Compile Data Set for Download or QSAR

Found 299 hits with Last Name = 'saku' and Initial = 'o'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50272596 (CHEMBL4126450) Show SMILES Cl.C[C@@H](N[C@H]1CCN(C1)c1ccc(cc1)-c1nn[nH]n1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C23H24N6.ClH/c1-16(21-8-4-6-17-5-2-3-7-22(17)21)24-19-13-14-29(15-19)20-11-9-18(10-12-20)23-25-27-28-26-23;/h2-12,16,19,24H,13-15H2,1H3,(H,25,26,27,28);1H/t16-,19+;/m1./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISA				Bioorg Med Chem Lett 28: 2055-2060 (2018) Article DOI: 10.1016/j.bmcl.2018.04.055 BindingDB Entry DOI: 10.7270/Q2DF6TP0
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220924 (US9302996, 39) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1ncc([nH]1)C1(CC1)C(F)(F)F Show InChI InChI=1S/C24H24F3N3O3/c1-14-10-19(33-13-22(2,3)21(31)32)28-11-17(14)15-4-6-16(7-5-15)20-29-12-18(30-20)23(8-9-23)24(25,26)27/h4-7,10-12H,8-9,13H2,1-3H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220966 (US9302996, 114 | US9302996, 81) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C21H21F3N4O3/c1-11-6-16(31-10-20(3,4)19(29)30)25-8-14(11)13-5-12(2)17(26-7-13)18-27-9-15(28-18)21(22,23)24/h5-9H,10H2,1-4H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220983 (US9302996, 98-3) Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1ccc(-c2nc(c[nH]2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H19F4N3O3/c1-12-7-18(32-11-21(20(30)31)5-2-6-21)27-9-15(12)13-3-4-14(16(23)8-13)19-28-10-17(29-19)22(24,25)26/h3-4,7-10H,2,5-6,11H2,1H3,(H,28,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220908 (US9302996, 23) Show SMILES CCC(CC)(COc1ccc(cn1)-c1ccc(nc1)-c1ncc([nH]1)C(F)(F)F)C(O)=O Show InChI InChI=1S/C21H21F3N4O3/c1-3-20(4-2,19(29)30)12-31-17-8-6-14(10-26-17)13-5-7-15(25-9-13)18-27-11-16(28-18)21(22,23)24/h5-11H,3-4,12H2,1-2H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220962 (US9302996, 77) Show SMILES Cc1cc(ccc1-c1ncc([nH]1)C(F)(F)F)-c1cnc(OCC(C)(C)C(O)=O)cc1C Show InChI InChI=1S/C22H22F3N3O3/c1-12-7-14(5-6-15(12)19-27-10-17(28-19)22(23,24)25)16-9-26-18(8-13(16)2)31-11-21(3,4)20(29)30/h5-10H,11H2,1-4H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.780	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395359 (US10308636, Example 44-6) Show SMILES OC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)c1Cl Show InChI InChI=1S/C22H20ClF3N4O3/c23-19-15(21(31)32)2-1-3-16(19)33-12-13-6-8-30(9-7-13)18-5-4-14(10-27-18)20-28-11-17(29-20)22(24,25)26/h1-5,10-11,13H,6-9,12H2,(H,28,29)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220986 (US9302996, 101-3) Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1ccc(-c2nc(c[nH]2)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C22H19ClF3N3O3/c1-12-7-18(32-11-21(20(30)31)5-2-6-21)27-9-15(12)13-3-4-14(16(23)8-13)19-28-10-17(29-19)22(24,25)26/h3-4,7-10H,2,5-6,11H2,1H3,(H,28,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.820	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220975 (US9302996, 90) Show SMILES CC(C)(COc1ncc(cc1F)-c1ccc(cc1)-c1ncc([nH]1)C(F)(F)F)C(O)=O Show InChI InChI=1S/C20H17F4N3O3/c1-19(2,18(28)29)10-30-17-14(21)7-13(8-26-17)11-3-5-12(6-4-11)16-25-9-15(27-16)20(22,23)24/h3-9H,10H2,1-2H3,(H,25,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.870	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50272602 (CHEMBL4126877) Show SMILES Cl.Cl.C[C@@H](N[C@H]1CCN(C1)c1ccc(cc1)C(=O)NCCO)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H29N3O2.2ClH/c1-18(23-8-4-6-19-5-2-3-7-24(19)23)27-21-13-15-28(17-21)22-11-9-20(10-12-22)25(30)26-14-16-29;;/h2-12,18,21,27,29H,13-17H2,1H3,(H,26,30);2*1H/t18-,21+;;/m1../s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISA				Bioorg Med Chem Lett 28: 2055-2060 (2018) Article DOI: 10.1016/j.bmcl.2018.04.055 BindingDB Entry DOI: 10.7270/Q2DF6TP0
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395327 (US10308636, Example 4-15) Show SMILES CCC(CC)(COc1cnc(cn1)-c1ccc(nc1)-c1ncc([nH]1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H25N5O3/c1-3-25(4-2,24(31)32)16-33-22-15-27-20(13-28-22)18-10-11-19(26-12-18)23-29-14-21(30-23)17-8-6-5-7-9-17/h5-15H,3-4,16H2,1-2H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220947 (US9302996, 62-3) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2nc(c[nH]2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C21H19F4N3O3/c1-11-6-17(31-10-20(2,3)19(29)30)26-8-14(11)12-4-5-13(15(22)7-12)18-27-9-16(28-18)21(23,24)25/h4-9H,10H2,1-3H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221020 (US9302996, 135) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C21H18ClF5N4O3/c1-10-4-15(34-9-19(2,3)18(32)33)28-7-12(10)11-5-13(22)16(29-6-11)17-30-8-14(31-17)20(23,24)21(25,26)27/h4-8H,9H2,1-3H3,(H,30,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395380 (US10308636, Example 75) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2ccc(cc2)C#N)n(COCC[Si](C)(C)C)n1 Show InChI InChI=1S/C32H37N5O5Si/c1-32(2,30(38)39-3)21-41-28-16-13-26(20-34-28)24-9-11-25(12-10-24)29-35-31(42-27-14-7-23(19-33)8-15-27)37(36-29)22-40-17-18-43(4,5)6/h7-16,20H,17-18,21-22H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395381 (US10308636, Example 74) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(OCC(F)(F)C(F)(F)F)n(COCC[Si](C)(C)C)n1 Show InChI InChI=1S/C28H35F5N4O5Si/c1-26(2,24(38)39-3)16-41-22-12-11-21(15-34-22)19-7-9-20(10-8-19)23-35-25(42-17-27(29,30)28(31,32)33)37(36-23)18-40-13-14-43(4,5)6/h7-12,15H,13-14,16-18H2,1-6H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395378 (US10308636, Example 110) Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(n[nH]1)-c1ccc(OC)cc1 Show InChI InChI=1S/C26H26N4O4/c1-26(2,25(31)33-4)16-34-22-14-11-20(15-27-22)17-5-7-18(8-6-17)23-28-24(30-29-23)19-9-12-21(32-3)13-10-19/h5-15H,16H2,1-4H3,(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220948 (US9302996, 63-3) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2nc(c[nH]2)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C21H19ClF3N3O3/c1-11-6-17(31-10-20(2,3)19(29)30)26-8-14(11)12-4-5-13(15(22)7-12)18-27-9-16(28-18)21(23,24)25/h4-9H,10H2,1-3H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220993 (US9302996, 108) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1ncc(CC2CC2)[nH]1 Show InChI InChI=1S/C24H27N3O3/c1-15-10-21(30-14-24(2,3)23(28)29)25-13-20(15)17-6-8-18(9-7-17)22-26-12-19(27-22)11-16-4-5-16/h6-10,12-13,16H,4-5,11,14H2,1-3H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395364 (US10308636, Example 46-5) Show SMILES Fc1ccccc1OC[C@H]1CC[C@@H](CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F |r,wU:12.16,wD:9.9,(-7.12,-1.57,;-7.12,-3.11,;-8.5,-3.85,;-8.45,-5.42,;-7.12,-6.19,;-5.79,-5.42,;-5.79,-3.88,;-4.45,-3.11,;-3.12,-3.88,;-1.78,-3.11,;-.45,-3.88,;.88,-3.11,;.88,-1.57,;-.45,-.8,;-1.78,-1.57,;2.22,-.8,;2.22,.74,;3.55,1.51,;4.88,.74,;4.88,-.8,;3.55,-1.57,;6.22,1.51,;6.22,3.05,;7.7,3.56,;8.59,2.28,;7.68,1.03,;8.17,5.03,;8.65,6.49,;9.64,4.55,;6.71,5.5,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220997 (US9302996, 112) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C20H18ClF3N4O3/c1-10-4-15(31-9-19(2,3)18(29)30)25-7-12(10)11-5-13(21)16(26-6-11)17-27-8-14(28-17)20(22,23)24/h4-8H,9H2,1-3H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50272605 (CHEMBL4128542) Show SMILES Cl.Cl.C[C@@H](N[C@@H]1CCCN(C1)c1cccc(OC(F)(F)F)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C24H25F3N2O.2ClH/c1-17(22-13-4-8-18-7-2-3-12-23(18)22)28-19-9-6-14-29(16-19)20-10-5-11-21(15-20)30-24(25,26)27;;/h2-5,7-8,10-13,15,17,19,28H,6,9,14,16H2,1H3;2*1H/t17-,19-;;/m1../s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISA				Bioorg Med Chem Lett 28: 2055-2060 (2018) Article DOI: 10.1016/j.bmcl.2018.04.055 BindingDB Entry DOI: 10.7270/Q2DF6TP0
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220992 (US9302996, 107) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C20H18F4N4O3/c1-10-4-15(31-9-19(2,3)18(29)30)25-7-12(10)11-5-13(21)16(26-6-11)17-27-8-14(28-17)20(22,23)24/h4-8H,9H2,1-3H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220886 (US9302996, 1-3) Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O Show InChI InChI=1S/C20H18F3N3O3/c1-19(2,18(27)28)11-29-14-6-3-12(4-7-14)15-8-5-13(9-24-15)17-25-10-16(26-17)20(21,22)23/h3-10H,11H2,1-2H3,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221019 (US9302996, 134) Show SMILES CCC(CC)(COc1cc(C)c(cn1)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(F)c1)C(O)=O Show InChI InChI=1S/C23H23F4N3O3/c1-4-22(5-2,21(31)32)12-33-19-8-13(3)16(10-28-19)14-6-7-15(17(24)9-14)20-29-11-18(30-20)23(25,26)27/h6-11H,4-5,12H2,1-3H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220939 (US9302996, 54-4) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C2(CC2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C24H23F4N3O3/c1-13-8-19(34-12-22(2,3)21(32)33)29-10-16(13)14-4-5-15(17(25)9-14)20-30-11-18(31-20)23(6-7-23)24(26,27)28/h4-5,8-11H,6-7,12H2,1-3H3,(H,30,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395361 (US10308636, Example 45-1) Show SMILES CCOC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cc2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1C Show InChI InChI=1S/C32H42F3N3O4Si/c1-6-41-31(39)27-8-7-9-28(23(27)2)42-21-24-14-16-37(17-15-24)26-12-10-25(11-13-26)30-36-29(32(33,34)35)20-38(30)22-40-18-19-43(3,4)5/h7-13,20,24H,6,14-19,21-22H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220961 (US9302996, 76) Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(F)c1)C(O)=O Show InChI InChI=1S/C20H17F4N3O3/c1-19(2,18(28)29)10-30-16-6-4-12(8-25-16)11-3-5-13(14(21)7-11)17-26-9-15(27-17)20(22,23)24/h3-9H,10H2,1-2H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220984 (US9302996, 99-6) Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1cnc(-c2nc(c[nH]2)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C21H18ClF3N4O3/c1-11-5-16(32-10-20(19(30)31)3-2-4-20)26-8-13(11)12-6-14(22)17(27-7-12)18-28-9-15(29-18)21(23,24)25/h5-9H,2-4,10H2,1H3,(H,28,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221018 (US9302996, 133) Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C21H17F4N3O3/c1-11-6-17(31-10-20(4-5-20)19(29)30)26-8-14(11)12-2-3-13(15(22)7-12)18-27-9-16(28-18)21(23,24)25/h2-3,6-9H,4-5,10H2,1H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395325 (US10308636, Example 4-1) Show SMILES Cc1cc(OCC(C)(C)C(=O)OC(C)(C)C)ncc1-c1cnc(-c2ncc([nH]2)-c2ccccc2)c(F)c1 Show InChI InChI=1S/C29H31FN4O3/c1-18-12-24(36-17-29(5,6)27(35)37-28(2,3)4)31-15-21(18)20-13-22(30)25(32-14-20)26-33-16-23(34-26)19-10-8-7-9-11-19/h7-16H,17H2,1-6H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221033 (US9302996, 148) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(cn1)-c1ncc([nH]1)C(F)(F)C(F)(F)F Show InChI InChI=1S/C20H18F5N5O3/c1-10-4-15(33-9-18(2,3)17(31)32)28-5-11(10)12-6-27-13(7-26-12)16-29-8-14(30-16)19(21,22)20(23,24)25/h4-8H,9H2,1-3H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220980 (US9302996, 95-6) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(cn1)-c1nc(c[nH]1)C(F)(F)F Show InChI InChI=1S/C19H18F3N5O3/c1-10-4-15(30-9-18(2,3)17(28)29)25-5-11(10)12-6-24-13(7-23-12)16-26-8-14(27-16)19(20,21)22/h4-8H,9H2,1-3H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221023 (US9302996, 138) Show SMILES CCC(CC)(COc1cc(C)c(cn1)-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1)C(O)=O Show InChI InChI=1S/C22H22F4N4O3/c1-4-21(5-2,20(31)32)11-33-17-6-12(3)14(9-27-17)13-7-15(23)18(28-8-13)19-29-10-16(30-19)22(24,25)26/h6-10H,4-5,11H2,1-3H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221011 (US9302996, 126) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)C(F)(F)F Show InChI InChI=1S/C19H18F3N5O3/c1-10-4-14(30-9-18(2,3)17(28)29)23-7-12(10)11-5-24-15(25-6-11)16-26-8-13(27-16)19(20,21)22/h4-8H,9H2,1-3H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395383 (US10308636, Example 78) Show SMILES NC(=O)c1ccc(Br)cc1F Show InChI InChI=1S/C7H5BrFNO/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H2,10,11)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395345 (US10308636, Example 32-2) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1nc(c[nH]1)C#N Show InChI InChI=1S/C21H20N4O3/c1-13-8-18(28-12-21(2,3)20(26)27)23-11-17(13)14-4-6-15(7-5-14)19-24-10-16(9-22)25-19/h4-8,10-11H,12H2,1-3H3,(H,24,25)(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221005 (US9302996, 120) Show SMILES CC(C)Cc1cnc([nH]1)-c1ccc(cc1Cl)-c1cnc(OCC(C)(C)C(O)=O)cc1C Show InChI InChI=1S/C24H28ClN3O3/c1-14(2)8-17-11-27-22(28-17)18-7-6-16(10-20(18)25)19-12-26-21(9-15(19)3)31-13-24(4,5)23(29)30/h6-7,9-12,14H,8,13H2,1-5H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395386 (US10308636, Example 83) Show SMILES C[Si](C)(C)CCOCn1nc(nc1Oc1ccc(F)cc1)-c1ccc(Br)cc1F Show InChI InChI=1S/C20H22BrF2N3O2Si/c1-29(2,3)11-10-27-13-26-20(28-16-7-5-15(22)6-8-16)24-19(25-26)17-9-4-14(21)12-18(17)23/h4-9,12H,10-11,13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220937 (US9302996, 52) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C2(CCC2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H25F4N3O3/c1-14-9-20(35-13-23(2,3)22(33)34)30-11-17(14)15-5-6-16(18(26)10-15)21-31-12-19(32-21)24(7-4-8-24)25(27,28)29/h5-6,9-12H,4,7-8,13H2,1-3H3,(H,31,32)(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221021 (US9302996, 136) Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C20H16F4N4O3/c1-10-4-15(31-9-19(2-3-19)18(29)30)25-7-12(10)11-5-13(21)16(26-6-11)17-27-8-14(28-17)20(22,23)24/h4-8H,2-3,9H2,1H3,(H,27,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220950 (US9302996, 65) Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)C(F)(F)F)CC(O)=O Show InChI InChI=1S/C21H20F3N3O3/c1-20(2,9-18(28)29)12-30-15-6-3-13(4-7-15)16-8-5-14(10-25-16)19-26-11-17(27-19)21(22,23)24/h3-8,10-11H,9,12H2,1-2H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220889 (US9302996, 4-2) Show SMILES CC(C)(COc1ccc(cc1F)-c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O Show InChI InChI=1S/C20H17F4N3O3/c1-19(2,18(28)29)10-30-15-6-4-11(7-13(15)21)14-5-3-12(8-25-14)17-26-9-16(27-17)20(22,23)24/h3-9H,10H2,1-2H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221022 (US9302996, 137) Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C21H18F4N4O3/c1-11-5-16(32-10-20(19(30)31)3-2-4-20)26-8-13(11)12-6-14(22)17(27-7-12)18-28-9-15(29-18)21(23,24)25/h5-9H,2-4,10H2,1H3,(H,28,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220969 (US9302996, 84) Show SMILES CC(C)(COc1ncc(cc1F)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(F)c1)C(O)=O Show InChI InChI=1S/C20H16F5N3O3/c1-19(2,18(29)30)9-31-17-14(22)6-11(7-27-17)10-3-4-12(13(21)5-10)16-26-8-15(28-16)20(23,24)25/h3-8H,9H2,1-2H3,(H,26,28)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395326 (US10308636, Example 4-3) Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)-c1ccccc1 Show InChI InChI=1S/C25H23N5O3/c1-16-10-21(33-15-25(24(31)32)8-5-9-25)26-13-19(16)18-11-27-22(28-12-18)23-29-14-20(30-23)17-6-3-2-4-7-17/h2-4,6-7,10-14H,5,8-9,15H2,1H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM220958 (US9302996, 73) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1ncc([nH]1)C(F)(F)F Show InChI InChI=1S/C21H20F3N3O3/c1-12-8-17(30-11-20(2,3)19(28)29)25-9-15(12)13-4-6-14(7-5-13)18-26-10-16(27-18)21(22,23)24/h4-10H,11H2,1-3H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50272606 (CHEMBL4125917) Show SMILES Cl.Cl.C[C@@H](N[C@@H]1CCCN(C1)c1cccc(c1)C(F)(F)F)c1cccc2ccccc12 |r| Show InChI InChI=1S/C24H25F3N2.2ClH/c1-17(22-13-4-8-18-7-2-3-12-23(18)22)28-20-10-6-14-29(16-20)21-11-5-9-19(15-21)24(25,26)27;;/h2-5,7-9,11-13,15,17,20,28H,6,10,14,16H2,1H3;2*1H/t17-,20-;;/m1../s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISA				Bioorg Med Chem Lett 28: 2055-2060 (2018) Article DOI: 10.1016/j.bmcl.2018.04.055 BindingDB Entry DOI: 10.7270/Q2DF6TP0
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221025 (US9302996, 140) Show SMILES CCC(CC)(COc1cc(C)c(cn1)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(Cl)c1)C(O)=O Show InChI InChI=1S/C23H23ClF3N3O3/c1-4-22(5-2,21(31)32)12-33-19-8-13(3)16(10-28-19)14-6-7-15(17(24)9-14)20-29-11-18(30-20)23(25,26)27/h6-11H,4-5,12H2,1-3H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM221009 (US9302996, 124) Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C(F)(F)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H19F6N3O3/c1-11-6-17(34-10-20(2,3)19(32)33)29-8-14(11)12-4-5-13(15(23)7-12)18-30-9-16(31-18)21(24,25)22(26,27)28/h4-9H,10H2,1-3H3,(H,30,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	30
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...				US Patent US9302996 (2016) BindingDB Entry DOI: 10.7270/Q2TM790N
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM395313 (US10308636, Example 1-34) Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1cccs1)C(O)=O Show InChI InChI=1S/C23H21N3O3S/c1-23(2,22(27)28)14-29-17-8-5-15(6-9-17)18-10-7-16(12-24-18)21-25-13-19(26-21)20-4-3-11-30-20/h3-13H,14H2,1-2H3,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...				Bioorg Med Chem Lett 19: 3485-8 (2009) BindingDB Entry DOI: 10.7270/Q28S4S76
					More data for this Ligand-Target Pair

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