Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324297 (4-(1-Piperazin-1-yl[2,6]naphthyridin-3-yl)pyridin-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324315 (CHEMBL1214998 | Cyclohexyl-[4-(1-piperazin-1-yl[2,...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324315 (CHEMBL1214998 | Cyclohexyl-[4-(1-piperazin-1-yl[2,...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577571 (2-((1-Methyl-3-(((R)-1 ,1 ,1-trifluoropropan-2-yl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324322 (4-(2-cyclohexylaminopyridin-4-yl)-6-(piperazin-1-y...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577575 (2-((1-Methyl-3-(oxetan-3-yloxy)-1 H-pyrazol-4-yl)a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycystin-2 (Homo sapiens (Human)) | BDBM50324324 (2'-Phenylamino-6-piperazin-1-yl[2,4']bipyridinyl-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD2 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycystin-2 (Homo sapiens (Human)) | BDBM50324346 (CHEMBL1215151 | Cyclohexyl-[6-piperazin-1-yl-4-(1H...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD2 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577571 (2-((1-Methyl-3-(((R)-1 ,1 ,1-trifluoropropan-2-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324346 (CHEMBL1215151 | Cyclohexyl-[6-piperazin-1-yl-4-(1H...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324347 (CHEMBL1215153 | Isopropyl-[6-piperazin-1-yl-4-(1H-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324348 (6-(piperazin-1-yl)-4-(4H-pyrazol-4-yl)-N-(tetrahyd...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324323 (2'-Cyclohexylamino-6-piperazin-1-yl[2,4']bipyridin...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324328 (2'-(2-Chlorophenylamino)-6-piperazin-1-yl[2,4']bip...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324327 (2'-(1-Methyl-1H-pyrazol-3-ylamino)-6-piperazin-1-y...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324324 (2'-Phenylamino-6-piperazin-1-yl[2,4']bipyridinyl-4...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324326 (4'-tert-Butylcarbamoyl-2''-isopropylamino-3,4,5,6-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324325 (6-Piperazin-1-yl-2'-(tetrahydropyran-4-ylamino)[2,...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324314 (1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324298 (CHEMBL1215712 | {4-[1-(4-Isobutylpiperazin-1-yl)[2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324296 (1-[3-(2-Cyclohexylaminopyridin-4-yl)[2,6]naphthyri...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324305 (CHEMBL1214711 | N-(2-(pyrrolidin-1-yl)ethyl)-1-(3-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577554 (2-[[1-[(1 R)-2,2-Difluoro-1-methyl-ethyl]-3-(oxeta...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577554 (2-[[1-[(1 R)-2,2-Difluoro-1-methyl-ethyl]-3-(oxeta...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577560 (7-[(3R,4R)-4-Methyltetrahydrofuran-3-yl]-2-[[1-(ox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577560 (7-[(3R,4R)-4-Methyltetrahydrofuran-3-yl]-2-[[1-(ox...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324306 (1-[3-(2-Cyclohexylaminopyridin-4-yl)[2,6]naphthyri...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324309 (1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324294 (CHEMBL1215643 | Cyclohexyl-{4-[1-(4-cyclopropylmet...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577568 (2-((3-(((S)-1-acetyl-2,2-dimethylazetidin-3-yl)oxy...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577568 (2-((3-(((S)-1-acetyl-2,2-dimethylazetidin-3-yl)oxy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577564 (2-[[1-(Methylsulfonylmethyl)-3-(oxetan-3-yloxy)pyr...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577564 (2-[[1-(Methylsulfonylmethyl)-3-(oxetan-3-yloxy)pyr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycystin-2 (Homo sapiens (Human)) | BDBM50324347 (CHEMBL1215153 | Isopropyl-[6-piperazin-1-yl-4-(1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD2 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324312 (1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577557 (2-((1-methyl-3-(((2S,3R)-2-methyloxetan-3-yl)oxy)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577557 (2-((1-methyl-3-(((2S,3R)-2-methyloxetan-3-yl)oxy)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324313 (1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324335 (2'-Cyclohexylamino-6-((R)-pyrrolidin-3-ylamino)[2,...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycystin-2 (Homo sapiens (Human)) | BDBM50324348 (6-(piperazin-1-yl)-4-(4H-pyrazol-4-yl)-N-(tetrahyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD2 by TR-FRET assay | J Med Chem 53: 5422-38 (2010) Article DOI: 10.1021/jm100076w BindingDB Entry DOI: 10.7270/Q2P84C2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324292 (CHEMBL1215641 | Cyclohexyl-{4-[1-(4-methylpiperazi...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577570 (2-((4-(2-Hydroxypropan-2-yl)-2-(oxetan-3-yloxy)phe...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577556 (2-((1-Methyl-3-(((2R,3S)-2-methyloxetan-3-yl)oxy)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577567 (2-((3-(((R)-1 -Acetyl-2, 2-dimethylazetidin-3-yl)o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM577567 (2-((3-(((R)-1 -Acetyl-2, 2-dimethylazetidin-3-yl)o...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM577570 (2-((4-(2-Hydroxypropan-2-yl)-2-(oxetan-3-yloxy)phe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022263472 | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The measurements of the activities were made using a LRRK2-G2019S(human) Kinase activity assay as described hereunder. The potency of compounds was e... | Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KKQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324310 (1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324304 (1-[3-(2-Cyclohexylaminopyridin-4-yl)[2,6]naphthyri...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324291 (CHEMBL1215640 | Cyclohexyl-{4-[1-((cis-3,5-dimethy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50324311 (1-{3-[2-(Tetrahydropyran-4-ylamino)pyridin-4-yl][2...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of PKD1 by TR-FRET assay | J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9 | |||||||||||
More data for this Ligand-Target Pair |
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