Compile Data Set for Download or QSAR

Found 178 hits with Last Name = 'slade' and Initial = 'dj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 [11-552] (Homo sapiens (Human))	BDBM97666 (US8476295, 1.1.04) Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO |THB:14:12:8.9:6| Show InChI InChI=1S/C24H30N4O2/c1-16-2-3-17(10-24(16)30-9-8-29)15-28-21-5-6-22(28)13-20(12-21)26-19-4-7-23-18(11-19)14-25-27-23/h2-4,7,10-11,14,20-22,26,29H,5-6,8-9,12-13,15H2,1H3,(H,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	10	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [11-552] (Homo sapiens (Human))	BDBM97664 (US8476295, 1.1.02) Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1 |THB:14:12:8.9:6| Show InChI InChI=1S/C22H26N4/c1-15-2-4-16(5-3-15)14-26-20-7-8-21(26)12-19(11-20)24-18-6-9-22-17(10-18)13-23-25-22/h2-6,9-10,13,19-21,24H,7-8,11-12,14H2,1H3,(H,23,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	20	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [11-552] (Homo sapiens (Human))	BDBM97665 (US8476295, 1.1.03) Show SMILES OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1 |THB:18:16:12.13:10| Show InChI InChI=1S/C23H28N4O2/c28-8-9-29-22-3-1-2-16(10-22)15-27-20-5-6-21(27)13-19(12-20)25-18-4-7-23-17(11-18)14-24-26-23/h1-4,7,10-11,14,19-21,25,28H,5-6,8-9,12-13,15H2,(H,24,26)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	21	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [11-552] (Homo sapiens (Human))	BDBM97663 (US8476295, 1.1.01) Show SMILES C(N1C2CCC1CC(C2)Nc1ccc2[nH]ncc2c1)c1ccccc1 |THB:9:7:3.4:1| Show InChI InChI=1S/C21H24N4/c1-2-4-15(5-3-1)14-25-19-7-8-20(25)12-18(11-19)23-17-6-9-21-16(10-17)13-22-24-21/h1-6,9-10,13,18-20,23H,7-8,11-12,14H2,(H,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	29	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [17-535] (Homo Sapiens (Human))	BDBM97666 (US8476295, 1.1.04) Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO |THB:14:12:8.9:6| Show InChI InChI=1S/C24H30N4O2/c1-16-2-3-17(10-24(16)30-9-8-29)15-28-21-5-6-22(28)13-20(12-21)26-19-4-7-23-18(11-19)14-25-27-23/h2-4,7,10-11,14,20-22,26,29H,5-6,8-9,12-13,15H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	35	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [17-535] (Homo Sapiens (Human))	BDBM97665 (US8476295, 1.1.03) Show SMILES OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1 |THB:18:16:12.13:10| Show InChI InChI=1S/C23H28N4O2/c28-8-9-29-22-3-1-2-16(10-22)15-27-20-5-6-21(27)13-19(12-20)25-18-4-7-23-17(11-18)14-24-26-23/h1-4,7,10-11,14,19-21,25,28H,5-6,8-9,12-13,15H2,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	59	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [17-535] (Homo Sapiens (Human))	BDBM97663 (US8476295, 1.1.01) Show SMILES C(N1C2CCC1CC(C2)Nc1ccc2[nH]ncc2c1)c1ccccc1 |THB:9:7:3.4:1| Show InChI InChI=1S/C21H24N4/c1-2-4-15(5-3-1)14-25-19-7-8-20(25)12-18(11-19)23-17-6-9-21-16(10-17)13-22-24-21/h1-6,9-10,13,18-20,23H,7-8,11-12,14H2,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	72	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [17-535] (Homo Sapiens (Human))	BDBM97664 (US8476295, 1.1.02) Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1 |THB:14:12:8.9:6| Show InChI InChI=1S/C22H26N4/c1-15-2-4-16(5-3-15)14-26-20-7-8-21(26)12-19(11-20)24-18-6-9-22-17(10-18)13-23-25-22/h2-6,9-10,13,19-21,24H,7-8,11-12,14H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	91	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [11-552] (Homo sapiens (Human))	BDBM97667 (US8476295, 2.1.01) Show SMILES C(N1C2CCC1CC(C2)Nc1cccc2[nH]ncc12)c1ccccc1 |THB:9:7:3.4:1| Show InChI InChI=1S/C23H25N3/c1-2-5-17(6-3-1)16-26-20-9-10-21(26)14-19(13-20)25-23-8-4-7-18-15-24-12-11-22(18)23/h1-8,11-12,15,19-21,25H,9-10,13-14,16H2	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	220	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 [11-552] (Homo sapiens (Human))	BDBM97668 (US8476295, 3.1.01) Show SMILES C(N1CC2CCC1C2Nc1ccc2[nH]ncc2c1)c1ccccc1 |TLB:0:1:5.4:7,8:7:1.2:5.4| Show InChI InChI=1S/C20H22N4/c1-2-4-14(5-3-1)12-24-13-15-6-9-19(24)20(15)22-17-7-8-18-16(10-17)11-21-23-18/h1-5,7-8,10-11,15,19-20,22H,6,9,12-13H2,(H,21,23)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	464	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [17-535] (Homo Sapiens (Human))	BDBM97667 (US8476295, 2.1.01) Show SMILES C(N1C2CCC1CC(C2)Nc1cccc2[nH]ncc12)c1ccccc1 |THB:9:7:3.4:1| Show InChI InChI=1S/C23H25N3/c1-2-5-17(6-3-1)16-26-20-9-10-21(26)14-19(13-20)25-23-8-4-7-18-15-24-12-11-22(18)23/h1-8,11-12,15,19-21,25H,9-10,13-14,16H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	806	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [17-535] (Homo Sapiens (Human))	BDBM97668 (US8476295, 3.1.01) Show SMILES C(N1CC2CCC1C2Nc1ccc2[nH]ncc2c1)c1ccccc1 |TLB:0:1:5.4:7,8:7:1.2:5.4| Show InChI InChI=1S/C20H22N4/c1-2-4-14(5-3-1)12-24-13-15-6-9-19(24)20(15)22-17-7-8-18-16(10-17)11-21-23-18/h1-5,7-8,10-11,15,19-20,22H,6,9,12-13H2,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	976	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107901 (US8604218, 1.052) Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccc2occc2c1 Show InChI InChI=1S/C21H22N4O/c1-2-19(23-18-4-5-20-17(11-18)12-22-24-20)14-25(8-1)13-15-3-6-21-16(10-15)7-9-26-21/h3-7,9-12,19,23H,1-2,8,13-14H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.3	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107948 (US8604218, 1.099) Show SMILES NC(=O)Cn1ccc2ccc(CN3CCCC(C3)Nc3ccc4[nH]ncc4c3)cc12 Show InChI InChI=1S/C23H26N6O/c24-23(30)15-29-9-7-17-4-3-16(10-22(17)29)13-28-8-1-2-20(14-28)26-19-5-6-21-18(11-19)12-25-27-21/h3-7,9-12,20,26H,1-2,8,13-15H2,(H2,24,30)(H,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25.8	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107938 (US8604218, 1.089) Show SMILES Nc1cc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)ccc1Cl Show InChI InChI=1S/C19H22ClN5/c20-17-5-3-13(8-18(17)21)11-25-7-1-2-16(12-25)23-15-4-6-19-14(9-15)10-22-24-19/h3-6,8-10,16,23H,1-2,7,11-12,21H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.4	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM108011 (US8604218, 2.025) Show SMILES Cc1ccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)cc1 |r| Show InChI InChI=1S/C21H23N3/c1-16-5-7-17(8-6-16)14-24-12-10-19(15-24)23-21-4-2-3-18-13-22-11-9-20(18)21/h2-9,11,13,19,23H,10,12,14-15H2,1H3/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.9	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107930 (US8604218, 1.081) Show SMILES Clc1ccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C19H21ClN4/c20-16-5-3-14(4-6-16)12-24-9-1-2-18(13-24)22-17-7-8-19-15(10-17)11-21-23-19/h3-8,10-11,18,22H,1-2,9,12-13H2,(H,21,23)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.1	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107931 (US8604218, 1.082) Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C21H23N5/c1-2-19(24-18-5-6-20-17(11-18)12-23-25-20)14-26(9-1)13-15-3-4-16-7-8-22-21(16)10-15/h3-8,10-12,19,22,24H,1-2,9,13-14H2,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.4	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107908 (US8604218, 1.059) Show SMILES Cc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1O Show InChI InChI=1S/C20H24N4O/c1-14-4-5-15(9-20(14)25)12-24-8-2-3-18(13-24)22-17-6-7-19-16(10-17)11-21-23-19/h4-7,9-11,18,22,25H,2-3,8,12-13H2,1H3,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107951 (US8604218, 1.102) Show SMILES CS(=O)(=O)Nc1cc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)ccc1Cl Show InChI InChI=1S/C20H24ClN5O2S/c1-29(27,28)25-20-9-14(4-6-18(20)21)12-26-8-2-3-17(13-26)23-16-5-7-19-15(10-16)11-22-24-19/h4-7,9-11,17,23,25H,2-3,8,12-13H2,1H3,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34.3	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107949 (US8604218, 1.100) Show SMILES C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C21H23N5/c1-2-19(24-18-4-6-21-17(11-18)12-23-25-21)14-26(9-1)13-15-3-5-20-16(10-15)7-8-22-20/h3-8,10-12,19,22,24H,1-2,9,13-14H2,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	42.9	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107907 (US8604218, 1.058) Show SMILES Cc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1OCCO Show InChI InChI=1S/C22H28N4O2/c1-16-4-5-17(11-22(16)28-10-9-27)14-26-8-2-3-20(15-26)24-19-6-7-21-18(12-19)13-23-25-21/h4-7,11-13,20,24,27H,2-3,8-10,14-15H2,1H3,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	47.5	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107940 (US8604218, 1.091) Show SMILES CS(=O)(=O)Nc1cccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)c1 |r| Show InChI InChI=1S/C20H25N5O2S/c1-28(26,27)24-18-5-2-4-15(10-18)13-25-9-3-6-19(14-25)22-17-7-8-20-16(11-17)12-21-23-20/h2,4-5,7-8,10-12,19,22,24H,3,6,9,13-14H2,1H3,(H,21,23)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	49.4	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107926 (US8604218, 1.077) Show SMILES C#Cc1ccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C21H22N4/c1-2-16-5-7-17(8-6-16)14-25-11-3-4-20(15-25)23-19-9-10-21-18(12-19)13-22-24-21/h1,5-10,12-13,20,23H,3-4,11,14-15H2,(H,22,24)/t20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	53.1	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107896 (US8604218, 1.047) Show SMILES C#Cc1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1 Show InChI InChI=1S/C21H22N4/c1-2-16-5-3-6-17(11-16)14-25-10-4-7-20(15-25)23-19-8-9-21-18(12-19)13-22-24-21/h1,3,5-6,8-9,11-13,20,23H,4,7,10,14-15H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107921 (US8604218, 1.072) Show SMILES Fc1ccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)cc1F |r| Show InChI InChI=1S/C19H20F2N4/c20-17-5-3-13(8-18(17)21)11-25-7-1-2-16(12-25)23-15-4-6-19-14(9-15)10-22-24-19/h3-6,8-10,16,23H,1-2,7,11-12H2,(H,22,24)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	58.5	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107973 (US8604218, 1.124) Show SMILES CCS(=O)(=O)Nc1cccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)c1 |r| Show InChI InChI=1S/C21H27N5O2S/c1-2-29(27,28)25-19-6-3-5-16(11-19)14-26-10-4-7-20(15-26)23-18-8-9-21-17(12-18)13-22-24-21/h3,5-6,8-9,11-13,20,23,25H,2,4,7,10,14-15H2,1H3,(H,22,24)/t20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	59.2	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107900 (US8604218, 1.051) Show SMILES CS(=O)(=O)Nc1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1 Show InChI InChI=1S/C20H25N5O2S/c1-28(26,27)24-18-5-2-4-15(10-18)13-25-9-3-6-19(14-25)22-17-7-8-20-16(11-17)12-21-23-20/h2,4-5,7-8,10-12,19,22,24H,3,6,9,13-14H2,1H3,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.6	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107927 (US8604218, 1.078) Show SMILES Cc1ccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C20H24N4/c1-15-4-6-16(7-5-15)13-24-10-2-3-19(14-24)22-18-8-9-20-17(11-18)12-21-23-20/h4-9,11-12,19,22H,2-3,10,13-14H2,1H3,(H,21,23)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	63.1	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107857 (US8604218, 1.008) Show SMILES CSc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C20H24N4S/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.8	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107950 (US8604218, 1.101) Show SMILES OCCn1ccc2ccc(CN3CCCC(C3)Nc3ccc4[nH]ncc4c3)cc12 Show InChI InChI=1S/C23H27N5O/c29-11-10-28-9-7-18-4-3-17(12-23(18)28)15-27-8-1-2-21(16-27)25-20-5-6-22-19(13-20)14-24-26-22/h3-7,9,12-14,21,25,29H,1-2,8,10-11,15-16H2,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	68.5	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107883 (US8604218, 1.034) Show SMILES C#Cc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H22N4/c1-2-16-5-7-17(8-6-16)14-25-11-3-4-20(15-25)23-19-9-10-21-18(12-19)13-22-24-21/h1,5-10,12-13,20,23H,3-4,11,14-15H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	69.1	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107955 (US8604218, 1.106) Show SMILES NC(=O)Cn1ccc2ccc(CN3CCC[C@H](C3)Nc3ccc4[nH]ncc4c3)cc12 |r| Show InChI InChI=1S/C23H26N6O/c24-23(30)15-29-9-7-17-4-3-16(10-22(17)29)13-28-8-1-2-20(14-28)26-19-5-6-21-18(11-19)12-25-27-21/h3-7,9-12,20,26H,1-2,8,13-15H2,(H2,24,30)(H,25,27)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	69.2	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107886 (US8604218, 1.037) Show SMILES C=Cc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H24N4/c1-2-16-5-7-17(8-6-16)14-25-11-3-4-20(15-25)23-19-9-10-21-18(12-19)13-22-24-21/h2,5-10,12-13,20,23H,1,3-4,11,14-15H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	69.5	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107923 (US8604218, 1.074) Show SMILES CSc1ccc(CN2CCC[C@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C20H24N4S/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	71.6	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107992 (US8604218, 2.006) Show SMILES C(N1CCC(C1)Nc1cccc2cnccc12)c1ccccc1 Show InChI InChI=1S/C20H21N3/c1-2-5-16(6-3-1)14-23-12-10-18(15-23)22-20-8-4-7-17-13-21-11-9-19(17)20/h1-9,11,13,18,22H,10,12,14-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73.9	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107924 (US8604218, 1.075) Show SMILES CSc1ccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C20H24N4S/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	74.5	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107882 (US8604218, 1.033) Show SMILES CCc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H26N4/c1-2-16-5-7-17(8-6-16)14-25-11-3-4-20(15-25)23-19-9-10-21-18(12-19)13-22-24-21/h5-10,12-13,20,23H,2-4,11,14-15H2,1H3,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	86.9	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM108017 (US8604218, 2.031) Show SMILES C#Cc1ccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)cc1 |r| Show InChI InChI=1S/C22H21N3/c1-2-17-6-8-18(9-7-17)15-25-13-11-20(16-25)24-22-5-3-4-19-14-23-12-10-21(19)22/h1,3-10,12,14,20,24H,11,13,15-16H2/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	87.1	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107909 (US8604218, 1.060) Show SMILES CCOC(=O)COc1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1 Show InChI InChI=1S/C23H28N4O3/c1-2-29-23(28)16-30-21-7-3-5-17(11-21)14-27-10-4-6-20(15-27)25-19-8-9-22-18(12-19)13-24-26-22/h3,5,7-9,11-13,20,25H,2,4,6,10,14-16H2,1H3,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	87.2	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107987 (US8604218, 2.001) Show SMILES COc1ccc(CN2CCCC(C2)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C22H25N3O/c1-26-20-9-7-17(8-10-20)15-25-13-3-5-19(16-25)24-22-6-2-4-18-14-23-12-11-21(18)22/h2,4,6-12,14,19,24H,3,5,13,15-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	98.8	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107942 (US8604218, 1.093) Show SMILES CS(=O)(=O)Nc1cccc(CN2CCC[C@H](C2)Nc2ccc3[nH]ncc3c2)c1 |r| Show InChI InChI=1S/C20H25N5O2S/c1-28(26,27)24-18-5-2-4-15(10-18)13-25-9-3-6-19(14-25)22-17-7-8-20-16(11-17)12-21-23-20/h2,4-5,7-8,10-12,19,22,24H,3,6,9,13-14H2,1H3,(H,21,23)/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	101	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM108025 (US8604218, 2.039) Show SMILES OCCOc1cccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)c1 |r| Show InChI InChI=1S/C22H25N3O2/c26-11-12-27-20-5-1-3-17(13-20)15-25-10-8-19(16-25)24-22-6-2-4-18-14-23-9-7-21(18)22/h1-7,9,13-14,19,24,26H,8,10-12,15-16H2/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	101	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107928 (US8604218, 1.079) Show SMILES COc1ccc(CN2CCC[C@@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C20H24N4O/c1-25-19-7-4-15(5-8-19)13-24-10-2-3-18(14-24)22-17-6-9-20-16(11-17)12-21-23-20/h4-9,11-12,18,22H,2-3,10,13-14H2,1H3,(H,21,23)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	102	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107873 (US8604218, 1.024) Show SMILES Cc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c(C)c1 Show InChI InChI=1S/C21H26N4/c1-15-5-6-17(16(2)10-15)13-25-9-3-4-20(14-25)23-19-7-8-21-18(11-19)12-22-24-21/h5-8,10-12,20,23H,3-4,9,13-14H2,1-2H3,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	107	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107953 (US8604218, 1.104) Show SMILES OCCN1CCc2ccc(CN3CCCC(C3)Nc3ccc4[nH]ncc4c3)cc12 Show InChI InChI=1S/C23H29N5O/c29-11-10-28-9-7-18-4-3-17(12-23(18)28)15-27-8-1-2-21(16-27)25-20-5-6-22-19(13-20)14-24-26-22/h3-6,12-14,21,25,29H,1-2,7-11,15-16H2,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	107	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107969 (US8604218, 1.120) Show SMILES CCS(=O)(=O)Nc1cccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)c1 Show InChI InChI=1S/C21H27N5O2S/c1-2-29(27,28)25-19-6-3-5-16(11-19)14-26-10-4-7-20(15-26)23-18-8-9-21-17(12-18)13-22-24-21/h3,5-6,8-9,11-13,20,23,25H,2,4,7,10,14-15H2,1H3,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107922 (US8604218, 1.073) Show SMILES Fc1ccc(CN2CCC[C@H](C2)Nc2ccc3[nH]ncc3c2)cc1F |r| Show InChI InChI=1S/C19H20F2N4/c20-17-5-3-13(8-18(17)21)11-25-7-1-2-16(12-25)23-15-4-6-19-14(9-15)10-22-24-19/h3-6,8-10,16,23H,1-2,7,11-12H2,(H,22,24)/t16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	111	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM107925 (US8604218, 1.076) Show SMILES C#Cc1ccc(CN2CCC[C@H](C2)Nc2ccc3[nH]ncc3c2)cc1 |r| Show InChI InChI=1S/C21H22N4/c1-2-16-5-7-17(8-6-16)14-25-11-3-4-20(15-25)23-19-9-10-21-18(12-19)13-22-24-21/h1,5-10,12-13,20,23H,3-4,11,14-15H2,(H,22,24)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	111	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM108024 (US8604218, 2.038) Show SMILES CS(=O)(=O)Nc1cccc(CN2CC[C@H](C2)Nc2cccc3cnccc23)c1 |r| Show InChI InChI=1S/C21H24N4O2S/c1-28(26,27)24-18-6-2-4-16(12-18)14-25-11-9-19(15-25)23-21-7-3-5-17-13-22-10-8-20(17)21/h2-8,10,12-13,19,23-24H,9,11,14-15H2,1H3/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	112	n/a	n/a	n/a	n/a	7.2	n/a
Inspire Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemi...				US Patent US8604218 (2013) BindingDB Entry DOI: 10.7270/Q2319TJD
					More data for this Ligand-Target Pair

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