Found 20 hits with Last Name = 'stolyar' and Initial = 'p' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120991
(CHEMBL3621444)Show InChI InChI=1S/C16H28N4O4/c1-16(2,3)10-11(21)17-12-13(23-6)18-15(19-14(12)24-7)20(4)8-9-22-5/h8-10H2,1-7H3,(H,17,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 206 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121057
(CHEMBL3621443)Show InChI InChI=1S/C16H26N4O4/c1-16(2,3)10-11(21)17-12-13(22-4)18-15(19-14(12)23-5)20-6-8-24-9-7-20/h6-10H2,1-5H3,(H,17,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 164 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120993
(CHEMBL3621446)Show SMILES COC1CN(C1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C16H26N4O4/c1-16(2,3)7-11(21)17-12-13(23-5)18-15(19-14(12)24-6)20-8-10(9-20)22-4/h10H,7-9H2,1-6H3,(H,17,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 961 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120994
(CHEMBL3621447)Show SMILES [H][C@]12CN(c3nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n3)[C@]([H])(CO1)C2 |r| Show InChI InChI=1S/C17H26N4O4/c1-17(2,3)7-12(22)18-13-14(23-4)19-16(20-15(13)24-5)21-8-11-6-10(21)9-25-11/h10-11H,6-9H2,1-5H3,(H,18,22)/t10-,11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120995
(CHEMBL3621448)Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CC2(COC2)C1 Show InChI InChI=1S/C17H26N4O4/c1-16(2,3)6-11(22)18-12-13(23-4)19-15(20-14(12)24-5)21-7-17(8-21)9-25-10-17/h6-10H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.19E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120996
(CHEMBL3621449)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CCC2CCCC2)c(OC)n1 Show InChI InChI=1S/C20H32N4O4/c1-26-15-10-12-24(13-11-15)20-22-18(27-2)17(19(23-20)28-3)21-16(25)9-8-14-6-4-5-7-14/h14-15H,4-13H2,1-3H3,(H,21,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120997
(CHEMBL3621795)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC2CCCCC2)c(OC)n1 Show InChI InChI=1S/C20H32N4O4/c1-26-15-9-11-24(12-10-15)20-22-18(27-2)17(19(23-20)28-3)21-16(25)13-14-7-5-4-6-8-14/h14-15H,4-13H2,1-3H3,(H,21,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 162 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120998
(CHEMBL3621796)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CCC(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-12(2)6-7-14(23)19-15-16(25-4)20-18(21-17(15)26-5)22-10-8-13(24-3)9-11-22/h12-13H,6-11H2,1-5H3,(H,19,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 304 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120999
(CHEMBL3621797)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC2CCCC2)c(OC)n1 Show InChI InChI=1S/C19H30N4O4/c1-25-14-8-10-23(11-9-14)19-21-17(26-2)16(18(22-19)27-3)20-15(24)12-13-6-4-5-7-13/h13-14H,4-12H2,1-3H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 343 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121050
(CHEMBL3621798)Show InChI InChI=1S/C17H28N4O4/c1-11(2)10-13(22)18-14-15(24-4)19-17(20-16(14)25-5)21-8-6-12(23-3)7-9-21/h11-12H,6-10H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 630 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 4
(Homo sapiens (Human)) | BDBM50121051
(CHEMBL3621437)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 625 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.4 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily E/KQT member 1
(Homo sapiens (Human)) | BDBM50121051
(CHEMBL3621437)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 4
(Rattus norvegicus) | BDBM50121051
(CHEMBL3621437)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 376 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of rat Kv7.4 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121051
(CHEMBL3621437)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 334 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121052
(CHEMBL3621438)Show InChI InChI=1S/C16H26N4O3S/c1-16(2,3)10-11(21)17-12-13(22-4)18-15(19-14(12)23-5)20-6-8-24-9-7-20/h6-10H2,1-5H3,(H,17,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121053
(CHEMBL3621439)Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CCC(F)(F)CC1 Show InChI InChI=1S/C17H26F2N4O3/c1-16(2,3)10-11(24)20-12-13(25-4)21-15(22-14(12)26-5)23-8-6-17(18,19)7-9-23/h6-10H2,1-5H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121054
(CHEMBL3621440)Show InChI InChI=1S/C17H28N4O4/c1-17(2,3)11-12(22)18-13-14(23-4)19-16(20-15(13)24-5)21-7-6-9-25-10-8-21/h6-11H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 62 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121055
(CHEMBL3621441)Show InChI InChI=1S/C17H28N4O3/c1-17(2,3)11-12(22)18-13-14(23-4)19-16(20-15(13)24-5)21-9-7-6-8-10-21/h6-11H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121056
(CHEMBL3621442)Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CC(F)(F)C1 Show InChI InChI=1S/C15H22F2N4O3/c1-14(2,3)6-9(22)18-10-11(23-4)19-13(20-12(10)24-5)21-7-15(16,17)8-21/h6-8H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120992
(CHEMBL3621445)Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CCC(CC1)OC(C)C Show InChI InChI=1S/C20H34N4O4/c1-13(2)28-14-8-10-24(11-9-14)19-22-17(26-6)16(18(23-19)27-7)21-15(25)12-20(3,4)5/h13-14H,8-12H2,1-7H3,(H,21,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 358 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
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