BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 262 hits with Last Name = 'rodriques' and Initial = 'ke'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin G/H synthase 1


(Homo sapiens (Human))		BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition activity against recombinant human Prostaglandin G/H synthase 1

J Med Chem 40: 819-24 (1997)


Article DOI: 10.1021/jm9606150
BindingDB Entry DOI: 10.7270/Q2DF6Q9T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50006805
PNG
(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50080258
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(thi...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cscn3)cc12
Show InChI InChI=1S/C28H31ClN2O3S2/c1-27(2,3)36-25-22-12-21(34-15-20-16-35-17-30-20)10-11-23(22)31(14-18-6-8-19(29)9-7-18)24(25)13-28(4,5)26(32)33/h6-12,16-17H,13-15H2,1-5H3,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
n/an/a 40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50080250
PNG
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccccn3)cc12
Show InChI InChI=1S/C30H33ClN2O3S/c1-29(2,3)37-27-24-16-23(36-19-22-8-6-7-15-32-22)13-14-25(24)33(18-20-9-11-21(31)12-10-20)26(27)17-30(4,5)28(34)35/h6-16H,17-19H2,1-5H3,(H,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
n/an/a 50n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50369261
PNG
(CHEMBL1907812)
Show SMILES C[C@H](CN(O)C(N)=O)C#Cc1ccc(Oc2ccc(F)cc2)o1 |r|
Show InChI InChI=1S/C16H15FN2O4/c1-11(10-19(21)16(18)20)2-5-13-8-9-15(22-13)23-14-6-3-12(17)4-7-14/h3-4,6-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058592
PNG
(CHEMBL291993 | N-hydroxy-N-[3-(3-phenoxyphenyl)pro...)
Show SMILES NC(=O)N(O)CC#Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C16H14N2O3/c17-16(19)18(20)11-5-7-13-6-4-10-15(12-13)21-14-8-2-1-3-9-14/h1-4,6,8-10,12,20H,11H2,(H2,17,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029778
PNG
(CHEMBL264717 | N-{3-[5-(4-fluorophenoxy)-2-furyl]p...)
Show SMILES NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-5-12(6-4-10)21-13-8-7-11(20-13)2-1-9-17(19)14(16)18/h3-8,19H,9H2,(H2,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058635
PNG
(CHEMBL60523 | N-{2-[({(1E)-[5-(4-fluorophenoxy)-2-...)
Show SMILES NC(=O)N(O)CCO\N=C\c1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C14H14FN3O5/c15-10-1-3-11(4-2-10)22-13-6-5-12(23-13)9-17-21-8-7-18(20)14(16)19/h1-6,9,20H,7-8H2,(H2,16,19)/b17-9+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029775
PNG
((R)-(+)-N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-met...)
Show SMILES CC(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50369260
PNG
(CHEMBL1907824)
Show SMILES C[C@@H](CN(O)C(N)=O)C#Cc1ccc(Oc2ccc(F)cc2)o1 |r|
Show InChI InChI=1S/C16H15FN2O4/c1-11(10-19(21)16(18)20)2-5-13-8-9-15(22-13)23-14-6-3-12(17)4-7-14/h3-4,6-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058554
PNG
(CHEMBL294028 | N-{(2Z)-2-fluoro-3-[5-(4-fluorophen...)
Show SMILES CC(N(O)C(N)=O)C(\F)=C\c1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C15H14F2N2O4/c1-9(19(21)15(18)20)13(17)8-12-6-7-14(23-12)22-11-4-2-10(16)3-5-11/h2-9,21H,1H3,(H2,18,20)/b13-8-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
DrugBank
PDB
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition activity against recombinant human Prostaglandin G/H synthase 2

J Med Chem 40: 819-24 (1997)


Article DOI: 10.1021/jm9606150
BindingDB Entry DOI: 10.7270/Q2DF6Q9T
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058615
PNG
(CHEMBL58335 | N-[1-(1-benzothien-2-yl)ethyl]-N-hyd...)
Show SMILES CCCCCNC(=O)N(O)C(C)c1cc2ccccc2s1
Show InChI InChI=1S/C16H22N2O2S/c1-3-4-7-10-17-16(19)18(20)12(2)15-11-13-8-5-6-9-14(13)21-15/h5-6,8-9,11-12,20H,3-4,7,10H2,1-2H3,(H,17,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058580
PNG
(CHEMBL300985 | N-hydroxy-N-{[2-(3-phenoxyphenyl)cy...)
Show SMILES NC(=O)N(O)CC1CC1c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)11-13-10-16(13)12-5-4-8-15(9-12)22-14-6-2-1-3-7-14/h1-9,13,16,21H,10-11H2,(H2,18,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058627
PNG
(CHEMBL60174 | N-[3-(1-benzothien-2-yl)-1-methylpro...)
Show SMILES CC(C#Cc1cc2ccccc2s1)N(O)C(N)=O
Show InChI InChI=1S/C13H12N2O2S/c1-9(15(17)13(14)16)6-7-11-8-10-4-2-3-5-12(10)18-11/h2-5,8-9,17H,1H3,(H2,14,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058590
PNG
(CHEMBL293743 | Fenleuton | N-{3-[3-(4-fluorophenox...)
Show SMILES CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50287317
PNG
(CHEMBL3349448 | CHEMBL37469 | [3-[3-tert-Butylsulf...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)\C=N\OCC(O)=O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C29H37ClN2O3S/c1-19(2)21-10-13-24-23(14-21)27(36-28(3,4)5)25(15-29(6,7)18-31-35-17-26(33)34)32(24)16-20-8-11-22(30)12-9-20/h8-14,18-19H,15-17H2,1-7H3,(H,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058533
PNG
(CHEMBL61888 | N-(1-{5-[(benzyloxy)methyl]-2-furyl}...)
Show SMILES CC(N(O)C(N)=O)c1ccc(COCc2ccccc2)o1
Show InChI InChI=1S/C15H18N2O4/c1-11(17(19)15(16)18)14-8-7-13(21-14)10-20-9-12-5-3-2-4-6-12/h2-8,11,19H,9-10H2,1H3,(H2,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50080256
PNG
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(6-c...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccc(Cl)n3)cc12
Show InChI InChI=1S/C30H32Cl2N2O3S/c1-29(2,3)38-27-23-15-22(37-18-21-7-6-8-26(32)33-21)13-14-24(23)34(17-19-9-11-20(31)12-10-19)25(27)16-30(4,5)28(35)36/h6-15H,16-18H2,1-5H3,(H,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
n/an/a 110n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058585
PNG
(CHEMBL61583 | N-{2-[({(1E)-[5-(4-fluorophenoxy)-2-...)
Show SMILES CC(CO\N=C\c1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H16FN3O5/c1-10(19(21)15(17)20)9-22-18-8-13-6-7-14(24-13)23-12-4-2-11(16)3-5-12/h2-8,10,21H,9H2,1H3,(H2,17,20)/b18-8+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058621
PNG
(CHEMBL59119 | N-hydroxy-N-[(2E)-3-(5-phenyl-2-fury...)
Show SMILES NC(=O)N(O)C\C=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O3/c15-14(17)16(18)10-4-7-12-8-9-13(19-12)11-5-2-1-3-6-11/h1-9,18H,10H2,(H2,15,17)/b7-4+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058650
PNG
(CHEMBL58314 | N-[1-(1-benzothien-2-yl)ethyl]-N'-be...)
Show SMILES CC(N(O)C(=O)NCc1ccccc1)c1cc2ccccc2s1
Show InChI InChI=1S/C18H18N2O2S/c1-13(17-11-15-9-5-6-10-16(15)23-17)20(22)18(21)19-12-14-7-3-2-4-8-14/h2-11,13,22H,12H2,1H3,(H,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058631
PNG
(CHEMBL59301 | N-hydroxy-N-[(5-phenoxy-2-furyl)meth...)
Show SMILES NC(=O)N(O)Cc1ccc(Oc2ccccc2)o1
Show InChI InChI=1S/C12H12N2O4/c13-12(15)14(16)8-10-6-7-11(18-10)17-9-4-2-1-3-5-9/h1-7,16H,8H2,(H2,13,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058628
PNG
(CHEMBL61974 | N-hydroxy-N-[1-(3-phenoxyphenyl)ethy...)
Show SMILES CC(N(O)C(N)=O)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C15H16N2O3/c1-11(17(19)15(16)18)12-6-5-9-14(10-12)20-13-7-3-2-4-8-13/h2-11,19H,1H3,(H2,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50287323
PNG
(3-{2-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-i...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)NC(=O)N(C)O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C28H38ClN3O2S/c1-18(2)20-11-14-23-22(15-20)25(35-27(3,4)5)24(16-28(6,7)30-26(33)31(8)34)32(23)17-19-9-12-21(29)13-10-19/h9-15,18,34H,16-17H2,1-8H3,(H,30,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058560
PNG
(CHEMBL413102 | N-hydroxy-N-(1-{5-[(E)-2-phenylviny...)
Show SMILES CC(N(O)C(N)=O)c1ccc(\C=C\c2ccccc2)s1
Show InChI InChI=1S/C15H16N2O2S/c1-11(17(19)15(16)18)14-10-9-13(20-14)8-7-12-5-3-2-4-6-12/h2-11,19H,1H3,(H2,16,18)/b8-7+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058623
PNG
(CHEMBL58425 | N-hydroxy-N-[1-methyl-3-(3-phenoxyph...)
Show SMILES CC(C#Cc1cccc(Oc2ccccc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H16N2O3/c1-13(19(21)17(18)20)10-11-14-6-5-9-16(12-14)22-15-7-3-2-4-8-15/h2-9,12-13,21H,1H3,(H2,18,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058614
PNG
(CHEMBL62146 | N-{3-[5-(4-fluorophenoxy)-2-furyl]-1...)
Show SMILES CC(C)(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O4/c1-16(2,19(21)15(18)20)10-9-13-7-8-14(23-13)22-12-5-3-11(17)4-6-12/h3-8,21H,1-2H3,(H2,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058612
PNG
(CHEMBL58336 | N-[1-(1-benzothien-2-yl)ethyl]-N'-bu...)
Show SMILES CCCCNC(=O)N(O)C(C)c1cc2ccccc2s1
Show InChI InChI=1S/C15H20N2O2S/c1-3-4-9-16-15(18)17(19)11(2)14-10-12-7-5-6-8-13(12)20-14/h5-8,10-11,19H,3-4,9H2,1-2H3,(H,16,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058580
PNG
(CHEMBL300985 | N-hydroxy-N-{[2-(3-phenoxyphenyl)cy...)
Show SMILES NC(=O)N(O)CC1CC1c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)11-13-10-16(13)12-5-4-8-15(9-12)22-14-6-2-1-3-7-14/h1-9,13,16,21H,10-11H2,(H2,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058623
PNG
(CHEMBL58425 | N-hydroxy-N-[1-methyl-3-(3-phenoxyph...)
Show SMILES CC(C#Cc1cccc(Oc2ccccc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H16N2O3/c1-13(19(21)17(18)20)10-11-14-6-5-9-16(12-14)22-15-7-3-2-4-8-15/h2-9,12-13,21H,1H3,(H2,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058643
PNG
(CHEMBL58664 | N-{(2E)-3-[5-(4-fluorophenoxy)-2-fur...)
Show SMILES CC(\C=C\c1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H15FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h2-10,20H,1H3,(H2,17,19)/b5-2+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058640
PNG
(CHEMBL61752 | N-hydroxy-N-[(2E)-3-(5-methyl-2-fury...)
Show SMILES Cc1ccc(\C=C\CN(O)C(N)=O)o1
Show InChI InChI=1S/C9H12N2O3/c1-7-4-5-8(14-7)3-2-6-11(13)9(10)12/h2-5,13H,6H2,1H3,(H2,10,12)/b3-2+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029781
PNG
((R)-(+)-N-{3-[5-(4-fluorobenzyl)thien-2-yl]-1-meth...)
Show SMILES C[C@H](C#Cc1ccc(Cc2ccc(F)cc2)s1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50287322
PNG
(1-{3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-i...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)CN(O)C(N)=O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C28H38ClN3O2S/c1-18(2)20-10-13-23-22(14-20)25(35-27(3,4)5)24(15-28(6,7)17-32(34)26(30)33)31(23)16-19-8-11-21(29)12-9-19/h8-14,18,34H,15-17H2,1-7H3,(H2,30,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50287321
PNG
(CHEMBL434401 | {3-[3-tert-Butylsulfanyl-1-(4-chlor...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)CNC(N)=O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C28H38ClN3OS/c1-18(2)20-10-13-23-22(14-20)25(34-27(3,4)5)24(15-28(6,7)17-31-26(30)33)32(23)16-19-8-11-21(29)12-9-19/h8-14,18H,15-17H2,1-7H3,(H3,30,31,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
n/an/a 180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50287327
PNG
(CHEMBL36331 | [3-[3-tert-Butylsulfanyl-1-(4-chloro...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)\C=N\OCC(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cscn3)cc12
Show InChI InChI=1S/C30H34ClN3O4S2/c1-29(2,3)40-28-24-12-23(37-15-22-17-39-19-32-22)10-11-25(24)34(14-20-6-8-21(31)9-7-20)26(28)13-30(4,5)18-33-38-16-27(35)36/h6-12,17-19H,13-16H2,1-5H3,(H,35,36)/b33-18+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058581
PNG
(CHEMBL59838 | N-hydroxy-N-{1-[4-(1-phenylethoxy)ph...)
Show SMILES CC(Oc1ccc(cc1)C(C)N(O)C(N)=O)c1ccccc1
Show InChI InChI=1S/C17H20N2O3/c1-12(19(21)17(18)20)14-8-10-16(11-9-14)22-13(2)15-6-4-3-5-7-15/h3-13,21H,1-2H3,(H2,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058573
PNG
(CHEMBL58779 | N-[1-(1-benzothien-2-yl)ethyl]-N-hyd...)
Show SMILES CC(N(O)C(N)=S)c1cc2ccccc2s1
Show InChI InChI=1S/C11H12N2OS2/c1-7(13(14)11(12)15)10-6-8-4-2-3-5-9(8)16-10/h2-7,14H,1H3,(H2,12,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058621
PNG
(CHEMBL59119 | N-hydroxy-N-[(2E)-3-(5-phenyl-2-fury...)
Show SMILES NC(=O)N(O)C\C=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O3/c15-14(17)16(18)10-4-7-12-8-9-13(19-12)11-5-2-1-3-6-11/h1-9,18H,10H2,(H2,15,17)/b7-4+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029559
PNG
(2-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12
Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058555
PNG
(CHEMBL58463 | N-[1-(4-chloro-1-benzothien-2-yl)eth...)
Show SMILES CC(N(O)C(N)=O)c1cc2c(Cl)cccc2s1
Show InChI InChI=1S/C11H11ClN2O2S/c1-6(14(16)11(13)15)10-5-7-8(12)3-2-4-9(7)17-10/h2-6,16H,1H3,(H2,13,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058556
PNG
(CHEMBL58078 | N-[1-(5-butyl-2-furyl)ethyl]-N-hydro...)
Show SMILES CCCCc1ccc(o1)C(C)N(O)C(N)=O
Show InChI InChI=1S/C11H18N2O3/c1-3-4-5-9-6-7-10(16-9)8(2)13(15)11(12)14/h6-8,15H,3-5H2,1-2H3,(H2,12,14)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50056764
PNG
(CHEMBL355423 | N'-Hydroxy-N'-methyl-N-[1-(4-chloro...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CNC(=O)N(C)O)c2c1
Show InChI InChI=1S/C20H20ClN3O4/c1-12-17(11-22-20(26)23(2)27)16-10-15(28-3)8-9-18(16)24(12)19(25)13-4-6-14(21)7-5-13/h4-10,27H,11H2,1-3H3,(H,22,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate

J Med Chem 40: 819-24 (1997)


Article DOI: 10.1021/jm9606150
BindingDB Entry DOI: 10.7270/Q2DF6Q9T
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058632
PNG
(CHEMBL293141 | N-[1-(2,2'-bithien-5-yl)ethyl]-N-hy...)
Show SMILES CC(N(O)C(N)=O)c1ccc(s1)-c1cccs1
Show InChI InChI=1S/C11H12N2O2S2/c1-7(13(15)11(12)14)8-4-5-10(17-8)9-3-2-6-16-9/h2-7,15H,1H3,(H2,12,14)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058625
PNG
(CHEMBL418475 | N-hydroxy-N-({5-[(E)-2-thien-2-ylvi...)
Show SMILES NC(=O)N(O)Cc1ccc(\C=C\c2cccs2)s1
Show InChI InChI=1S/C12H12N2O2S2/c13-12(15)14(16)8-11-6-5-10(18-11)4-3-9-2-1-7-17-9/h1-7,16H,8H2,(H2,13,15)/b4-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058539
PNG
(CHEMBL302169 | N-hydroxy-N-{[5-(phenylthio)-2-fury...)
Show SMILES NC(=O)N(O)Cc1ccc(Sc2ccccc2)o1
Show InChI InChI=1S/C12H12N2O3S/c13-12(15)14(16)8-9-6-7-11(17-9)18-10-4-2-1-3-5-10/h1-7,16H,8H2,(H2,13,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058579
PNG
(CHEMBL294092 | N-{[2-(3-furyl)cyclopropyl]methyl}-...)
Show SMILES NC(=O)N(O)CC1CC1c1ccoc1
Show InChI InChI=1S/C9H12N2O3/c10-9(12)11(13)4-7-3-8(7)6-1-2-14-5-6/h1-2,5,7-8,13H,3-4H2,(H2,10,12)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50287319
PNG
(CHEMBL38949 | [3-[3-tert-Butylsulfanyl-1-(4-chloro...)
Show SMILES CC(C)(C)Sc1c(CC(C)(C)\C=N\OCC(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccc(Cl)n3)cc12
Show InChI InChI=1S/C32H35Cl2N3O4S/c1-31(2,3)42-30-25-15-24(40-18-23-7-6-8-28(34)36-23)13-14-26(25)37(17-21-9-11-22(33)12-10-21)27(30)16-32(4,5)20-35-41-19-29(38)39/h6-15,20H,16-19H2,1-5H3,(H,38,39)/b35-20+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 230n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay

Bioorg Med Chem Lett 6: 1547-1552 (1996)


Article DOI: 10.1016/S0960-894X(96)00271-5
BindingDB Entry DOI: 10.7270/Q2DF6R6W
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058544
PNG
(CHEMBL58021 | N-({5-[(4-chlorophenyl)thio]thien-2-...)
Show SMILES NC(=O)N(O)Cc1ccc(Sc2ccc(Cl)cc2)s1
Show InChI InChI=1S/C12H11ClN2O2S2/c13-8-1-3-9(4-2-8)18-11-6-5-10(19-11)7-15(17)12(14)16/h1-6,17H,7H2,(H2,14,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 262 total )  |  Next  |  Last  >>
Jump to: