Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine deaminase (Homo sapiens (Human)) | BDBM22925 ((8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PubMed | 0.00250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminase. | J Med Chem 26: 1478-82 (1983) Checked by Author BindingDB Entry DOI: 10.7270/Q29Z95GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Homo sapiens (Human)) | BDBM50367032 (COFORMYCIN) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PubMed | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminase | J Med Chem 26: 1478-82 (1983) Checked by Author BindingDB Entry DOI: 10.7270/Q29Z95GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
6-phosphogluconate dehydrogenase, decarboxylating (Trypanosoma brucei brucei (strain 927/4 GUTat10.1)) | BDBM50148767 (2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrog...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase | Bioorg Med Chem Lett 21: 2679-82 (2011) Article DOI: 10.1016/j.bmcl.2010.12.066 BindingDB Entry DOI: 10.7270/Q20C4W2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Bos taurus (bovine)) | BDBM50028153 (3-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of adenosine deaminase in calf intestinal mucosa | J Med Chem 26: 1478-82 (1983) Checked by Author BindingDB Entry DOI: 10.7270/Q29Z95GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
6-phosphogluconate dehydrogenase, decarboxylating (Trypanosoma brucei brucei (strain 927/4 GUTat10.1)) | BDBM50148780 (((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dio...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase | Bioorg Med Chem Lett 21: 2679-82 (2011) Article DOI: 10.1016/j.bmcl.2010.12.066 BindingDB Entry DOI: 10.7270/Q20C4W2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
6-phosphogluconate dehydrogenase, decarboxylating (Trypanosoma brucei brucei (strain 927/4 GUTat10.1)) | BDBM50148765 (1-(hydroxyamino)-1-oxo-4-(phosphonooxy)butane-2,3-...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase | Bioorg Med Chem Lett 21: 2679-82 (2011) Article DOI: 10.1016/j.bmcl.2010.12.066 BindingDB Entry DOI: 10.7270/Q20C4W2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Bos taurus (bovine)) | BDBM50028156 (3-(2-Hydroxy-ethoxymethyl)-3,6,7,8-tetrahydro-imid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of adenosine deaminase in calf intestinal mucosa | J Med Chem 26: 1478-82 (1983) Checked by Author BindingDB Entry DOI: 10.7270/Q29Z95GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-6-phosphate isomerase (Oryctolagus cuniculus) | BDBM50342610 ((2R,3R,4S)-2,3,4-trihydroxy-5-(hydroxyamino)-5-oxo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of rabbit cytosolic phosphoglucose isomerase | Bioorg Med Chem Lett 21: 2679-82 (2011) Article DOI: 10.1016/j.bmcl.2010.12.066 BindingDB Entry DOI: 10.7270/Q20C4W2K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50450976 (CHEMBL4210672) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 123 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as reduction in acetylcholine-induced peak current at -60... | Bioorg Med Chem Lett 27: 4350-4353 (2017) Article DOI: 10.1016/j.bmcl.2017.08.025 BindingDB Entry DOI: 10.7270/Q2H70JDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238185 (US9394303, 57) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | 130 | -39.3 | 670 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013865 (CHEMBL3265297) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013867 (CHEMBL3265299) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238190 (US9394303, 16) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 210 | -38.1 | 1.11E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013891 (CHEMBL3260032) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013866 (CHEMBL3265298) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238186 (US9394303, 58) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 250 | -37.7 | 1.28E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238181 (US9394303, 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 290 | -37.3 | 1.52E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013868 (CHEMBL3265300) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
6-phosphogluconate dehydrogenase, decarboxylating (Ovis aries) | BDBM50148765 (1-(hydroxyamino)-1-oxo-4-(phosphonooxy)butane-2,3-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of sheep 6-phosphogluconate dehydrogenase | Bioorg Med Chem Lett 21: 2679-82 (2011) Article DOI: 10.1016/j.bmcl.2010.12.066 BindingDB Entry DOI: 10.7270/Q20C4W2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013862 (CHEMBL3265294) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013863 (CHEMBL3265295) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238192 (US9394303, 18) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 490 | -36.0 | 2.54E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM53290 (2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynapht...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013838 (CHEMBL3260042) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013861 (CHEMBL3235895) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013845 (CHEMBL3265290) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238187 (US9394303, 59) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 820 | -34.7 | 4.27E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM53262 (2-[4-[(4-chlorophenyl)sulfonylamino]-1-hydroxynaph...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238196 (US9394303, 62) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 880 | -34.6 | 4.51E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238184 (US9394303, 56) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 900 | -34.5 | 4.68E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013882 (CHEMBL3265313) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013844 (CHEMBL3235886) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-related protein A1 (Homo sapiens (Human)) | BDBM50013865 (CHEMBL3265297) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged A1-BFL-1 (1 to 151) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluoresce... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013883 (CHEMBL3260033) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238191 (US9394303, 17) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.21E+3 | -33.8 | 6.30E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238195 (US9394303, 61) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30E+3 | -33.6 | 6.76E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 2 (Homo sapiens (Human)) | BDBM50013865 (CHEMBL3265297) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238182 (US9394303, 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40E+3 | -33.4 | 7.30E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238180 (US9394303, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40E+3 | -33.4 | 7.30E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Bos taurus (bovine)) | BDBM50028152 (5-Ethyl-3-(4-hydroxy-5-hydroxymethyl-tetrahydro-fu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of adenosine deaminase in calf intestinal mucosa | J Med Chem 26: 1478-82 (1983) Checked by Author BindingDB Entry DOI: 10.7270/Q29Z95GT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
6-phosphogluconate dehydrogenase, decarboxylating (Trypanosoma brucei brucei (strain 927/4 GUTat10.1)) | BDBM50148769 ((R)-Phosphoric acid mono-((R)-3-carbamoyl-2,3-dihy...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase | Bioorg Med Chem Lett 21: 2679-82 (2011) Article DOI: 10.1016/j.bmcl.2010.12.066 BindingDB Entry DOI: 10.7270/Q20C4W2K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mus musculus (Mouse)) | BDBM238194 (US9394303, 60) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.53E+3 | -33.2 | 7.97E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013860 (CHEMBL3265293) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013839 (CHEMBL2030270) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM52608 (2-[4-[(4-ethylphenyl)sulfonylamino]-1-hydroxynapht...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 2 (Homo sapiens (Human)) | BDBM50013867 (CHEMBL3265299) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013879 (CHEMBL3265310) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 2 (Homo sapiens (Human)) | BDBM50013862 (CHEMBL3265294) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence ... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apoptosis regulator Bcl-2 (Mus musculus (Mouse)) | BDBM238185 (US9394303, 57) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | 1.95E+3 | -32.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t... | US Patent US9394303 (2016) BindingDB Entry DOI: 10.7270/Q2RJ4HCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50013864 (CHEMBL3265296) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Displacement of Flu-BID/FAM-BID from His-tagged MCL1 (171 to 327) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescenc... | J Med Chem 57: 4111-33 (2014) Article DOI: 10.1021/jm500010b BindingDB Entry DOI: 10.7270/Q20003NC | |||||||||||
More data for this Ligand-Target Pair |
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