Found 20 hits with Last Name = 'shinozuka' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370219
(CHEMBL610868)Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OC6[C@H](O)[C@@H](COP(O)(O)=O)OC6n6c(N=[N+]=[N-])nc7c(N)ncnc67)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r| Show InChI InChI=1S/C40H46N32O25P4/c41-25-13-29(53-5-49-25)69(37(57-13)61-65-45)33-21(77)17(73)9(91-33)2-88-99(81,82)96-23-19(75)11(93-35(23)71-31-15(27(43)51-7-55-31)59-39(71)63-67-47)4-90-101(85,86)97-24-20(76)12(94-36(24)72-32-16(28(44)52-8-56-32)60-40(72)64-68-48)3-89-100(83,84)95-22-18(74)10(1-87-98(78,79)80)92-34(22)70-30-14(26(42)50-6-54-30)58-38(70)62-66-46/h5-12,17-24,33-36,73-77H,1-4H2,(H,81,82)(H,83,84)(H,85,86)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)(H2,78,79,80)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22?,23-,24-,33?,34?,35?,36?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370220
(CHEMBL1163094)Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OC4C(O)C(COP(O)(=O)OC5C(O)C(COP(O)(O)=O)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r| Show InChI InChI=1S/C30H35N24O19P3/c31-19-10-22(40-4-37-19)52(28(43-10)46-49-34)25-16(58)13(55)7(69-25)2-67-75(62,63)73-18-15(57)9(71-27(18)54-24-12(21(33)39-6-42-24)45-30(54)48-51-36)3-68-76(64,65)72-17-14(56)8(1-66-74(59,60)61)70-26(17)53-23-11(20(32)38-5-41-23)44-29(53)47-50-35/h4-9,13-18,25-27,55-58H,1-3H2,(H,62,63)(H,64,65)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)(H2,59,60,61)/t7-,8?,9?,13-,14?,15?,16-,17?,18?,25?,26?,27?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50373177
(CHEMBL404038)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |w:25.27,15.17,35.37,39.41| Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50421415
(CHEMBL414948)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50366437
(CHEMBL608874)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27-,28-,29-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract |
Bioorg Med Chem Lett 6: 1785-1790 (1996)
Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370222
(CHEMBL610866)Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OC4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](CO)OC6n6c(N=[N+]=[N-])nc7c(N)ncnc67)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r| Show InChI InChI=1S/C40H45N32O22P3/c41-25-13-29(53-5-49-25)69(37(57-13)61-65-45)33-21(78)17(74)10(89-33)2-85-95(79,80)93-23-19(76)12(91-35(23)71-31-15(27(43)51-7-55-31)59-39(71)63-67-47)4-87-97(83,84)94-24-20(77)11(90-36(24)72-32-16(28(44)52-8-56-32)60-40(72)64-68-48)3-86-96(81,82)92-22-18(75)9(1-73)88-34(22)70-30-14(26(42)50-6-54-30)58-38(70)62-66-46/h5-12,17-24,33-36,73-78H,1-4H2,(H,79,80)(H,81,82)(H,83,84)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23?,24-,33?,34?,35?,36?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370227
(CHEMBL610609)Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)C(COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](CO)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r| Show InChI InChI=1S/C30H34N24O16P2/c31-19-10-22(40-4-37-19)52(28(43-10)46-49-34)25-16(59)13(56)8(67-25)2-64-71(60,61)70-18-15(58)9(68-27(18)54-24-12(21(33)39-6-42-24)45-30(54)48-51-36)3-65-72(62,63)69-17-14(57)7(1-55)66-26(17)53-23-11(20(32)38-5-41-23)44-29(53)47-50-35/h4-9,13-18,25-27,55-59H,1-3H2,(H,60,61)(H,62,63)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)/t7-,8-,9?,13-,14-,15-,16-,17-,18-,25?,26?,27?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370221
(CHEMBL610855)Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)OC4n4c(N)nc5c(N)ncnc45)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C40H54N24O25P4/c41-25-13-29(53-5-49-25)61(37(45)57-13)33-21(69)17(65)9(83-33)2-80-91(73,74)88-23-19(67)11(85-35(23)63-31-15(59-39(63)47)27(43)51-7-55-31)4-82-93(77,78)89-24-20(68)12(86-36(24)64-32-16(60-40(64)48)28(44)52-8-56-32)3-81-92(75,76)87-22-18(66)10(1-79-90(70,71)72)84-34(22)62-30-14(58-38(62)46)26(42)50-6-54-30/h5-12,17-24,33-36,65-69H,1-4H2,(H2,45,57)(H2,46,58)(H2,47,59)(H2,48,60)(H,73,74)(H,75,76)(H,77,78)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)(H2,70,71,72)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23-,24-,33?,34?,35?,36?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50366437
(CHEMBL608874)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27-,28-,29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate |
Bioorg Med Chem Lett 6: 1785-1790 (1996)
Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370224
(CHEMBL610867)Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OC2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)OC4n4c(N)nc5c(N)ncnc45)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C40H53N24O22P3/c41-25-13-29(53-5-49-25)61(37(45)57-13)33-21(70)17(66)10(81-33)2-77-87(71,72)85-23-19(68)12(83-35(23)63-31-15(59-39(63)47)27(43)51-7-55-31)4-79-89(75,76)86-24-20(69)11(82-36(24)64-32-16(60-40(64)48)28(44)52-8-56-32)3-78-88(73,74)84-22-18(67)9(1-65)80-34(22)62-30-14(58-38(62)46)26(42)50-6-54-30/h5-12,17-24,33-36,65-70H,1-4H2,(H2,45,57)(H2,46,58)(H2,47,59)(H2,48,60)(H,71,72)(H,73,74)(H,75,76)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23?,24-,33?,34?,35?,36?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370229
(CHEMBL607600)Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r| Show InChI InChI=1S/C20H24N16O13P2/c21-13-7-15(27-3-25-13)35(19(29-7)31-33-23)17-11(39)9(37)5(47-17)2-46-51(43,44)49-12-10(38)6(1-45-50(40,41)42)48-18(12)36-16-8(14(22)26-4-28-16)30-20(36)32-34-24/h3-6,9-12,17-18,37-39H,1-2H2,(H,43,44)(H2,21,25,27)(H2,22,26,28)(H2,40,41,42)/t5-,6-,9-,10-,11-,12-,17?,18?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50366438
(CHEMBL608875)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@@H]3n3cnc4c(N)ncnc34)O[C@@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27+,28+,29-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract |
Bioorg Med Chem Lett 6: 1785-1790 (1996)
Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50366436
(CHEMBL605454)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](COP(O)(=O)O[C@@H]3[C@@H](OP(O)(O)=O)O[C@@H]([C@@H]3O)n3cnc4c(N)ncnc34)O[C@@H]([C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-15(46)14(45)9(58-26)1-56-65(52,53)61-18-10(59-27(16(18)47)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)28(60-29(19)63-64(49,50)51)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17-,18-,19+,26?,27+,28+,29-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract |
Bioorg Med Chem Lett 6: 1785-1790 (1996)
Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50366436
(CHEMBL605454)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](COP(O)(=O)O[C@@H]3[C@@H](OP(O)(O)=O)O[C@@H]([C@@H]3O)n3cnc4c(N)ncnc34)O[C@@H]([C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-15(46)14(45)9(58-26)1-56-65(52,53)61-18-10(59-27(16(18)47)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)28(60-29(19)63-64(49,50)51)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17-,18-,19+,26?,27+,28+,29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate |
Bioorg Med Chem Lett 6: 1785-1790 (1996)
Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50366438
(CHEMBL608875)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@@H]3n3cnc4c(N)ncnc34)O[C@@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27+,28+,29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate |
Bioorg Med Chem Lett 6: 1785-1790 (1996)
Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370230
(CHEMBL610610)Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OC2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H41N18O19P3/c31-19-10-22(40-4-37-19)46(28(34)43-10)25-16(52)13(49)7(63-25)2-61-69(56,57)67-18-15(51)9(65-27(18)48-24-12(45-30(48)36)21(33)39-6-42-24)3-62-70(58,59)66-17-14(50)8(1-60-68(53,54)55)64-26(17)47-23-11(44-29(47)35)20(32)38-5-41-23/h4-9,13-18,25-27,49-52H,1-3H2,(H2,34,43)(H2,35,44)(H2,36,45)(H,56,57)(H,58,59)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)(H2,53,54,55)/t7-,8-,9-,13-,14-,15-,16-,17-,18?,25?,26?,27?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370228
(CHEMBL607882)Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r| Show InChI InChI=1S/C20H23N16O10P/c21-13-7-15(27-3-25-13)35(19(29-7)31-33-23)17-11(40)9(38)6(45-17)2-43-47(41,42)46-12-10(39)5(1-37)44-18(12)36-16-8(14(22)26-4-28-16)30-20(36)32-34-24/h3-6,9-12,17-18,37-40H,1-2H2,(H,41,42)(H2,21,25,27)(H2,22,26,28)/t5-,6-,9-,10-,11-,12-,17?,18?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370226
(CHEMBL607595)Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(P)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H41N18O15P3/c31-19-10-22(40-4-37-19)46(28(34)43-10)25-16(53)13(50)8(60-25)3-58-66(56,64)63-18-15(52)9(61-27(18)48-24-12(45-30(48)36)21(33)39-6-42-24)2-57-65(54,55)62-17-14(51)7(1-49)59-26(17)47-23-11(44-29(47)35)20(32)38-5-41-23/h4-9,13-18,25-27,49-53H,1-3,64H2,(H2,34,43)(H2,35,44)(H2,36,45)(H,54,55)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)/t7-,8-,9-,13-,14-,15-,16-,17-,18-,25?,26?,27?,66?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370223
(CHEMBL607888)Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](CO)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H27N12O10P/c21-13-7-15(27-3-25-13)31(19(23)29-7)17-11(36)9(34)6(41-17)2-39-43(37,38)42-12-10(35)5(1-33)40-18(12)32-16-8(30-20(32)24)14(22)26-4-28-16/h3-6,9-12,17-18,33-36H,1-2H2,(H2,23,29)(H2,24,30)(H,37,38)(H2,21,25,27)(H2,22,26,28)/t5-,6-,9-,10-,11-,12-,17?,18?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Mus musculus) | BDBM50370225
(CHEMBL608161)Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(O)=O)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H28N12O13P2/c21-13-7-15(27-3-25-13)31(19(23)29-7)17-11(35)9(33)5(43-17)2-42-47(39,40)45-12-10(34)6(1-41-46(36,37)38)44-18(12)32-16-8(30-20(32)24)14(22)26-4-28-16/h3-6,9-12,17-18,33-35H,1-2H2,(H2,23,29)(H2,24,30)(H,39,40)(H2,21,25,27)(H2,22,26,28)(H2,36,37,38)/t5-,6-,9-,10-,11-,12-,17?,18?/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver |
J Med Chem 46: 4926-32 (2003)
Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM |
More data for this
Ligand-Target Pair | |
Search and Browse
