Found 403 hits with Last Name = 'jimenez' and Initial = 'h' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355854
(CHEMBL1909727)Show InChI InChI=1S/C17H27N5O2S2/c1-3-22(4-2)26(23,24)20-13-8-5-7-12-19-17-21-16(14-25-17)15-10-6-9-11-18-15/h6,9-11,14,20H,3-5,7-8,12-13H2,1-2H3,(H,19,21) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355840
(CHEMBL1912082)Show SMILES COc1ccc(C)cc1S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C21H26N4O3S2/c1-16-9-10-19(28-2)20(14-16)30(26,27)24-13-6-3-5-12-23-21-25-18(15-29-21)17-8-4-7-11-22-17/h4,7-11,14-15,24H,3,5-6,12-13H2,1-2H3,(H,23,25) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355849
(CHEMBL1909722)Show SMILES CC(C)S(=O)(=O)NCCCCCNc1nc-2c(CCSc3ccccc-23)s1 Show InChI InChI=1S/C19H27N3O2S3/c1-14(2)27(23,24)21-12-7-3-6-11-20-19-22-18-15-8-4-5-9-16(15)25-13-10-17(18)26-19/h4-5,8-9,14,21H,3,6-7,10-13H2,1-2H3,(H,20,22) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50084137
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation counting |
Bioorg Med Chem Lett 23: 1398-406 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.078
BindingDB Entry DOI: 10.7270/Q2Q241KC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355844
(CHEMBL1912087)Show SMILES Cc1nc(C)c(s1)S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C18H23N5O2S3/c1-13-17(27-14(2)22-13)28(24,25)21-11-6-3-5-10-20-18-23-16(12-26-18)15-8-4-7-9-19-15/h4,7-9,12,21H,3,5-6,10-11H2,1-2H3,(H,20,23) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355847
(CHEMBL1909720)Show InChI InChI=1S/C15H23N3O2S3/c1-12(2)23(19,20)17-8-5-3-4-7-16-15-18-14(11-22-15)13-6-9-21-10-13/h6,9-12,17H,3-5,7-8H2,1-2H3,(H,16,18) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187911
(1,3-dihydro-1-[3-(2-pyrrolidinylethoxy)phenyl]-3-[...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1cccc(OCCN2CCCC2)c1 Show InChI InChI=1S/C27H24F3N3O2/c28-27(29,30)19-7-5-8-20(17-19)31-25-23-11-1-2-12-24(23)33(26(25)34)21-9-6-10-22(18-21)35-16-15-32-13-3-4-14-32/h1-2,5-12,17-18H,3-4,13-16H2/b31-25+ | Reactome pathway
KEGG
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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Rat 6B) | BDBM50355852
(CHEMBL1909725)Show InChI InChI=1S/C15H23N5O2S2/c1-20(2)24(21,22)18-11-6-3-5-10-17-15-19-14(12-23-15)13-8-4-7-9-16-13/h4,7-9,12,18H,3,5-6,10-11H2,1-2H3,(H,17,19) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat NPY Y5 receptor |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355852
(CHEMBL1909725)Show InChI InChI=1S/C15H23N5O2S2/c1-20(2)24(21,22)18-11-6-3-5-10-17-15-19-14(12-23-15)13-8-4-7-9-16-13/h4,7-9,12,18H,3,5-6,10-11H2,1-2H3,(H,17,19) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187925
(1-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(3-(trifl...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1cccc(OCCN2CCCCC2)c1 Show InChI InChI=1S/C28H26F3N3O2/c29-28(30,31)20-8-6-9-21(18-20)32-26-24-12-2-3-13-25(24)34(27(26)35)22-10-7-11-23(19-22)36-17-16-33-14-4-1-5-15-33/h2-3,6-13,18-19H,1,4-5,14-17H2/b32-26+ | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355839
(CHEMBL1912081)Show SMILES Fc1ccccc1S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C19H21FN4O2S2/c20-15-8-2-3-10-18(15)28(25,26)23-13-6-1-5-12-22-19-24-17(14-27-19)16-9-4-7-11-21-16/h2-4,7-11,14,23H,1,5-6,12-13H2,(H,22,24) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349543
(CHEMBL1808901)Show SMILES Cc1cc(ncc1[C@H]1CCCN1C(=O)c1nccs1)-c1cccc(Cl)c1 |r| Show InChI InChI=1S/C20H18ClN3OS/c1-13-10-17(14-4-2-5-15(21)11-14)23-12-16(13)18-6-3-8-24(18)20(25)19-22-7-9-26-19/h2,4-5,7,9-12,18H,3,6,8H2,1H3/t18-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355832
(CHEMBL1912068)Show InChI InChI=1S/C16H24N4O2S2/c1-13(2)24(21,22)19-11-6-3-5-10-18-16-20-15(12-23-16)14-8-4-7-9-17-14/h4,7-9,12-13,19H,3,5-6,10-11H2,1-2H3,(H,18,20) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349559
(CHEMBL1808885)Show SMILES COc1cc(ncc1C1CCCN1C(=O)C1CCC1)-c1cccc(Cl)c1 Show InChI InChI=1S/C21H23ClN2O2/c1-26-20-12-18(15-7-3-8-16(22)11-15)23-13-17(20)19-9-4-10-24(19)21(25)14-5-2-6-14/h3,7-8,11-14,19H,2,4-6,9-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349563
(CHEMBL1808881)Show InChI InChI=1S/C21H23ClN2O/c1-14-11-19(16-7-3-8-17(22)12-16)23-13-18(14)20-9-4-10-24(20)21(25)15-5-2-6-15/h3,7-8,11-13,15,20H,2,4-6,9-10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187919
(1-(3-(3-(diethylamino)-2-hydroxypropoxy)phenyl)-3-...)Show SMILES CCN(CC)CC(O)COc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C28H28F3N3O3/c1-3-33(4-2)17-22(35)18-37-23-12-8-11-21(16-23)34-25-14-6-5-13-24(25)26(27(34)36)32-20-10-7-9-19(15-20)28(29,30)31/h5-16,22,35H,3-4,17-18H2,1-2H3/b32-26+ | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187923
(1,3-dihydro-1-phenyl-3-[[3-(trilfluoromethyl)pheny...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1ccccc1 Show InChI InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19+ | Reactome pathway
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CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187923
(1,3-dihydro-1-phenyl-3-[[3-(trilfluoromethyl)pheny...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1ccccc1 Show InChI InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19+ | Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human GAL3 |
J Med Chem 49: 3757-8 (2006)
Article DOI: 10.1021/jm060001n
BindingDB Entry DOI: 10.7270/Q2T72H2B |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355859
(CHEMBL1912086)Show SMILES Cc1noc(C)c1S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C18H23N5O3S2/c1-13-17(14(2)26-23-13)28(24,25)21-11-6-3-5-10-20-18-22-16(12-27-18)15-8-4-7-9-19-15/h4,7-9,12,21H,3,5-6,10-11H2,1-2H3,(H,20,22) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349543
(CHEMBL1808901)Show SMILES Cc1cc(ncc1[C@H]1CCCN1C(=O)c1nccs1)-c1cccc(Cl)c1 |r| Show InChI InChI=1S/C20H18ClN3OS/c1-13-10-17(14-4-2-5-15(21)11-14)23-12-16(13)18-6-3-8-24(18)20(25)19-22-7-9-26-19/h2,4-5,7,9-12,18H,3,6,8H2,1H3/t18-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349560
(CHEMBL1808884)Show SMILES COc1cc(ncc1C1CCCN1C(=O)c1cncs1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H18ClN3O2S/c1-26-18-9-16(13-4-2-5-14(21)8-13)23-10-15(18)17-6-3-7-24(17)20(25)19-11-22-12-27-19/h2,4-5,8-12,17H,3,6-7H2,1H3 | PDB
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PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187922
(1-(3-(3-(diethylamino)propoxy)phenyl)-3-(3-(triflu...)Show SMILES CCN(CC)CCCOc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C28H28F3N3O2/c1-3-33(4-2)16-9-17-36-23-13-8-12-22(19-23)34-25-15-6-5-14-24(25)26(27(34)35)32-21-11-7-10-20(18-21)28(29,30)31/h5-8,10-15,18-19H,3-4,9,16-17H2,1-2H3/b32-26+ | Reactome pathway
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187912
(1-(3-(2-(dimethylamino)ethoxy)phenyl)-3-(3-(triflu...)Show SMILES CN(C)CCOc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C25H22F3N3O2/c1-30(2)13-14-33-20-10-6-9-19(16-20)31-22-12-4-3-11-21(22)23(24(31)32)29-18-8-5-7-17(15-18)25(26,27)28/h3-12,15-16H,13-14H2,1-2H3/b29-23+ | Reactome pathway
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187908
((S)-1-(3-(3-(diethylamino)-2-hydroxypropoxy)phenyl...)Show SMILES CCN(CC)C[C@H](O)COc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C28H28F3N3O3/c1-3-33(4-2)17-22(35)18-37-23-12-8-11-21(16-23)34-25-14-6-5-13-24(25)26(27(34)36)32-20-10-7-9-19(15-20)28(29,30)31/h5-16,22,35H,3-4,17-18H2,1-2H3/b32-26+/t22-/m0/s1 | Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187916
(1-(3-(3-(dimethylamino)propoxy)phenyl)-3-(3-(trifl...)Show SMILES CN(C)CCCOc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C26H24F3N3O2/c1-31(2)14-7-15-34-21-11-6-10-20(17-21)32-23-13-4-3-12-22(23)24(25(32)33)30-19-9-5-8-18(16-19)26(27,28)29/h3-6,8-13,16-17H,7,14-15H2,1-2H3/b30-24+ | Reactome pathway
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349571
(CHEMBL1808873)Show SMILES Cc1cc(ncc1C1CCCN1C(=O)c1cncs1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H18ClN3OS/c1-13-8-17(14-4-2-5-15(21)9-14)23-10-16(13)18-6-3-7-24(18)20(25)19-11-22-12-26-19/h2,4-5,8-12,18H,3,6-7H2,1H3 | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50429412
(CHEMBL2338582)Show SMILES Clc1cccc(c1)C1=NC[C@]2(CCC[C@@H](C2)NC(=O)c2ccccn2)O1 |r,t:8| Show InChI InChI=1S/C20H20ClN3O2/c21-15-6-3-5-14(11-15)19-23-13-20(26-19)9-4-7-16(12-20)24-18(25)17-8-1-2-10-22-17/h1-3,5-6,8,10-11,16H,4,7,9,12-13H2,(H,24,25)/t16-,20+/m0/s1 | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation counting |
Bioorg Med Chem Lett 23: 1398-406 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.078
BindingDB Entry DOI: 10.7270/Q2Q241KC |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355841
(CHEMBL1912083)Show InChI InChI=1S/C17H20N4O2S3/c22-26(23,16-8-6-12-24-16)20-11-4-1-3-10-19-17-21-15(13-25-17)14-7-2-5-9-18-14/h2,5-9,12-13,20H,1,3-4,10-11H2,(H,19,21) | KEGG
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PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355848
(CHEMBL1909721)Show InChI InChI=1S/C16H26N4O2S3/c1-11(2)25(21,22)18-9-7-5-6-8-17-16-20-14(10-23-16)15-12(3)19-13(4)24-15/h10-11,18H,5-9H2,1-4H3,(H,17,20) | KEGG
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PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187918
(1-(4-(3-(diethylamino)propoxy)phenyl)-3-(3-(triflu...)Show SMILES CCN(CC)CCCOc1ccc(cc1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C28H28F3N3O2/c1-3-33(4-2)17-8-18-36-23-15-13-22(14-16-23)34-25-12-6-5-11-24(25)26(27(34)35)32-21-10-7-9-20(19-21)28(29,30)31/h5-7,9-16,19H,3-4,8,17-18H2,1-2H3/b32-26+ | Reactome pathway
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187914
(1-(3-((diethylamino)methoxy)phenyl)-3-(3-(trifluor...)Show SMILES CCN(CC)COc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C26H24F3N3O2/c1-3-31(4-2)17-34-21-12-8-11-20(16-21)32-23-14-6-5-13-22(23)24(25(32)33)30-19-10-7-9-18(15-19)26(27,28)29/h5-16H,3-4,17H2,1-2H3/b30-24+ | Reactome pathway
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355855
(CHEMBL1909728)Show InChI InChI=1S/C17H25N5O3S2/c23-27(24,22-10-12-25-13-11-22)20-9-4-1-3-8-19-17-21-16(14-26-17)15-6-2-5-7-18-15/h2,5-7,14,20H,1,3-4,8-13H2,(H,19,21) | KEGG
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187913
(1-(3-(4-(diethylamino)butoxy)phenyl)-3-(3-(trifluo...)Show SMILES CCN(CC)CCCCOc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C29H30F3N3O2/c1-3-34(4-2)17-7-8-18-37-24-14-10-13-23(20-24)35-26-16-6-5-15-25(26)27(28(35)36)33-22-12-9-11-21(19-22)29(30,31)32/h5-6,9-16,19-20H,3-4,7-8,17-18H2,1-2H3/b33-27+ | Reactome pathway
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| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355833
(CHEMBL1912071)Show InChI InChI=1S/C16H22N4O2S2/c21-24(22,13-7-8-13)19-11-4-1-3-10-18-16-20-15(12-23-16)14-6-2-5-9-17-14/h2,5-6,9,12-13,19H,1,3-4,7-8,10-11H2,(H,18,20) | KEGG
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| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187926
(1-(3-(3-(pyrrolidin-1-yl)propoxy)phenyl)-3-(3-(tri...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1cccc(OCCCN2CCCC2)c1 Show InChI InChI=1S/C28H26F3N3O2/c29-28(30,31)20-8-5-9-21(18-20)32-26-24-12-1-2-13-25(24)34(27(26)35)22-10-6-11-23(19-22)36-17-7-16-33-14-3-4-15-33/h1-2,5-6,8-13,18-19H,3-4,7,14-17H2/b32-26+ | Reactome pathway
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| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355834
(CHEMBL1912072)Show InChI InChI=1S/C17H26N4O2S2/c1-3-14(2)25(22,23)20-12-7-4-6-11-19-17-21-16(13-24-17)15-9-5-8-10-18-15/h5,8-10,13-14,20H,3-4,6-7,11-12H2,1-2H3,(H,19,21) | KEGG
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| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50189598
(1-(ethylpropyl)-3-{[3-(trifluoromethyl)phenyl]azam...)Show SMILES CCC(CC)N1C(=O)\C(=N\c2ccc(cc2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C20H19F3N2O/c1-3-15(4-2)25-17-8-6-5-7-16(17)18(19(25)26)24-14-11-9-13(10-12-14)20(21,22)23/h5-12,15H,3-4H2,1-2H3/b24-18+ | Reactome pathway
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| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human GAL3 |
J Med Chem 49: 3757-8 (2006)
Article DOI: 10.1021/jm060001n
BindingDB Entry DOI: 10.7270/Q2T72H2B |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355858
(CHEMBL1909731)Show SMILES COCCN(CCOC)S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C19H31N5O4S2/c1-27-14-12-24(13-15-28-2)30(25,26)22-11-6-3-5-10-21-19-23-18(16-29-19)17-8-4-7-9-20-17/h4,7-9,16,22H,3,5-6,10-15H2,1-2H3,(H,21,23) | KEGG
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| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187915
(1-(4-(4-(diethylamino)butoxy)phenyl)-3-(3-(trifluo...)Show SMILES CCN(CC)CCCCOc1ccc(cc1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C29H30F3N3O2/c1-3-34(4-2)18-7-8-19-37-24-16-14-23(15-17-24)35-26-13-6-5-12-25(26)27(28(35)36)33-22-11-9-10-21(20-22)29(30,31)32/h5-6,9-17,20H,3-4,7-8,18-19H2,1-2H3/b33-27+ | Reactome pathway
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| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Homo sapiens (Human)) | BDBM50187923
(1,3-dihydro-1-phenyl-3-[[3-(trilfluoromethyl)pheny...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1ccccc1 Show InChI InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19+ | PDB
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PubMed
| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT4 |
J Med Chem 49: 3757-8 (2006)
Article DOI: 10.1021/jm060001n
BindingDB Entry DOI: 10.7270/Q2T72H2B |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355856
(CHEMBL1909729)Show SMILES CC1CN(CC(C)O1)S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1 Show InChI InChI=1S/C19H29N5O3S2/c1-15-12-24(13-16(2)27-15)29(25,26)22-11-6-3-5-10-21-19-23-18(14-28-19)17-8-4-7-9-20-17/h4,7-9,14-16,22H,3,5-6,10-13H2,1-2H3,(H,21,23) | KEGG
UniProtKB/SwissProt
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PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187910
(1-(4-(2-(diethylamino)ethoxy)phenyl)-3-(3-(trifluo...)Show SMILES CCN(CC)CCOc1ccc(cc1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C27H26F3N3O2/c1-3-32(4-2)16-17-35-22-14-12-21(13-15-22)33-24-11-6-5-10-23(24)25(26(33)34)31-20-9-7-8-19(18-20)27(28,29)30/h5-15,18H,3-4,16-17H2,1-2H3/b31-25+ | Reactome pathway
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PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50187911
(1,3-dihydro-1-[3-(2-pyrrolidinylethoxy)phenyl]-3-[...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(c2ccccc12)c1cccc(OCCN2CCCC2)c1 Show InChI InChI=1S/C27H24F3N3O2/c28-27(29,30)19-7-5-8-20(17-19)31-25-23-11-1-2-12-24(23)33(26(25)34)21-9-6-10-22(18-21)35-16-15-32-13-3-4-14-32/h1-2,5-12,17-18H,3-4,13-16H2/b31-25+ | PDB
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| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human adrenergic alpha1A receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355825
(CHEMBL1912074)Show InChI InChI=1S/C13H19N3O2S3/c1-21(17,18)15-7-4-2-3-6-14-13-16-12(10-20-13)11-5-8-19-9-11/h5,8-10,15H,2-4,6-7H2,1H3,(H,14,16) | KEGG
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UniChem
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PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187909
(1-(3-(2-(diethylamino)ethoxy)phenyl)-3-(3-(trifluo...)Show SMILES CCN(CC)CCOc1cccc(c1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C27H26F3N3O2/c1-3-32(4-2)15-16-35-22-12-8-11-21(18-22)33-24-14-6-5-13-23(24)25(26(33)34)31-20-10-7-9-19(17-20)27(28,29)30/h5-14,17-18H,3-4,15-16H2,1-2H3/b31-25+ | Reactome pathway
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PubMed
| 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50189596
(1-(2-propynyl)-3-{[3-(trifluoromethyl)phenyl]azame...)Show SMILES FC(F)(F)c1cccc(c1)\N=C1\C(=O)N(CC#C)c2ccccc12 Show InChI InChI=1S/C18H11F3N2O/c1-2-10-23-15-9-4-3-8-14(15)16(17(23)24)22-13-7-5-6-12(11-13)18(19,20)21/h1,3-9,11H,10H2/b22-16+ | Reactome pathway
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PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human GAL3 |
J Med Chem 49: 3757-8 (2006)
Article DOI: 10.1021/jm060001n
BindingDB Entry DOI: 10.7270/Q2T72H2B |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349542
(CHEMBL1808866)Show InChI InChI=1S/C20H17ClN2OS/c21-16-5-1-4-14(12-16)17-9-8-15(13-22-17)18-6-2-10-23(18)20(24)19-7-3-11-25-19/h1,3-5,7-9,11-13,18H,2,6,10H2 | PDB
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PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Galanin receptor type 3
(Homo sapiens (Human)) | BDBM50187917
(1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-(3-(triflu...)Show SMILES CN(C)CCOc1ccc(cc1)N1C(=O)\C(=N\c2cccc(c2)C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C25H22F3N3O2/c1-30(2)14-15-33-20-12-10-19(11-13-20)31-22-9-4-3-8-21(22)23(24(31)32)29-18-7-5-6-17(16-18)25(26,27)28/h3-13,16H,14-15H2,1-2H3/b29-23+ | Reactome pathway
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PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]galanin from human galanin Gal3 receptor |
Bioorg Med Chem Lett 16: 3950-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.025
BindingDB Entry DOI: 10.7270/Q2DB81F2 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50349546
(CHEMBL1808899)Show SMILES Cc1cc(ncc1C1CC(F)CN1C(=O)c1cncs1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H17ClFN3OS/c1-12-5-17(13-3-2-4-14(21)6-13)24-8-16(12)18-7-15(22)10-25(18)20(26)19-9-23-11-27-19/h2-6,8-9,11,15,18H,7,10H2,1H3 | PDB
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PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins |
Bioorg Med Chem Lett 21: 4891-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.014
BindingDB Entry DOI: 10.7270/Q2CN748G |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50355830
(CHEMBL1912067)Show InChI InChI=1S/C14H17F3N4O2S2/c15-14(16,17)25(22,23)20-9-4-1-3-8-19-13-21-12(10-24-13)11-6-2-5-7-18-11/h2,5-7,10,20H,1,3-4,8-9H2,(H,19,21) | KEGG
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PubMed
| 109 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay |
Bioorg Med Chem Lett 21: 6500-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.072
BindingDB Entry DOI: 10.7270/Q2V1257P |
More data for this
Ligand-Target Pair | |
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