Compile Data Set for Download or QSAR

Found 134 hits with Last Name = 'henley' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414916 (CHEMBL567005) Show SMILES CCCc1[nH]c(=O)c(cc1C(=O)OCC)-c1csc(CS(=O)(=O)c2ccccc2)n1 Show InChI InChI=1S/C21H22N2O5S2/c1-3-8-17-16(21(25)28-4-2)11-15(20(24)23-17)18-12-29-19(22-18)13-30(26,27)14-9-6-5-7-10-14/h5-7,9-12H,3-4,8,13H2,1-2H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20870 (3-{2-[(thiophene-2-sulfonyl)methyl]-1,3-thiazol-4-...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(CS(=O)(=O)c2cccs2)n1 Show InChI InChI=1S/C17H12N2O3S3/c20-17-12(8-11-4-1-2-5-13(11)19-17)14-9-24-15(18-14)10-25(21,22)16-6-3-7-23-16/h1-9H,10H2,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20851 (7-(piperidin-1-ylcarbonyl)-3-[2-(pyridin-4-yl)-1,3...) Show SMILES O=C(N1CCCCC1)c1ccc2cc(-c3csc(n3)-c3ccncc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C23H20N4O2S/c28-21-18(20-14-30-22(26-20)15-6-8-24-9-7-15)12-16-4-5-17(13-19(16)25-21)23(29)27-10-2-1-3-11-27/h4-9,12-14H,1-3,10-11H2,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414917 (CHEMBL567004) Show SMILES CCOC(=O)c1cc(-c2csc(CS(=O)(=O)c3ccccc3)n2)c(=O)[nH]c1C Show InChI InChI=1S/C19H18N2O5S2/c1-3-26-19(23)14-9-15(18(22)20-12(14)2)16-10-27-17(21-16)11-28(24,25)13-7-5-4-6-8-13/h4-10H,3,11H2,1-2H3,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20856 (4-amino-6-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4...) Show SMILES Nc1c(-c2csc(n2)-c2ccncc2)c(=O)[nH]c2ccc(Cl)cc12 Show InChI InChI=1S/C17H11ClN4OS/c18-10-1-2-12-11(7-10)15(19)14(16(23)21-12)13-8-24-17(22-13)9-3-5-20-6-4-9/h1-8H,(H3,19,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414912 (CHEMBL566532) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1CC Show InChI InChI=1S/C18H17N3O3S/c1-3-14-13(18(23)24-4-2)9-12(16(22)20-14)15-10-25-17(21-15)11-5-7-19-8-6-11/h5-10H,3-4H2,1-2H3,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20850 (7-[(4-methylpiperazin-1-yl)carbonyl]-3-[2-(pyridin...) Show SMILES CN1CCN(CC1)C(=O)c1ccc2cc(-c3csc(n3)-c3ccncc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C23H21N5O2S/c1-27-8-10-28(11-9-27)23(30)17-3-2-16-12-18(21(29)25-19(16)13-17)20-14-31-22(26-20)15-4-6-24-7-5-15/h2-7,12-14H,8-11H2,1H3,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414918 (CHEMBL567832) Show SMILES CCOC(=O)c1cc(-c2csc(CS(=O)(=O)c3ccccc3)n2)c(=O)[nH]c1COCc1ccccc1 Show InChI InChI=1S/C26H24N2O6S2/c1-2-34-26(30)21-13-20(25(29)28-22(21)15-33-14-18-9-5-3-6-10-18)23-16-35-24(27-23)17-36(31,32)19-11-7-4-8-12-19/h3-13,16H,2,14-15,17H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20848 (3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-7-(trifluoro...) Show SMILES FC(F)(F)c1ccc2cc(-c3csc(n3)-c3ccncc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C18H10F3N3OS/c19-18(20,21)12-2-1-11-7-13(16(25)23-14(11)8-12)15-9-26-17(24-15)10-3-5-22-6-4-10/h1-9H,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20849 (N-[2-(dimethylamino)ethyl]-N-ethyl-2-oxo-3-[2-(pyr...) Show SMILES CCN(CCN(C)C)C(=O)c1ccc2cc(-c3csc(n3)-c3ccncc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C24H25N5O2S/c1-4-29(12-11-28(2)3)24(31)18-6-5-17-13-19(22(30)26-20(17)14-18)21-15-32-23(27-21)16-7-9-25-10-8-16/h5-10,13-15H,4,11-12H2,1-3H3,(H,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20869 (3-{2-[(pyridine-2-sulfonyl)methyl]-1,3-thiazol-4-y...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(CS(=O)(=O)c2ccccn2)n1 Show InChI InChI=1S/C18H13N3O3S2/c22-18-13(9-12-5-1-2-6-14(12)21-18)15-10-25-16(20-15)11-26(23,24)17-7-3-4-8-19-17/h1-10H,11H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20847 (6-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...) Show SMILES Clc1ccc2[nH]c(=O)c(cc2c1)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C17H10ClN3OS/c18-12-1-2-14-11(7-12)8-13(16(22)20-14)15-9-23-17(21-15)10-3-5-19-6-4-10/h1-9H,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20855 (4-amino-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-...) Show SMILES Nc1c(-c2csc(n2)-c2ccncc2)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C17H12N4OS/c18-15-11-3-1-2-4-12(11)20-16(22)14(15)13-9-23-17(21-13)10-5-7-19-8-6-10/h1-9H,(H3,18,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414898 (CHEMBL584268) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccnc(NCC(C)C)c2)c(=O)[nH]c1C Show InChI InChI=1S/C21H24N4O3S/c1-5-28-21(27)15-9-16(19(26)24-13(15)4)17-11-29-20(25-17)14-6-7-22-18(8-14)23-10-12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,23)(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414914 (CHEMBL577495) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccnc(N)c2)c(=O)[nH]c1C Show InChI InChI=1S/C17H16N4O3S/c1-3-24-17(23)11-7-12(15(22)20-9(11)2)13-8-25-16(21-13)10-4-5-19-14(18)6-10/h4-8H,3H2,1-2H3,(H2,18,19)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20866 (3-[2-(4-hydroxyphenyl)-1,3-thiazol-4-yl]-1,2-dihyd...) Show SMILES Oc1ccc(cc1)-c1nc(cs1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C18H12N2O2S/c21-13-7-5-11(6-8-13)18-20-16(10-23-18)14-9-12-3-1-2-4-15(12)19-17(14)22/h1-10,21H,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414900 (CHEMBL583636) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccnc(NC)c2)c(=O)[nH]c1C(C)C Show InChI InChI=1S/C20H22N4O3S/c1-5-27-20(26)14-9-13(18(25)24-17(14)11(2)3)15-10-28-19(23-15)12-6-7-22-16(8-12)21-4/h6-11H,5H2,1-4H3,(H,21,22)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20868 (3-{2-[(benzenesulfonyl)methyl]-1,3-thiazol-4-yl}-1...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(CS(=O)(=O)c2ccccc2)n1 Show InChI InChI=1S/C19H14N2O3S2/c22-19-15(10-13-6-4-5-9-16(13)21-19)17-11-25-18(20-17)12-26(23,24)14-7-2-1-3-8-14/h1-11H,12H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20843 (methyl 2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]...) Show SMILES COC(=O)c1cccc2[nH]c(=O)c(cc12)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C19H13N3O3S/c1-25-19(24)12-3-2-4-15-13(12)9-14(17(23)21-15)16-10-26-18(22-16)11-5-7-20-8-6-11/h2-10H,1H3,(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414901 (CHEMBL567006) Show SMILES CCN(CC)CC(C)OC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C(C)C Show InChI InChI=1S/C24H30N4O3S/c1-6-28(7-2)13-16(5)31-24(30)19-12-18(22(29)27-21(19)15(3)4)20-14-32-23(26-20)17-8-10-25-11-9-17/h8-12,14-16H,6-7,13H2,1-5H3,(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414897 (CHEMBL566767) Show SMILES CCN(CC)CCCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C(C)C Show InChI InChI=1S/C24H30N4O3S/c1-5-28(6-2)12-7-13-31-24(30)19-14-18(22(29)27-21(19)16(3)4)20-15-32-23(26-20)17-8-10-25-11-9-17/h8-11,14-16H,5-7,12-13H2,1-4H3,(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20861 (3-[2-(pyridin-3-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(n1)-c1cccnc1 Show InChI InChI=1S/C17H11N3OS/c21-16-13(8-11-4-1-2-6-14(11)19-16)15-10-22-17(20-15)12-5-3-7-18-9-12/h1-10H,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414904 (CHEMBL565471) Show SMILES CCN(CC)CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C(C)C Show InChI InChI=1S/C23H28N4O3S/c1-5-27(6-2)11-12-30-23(29)18-13-17(21(28)26-20(18)15(3)4)19-14-31-22(25-19)16-7-9-24-10-8-16/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20842 (3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C17H11N3OS/c21-16-13(9-12-3-1-2-4-14(12)19-16)15-10-22-17(20-15)11-5-7-18-8-6-11/h1-10H,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Homo sapiens (Human))	BDBM20842 (3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C17H11N3OS/c21-16-13(9-12-3-1-2-4-14(12)19-16)15-10-22-17(20-15)11-5-7-18-8-6-11/h1-10H,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414899 (CHEMBL566114) Show SMILES CCCc1[nH]c(=O)c(cc1C(=O)OCC)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C19H19N3O3S/c1-3-5-15-14(19(24)25-4-2)10-13(17(23)21-15)16-11-26-18(22-16)12-6-8-20-9-7-12/h6-11H,3-5H2,1-2H3,(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414903 (CHEMBL583632) Show SMILES CC(C)c1[nH]c(=O)c(cc1C(=O)OC1CCCN(C)C1)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C23H26N4O3S/c1-14(2)20-18(23(29)30-16-5-4-10-27(3)12-16)11-17(21(28)26-20)19-13-31-22(25-19)15-6-8-24-9-7-15/h6-9,11,13-14,16H,4-5,10,12H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Homo sapiens (Human))	BDBM20819 (3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...) Show SMILES O=C1Nc2ccccc2CN1c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C16H12N4OS/c21-16-18-13-4-2-1-3-12(13)9-20(16)14-10-22-15(19-14)11-5-7-17-8-6-11/h1-8,10H,9H2,(H,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20846 (6-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...) Show SMILES Fc1ccc2[nH]c(=O)c(cc2c1)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C17H10FN3OS/c18-12-1-2-14-11(7-12)8-13(16(22)20-14)15-9-23-17(21-15)10-3-5-19-6-4-10/h1-9H,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414902 (CHEMBL568084) Show SMILES CC(C)c1[nH]c(=O)c(cc1C(=O)OCCN1CCCC1)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C23H26N4O3S/c1-15(2)20-18(23(29)30-12-11-27-9-3-4-10-27)13-17(21(28)26-20)19-14-31-22(25-19)16-5-7-24-8-6-16/h5-8,13-15H,3-4,9-12H2,1-2H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414915 (CHEMBL566115) Show SMILES CC(C)c1[nH]c(=O)c(cc1C(=O)OCCc1ccccc1)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C25H23N3O3S/c1-16(2)22-20(25(30)31-13-10-17-6-4-3-5-7-17)14-19(23(29)28-22)21-15-32-24(27-21)18-8-11-26-12-9-18/h3-9,11-12,14-16H,10,13H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20858 (4-amino-6-(4-methylpiperazin-1-yl)-3-[2-(pyridin-4...) Show SMILES CN1CCN(CC1)c1ccc2[nH]c(=O)c(-c3csc(n3)-c3ccncc3)c(N)c2c1 Show InChI InChI=1S/C22H22N6OS/c1-27-8-10-28(11-9-27)15-2-3-17-16(12-15)20(23)19(21(29)25-17)18-13-30-22(26-18)14-4-6-24-7-5-14/h2-7,12-13H,8-11H2,1H3,(H3,23,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20874 (3-{2-[(benzenesulfinyl)methyl]-1,3-thiazol-4-yl}-1...) Show SMILES O=S(Cc1nc(cs1)-c1cc2ccccc2[nH]c1=O)c1ccccc1 Show InChI InChI=1S/C19H14N2O2S2/c22-19-15(10-13-6-4-5-9-16(13)21-19)17-11-24-18(20-17)12-25(23)14-7-2-1-3-8-14/h1-11H,12H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50299869 (CHEMBL577030 | ethyl 2-methyl-6-oxo-5-(2-(pyridin-...) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C Show InChI InChI=1S/C17H15N3O3S/c1-3-23-17(22)12-8-13(15(21)19-10(12)2)14-9-24-16(20-14)11-4-6-18-7-5-11/h4-9H,3H2,1-2H3,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Homo sapiens (Human))	BDBM50299869 (CHEMBL577030 | ethyl 2-methyl-6-oxo-5-(2-(pyridin-...) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C Show InChI InChI=1S/C17H15N3O3S/c1-3-23-17(22)12-8-13(15(21)19-10(12)2)14-9-24-16(20-14)11-4-6-18-7-5-11/h4-9H,3H2,1-2H3,(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414905 (CHEMBL565918) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccnc(NCCN(CC)CC)c2)c(=O)[nH]c1C Show InChI InChI=1S/C23H29N5O3S/c1-5-28(6-2)11-10-25-20-12-16(8-9-24-20)22-27-19(14-32-22)18-13-17(23(30)31-7-3)15(4)26-21(18)29/h8-9,12-14H,5-7,10-11H2,1-4H3,(H,24,25)(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414908 (CHEMBL566994) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C(C)C Show InChI InChI=1S/C19H19N3O3S/c1-4-25-19(24)14-9-13(17(23)22-16(14)11(2)3)15-10-26-18(21-15)12-5-7-20-8-6-12/h5-11H,4H2,1-3H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414913 (CHEMBL578375) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccnc(Cl)c2)c(=O)[nH]c1C Show InChI InChI=1S/C17H14ClN3O3S/c1-3-24-17(23)11-7-12(15(22)20-9(11)2)13-8-25-16(21-13)10-4-5-19-14(18)6-10/h4-8H,3H2,1-2H3,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20852 (4-hydroxy-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,...) Show SMILES Oc1c(-c2csc(n2)-c2ccncc2)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C17H11N3O2S/c21-15-11-3-1-2-4-12(11)19-16(22)14(15)13-9-23-17(20-13)10-5-7-18-8-6-10/h1-9H,(H2,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20865 (3-[2-(4-aminophenyl)-1,3-thiazol-4-yl]-1,2-dihydro...) Show SMILES Nc1ccc(cc1)-c1nc(cs1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C18H13N3OS/c19-13-7-5-11(6-8-13)18-21-16(10-23-18)14-9-12-3-1-2-4-15(12)20-17(14)22/h1-10H,19H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414907 (CHEMBL584506) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C1CC1 Show InChI InChI=1S/C19H17N3O3S/c1-2-25-19(24)14-9-13(17(23)22-16(14)11-3-4-11)15-10-26-18(21-15)12-5-7-20-8-6-12/h5-11H,2-4H2,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20871 (3-(2-{[(4-chlorobenzene)sulfonyl]methyl}-1,3-thiaz...) Show SMILES Clc1ccc(cc1)S(=O)(=O)Cc1nc(cs1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C19H13ClN2O3S2/c20-13-5-7-14(8-6-13)27(24,25)11-18-21-17(10-26-18)15-9-12-3-1-2-4-16(12)22-19(15)23/h1-10H,11H2,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20857 (4-amino-6-(piperidin-1-yl)-3-[2-(pyridin-4-yl)-1,3...) Show SMILES Nc1c(-c2csc(n2)-c2ccncc2)c(=O)[nH]c2ccc(cc12)N1CCCCC1 Show InChI InChI=1S/C22H21N5OS/c23-20-16-12-15(27-10-2-1-3-11-27)4-5-17(16)25-21(28)19(20)18-13-29-22(26-18)14-6-8-24-9-7-14/h4-9,12-13H,1-3,10-11H2,(H3,23,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20872 (3-[2-(methanesulfonylmethyl)-1,3-thiazol-4-yl]-1,2...) Show SMILES CS(=O)(=O)Cc1nc(cs1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C14H12N2O3S2/c1-21(18,19)8-13-15-12(7-20-13)10-6-9-4-2-3-5-11(9)16-14(10)17/h2-7H,8H2,1H3,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20860 (3-[2-(thiophen-3-yl)-1,3-thiazol-4-yl]-1,2-dihydro...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(n1)-c1ccsc1 Show InChI InChI=1S/C16H10N2OS2/c19-15-12(7-10-3-1-2-4-13(10)17-15)14-9-21-16(18-14)11-5-6-20-8-11/h1-9H,(H,17,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20853 (4-phenyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...) Show SMILES O=c1[nH]c2ccccc2c(-c2ccccc2)c1-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C23H15N3OS/c27-22-21(19-14-28-23(26-19)16-10-12-24-13-11-16)20(15-6-2-1-3-7-15)17-8-4-5-9-18(17)25-22/h1-14H,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM20845 (N,N-diethyl-2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-...) Show SMILES CCN(CC)C(=O)c1cccc2[nH]c(=O)c(cc12)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C22H20N4O2S/c1-3-26(4-2)22(28)15-6-5-7-18-16(15)12-17(20(27)24-18)19-13-29-21(25-19)14-8-10-23-11-9-14/h5-13H,3-4H2,1-2H3,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414910 (CHEMBL567437) Show SMILES CC(C)c1[nH]c(=O)c(cc1C(=O)OC1CCN(C)CC1)-c1csc(n1)-c1ccncc1 Show InChI InChI=1S/C23H26N4O3S/c1-14(2)20-18(23(29)30-16-6-10-27(3)11-7-16)12-17(21(28)26-20)19-13-31-22(25-19)15-4-8-24-9-5-15/h4-5,8-9,12-14,16H,6-7,10-11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	647	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414906 (CHEMBL567223) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccnc(OC)c2)c(=O)[nH]c1C(C)C Show InChI InChI=1S/C20H21N3O4S/c1-5-27-20(25)14-9-13(18(24)23-17(14)11(2)3)15-10-28-19(22-15)12-6-7-21-16(8-12)26-4/h6-11H,5H2,1-4H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	672	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50414909 (CHEMBL568083) Show SMILES CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1COCc1ccccc1 Show InChI InChI=1S/C24H21N3O4S/c1-2-31-24(29)19-12-18(21-15-32-23(27-21)17-8-10-25-11-9-17)22(28)26-20(19)14-30-13-16-6-4-3-5-7-16/h3-12,15H,2,13-14H2,1H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	779	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATP				Bioorg Med Chem Lett 19: 6591-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.027 BindingDB Entry DOI: 10.7270/Q2K937KN
					More data for this Ligand-Target Pair

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