[nH]c(Sc2ccc3ccccc3c2)c(C#N)c1C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM13472 (({4-[(2S)-2-carbamoyl-2-[(2S)-2-acetamido-3-phenyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against protein-tyrosine phosphatase 1B by PNPP enzyme assay				J Med Chem 48: 6544-8 (2005) Article DOI: 10.1021/jm0504555 BindingDB Entry DOI: 10.7270/Q2805252
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072157 (2,3-Bis-[1-amino-1-(3-chloro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072146 (CHEMBL316635 \| N-[3,4-Dicyano-5-(naphthalen-2-ylsu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072161 (2,3-Bis-[1-amino-1-o-tolylsulfanyl-meth-(Z)-yliden...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072158 (2,3-Bis-[1-amino-1-(1-amino-naphthalen-2-ylsulfany...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072152 (2,3-Bis-[1-amino-1-(4-chloro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072160 (2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072147 ((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of the dual specificity kinase MEK-1				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072159 (2,3-Bis-[1-amino-1-(2,6-dichloro-phenylsulfanyl)-m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM13811 ((2S)-N-[(1S)-1-carbamoyl-2-[4-(1,1,3-trioxo-2,3-di...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against protein-tyrosine phosphatase 1B by PNPP enzyme assay				J Med Chem 48: 6544-8 (2005) Article DOI: 10.1021/jm0504555 BindingDB Entry DOI: 10.7270/Q2805252
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072165 (2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-yli...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072155 (2,3-Bis-[1-amino-1-(2-methoxy-phenylsulfanyl)-meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072149 (2,3-Bis-[1-amino-1-(3-amino-phenylsulfanyl)-meth-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072159 (2,3-Bis-[1-amino-1-(2,6-dichloro-phenylsulfanyl)-m...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072162 (2,3-Bis-[1-amino-1-(2-chloro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072156 (2,3-Bis-[1-amino-1-(2-fluoro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072150 (2,3-Bis-[1-amino-1-(2-bromo-phenylsulfanyl)-meth-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072146 (CHEMBL316635 \| N-[3,4-Dicyano-5-(naphthalen-2-ylsu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072151 (2,3-Bis-[1-amino-1-(4-amino-phenylsulfanyl)-meth-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072164 (2,3-Bis-[1-amino-1-phenylsulfanyl-meth-(Z)-ylidene...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072161 (2,3-Bis-[1-amino-1-o-tolylsulfanyl-meth-(Z)-yliden...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50072145 (2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-...) Show SMILES Nc1[nH]c(Sc2ccccc2N)c(C#N)c1C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Non-competitive inhibition of the dual specificity kinase MEK				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM13812 ((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5R)-1,1,3-trioxo-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibitory concentration against protein-tyrosine phosphatase 1B by PNPP enzyme assay				J Med Chem 48: 6544-8 (2005) Article DOI: 10.1021/jm0504555 BindingDB Entry DOI: 10.7270/Q2805252
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072155 (2,3-Bis-[1-amino-1-(2-methoxy-phenylsulfanyl)-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Inhibition of the dual specificity kinase MEK-1				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072149 (2,3-Bis-[1-amino-1-(3-amino-phenylsulfanyl)-meth-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072157 (2,3-Bis-[1-amino-1-(3-chloro-phenylsulfanyl)-meth-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.84E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50072165 (2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-yli...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Ability to antagonise AP-1 transcriptional activity				Bioorg Med Chem Lett 8: 2839-44 (1999) BindingDB Entry DOI: 10.7270/Q2MW2HNN
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair

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