Found 135 hits with Last Name = 'rao' and Initial = 'ss' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139601
(1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(met...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16BrF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442406
(CHEMBL2443061)Show SMILES O[C@@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Cl)cccc12 |r| Show InChI InChI=1S/C21H20ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442408
(CHEMBL2443079)Show SMILES O[C@@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(F)cccc12 |r| Show InChI InChI=1S/C21H20F4N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442406
(CHEMBL2443061)Show SMILES O[C@@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Cl)cccc12 |r| Show InChI InChI=1S/C21H20ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50442406
(CHEMBL2443061)Show SMILES O[C@@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Cl)cccc12 |r| Show InChI InChI=1S/C21H20ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 by 45Ca2+ uptake assay |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442404
(CHEMBL2443063)Show SMILES O[C@@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Br)cccc12 |r| Show InChI InChI=1S/C21H20BrF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442426
(CHEMBL2443085)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Br)c2O3)cc1 Show InChI InChI=1S/C21H20BrF3N2O2/c22-17-3-1-2-14-8-9-20(29-18(14)17)10-12-27(13-11-20)19(28)26-16-6-4-15(5-7-16)21(23,24)25/h1-7H,8-13H2,(H,26,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442405
(CHEMBL2443062)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Br)cccc12 |r| Show InChI InChI=1S/C21H20BrF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442408
(CHEMBL2443079)Show SMILES O[C@@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(F)cccc12 |r| Show InChI InChI=1S/C21H20F4N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139614
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C22H18ClF3N4O3/c1-2-27-20(31)19-12-16(9-10-28-19)33-15-6-3-13(4-7-15)29-21(32)30-14-5-8-18(23)17(11-14)22(24,25)26/h3-12H,2H2,1H3,(H,27,31)(H2,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50133817
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of TRPV1 (unknown origin) |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442425
(CHEMBL2443086)Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Cl)c2O3)cc1 Show InChI InChI=1S/C21H20ClF3N2O3/c22-17-3-1-2-14-8-9-20(30-18(14)17)10-12-27(13-11-20)19(28)26-15-4-6-16(7-5-15)29-21(23,24)25/h1-7H,8-13H2,(H,26,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249245
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)C(=O)Nc3cccnc3)cc2)ccc1Cl Show InChI InChI=1S/C25H17ClF3N5O3/c26-21-8-5-16(12-20(21)25(27,28)29)34-24(36)33-15-3-6-18(7-4-15)37-19-9-11-31-22(13-19)23(35)32-17-2-1-10-30-14-17/h1-14H,(H,32,35)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442410
(CHEMBL2443074)Show SMILES OC1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)Oc2c(Br)cccc12 Show InChI InChI=1S/C21H20BrF3N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442407
(CHEMBL2443060)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Cl)cccc12 |r| Show InChI InChI=1S/C21H20ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442427
(CHEMBL2443084)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Cl)c2O3)cc1 Show InChI InChI=1S/C21H20ClF3N2O2/c22-17-3-1-2-14-8-9-20(29-18(14)17)10-12-27(13-11-20)19(28)26-16-6-4-15(5-7-16)21(23,24)25/h1-7H,8-13H2,(H,26,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139597
(4-(4-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureid...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3OC)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C22H19F3N4O4/c1-26-20(30)18-12-16(9-10-27-18)33-15-6-4-14(5-7-15)28-21(31)29-17-11-13(22(23,24)25)3-8-19(17)32-2/h3-12H,1-2H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442405
(CHEMBL2443062)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Br)cccc12 |r| Show InChI InChI=1S/C21H20BrF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442411
(CHEMBL2443073)Show SMILES OC1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)Oc2c(Cl)cccc12 Show InChI InChI=1S/C21H20ClF3N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139596
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)C(=O)NCCN3CCOCC3)cc2)ccc1Cl Show InChI InChI=1S/C26H25ClF3N5O4/c27-22-6-3-18(15-21(22)26(28,29)30)34-25(37)33-17-1-4-19(5-2-17)39-20-7-8-31-23(16-20)24(36)32-9-10-35-11-13-38-14-12-35/h1-8,15-16H,9-14H2,(H,32,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249276
(4-(4-(3-(4-chloro-2-methoxy-5-(trifluoromethyl)phe...)Show SMILES CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(c(Cl)cc3OC)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C23H20ClF3N4O4/c1-3-28-21(32)19-10-15(8-9-29-19)35-14-6-4-13(5-7-14)30-22(33)31-18-11-16(23(25,26)27)17(24)12-20(18)34-2/h4-12H,3H2,1-2H3,(H,28,32)(H2,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442412
(CHEMBL2443072)Show SMILES OC1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)Oc2c(F)cccc12 Show InChI InChI=1S/C21H20F4N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442409
(CHEMBL2443078)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(F)cccc12 |r| Show InChI InChI=1S/C21H20F4N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442428
(CHEMBL2443083)Show SMILES Fc1cccc2CCC3(CCN(CC3)C(=O)Nc3ccc(cc3)C(F)(F)F)Oc12 Show InChI InChI=1S/C21H20F4N2O2/c22-17-3-1-2-14-8-9-20(29-18(14)17)10-12-27(13-11-20)19(28)26-16-6-4-15(5-7-16)21(23,24)25/h1-7H,8-13H2,(H,26,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442413
(CHEMBL2443071)Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(CC2)CC(=O)c2cccc(Br)c2O3)cc1 Show InChI InChI=1S/C21H18BrF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442414
(CHEMBL2443070)Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(CC2)CC(=O)c2cccc(Cl)c2O3)cc1 Show InChI InChI=1S/C21H18ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442419
(CHEMBL2443066)Show SMILES Fc1ccc2nc(NC(=O)N3CCC4(CC3)CCc3cccc(Cl)c3O4)sc2c1 Show InChI InChI=1S/C21H19ClFN3O2S/c22-15-3-1-2-13-6-7-21(28-18(13)15)8-10-26(11-9-21)20(27)25-19-24-16-5-4-14(23)12-17(16)29-19/h1-5,12H,6-11H2,(H,24,25,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139609
(3-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenoxy)...)Show SMILES CNC(=O)c1cccc(Oc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)c1 Show InChI InChI=1S/C22H24N4O4/c1-22(2,3)18-13-19(26-30-18)25-21(28)24-15-8-10-16(11-9-15)29-17-7-5-6-14(12-17)20(27)23-4/h5-13H,1-4H3,(H,23,27)(H2,24,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249376
(1-(3-tert-butylisoxazol-5-yl)-3-(4-(pyridin-4-ylox...)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)on1 Show InChI InChI=1S/C19H20N4O3/c1-19(2,3)16-12-17(26-23-16)22-18(24)21-13-4-6-14(7-5-13)25-15-8-10-20-11-9-15/h4-12H,1-3H3,(H2,21,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249277
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)C(=O)Nc3ccc(cc3)N3CCOCC3)cc2)ccc1Cl Show InChI InChI=1S/C30H25ClF3N5O4/c31-26-10-5-21(17-25(26)30(32,33)34)38-29(41)37-20-3-8-23(9-4-20)43-24-11-12-35-27(18-24)28(40)36-19-1-6-22(7-2-19)39-13-15-42-16-14-39/h1-12,17-18H,13-16H2,(H,36,40)(H2,37,38,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442422
(CHEMBL2443089)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Cl)c2O3)c(Cl)c1 Show InChI InChI=1S/C21H19Cl2F3N2O2/c22-15-3-1-2-13-6-7-20(30-18(13)15)8-10-28(11-9-20)19(29)27-17-5-4-14(12-16(17)23)21(24,25)26/h1-5,12H,6-11H2,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 178 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442415
(CHEMBL2440148)Show SMILES Fc1cccc2C(=O)CC3(CCN(CC3)C(=O)Nc3ccc(OC(F)(F)F)cc3)Oc12 Show InChI InChI=1S/C21H18F4N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50442407
(CHEMBL2443060)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Cl)cccc12 |r| Show InChI InChI=1S/C21H20ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 218 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ uptake incubated for 10 mins prior to ca... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249278
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES CN(C)c1ccc(NC(=O)c2cc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)ccn2)cc1 Show InChI InChI=1S/C28H23ClF3N5O3/c1-37(2)20-8-3-17(4-9-20)34-26(38)25-16-22(13-14-33-25)40-21-10-5-18(6-11-21)35-27(39)36-19-7-12-24(29)23(15-19)28(30,31)32/h3-16H,1-2H3,(H,34,38)(H2,35,36,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139604
(1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-ylo...)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)no1 Show InChI InChI=1S/C19H20N4O3/c1-19(2,3)16-12-17(23-26-16)22-18(24)21-13-4-6-14(7-5-13)25-15-8-10-20-11-9-15/h4-12H,1-3H3,(H2,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442417
(CHEMBL2443068)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CC(=O)c2cccc(Cl)c2O3)cc1 Show InChI InChI=1S/C21H18ClF3N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50442409
(CHEMBL2443078)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(F)cccc12 |r| Show InChI InChI=1S/C21H20F4N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 266 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ uptake incubated for 10 mins prior to ca... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442420
(CHEMBL2443065)Show SMILES FC(F)(F)c1csc(NC(=O)N2CCC3(CC2)CCc2cccc(Cl)c2O3)n1 Show InChI InChI=1S/C18H17ClF3N3O2S/c19-12-3-1-2-11-4-5-17(27-14(11)12)6-8-25(9-7-17)16(26)24-15-23-13(10-28-15)18(20,21)22/h1-3,10H,4-9H2,(H,23,24,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 266 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442430
(CHEMBL2443081)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CCc2ccccc2O3)cc1 Show InChI InChI=1S/C21H21F3N2O2/c22-21(23,24)16-5-7-17(8-6-16)25-19(27)26-13-11-20(12-14-26)10-9-15-3-1-2-4-18(15)28-20/h1-8H,9-14H2,(H,25,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 281 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442423
(CHEMBL2443088)Show SMILES Cc1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Cl)c2O3)cc1 Show InChI InChI=1S/C21H23ClN2O2/c1-15-5-7-17(8-6-15)23-20(25)24-13-11-21(12-14-24)10-9-16-3-2-4-18(22)19(16)26-21/h2-8H,9-14H2,1H3,(H,23,25) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442418
(CHEMBL2443067)Show SMILES Fc1cccc2C(=O)CC3(CCN(CC3)C(=O)Nc3ccc(cc3)C(F)(F)F)Oc12 Show InChI InChI=1S/C21H18F4N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 295 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50442405
(CHEMBL2443062)Show SMILES O[C@H]1CC2(CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)Oc2c(Br)cccc12 |r| Show InChI InChI=1S/C21H20BrF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 413 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ uptake incubated for 10 mins prior to ca... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249279
(1-(3-methoxyphenyl)-3-(4-(pyridin-4-yloxy)phenyl)u...)Show InChI InChI=1S/C19H17N3O3/c1-24-18-4-2-3-15(13-18)22-19(23)21-14-5-7-16(8-6-14)25-17-9-11-20-12-10-17/h2-13H,1H3,(H2,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442421
(CHEMBL2443064)Show SMILES Fc1cc(Cl)c2OC3(CCN(CC3)C(=O)Nc3ccc(cc3)C(F)(F)F)CCc2c1 Show InChI InChI=1S/C21H19ClF4N2O2/c22-17-12-15(23)11-13-5-6-20(30-18(13)17)7-9-28(10-8-20)19(29)27-16-3-1-14(2-4-16)21(24,25)26/h1-4,11-12H,5-10H2,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 457 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249313
(1-(5-tert-butylisoxazol-3-yl)-3-(4-(4-methoxypheno...)Show SMILES COc1ccc(Oc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)cc1 Show InChI InChI=1S/C21H23N3O4/c1-21(2,3)18-13-19(24-28-18)23-20(25)22-14-5-7-16(8-6-14)27-17-11-9-15(26-4)10-12-17/h5-13H,1-4H3,(H2,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442424
(CHEMBL2443087)Show SMILES Clc1cccc2CCC3(CCN(CC3)C(=O)Nc3ccc(cc3)C#N)Oc12 Show InChI InChI=1S/C21H20ClN3O2/c22-18-3-1-2-16-8-9-21(27-19(16)18)10-12-25(13-11-21)20(26)24-17-6-4-15(14-23)5-7-17/h1-7H,8-13H2,(H,24,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 544 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249409
(1-(5-tert-butylisoxazol-3-yl)-3-(4-(pyridin-4-ylme...)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Cc3ccncc3)cc2)no1 Show InChI InChI=1S/C20H22N4O2/c1-20(2,3)17-13-18(24-26-17)23-19(25)22-16-6-4-14(5-7-16)12-15-8-10-21-11-9-15/h4-11,13H,12H2,1-3H3,(H2,22,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50249377
(1-(5-tert-butylisoxazol-3-yl)-3-(2,3-dimethyl-4-ph...)Show SMILES Cc1c(NC(=O)Nc2cc(on2)C(C)(C)C)ccc(Oc2ccccc2)c1C Show InChI InChI=1S/C22H25N3O3/c1-14-15(2)18(27-16-9-7-6-8-10-16)12-11-17(14)23-21(26)24-20-13-19(28-25-20)22(3,4)5/h6-13H,1-5H3,(H2,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf1 (unknown origin) |
Eur J Med Chem 44: 1240-9 (2009)
Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50442416
(CHEMBL2443069)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CC(=O)c2cccc(Br)c2O3)cc1 Show InChI InChI=1S/C21H18BrF3N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7H,8-12H2,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 657 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili... |
Bioorg Med Chem 21: 6542-53 (2013)
Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S |
More data for this
Ligand-Target Pair | |
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